Standard name Systematic name Name description Description
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
Visualize the interactome of RPN4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.758 0.841 0.841
Mito 0.258 0.122 0.155
Vac/Vac Memb NaN 0.079 NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus low signal

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
RPN4 17 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 10 3 7 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Dosage Rescue, Synthetic Growth Defect
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 9 2 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 9 2 6 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 8 2 8 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 8 3 6 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
IRE1 YHR079C Serine-threonine kinase and endoribonuclease genetic 8 3 6 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 8 2 6 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 8 2 6 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 7 3 7 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Negative Genetic, Negative Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 7 3 6 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Negative Genetic
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 7 2 6 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 7 1 6 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 7 3 5 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
PBA1 YLR199C Protein involved in 20S proteasome assembly genetic 7 2 5 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 7 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 7 3 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
POL32 YJR043C Third subunit of DNA polymerase delta genetic 7 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 6 3 6 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
ADD66 YKL206C Protein involved in 20S proteasome assembly genetic 6 2 5 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
PHO80 YOL001W Cyclin genetic 6 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 6 2 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 6 2 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 6 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
EMC1 YCL045C Member of conserved endoplasmic reticulum membrane complex genetic 6 3 4 Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 6 3 4 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Negative Genetic, Negative Genetic
EMC2 YJR088C Member of conserved ER transmembrane complex genetic 6 3 4 Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic
SRC1 YML034W Inner nuclear membrane protein genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 5 3 5 Negative Genetic, Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 5 3 5 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 5 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 5 2 5 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 5 2 5 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 5 2 5 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 5 2 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 5 2 5 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 5 2 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 5 2 5 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 5 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 5 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 5 3 4 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) physical 5 3 4 Affinity Capture-Western, Reconstituted Complex, Biochemical Activity, Biochemical Activity, Reconstituted Complex
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 5 3 4 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 5 2 4 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression
CTF4 YPR135W Chromatin-associated protein genetic 5 2 4 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 5 2 4 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 5 2 4 Positive Genetic, Positive Genetic, Positive Genetic, Phenotypic Enhancement, Positive Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 5 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
EMC4 YGL231C Member of conserved ER transmembrane complex genetic 5 2 3 Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic
ENV9 YOR246C Conserved oxidoreductase involved in lipid droplet morphology genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 4 3 4 Negative Genetic, Dosage Rescue, Dosage Rescue, Synthetic Lethality
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 4 3 4 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
BLM10 YFL007W Proteasome activator genetic 4 3 4 Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic
ESC2 YDR363W Sumo-like domain protein genetic 4 3 4 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 4 3 4 Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression, Negative Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 4 3 4 Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
HSM3 YBR272C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 4 2 4 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 4 2 4 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 4 2 4 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 4 2 4 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD51 YER095W Strand exchange protein genetic 4 3 3 Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic, Phenotypic Enhancement
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 4 3 3 Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 4 3 3 Positive Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 4 3 3 Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Negative Genetic
EMC3 YKL207W Member of conserved ER transmembrane complex genetic 4 3 3 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family genetic 4 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
CNB1 YKL190W Calcineurin B genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 4 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 4 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 4 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
EMC6 YLL014W Member of conserved ER transmembrane complex genetic 4 2 3 Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DGK1 YOR311C Diacylglycerol kinase genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 3 3 3 Synthetic Growth Defect, Negative Genetic, Positive Genetic
SWI6 YLR182W Transcription cofactor genetic 3 3 3 Phenotypic Suppression, Synthetic Growth Defect, Positive Genetic
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
IKI3 YLR384C Subunit of Elongator complex genetic 3 2 3 Phenotypic Enhancement, Negative Genetic, Negative Genetic
RPA49 YNL248C RNA polymerase I subunit A49 genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 3 2 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 3 2 3 Positive Genetic, Negative Genetic, Negative Genetic
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
HIR1 YBL008W Subunit of the HIR complex genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
RTT106 YNL206C Histone chaperone genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
TRM9 YML014W tRNA methyltransferase genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
NSI1 YDR026C RNA polymerase I termination factor genetic 3 2 3 Phenotypic Enhancement, Negative Genetic, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
KSP1 YHR082C Serine/threonine protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
NNF2 YGR089W Protein that exhibits physical and genetic interactions with Rpb8p genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SAC3 YDR159W mRNA export factor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SKI3 YPR189W Ski complex component and TPR protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RRP6 YOR001W Nuclear exosome exonuclease component genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor physical 3 2 2 Affinity Capture-Western, Co-fractionation, Affinity Capture-Western
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 3 2 2 Phenotypic Suppression, Phenotypic Suppression, Negative Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 3 2 2 Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 3 2 2 Negative Genetic, Positive Genetic, Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 3 2 2 Synthetic Rescue, Negative Genetic, Negative Genetic
SNN1 YNL086W Subunit of the BLOC-1 complex involved in endosomal maturation genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Growth Defect
SWC5 YBR231C Component of the SWR1 complex genetic 3 2 2 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 3 2 2 Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 3 2 2 Dosage Rescue, Negative Genetic, Negative Genetic
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 3 2 2 Negative Genetic, Negative Genetic, Dosage Rescue
ERG2 YMR202W C-8 sterol isomerase genetic 3 2 2 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement
RPL21B YPL079W Ribosomal 60S subunit protein L21B genetic 3 2 2 Negative Genetic, Negative Genetic, Phenotypic Suppression
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CAF130 YGR134W Subunit of the CCR4-NOT transcriptional regulatory complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL2A YFR031C-A Ribosomal 60S subunit protein L2A genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FAR11 YNL127W Protein involved in recovery from cell cycle arrest genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FAR7 YFR008W Protein involved in recovery from pheromone-induced cell cycle arrest genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HUL5 YGL141W Multiubiquitin chain assembly factor (E4) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RAS2 YNL098C GTP-binding protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FAR3 YMR052W Protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GDS1 YOR355W Protein involved in histone H4 acetylation at ribosomal protein genes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL9B YNL067W Ribosomal 60S subunit protein L9B genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YNR021W YNR021W Putative protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL8A YHL033C Ribosomal 60S subunit protein L8A genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HLJ1 YMR161W Co-chaperone for Hsp40p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
COX23 YHR116W Protein that functions in mitochondrial copper homeostasis genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SRP1 YNL189W Karyopherin alpha homolog physical 3 2 1 Two-hybrid, Reconstituted Complex, Reconstituted Complex
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
PRE3 YJL001W Beta 1 subunit of the 20S proteasome regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
PRE1 YER012W Beta 4 subunit of the 20S proteasome regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
CUZ1 YNL155W Protein with a role in the ubiquitin-proteasome pathway regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
RPN2 YIL075C Subunit of the 26S proteasome regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 2 2 2 Synthetic Lethality, Negative Genetic
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RPN2 YIL075C Subunit of the 26S proteasome physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex genetic 2 2 2 Synthetic Growth Defect, Synthetic Rescue
HEL2 YDR266C RING finger ubiquitin ligase (E3) genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
ADO1 YJR105W Adenosine kinase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
KDX1 YKL161C Protein kinase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
LIA1 YJR070C Deoxyhypusine hydroxylase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 2 2 2 Synthetic Growth Defect, Dosage Growth Defect
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
JJJ1 YNL227C Co-chaperone that stimulates the ATPase activity of Ssa1p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 2 2 2 Positive Genetic, Synthetic Growth Defect
DOC1 YGL240W Processivity factor genetic 2 2 2 Synthetic Lethality, Negative Genetic
MGM1 YOR211C Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
RPL1B YGL135W Ribosomal 60S subunit protein L1B genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
PFY1 YOR122C Profilin genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SUB1 YMR039C Transcriptional regulator genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 2 2 2 Synthetic Rescue, Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 2 2 2 Negative Genetic, Dosage Growth Defect
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 2 2 2 Negative Genetic, Dosage Growth Defect
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RPL21A YBR191W Ribosomal 60S subunit protein L21A genetic 2 2 2 Synthetic Lethality, Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CYB5 YNL111C Cytochrome b5 genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
LDB7 YBL006C Component of the RSC chromatin remodeling complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
ERG24 YNL280C C-14 sterol reductase genetic 2 2 2 Synthetic Lethality, Negative Genetic
PPT2 YPL148C Phosphopantetheine:protein transferase (PPTase) genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 2 1 2 Positive Genetic, Positive Genetic
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 2 1 2 Negative Genetic, Negative Genetic
PAB1 YER165W Poly(A) binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 2 1 2 Negative Genetic, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
RPN2 YIL075C Subunit of the 26S proteasome genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity genetic 2 1 2 Negative Genetic, Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 2 1 2 Positive Genetic, Positive Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
INO80 YGL150C Nucleosome spacing factor genetic 2 1 2 Negative Genetic, Negative Genetic
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 2 1 2 Negative Genetic, Negative Genetic
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase genetic 2 1 2 Negative Genetic, Negative Genetic
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 2 1 2 Negative Genetic, Negative Genetic
DOT6 YER088C Protein involved in rRNA and ribosome biogenesis genetic 2 1 2 Negative Genetic, Negative Genetic
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 2 1 2 Negative Genetic, Negative Genetic
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 2 1 2 Negative Genetic, Negative Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 2 1 2 Negative Genetic, Negative Genetic
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 2 1 2 Negative Genetic, Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 2 1 2 Negative Genetic, Negative Genetic
ERG25 YGR060W C-4 methyl sterol oxidase genetic 2 1 2 Negative Genetic, Negative Genetic
PRP16 YKR086W DEAH-box RNA helicase genetic 2 1 2 Negative Genetic, Negative Genetic
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 2 1 2 Negative Genetic, Negative Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 2 1 2 Positive Genetic, Positive Genetic
STP3 YLR375W Zinc-finger protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
SND1 YDR186C Protein involved in SRP-independent targeting of substrates to the ER genetic 2 1 2 Negative Genetic, Negative Genetic
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation genetic 2 1 2 Negative Genetic, Negative Genetic
SSP2 YOR242C Sporulation specific protein that localizes to the spore wall genetic 2 1 2 Negative Genetic, Negative Genetic
YPI1 YFR003C Regulatory subunit of the type I protein phosphatase (PP1) Glc7p genetic 2 1 2 Negative Genetic, Negative Genetic
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 2 1 2 Positive Genetic, Positive Genetic
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 2 1 2 Negative Genetic, Negative Genetic
YCS4 YLR272C Subunit of the condensin complex genetic 2 1 2 Negative Genetic, Negative Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 2 1 2 Negative Genetic, Negative Genetic
HCM1 YCR065W Forkhead transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 2 1 2 Negative Genetic, Negative Genetic
OLE1 YGL055W Delta(9) fatty acid desaturase genetic 2 1 2 Negative Genetic, Negative Genetic
RPL24A YGL031C Ribosomal 60S subunit protein L24A genetic 2 1 2 Negative Genetic, Negative Genetic
RPL6A YML073C Ribosomal 60S subunit protein L6A genetic 2 1 2 Negative Genetic, Negative Genetic
NCR1 YPL006W Vacuolar membrane protein involved with Npc2p in sterol trafficking genetic 2 1 2 Negative Genetic, Negative Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 2 1 2 Negative Genetic, Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 2 1 2 Positive Genetic, Positive Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 2 1 2 Positive Genetic, Positive Genetic
FZO1 YBR179C Mitofusin, protein involved in mitochondrial outer membrane fusion genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 2 1 1 Negative Genetic, Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 2 1 1 Negative Genetic, Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
APL1 YJR005W Beta-adaptin genetic 2 1 1 Negative Genetic, Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 2 1 1 Negative Genetic, Negative Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
CMD1 YBR109C Calmodulin genetic 2 1 1 Negative Genetic, Negative Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 2 1 1 Negative Genetic, Negative Genetic
NEM1 YHR004C Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD55 YDR076W Protein that stimulates strand exchange genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD18 YCR066W E3 ubiquitin ligase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DIA2 YOR080W Origin-binding F-box protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CYS3 YAL012W Cystathionine gamma-lyase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 2 1 1 Negative Genetic, Negative Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
CSM3 YMR048W Replication fork associated factor genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 2 1 1 Positive Genetic, Positive Genetic
BRN1 YBL097W Subunit of the condensin complex genetic 2 1 1 Negative Genetic, Negative Genetic
ELO3 YLR372W Elongase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
EMC5 YIL027C Member of conserved ER transmembrane complex genetic 2 1 1 Negative Genetic, Negative Genetic
RER1 YCL001W Protein involved in retention of membrane proteins genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
YUH1 YJR099W Ubiquitin C-terminal hydrolase genetic 2 1 1 Negative Genetic, Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 2 1 1 Positive Genetic, Positive Genetic
SKI2 YLR398C Ski complex component and putative RNA helicase genetic 2 1 1 Negative Genetic, Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 2 1 1 Positive Genetic, Positive Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SKY1 YMR216C SR protein kinase (SRPK) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SPC2 YML055W Subunit of signal peptidase complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 2 1 1 Negative Genetic, Negative Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 2 1 1 Negative Genetic, Negative Genetic
SMC4 YLR086W Subunit of the condensin complex genetic 2 1 1 Negative Genetic, Negative Genetic
TPT1 YOL102C tRNA 2'-phosphotransferase that catalyzes final step in tRNA splicing genetic 2 1 1 Negative Genetic, Negative Genetic
YTM1 YOR272W Ribosomal assembly factor and 66S pre-ribosomal particle constituent genetic 2 1 1 Negative Genetic, Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 2 1 1 Negative Genetic, Negative Genetic
TIF6 YPR016C Constituent of 66S pre-ribosomal particles genetic 2 1 1 Negative Genetic, Negative Genetic
RPP2B YDR382W Ribosomal protein P2 beta genetic 2 1 1 Negative Genetic, Negative Genetic
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 2 1 1 Positive Genetic, Positive Genetic
PDS5 YMR076C Cohesion maintenance factor genetic 2 1 1 Negative Genetic, Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 2 1 1 Positive Genetic, Positive Genetic
GVP36 YIL041W BAR domain protein that localizes to early and late Golgi vesicles genetic 2 1 1 Negative Genetic, Negative Genetic
EUG1 YDR518W Protein disulfide isomerase of the endoplasmic reticulum lumen genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ALG6 YOR002W ER-luminal alpha 1,3 glucosyltransferase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
RAD57 YDR004W Protein that stimulates strand exchange genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CCW12 YLR110C Cell wall mannoprotein genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
RFU1 YLR073C Protein that inhibits Doa4p deubiquitinating activity genetic 2 1 1 Negative Genetic, Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
EMC10 YDR056C Putative protein of unknown function genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
MSC1 YML128C Protein of unknown function genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
LCL2 YLR104W Putative protein of unknown function genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
BNA4 YBL098W Kynurenine 3-monooxygenase genetic 2 1 1 Negative Genetic, Negative Genetic
GYP8 YFL027C GTPase-activating protein for yeast Rab family members genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BMH1 YER177W 14-3-3 protein, major isoform regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ACO1 YLR304C Aconitase regulation 1 1 1 DNA to cDNA expression microarray evidence
AGA2 YGL032C Adhesion subunit of a-agglutinin of a-cells regulation 1 1 1 DNA to cDNA expression microarray evidence
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PRE8 YML092C Alpha 2 subunit of the 20S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
OST1 YJL002C Alpha subunit of the oligosaccharyltransferase complex of the ER lumen regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TMC1 YOR052C AN1-type zinc finger protein, effector of proteotoxic stress response regulation 1 1 1 chromatin immunoprecipitation-chip evidence
AGA1 YNR044W Anchorage subunit of a-agglutinin of a-cells regulation 1 1 1 DNA to cDNA expression microarray evidence
BAR1 YIL015W Aspartyl protease secreted to periplasmic space of mating type a cell regulation 1 1 1 DNA to cDNA expression microarray evidence
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PIM1 YBL022C ATP-dependent Lon protease regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PUP1 YOR157C Beta 2 subunit of the 20S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PUP3 YER094C Beta 3 subunit of the 20S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PRE4 YFR050C Beta 7 subunit of the 20S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ERG4 YGL012W C-24(28) sterol reductase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CMK2 YOL016C Calmodulin-dependent protein kinase regulation 1 1 1 DNA to cDNA expression microarray evidence
ALG13 YGL047W Catalytic component of UDP-GlcNAc transferase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YGP1 YNL160W Cell wall-related secretory glycoprotein regulation 1 1 1 DNA to cDNA expression microarray evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
AHC2 YCR082W Component of the ADA histone acetyltransferase complex regulation 1 1 1 DNA to cDNA expression microarray evidence
CIP1 YPL014W Cyclin-dependent kinase inhibitor regulation 1 1 1 DNA to cDNA expression microarray evidence
ALD6 YPL061W Cytosolic aldehyde dehydrogenase regulation 1 1 1 DNA to cDNA expression microarray evidence
BAT2 YJR148W Cytosolic branched-chain amino acid (BCAA) aminotransferase regulation 1 1 1 DNA to cDNA expression microarray evidence
MPO1 YGL010W Dioxygenase that catalyzes alpha-oxygenation of 2-hydroxy fatty acids regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HSP104 YLL026W Disaggregase regulation 1 1 1 DNA to cDNA expression microarray evidence
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ENO1 YGR254W Enolase I, a phosphopyruvate hydratase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YTH1 YPR107C Essential RNA-binding component of cleavage and polyadenylation factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ENB1 YOL158C Ferric enterobactin transmembrane transporter regulation 1 1 1 DNA to cDNA expression microarray evidence
NUP49 YGL172W FG-nucleoporin component of central core of the nuclear pore complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCG1 YER163C Gamma-glutamyl cyclotransferase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) regulation 1 1 1 DNA to cDNA expression microarray evidence
SPI1 YER150W GPI-anchored cell wall protein involved in weak acid resistance regulation 1 1 1 DNA to cDNA expression microarray evidence
SST2 YLR452C GTPase-activating protein for Gpa1p regulation 1 1 1 DNA to cDNA expression microarray evidence
GYP7 YDL234C GTPase-activating protein for yeast Rab family members regulation 1 1 1 DNA to cDNA expression microarray evidence
FUI1 YBL042C High affinity uridine permease, localizes to the plasma membrane regulation 1 1 1 DNA to cDNA expression microarray evidence
PTR2 YKR093W Integral membrane peptide transporter regulation 1 1 1 DNA to cDNA expression microarray evidence
FIT2 YOR382W Mannoprotein that is incorporated into the cell wall regulation 1 1 1 DNA to cDNA expression microarray evidence
MFA1 YDR461W Mating pheromone a-factor regulation 1 1 1 DNA to cDNA expression microarray evidence
HOP2 YGL033W Meiosis-specific protein that localizes to chromosomes regulation 1 1 1 DNA to cDNA expression microarray evidence
FUS1 YCL027W Membrane protein localized to the shmoo tip regulation 1 1 1 DNA to cDNA expression microarray evidence
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSH3 YCR092C Mismatch repair protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PET123 YOR158W Mitochondrial ribosomal protein of the small subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YIH1 YCR059C Negative regulator of eIF2 kinase Gcn2p regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HSP30 YCR021C Negative regulator of the H(+)-ATPase Pma1p regulation 1 1 1 DNA to cDNA expression microarray evidence
RPN9 YDR427W Non-ATPase regulatory subunit of the 26S proteasome regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein regulation 1 1 1 DNA to cDNA expression microarray evidence
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PHO11 YAR071W One of three repressible acid phosphatases regulation 1 1 1 DNA to cDNA expression microarray evidence
PHO12 YHR215W One of three repressible acid phosphatases regulation 1 1 1 DNA to cDNA expression microarray evidence
PHO89 YBR296C Plasma membrane Na+/Pi cotransporter regulation 1 1 1 DNA to cDNA expression microarray evidence
HSP12 YFL014W Plasma membrane protein involved in maintaining membrane organization regulation 1 1 1 DNA to cDNA expression microarray evidence
TPO2 YGR138C Polyamine transporter of the major facilitator superfamily regulation 1 1 1 DNA to cDNA expression microarray evidence
BLM10 YFL007W Proteasome activator regulation 1 1 1 quantitative western immunoblotting evidence used in manual assertion
STP4 YDL048C Protein containing a Kruppel-type zinc-finger domain regulation 1 1 1 DNA to cDNA expression microarray evidence
NSG2 YNL156C Protein involved in regulation of sterol biosynthesis regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STF2 YGR008C Protein involved in resistance to desiccation stress regulation 1 1 1 DNA to cDNA expression microarray evidence
PHM6 YDR281C Protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YDL144C YDL144C Protein of unknown function regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TVS1 YCR061W Protein of unknown function regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YDR222W YDR222W Protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
DIA1 YMR316W Protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YMR181C YMR181C Protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YLR162W YLR162W Protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YMR316C-A YMR316C-A Protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
LSO1 YJR005C-A Protein with a potential role in response to iron deprivation regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YRO2 YBR054W Protein with a putative role in response to acid stress regulation 1 1 1 DNA to cDNA expression microarray evidence
RAD23 YEL037C Protein with ubiquitin-like N terminus regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FCY2 YER056C Purine-cytosine permease regulation 1 1 1 DNA to cDNA expression microarray evidence
GPN2 YOR262W Putative GTPase with a specific role in RNA pol II and polIII biogenes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YOR385W YOR385W Putative protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YNL146W YNL146W Putative protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YOL038C-A YOL038C-A Putative protein of unknown function regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YFR006W YFR006W Putative X-Pro aminopeptidase regulation 1 1 1 DNA to cDNA expression microarray evidence
STE2 YFL026W Receptor for alpha-factor pheromone regulation 1 1 1 DNA to cDNA expression microarray evidence
YPI1 YFR003C Regulatory subunit of the type I protein phosphatase (PP1) Glc7p regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RIE1 YGR250C RNA binding protein and negative regulator of START regulation 1 1 1 DNA to cDNA expression microarray evidence
NRD1 YNL251C RNA-binding subunit of Nrd1 complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DEF1 YKL054C RNAPII degradation factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
LAF1 YMR102C Sterol-binding beta-propeller protein regulation 1 1 1 DNA to cDNA expression microarray evidence
RAD51 YER095W Strand exchange protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p regulation 1 1 1 chromatin immunoprecipitation-chip evidence
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC4 YGR047C Subunit of RNA polymerase III transcription initiation factor complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPN13 YLR421C Subunit of the 19S regulatory particle of the 26S proteasome lid regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UBI4 YLL039C Ubiquitin regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UBA1 YKL210W Ubiquitin activating enzyme (E1) regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UBP6 YFR010W Ubiquitin-specific protease regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BTN2 YGR142W v-SNARE binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HSF1 YGL073W Trimeric heat shock transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT6 YGR116W Nucleosome remodeling protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Negative Genetic
CDC40 YDR364C Pre-mRNA splicing factor genetic 1 1 1 Negative Genetic
AME1 YBR211C Essential kinetochore protein associated with microtubules and SPBs genetic 1 1 1 Positive Genetic
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 1 1 1 Synthetic Growth Defect
CTF3 YLR381W Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p genetic 1 1 1 Synthetic Growth Defect
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs genetic 1 1 1 Negative Genetic
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 1 1 1 Affinity Capture-MS
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Lethality
EBP2 YKL172W Required for 25S rRNA maturation and 60S ribosomal subunit assembly genetic 1 1 1 Negative Genetic
MAK16 YAL025C Essential nuclear protein genetic 1 1 1 Negative Genetic
RPL16A YIL133C Ribosomal 60S subunit protein L16A genetic 1 1 1 Negative Genetic
RPL17A YKL180W Ribosomal 60S subunit protein L17A genetic 1 1 1 Negative Genetic
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins genetic 1 1 1 Negative Genetic
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Positive Genetic
POP4 YBR257W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 1 1 1 Negative Genetic
LTO1 YNL260C Substrate-specific adaptor protein involved in apo-Rli1p maturation genetic 1 1 1 Positive Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
MES1 YGR264C Methionyl-tRNA synthetase genetic 1 1 1 Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Negative Genetic
LSM3 YLR438C-A Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
RPC40 YPR110C RNA polymerase subunit AC40 genetic 1 1 1 Negative Genetic
RPC19 YNL113W RNA polymerase subunit AC19 genetic 1 1 1 Positive Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Negative Genetic
MFT1 YML062C Subunit of the THO complex genetic 1 1 1 Positive Genetic
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Positive Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Phenotypic Enhancement
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Dosage Rescue
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 1 1 1 Negative Genetic
MPE1 YKL059C Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase genetic 1 1 1 Negative Genetic
PRE1 YER012W Beta 4 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome physical 1 1 1 Co-purification
PRE3 YJL001W Beta 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome physical 1 1 1 Two-hybrid
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ARC15 YIL062C Subunit of the ARP2/3 complex genetic 1 1 1 Positive Genetic
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 1 1 1 Positive Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Positive Genetic
BDF1 YLR399C BET family transcriptional regulator genetic 1 1 1 Negative Genetic
CAR1 YPL111W Arginase, catabolizes arginine to ornithine and urea genetic 1 1 1 Negative Genetic
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Negative Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 1 1 1 Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
CYS4 YGR155W Cystathionine beta-synthase genetic 1 1 1 Negative Genetic
DPB2 YPR175W Second largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 1 1 1 Affinity Capture-MS
ERO1 YML130C Thiol oxidase required for oxidative protein folding in the ER genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
KGD2 YDR148C Dihydrolipoyl transsuccinylase genetic 1 1 1 Negative Genetic
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Synthetic Growth Defect
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Positive Genetic
MAK10 YEL053C Non-catalytic subunit of the NatC N-terminal acetyltransferase genetic 1 1 1 Negative Genetic
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 1 1 1 Negative Genetic
MBP1 YDL056W Transcription factor genetic 1 1 1 Negative Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED2 YDL005C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
ADA2 YDR448W Transcription coactivator genetic 1 1 1 Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
MRPL19 YNL185C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
MRPL24 YMR193W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Synthetic Growth Defect
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Negative Genetic
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Dosage Rescue
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Positive Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Negative Genetic
PCF11 YDR228C mRNA 3' end processing factor genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
HTA1 YDR225W Histone H2A genetic 1 1 1 Negative Genetic
PRP4 YPR178W Splicing factor genetic 1 1 1 Negative Genetic
MDS3 YGL197W Putative component of the TOR regulatory pathway genetic 1 1 1 Negative Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Positive Genetic
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
REF2 YDR195W RNA-binding protein genetic 1 1 1 Negative Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Positive Genetic
RPC11 YDR045C RNA polymerase III subunit C11 genetic 1 1 1 Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Negative Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 1 1 1 Positive Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 1 1 1 Positive Genetic
HOS4 YIL112W Subunit of the Set3 complex genetic 1 1 1 Negative Genetic
ABF2 YMR072W Mitochondrial DNA-binding protein genetic 1 1 1 Positive Genetic
CCT2 YIL142W Subunit beta of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
MSL1 YIR009W U2B component of U2 snRNP genetic 1 1 1 Synthetic Lethality
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p genetic 1 1 1 Synthetic Lethality
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Negative Genetic
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 1 1 1 Negative Genetic
BUR2 YLR226W Cyclin for the Sgv1p (Bur1p) protein kinase genetic 1 1 1 Synthetic Lethality
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Positive Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Synthetic Growth Defect
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Synthetic Growth Defect
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Synthetic Growth Defect
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Synthetic Growth Defect
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Dosage Growth Defect
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Synthetic Growth Defect
PEP5 YMR231W Histone E3 ligase, component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Growth Defect
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 1 1 1 Synthetic Growth Defect
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Positive Genetic
FAR8 YMR029C Protein involved in recovery from arrest in response to pheromone genetic 1 1 1 Negative Genetic
NGL2 YMR285C Protein involved in 5.8S rRNA processing genetic 1 1 1 Negative Genetic
ISA2 YPR067W Protein required for maturation of mitochondrial [4Fe-4S] proteins genetic 1 1 1 Synthetic Growth Defect
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Synthetic Growth Defect
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
KIN1 YDR122W S/T protein kinase genetic 1 1 1 Negative Genetic
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Synthetic Growth Defect
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 1 1 1 Negative Genetic
FET3 YMR058W Ferro-O2-oxidoreductase genetic 1 1 1 Synthetic Growth Defect
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) genetic 1 1 1 Negative Genetic
BUD13 YGL174W Subunit of the RES complex genetic 1 1 1 Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Negative Genetic
GLC8 YMR311C Regulatory subunit of protein phosphatase 1 (Glc7p) genetic 1 1 1 Negative Genetic
EGD1 YPL037C Subunit beta1 of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Negative Genetic
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Phenotypic Suppression
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 1 1 1 Positive Genetic
ATG42 YBR139W Vacuolar serine-type carboxypeptidase genetic 1 1 1 Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Positive Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Positive Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Synthetic Growth Defect
AIM46 YHR199C Protein of unknown function genetic 1 1 1 Negative Genetic
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 genetic 1 1 1 Negative Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Dosage Growth Defect
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation genetic 1 1 1 Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Positive Genetic
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Negative Genetic
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Negative Genetic
FKH2 YNL068C Forkhead family transcription factor genetic 1 1 1 Negative Genetic
MIG1 YGL035C Transcription factor involved in glucose repression genetic 1 1 1 Negative Genetic
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
DEF1 YKL054C RNAPII degradation factor genetic 1 1 1 Negative Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Positive Genetic
MIC19 YFR011C Component of the MICOS complex genetic 1 1 1 Negative Genetic
ISA1 YLL027W Protein required for maturation of mitochondrial [4Fe-4S] proteins genetic 1 1 1 Synthetic Growth Defect
GPA1 YHR005C Subunit of G protein involved in pheromone response genetic 1 1 1 Synthetic Rescue
MDJ1 YFL016C Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity genetic 1 1 1 Synthetic Lethality
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Positive Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Synthetic Growth Defect
MTQ2 YDR140W S-adenosylmethionine-dependent methyltransferase genetic 1 1 1 Synthetic Growth Defect
PRS1 YKL181W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 1 1 1 Synthetic Lethality
NAS2 YIL007C Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 1 1 1 Two-hybrid
CDD1 YLR245C Cytidine deaminase genetic 1 1 1 Positive Genetic
ECM19 YLR390W Protein of unknown function genetic 1 1 1 Positive Genetic
GRX5 YPL059W Glutathione-dependent oxidoreductase genetic 1 1 1 Synthetic Lethality
INO2 YDR123C Transcription factor genetic 1 1 1 Negative Genetic
CWC24 YLR323C General splicing factor genetic 1 1 1 Negative Genetic
IBA57 YJR122W Protein involved in incorporating iron-sulfur clusters into proteins genetic 1 1 1 Synthetic Growth Defect
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
HAA1 YPR008W Transcriptional activator involved in adaptation to weak acid stress genetic 1 1 1 Positive Genetic
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
PPG1 YNR032W Serine protein phosphatase involved in formation of FAR complex genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Positive Genetic
NBA1 YOL070C Protein involved in axial bud site selection genetic 1 1 1 Negative Genetic
BMT2 YBR141C Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 1 1 1 Negative Genetic
KEG1 YFR042W Integral membrane protein of the ER genetic 1 1 1 Positive Genetic
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 1 1 1 Negative Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Positive Genetic
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 1 1 1 Positive Genetic
RNA15 YGL044C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Negative Genetic
RFT1 YBL020W Membrane protein required for translocation of Man5GlcNac2-PP-Dol genetic 1 1 1 Positive Genetic
RPL23B YER117W Ribosomal 60S subunit protein L23B genetic 1 1 1 Negative Genetic
NHP6A YPR052C High-mobility group (HMG) protein genetic 1 1 1 Phenotypic Suppression
IES6 YEL044W Component of the INO80 chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Positive Genetic
RPL20B YOR312C Ribosomal 60S subunit protein L20B genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Negative Genetic
ALF1 YNL148C Alpha-tubulin folding protein genetic 1 1 1 Synthetic Lethality
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 1 1 1 Synthetic Growth Defect
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Positive Genetic
CLC1 YGR167W Clathrin light chain genetic 1 1 1 Negative Genetic
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Growth Defect
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
GCD10 YNL062C Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p genetic 1 1 1 Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Negative Genetic
ERV41 YML067C Protein localized to COPII-coated vesicles genetic 1 1 1 Phenotypic Suppression
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
PEP7 YDR323C Adaptor protein involved in vesicle-mediated vacuolar protein sorting genetic 1 1 1 Synthetic Growth Defect
DPH2 YKL191W Protein required for synthesis of diphthamide genetic 1 1 1 Synthetic Growth Defect
CIN1 YOR349W Tubulin folding factor D involved in beta-tubulin (Tub2p) folding genetic 1 1 1 Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Negative Genetic
ERV46 YAL042W Protein localized to COPII-coated vesicles genetic 1 1 1 Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 1 1 1 Negative Genetic
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 1 1 1 Negative Genetic
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Negative Genetic
BCH1 YMR237W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) genetic 1 1 1 Negative Genetic
MET31 YPL038W Zinc-finger DNA-binding transcription factor genetic 1 1 1 Negative Genetic
ARK1 YNL020C Ser/Thr protein kinase genetic 1 1 1 Dosage Growth Defect
PRP22 YER013W DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Dosage Growth Defect
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 1 1 1 Negative Genetic
KAP120 YPL125W Karyopherin responsible for the nuclear import of Rpf1p genetic 1 1 1 Negative Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
RPL11B YGR085C Ribosomal 60S subunit protein L11B genetic 1 1 1 Negative Genetic
ATM1 YMR301C Mitochondrial inner membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response genetic 1 1 1 Negative Genetic
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-Western
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-Western
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-Western
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-Western
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component physical 1 1 1 Affinity Capture-Western
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes physical 1 1 1 Affinity Capture-MS
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Synthetic Rescue
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Synthetic Lethality
SWD2 YKL018W Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex genetic 1 1 1 Negative Genetic
SET4 YJL105W Chromatin-associated protein involved in control of stress response genetic 1 1 1 Phenotypic Suppression
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Negative Genetic
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Positive Genetic
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Positive Genetic
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Growth Defect
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes genetic 1 1 1 Synthetic Growth Defect
STE6 YKL209C Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Synthetic Lethality
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
SRP101 YDR292C Signal recognition particle (SRP) receptor alpha subunit genetic 1 1 1 Negative Genetic
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase genetic 1 1 1 Positive Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Positive Genetic
TAF8 YML114C TFIID subunit (65 kDa) genetic 1 1 1 Positive Genetic
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Synthetic Growth Defect
RPS0A YGR214W Ribosomal 40S subunit protein S0A genetic 1 1 1 Synthetic Growth Defect
RPS29A YLR388W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Synthetic Growth Defect
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Synthetic Growth Defect
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Synthetic Growth Defect
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Synthetic Growth Defect
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Synthetic Growth Defect
UBP1 YDL122W Ubiquitin-specific protease genetic 1 1 1 Synthetic Growth Defect
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Synthetic Growth Defect
VMA4 YOR332W Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase) genetic 1 1 1 Synthetic Growth Defect
VMA6 YLR447C Subunit d of the V0 integral membrane domain of V-ATPase genetic 1 1 1 Synthetic Growth Defect
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
VPS3 YDR495C Component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Growth Defect
VPS33 YLR396C ATP-binding protein that is a subunit of the HOPS and CORVET complexes genetic 1 1 1 Synthetic Growth Defect
VPS45 YGL095C Protein of the Sec1p/Munc-18 family genetic 1 1 1 Synthetic Growth Defect
VPS5 YOR069W Nexin-1 homolog genetic 1 1 1 Synthetic Growth Defect
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 1 1 1 Synthetic Growth Defect
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Synthetic Growth Defect
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit genetic 1 1 1 Synthetic Growth Defect
RPS4A YJR145C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Synthetic Growth Defect
SGO1 YOR073W Component of the spindle checkpoint genetic 1 1 1 Synthetic Growth Defect
SNF8 YPL002C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Synthetic Growth Defect
TRK1 YJL129C Component of the Trk1p-Trk2p potassium transport system genetic 1 1 1 Synthetic Growth Defect
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Synthetic Growth Defect
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 1 1 1 Synthetic Growth Defect
VPH2 YKL119C Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VPS20 YMR077C Myristoylated subunit of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
VPS25 YJR102C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate genetic 1 1 1 Synthetic Growth Defect
VPS36 YLR417W Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Synthetic Growth Defect
YAR1 YPL239W Nucleocytoplasmic shuttling assembly chaperone genetic 1 1 1 Synthetic Growth Defect
TMA23 YMR269W Nucleolar protein implicated in ribosome biogenesis genetic 1 1 1 Synthetic Growth Defect
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 1 1 1 Synthetic Growth Defect
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway genetic 1 1 1 Synthetic Lethality
SSQ1 YLR369W Mitochondrial hsp70-type molecular chaperone genetic 1 1 1 Synthetic Lethality
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) genetic 1 1 1 Synthetic Lethality
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Synthetic Lethality
RPS4B YHR203C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Phenotypic Suppression
SEC72 YLR292C Non-essential subunit of Sec63 complex genetic 1 1 1 Phenotypic Suppression
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Synthetic Growth Defect
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Negative Genetic
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 1 1 1 Negative Genetic
YPR015C YPR015C Putative zinc finger transcription factor genetic 1 1 1 Negative Genetic
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Positive Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Positive Genetic
YAP3 YHL009C Basic leucine zipper (bZIP) transcription factor genetic 1 1 1 Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Negative Genetic
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Negative Genetic
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein genetic 1 1 1 Synthetic Rescue
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Synthetic Rescue
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport genetic 1 1 1 Phenotypic Suppression
SSA2 YLL024C HSP70 family ATP-binding protein genetic 1 1 1 Phenotypic Suppression
RRP43 YCR035C Exosome non-catalytic core component genetic 1 1 1 Positive Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Positive Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Positive Genetic
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Positive Genetic
VRG4 YGL225W Golgi GDP-mannose transporter genetic 1 1 1 Positive Genetic
TAH11 YJR046W DNA replication licensing factor genetic 1 1 1 Positive Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 1 1 1 Positive Genetic
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 1 1 1 Positive Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Positive Genetic
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
TFB2 YPL122C Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Positive Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Positive Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 1 1 1 Positive Genetic
RPO41 YFL036W Mitochondrial RNA polymerase genetic 1 1 1 Positive Genetic
TRX2 YGR209C Cytoplasmic thioredoxin isoenzyme genetic 1 1 1 Positive Genetic
TRM12 YML005W S-adenosylmethionine-dependent methyltransferase genetic 1 1 1 Positive Genetic
SNT309 YPR101W Member of the NineTeen Complex (NTC) genetic 1 1 1 Positive Genetic
SUP45 YBR143C Polypeptide release factor (eRF1) in translation termination genetic 1 1 1 Negative Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Negative Genetic
UTR5 YEL035C Protein of unknown function genetic 1 1 1 Negative Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Negative Genetic
UTP25 YIL091C Nucleolar protein genetic 1 1 1 Negative Genetic
SPC42 YKL042W Central plaque component of spindle pole body (SPB) genetic 1 1 1 Negative Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Negative Genetic
RSC9 YML127W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
TIF34 YMR146C eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
SSU72 YNL222W Phosphatase and transcription/RNA-processing factor genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding genetic 1 1 1 Negative Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
SRP54 YPR088C Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) genetic 1 1 1 Negative Genetic
SLM5 YCR024C Mitochondrial asparaginyl-tRNA synthetase genetic 1 1 1 Negative Genetic
SPR28 YDR218C Sporulation-specific homolog of the CDC3/10/11/12 family of genes genetic 1 1 1 Negative Genetic
SOM1 YEL059C-A Subunit of the mitochondrial inner membrane peptidase (IMP) genetic 1 1 1 Negative Genetic
SBH2 YER019C-A Ssh1p-Sss1p-Sbh2p complex component genetic 1 1 1 Negative Genetic
YER134C YER134C Magnesium-dependent acid phosphatase genetic 1 1 1 Negative Genetic
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 1 1 1 Negative Genetic
YGL188C-A YGL188C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHK8 YHR048W Presumed antiporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
VMA22 YHR060W Protein that is required for vacuolar H+-ATPase (V-ATPase) function genetic 1 1 1 Negative Genetic
SOP4 YJL192C ER-membrane protein genetic 1 1 1 Negative Genetic
TIM8 YJR135W-A Mitochondrial intermembrane space protein genetic 1 1 1 Negative Genetic
YET1 YKL065C Endoplasmic reticulum transmembrane protein genetic 1 1 1 Negative Genetic
ZRT3 YKL175W Vacuolar membrane zinc transporter genetic 1 1 1 Negative Genetic
YPS1 YLR120C Aspartic protease genetic 1 1 1 Negative Genetic
YLR407W YLR407W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YML018C YML018C Protein of unknown function genetic 1 1 1 Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Negative Genetic
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Negative Genetic
YML108W YML108W Protein of unknown function genetic 1 1 1 Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Negative Genetic
YMR321C YMR321C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Growth Defect
YNL067W-B YNL067W-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 1 1 1 Negative Genetic
YNR071C YNR071C Putative aldose 1-epimerase genetic 1 1 1 Negative Genetic
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 1 1 1 Negative Genetic
YOR072W-B YOR072W-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
YPR063C YPR063C ER-localized protein of unknown function genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Synthetic Growth Defect
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 1 1 1 Synthetic Growth Defect
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Phenotypic Suppression
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
ASG1 YIL130W Zinc cluster protein proposed to be a transcriptional regulator genetic 1 1 1 Positive Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Synthetic Growth Defect
RPL15A YLR029C Ribosomal 60S subunit protein L15A genetic 1 1 1 Negative Genetic
ERG5 YMR015C C-22 sterol desaturase genetic 1 1 1 Negative Genetic
CRG1 YHR209W S-AdoMet-dependent methyltransferase involved in lipid homeostasis genetic 1 1 1 Synthetic Growth Defect
ECM21 YBL101C Alpha-arrestin, ubiquitin ligase adaptor for Rsp5p genetic 1 1 1 Negative Genetic
GTA1 YEL043W Protein of unknown function genetic 1 1 1 Negative Genetic
RPL16B YNL069C Ribosomal 60S subunit protein L16B genetic 1 1 1 Negative Genetic
PIH1 YHR034C Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Positive Genetic
HEM14 YER014W Protoporphyrinogen oxidase genetic 1 1 1 Synthetic Growth Defect
DAL5 YJR152W Allantoate permease genetic 1 1 1 Negative Genetic
CFD1 YIL003W Highly conserved iron-sulfur cluster binding protein genetic 1 1 1 Negative Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
IRC7 YFR055W Cysteine desulphydrase, enables growth on cysteine as nitrogen source genetic 1 1 1 Negative Genetic
NGR1 YBR212W RNA binding protein that negatively regulates growth rate genetic 1 1 1 Negative Genetic
MRPL11 YDL202W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 1 1 1 Synthetic Growth Defect
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
MET12 YPL023C Protein with MTHFR activity in vitro genetic 1 1 1 Negative Genetic
MPP6 YNR024W Nuclear exosome-associated RNA binding protein genetic 1 1 1 Negative Genetic
IMP21 YIL154C Transcriptional activator involved in maintenance of ion homeostasis genetic 1 1 1 Synthetic Growth Defect
LYS14 YDR034C Transcriptional activator involved in regulating lysine biosynthesis genetic 1 1 1 Negative Genetic
ETR1 YBR026C 2-enoyl thioester reductase genetic 1 1 1 Negative Genetic
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase genetic 1 1 1 Negative Genetic
RPL37A YLR185W Ribosomal 60S subunit protein L37A genetic 1 1 1 Negative Genetic
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Negative Genetic
MRPL40 YPL173W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Negative Genetic
MRPS17 YMR188C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Synthetic Growth Defect
CUP9 YPL177C Homeodomain-containing transcriptional repressor genetic 1 1 1 Negative Genetic
MUB1 YMR100W MYND domain-containing protein physical 1 1 1 Reconstituted Complex
EGH1 YIR007W Steryl-beta-glucosidase with broad specificity for aglycones genetic 1 1 1 Negative Genetic
RPL20A YMR242C Ribosomal 60S subunit protein L20A genetic 1 1 1 Synthetic Growth Defect
RPL19A YBR084C-A Ribosomal 60S subunit protein L19A genetic 1 1 1 Negative Genetic
RPL6B YLR448W Ribosomal 60S subunit protein L6B genetic 1 1 1 Negative Genetic
GPI17 YDR434W Transmembrane protein genetic 1 1 1 Positive Genetic
RPL34B YIL052C Ribosomal 60S subunit protein L34B genetic 1 1 1 Negative Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
GPI12 YMR281W ER membrane protein involved in the second step of GPI anchor assembly genetic 1 1 1 Positive Genetic
DUS1 YML080W Dihydrouridine synthase genetic 1 1 1 Negative Genetic
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase genetic 1 1 1 Negative Genetic
DGR2 YKL121W Protein of unknown function genetic 1 1 1 Negative Genetic
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p genetic 1 1 1 Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Synthetic Growth Defect
DDP1 YOR163W Diadenosine and diphosphoinositol polyphosphate phosphatase genetic 1 1 1 Positive Genetic
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 1 1 1 Phenotypic Enhancement
RIB1 YBL033C GTP cyclohydrolase II genetic 1 1 1 Synthetic Lethality
QNS1 YHR074W Glutamine-dependent NAD(+) synthetase genetic 1 1 1 Negative Genetic
HIT1 YJR055W Protein involved in C/D snoRNP assembly genetic 1 1 1 Synthetic Growth Defect
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Positive Genetic
MET7 YOR241W Folylpolyglutamate synthetase genetic 1 1 1 Positive Genetic
COM2 YER130C Transcription factor that binds IME1 Upstream Activation Signal (UAS) genetic 1 1 1 Positive Genetic
COS1 YNL336W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 1 1 1 Synthetic Growth Defect
LYP1 YNL268W Lysine permease genetic 1 1 1 Synthetic Lethality
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Positive Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 1 1 1 Synthetic Growth Defect
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 1 1 1 Synthetic Growth Defect
CDS1 YBR029C Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) genetic 1 1 1 Negative Genetic
HAL9 YOL089C Putative transcription factor containing a zinc finger genetic 1 1 1 Negative Genetic
CCW14 YLR390W-A Covalently linked cell wall glycoprotein genetic 1 1 1 Positive Genetic
BSC4 YNL269W Protein of unknown function genetic 1 1 1 Synthetic Lethality
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Negative Genetic
ERG9 YHR190W Farnesyl-diphosphate farnesyl transferase (squalene synthase) genetic 1 1 1 Negative Genetic
RPL33A YPL143W Ribosomal 60S subunit protein L33A genetic 1 1 1 Negative Genetic
MRPL33 YMR286W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
CPR8 YNR028W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
LIP2 YLR239C Lipoyl ligase genetic 1 1 1 Synthetic Growth Defect
KNH1 YDL049C Protein with similarity to Kre9p genetic 1 1 1 Synthetic Growth Defect
CHM7 YJL049W Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Positive Genetic
RPL24B YGR148C Ribosomal 60S subunit protein L24B genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
AIM10 YER087W Protein with similarity to tRNA synthetases genetic 1 1 1 Synthetic Growth Defect
PAN6 YIL145C Pantothenate synthase genetic 1 1 1 Positive Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Positive Genetic
RAD61 YDR014W Subunit of a complex that inhibits sister chromatid cohesion genetic 1 1 1 Negative Genetic
RMD9 YGL107C Mitochondrial protein that controls mitochondrial gene expression genetic 1 1 1 Positive Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Positive Genetic
PRM6 YML047C Potassium transporter that mediates K+ influx genetic 1 1 1 Synthetic Growth Defect
PAU3 YCR104W Member of the seripauperin multigene family genetic 1 1 1 Negative Genetic