Standard name Systematic name Name description Description
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions Ubiquitin-specific protease that cleaves Ub-protein fusions; interacts with cofactor Bre5p to regulate transport between ER and Golgi, deubiquitinating COPII and COPI proteins, Sec23p and Sec27p; mediates steady-state retention of Golgi membrane proteins with Bre5p; phosphorylation (S695) by Hog1p regulates transcriptional activation by osmostress; inhibits Ras/PKA signaling through Ira2p; inhibits silencing; role in ribophagy; protein abundance increases in response to DNA replication stress
Visualize the interactome of UBP3
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.97 0.954 0.922
ER NaN NaN 0.078

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 2210

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
UBP3 5 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
BRE5 YNR051C Ubiquitin protease cofactor physical 18 6 11 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Co-crystal Structure, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Co-purification, Reconstituted Complex, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
BRE5 YNR051C Ubiquitin protease cofactor genetic 9 3 8 Positive Genetic, Positive Genetic, Synthetic Growth Defect, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Dosage Rescue, Positive Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 8 3 8 Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 8 2 7 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 8 2 7 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 8 1 6 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 7 3 6 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 7 2 6 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 7 2 6 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
THP2 YHR167W Subunit of the THO and TREX complexes genetic 7 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 6 2 6 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 6 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 6 2 5 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 6 2 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 6 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 6 2 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 5 2 5 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 5 2 5 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 5 3 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 5 3 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 5 2 4 Positive Genetic, Positive Genetic, Positive Genetic, Negative Genetic, Positive Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 5 2 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 5 2 4 Positive Genetic, Positive Genetic, Negative Genetic, Positive Genetic, Positive Genetic
SUB1 YMR039C Transcriptional regulator genetic 5 2 4 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 5 1 4 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS74 YDR372C Golgi PI4K effector, PtdIns4P sensor, and retention receptor genetic 5 4 3 Negative Genetic, Negative Genetic, Dosage Rescue, Synthetic Growth Defect, Phenotypic Enhancement
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 5 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
UPF3 YGR072W Component of the nonsense-mediated mRNA decay (NMD) pathway genetic 5 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 5 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 5 2 3 Negative Genetic, Negative Genetic, Dosage Rescue, Negative Genetic, Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 5 1 3 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 4 3 4 Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression, Negative Genetic
BUD14 YAR014C Protein involved in bud-site selection genetic 4 2 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 4 2 4 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 4 3 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Rescue
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 4 3 3 Affinity Capture-MS, Proximity Label-MS, Affinity Capture-Western, Affinity Capture-MS
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 4 2 3 Positive Genetic, Positive Genetic, Negative Genetic, Positive Genetic
SWC3 YAL011W Protein of unknown function genetic 4 2 3 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 4 2 3 Positive Genetic, Positive Genetic, Positive Genetic, Negative Genetic
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CNB1 YKL190W Calcineurin B genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SSK2 YNR031C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MVP1 YMR004W Protein required for sorting proteins to the vacuole genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
UTH1 YKR042W Mitochondrial inner membrane protein genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SMT1 YJL147C Translational repressor of the mitochondrial ATP6/8 mRNA genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CUP9 YPL177C Homeodomain-containing transcriptional repressor genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ATG21 YPL100W Phosphoinositide binding protein genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEC72 YLR292C Non-essential subunit of Sec63 complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
KRE5 YOR336W Protein required for beta-1,6 glucan biosynthesis genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 4 4 2 Affinity Capture-Western, Co-purification, Biochemical Activity, Affinity Capture-MS
LSM12 YHR121W Protein of unknown function that may function in RNA processing physical 4 3 2 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PAA1 YDR071C Polyamine acetyltransferase genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SCJ1 YMR214W One of several homologs of bacterial chaperone DnaJ genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FAR11 YNL127W Protein involved in recovery from cell cycle arrest genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PSR1 YLL010C Plasma membrane-associated protein phosphatase genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ATP10 YLR393W Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ENT5 YDR153C Protein containing an N-terminal epsin-like domain genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
URA7 YBL039C Major CTP synthase isozyme (see also URA8) genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BST1 YFL025C GPI inositol deacylase of the endoplasmic reticulum (ER) genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
AGE2 YIL044C ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ENT4 YLL038C Protein of unknown function genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SCS3 YGL126W Protein required for normal ER membrane biosynthesis in response to ER genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 3 2 3 Phenotypic Enhancement, Negative Genetic, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-RNA
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 3 2 3 Affinity Capture-MS, Affinity Capture-RNA, Affinity Capture-RNA
GET2 YER083C Subunit of the GET complex genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 3 2 3 Phenotypic Enhancement, Negative Genetic, Negative Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
KIN3 YAR018C Nonessential serine/threonine protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
OPY1 YBR129C Protein of unknown function genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PPG1 YNR032W Serine protein phosphatase involved in formation of FAR complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BAS1 YKR099W Myb-related transcription factor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SKY1 YMR216C SR protein kinase (SRPK) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SEY1 YOR165W Dynamin-like GTPase that mediates homotypic ER fusion genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p physical 3 2 2 Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 3 2 2 Positive Genetic, Negative Genetic, Positive Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PRP28 YDR243C Pre-mRNA splicing factor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BSP1 YPR171W Adapter that links synaptojanins to the cortical actin cytoskeleton genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEC17 YBL050W Alpha-SNAP cochaperone genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DNM1 YLL001W Dynamin-related GTPase involved in mitochondrial organization genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BUD13 YGL174W Subunit of the RES complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
IST3 YIR005W Component of the U2 snRNP genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MSN5 YDR335W Karyopherin genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
GPB2 YAL056W Multistep regulator of cAMP-PKA signaling genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ERV14 YGL054C COPII-coated vesicle protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MHP1 YJL042W Microtubule-associated protein involved in microtubule organization genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TRM8 YDL201W Catalytic subunit of a tRNA methyltransferase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YGR016W YGR016W Putative protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ANR2 YKL047W Protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PMT6 YGR199W Protein O-mannosyltransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MNN2 YBR015C Alpha-1,2-mannosyltransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MSC1 YML128C Protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PTH1 YHR189W One of two mitochondrially-localized peptidyl-tRNA hydrolases genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
RCF1 YML030W Cytochrome c oxidase subunit genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TRM82 YDR165W Noncatalytic subunit of a tRNA methyltransferase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TMH18 YPR098C Mitochondrial protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 3 2 1 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 3 2 1 Affinity Capture-Western, Affinity Capture-Western, Co-fractionation
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 3 2 1 Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity
ASR1 YPR093C Ubiquitin ligase that modifies and regulates RNA Pol II physical 3 2 1 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RPB2 YOR151C RNA polymerase II second largest subunit B150 physical 2 2 2 Co-purification, Affinity Capture-MS
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
BDF1 YLR399C BET family transcriptional regulator genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 2 2 2 Positive Genetic, Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
ABF2 YMR072W Mitochondrial DNA-binding protein genetic 2 2 2 Phenotypic Suppression, Positive Genetic
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination genetic 2 2 2 Positive Genetic, Phenotypic Suppression
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
MIG1 YGL035C Transcription factor involved in glucose repression genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
DEF1 YKL054C RNAPII degradation factor physical 2 2 2 Co-purification, Affinity Capture-MS
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CHA4 YLR098C DNA binding transcriptional activator genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 2 2 2 Negative Genetic, Positive Genetic
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
SSA2 YLL024C HSP70 family ATP-binding protein physical 2 2 2 Co-purification, Affinity Capture-MS
SSA2 YLL024C HSP70 family ATP-binding protein genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
MBF1 YOR298C-A Transcriptional coactivator genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
INP51 YIL002C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
UBP2 YOR124C Ubiquitin-specific protease genetic 2 2 2 Phenotypic Suppression, Phenotypic Enhancement
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) genetic 2 1 2 Negative Genetic, Negative Genetic
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPL16A YIL133C Ribosomal 60S subunit protein L16A physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PAB1 YER165W Poly(A) binding protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TIF2 YJL138C Translation initiation factor eIF4A genetic 2 1 2 Negative Genetic, Negative Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 2 1 2 Negative Genetic, Negative Genetic
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MFT1 YML062C Subunit of the THO complex genetic 2 1 2 Negative Genetic, Negative Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
CEX1 YOR112W Component of nuclear aminoacylation-dependent tRNA export pathway genetic 2 1 2 Negative Genetic, Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 2 1 2 Negative Genetic, Negative Genetic
RTT10 YPL183C WD40 domain-containing protein involved in endosomal recycling genetic 2 1 2 Negative Genetic, Negative Genetic
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex genetic 2 1 2 Negative Genetic, Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 2 1 2 Negative Genetic, Negative Genetic
ENO2 YHR174W Enolase II, a phosphopyruvate hydratase genetic 2 1 2 Negative Genetic, Negative Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 2 1 2 Negative Genetic, Negative Genetic
MLC1 YGL106W Essential light chain for Myo1p physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
APM1 YPL259C Mu1-like medium subunit of the AP-1 complex genetic 2 1 2 Negative Genetic, Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 2 1 2 Negative Genetic, Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 2 1 2 Negative Genetic, Negative Genetic
RXT3 YDL076C Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
NGG1 YDR176W Subunit of chromatin modifying histone acetyltransferase complexes physical 2 1 2 Two-hybrid, Two-hybrid
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 2 1 2 Negative Genetic, Negative Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 2 1 2 Negative Genetic, Negative Genetic
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 2 1 2 Negative Genetic, Negative Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 2 1 2 Negative Genetic, Negative Genetic
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex genetic 2 1 2 Negative Genetic, Negative Genetic
CYM1 YDR430C Lysine-specific metalloprotease of the pitrilysin family genetic 2 1 2 Negative Genetic, Negative Genetic
DBF20 YPR111W Ser/Thr kinase involved in late nuclear division genetic 2 1 2 Negative Genetic, Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 2 1 2 Negative Genetic, Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 2 1 2 Negative Genetic, Negative Genetic
MSG5 YNL053W Dual-specificity protein phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating physical 2 1 2 Biochemical Activity, Biochemical Activity
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 2 1 2 Negative Genetic, Negative Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 2 1 2 Negative Genetic, Negative Genetic
CLG1 YGL215W Cyclin-like protein that interacts with Pho85p genetic 2 1 2 Negative Genetic, Negative Genetic
SOR2 YDL246C Sorbitol dehydrogenase genetic 2 1 2 Negative Genetic, Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 2 1 2 Negative Genetic, Negative Genetic
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 2 1 2 Negative Genetic, Negative Genetic
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 2 1 2 Negative Genetic, Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Positive Genetic, Positive Genetic
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SSC1 YJR045C Hsp70 family ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Positive Genetic, Positive Genetic
SEC22 YLR268W R-SNARE protein genetic 2 1 2 Negative Genetic, Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 2 1 2 Negative Genetic, Negative Genetic
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 2 1 2 Negative Genetic, Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 2 1 2 Positive Genetic, Positive Genetic
CDC19 YAL038W Pyruvate kinase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 2 1 2 Negative Genetic, Negative Genetic
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 2 1 2 Negative Genetic, Negative Genetic
GPB1 YOR371C Multistep regulator of cAMP-PKA signaling genetic 2 1 2 Negative Genetic, Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 2 1 2 Negative Genetic, Negative Genetic
GDA1 YEL042W Guanosine diphosphatase located in the Golgi genetic 2 1 2 Negative Genetic, Negative Genetic
TFA2 YKR062W TFIIE small subunit genetic 2 1 2 Negative Genetic, Negative Genetic
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance genetic 2 1 2 Negative Genetic, Negative Genetic
MBA1 YBR185C Membrane-associated mitochondrial ribosome receptor genetic 2 1 2 Negative Genetic, Negative Genetic
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform genetic 2 1 2 Negative Genetic, Negative Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 2 1 2 Negative Genetic, Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 2 1 2 Negative Genetic, Negative Genetic
YKR041W YKR041W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
YML119W YML119W Putative protein of unknown function genetic 2 1 2 Positive Genetic, Positive Genetic
URA5 YML106W Major orotate phosphoribosyltransferase (OPRTase) isozyme genetic 2 1 2 Negative Genetic, Negative Genetic
YPT7 YML001W Rab family GTPase genetic 2 1 2 Positive Genetic, Positive Genetic
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 2 1 2 Negative Genetic, Negative Genetic
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic genetic 2 1 2 Negative Genetic, Negative Genetic
TFG2 YGR005C TFIIF (Transcription Factor II) middle subunit genetic 2 1 2 Negative Genetic, Negative Genetic
IMP21 YIL154C Transcriptional activator involved in maintenance of ion homeostasis genetic 2 1 2 Negative Genetic, Negative Genetic
OCA4 YCR095C Cytoplasmic protein required for replication of Brome mosaic virus genetic 2 1 2 Negative Genetic, Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 2 1 2 Negative Genetic, Negative Genetic
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 2 1 2 Negative Genetic, Negative Genetic
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs genetic 2 1 2 Negative Genetic, Negative Genetic
IDP1 YDL066W Mitochondrial NADP-specific isocitrate dehydrogenase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TMA46 YOR091W Protein of unknown function that associates with translating ribosomes physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SCH9 YHR205W AGC family protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
AGE1 YDR524C ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector genetic 2 1 2 Negative Genetic, Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 2 1 2 Negative Genetic, Negative Genetic
NPR1 YNL183C Protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
SUR7 YML052W Plasma membrane protein, component of eisosomes genetic 2 1 2 Negative Genetic, Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 2 1 2 Positive Genetic, Positive Genetic
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs genetic 2 1 2 Negative Genetic, Negative Genetic
BER1 YLR412W Protein involved in microtubule-related processes genetic 2 1 2 Positive Genetic, Positive Genetic
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ATP23 YNR020C Putative metalloprotease of the mitochondrial inner membrane genetic 2 1 2 Negative Genetic, Negative Genetic
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 2 1 2 Negative Genetic, Negative Genetic
AAT1 YKL106W Mitochondrial aspartate aminotransferase genetic 2 1 2 Negative Genetic, Negative Genetic
MRX4 YPL168W Protein that associates with mitochondrial ribosome genetic 2 1 2 Negative Genetic, Negative Genetic
PAU10 YDR542W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) regulation 2 2 1 co-immunoprecipitation evidence, qualitative western immunoblotting evidence
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 2 2 1 Negative Genetic, Positive Genetic
SPT15 YER148W TATA-binding protein (TBP) physical 2 2 1 Affinity Capture-Western, Biochemical Activity
SPT15 YER148W TATA-binding protein (TBP) genetic 2 2 1 Synthetic Growth Defect, Dosage Rescue
RCK1 YGL158W Protein kinase involved in oxidative stress response physical 2 2 1 Two-hybrid, Affinity Capture-Western
ATG19 YOL082W Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway physical 2 2 1 Two-hybrid, Reconstituted Complex
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 2 1 1 Negative Genetic, Negative Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
PRP43 YGL120C RNA helicase in the DEAH-box family genetic 2 1 1 Negative Genetic, Negative Genetic
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 2 1 1 Negative Genetic, Negative Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 2 1 1 Negative Genetic, Negative Genetic
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export genetic 2 1 1 Negative Genetic, Negative Genetic
ILS1 YBL076C Cytoplasmic isoleucine-tRNA synthetase genetic 2 1 1 Negative Genetic, Negative Genetic
RPG1 YBR079C eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 2 1 1 Negative Genetic, Negative Genetic
AAR2 YBL074C Component of the U5 snRNP complex genetic 2 1 1 Negative Genetic, Negative Genetic
ARC15 YIL062C Subunit of the ARP2/3 complex genetic 2 1 1 Positive Genetic, Positive Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 2 1 1 Negative Genetic, Negative Genetic
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B genetic 2 1 1 Negative Genetic, Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 2 1 1 Negative Genetic, Negative Genetic
PIL1 YGR086C Eisosome core component genetic 2 1 1 Negative Genetic, Negative Genetic
RET3 YPL010W Zeta subunit of the coatomer complex (COPI) genetic 2 1 1 Negative Genetic, Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 2 1 1 Negative Genetic, Negative Genetic
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p genetic 2 1 1 Negative Genetic, Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 2 1 1 Negative Genetic, Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 2 1 1 Negative Genetic, Negative Genetic
ARF1 YDL192W ADP-ribosylation factor genetic 2 1 1 Positive Genetic, Positive Genetic
DPB11 YJL090C DNA replication initiation protein genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
CDC123 YLR215C Assembly factor for the eIF2 translation initiation factor complex genetic 2 1 1 Negative Genetic, Negative Genetic
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 2 1 1 Negative Genetic, Negative Genetic
ADH6 YMR318C NADPH-dependent medium chain alcohol dehydrogenase genetic 2 1 1 Negative Genetic, Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 2 1 1 Negative Genetic, Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 2 1 1 Negative Genetic, Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 2 1 1 Positive Genetic, Positive Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) genetic 2 1 1 Negative Genetic, Negative Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 2 1 1 Positive Genetic, Positive Genetic
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat genetic 2 1 1 Negative Genetic, Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 2 1 1 Negative Genetic, Negative Genetic
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 2 1 1 Positive Genetic, Positive Genetic
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 2 1 1 Negative Genetic, Negative Genetic
ATP18 YML081C-A Subunit of the mitochondrial F1F0 ATP synthase genetic 2 1 1 Negative Genetic, Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 2 1 1 Negative Genetic, Negative Genetic
YJR120W YJR120W Protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
YPT1 YFL038C Rab family GTPase genetic 2 1 1 Negative Genetic, Negative Genetic
YIP1 YGR172C Integral membrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
NMT1 YLR195C N-myristoyl transferase genetic 2 1 1 Negative Genetic, Negative Genetic
HXT2 YMR011W High-affinity glucose transporter of the major facilitator superfamily genetic 2 1 1 Negative Genetic, Negative Genetic
GOT1 YMR292W Homodimeric protein that is packaged into COPII vesicles genetic 2 1 1 Negative Genetic, Negative Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
ALG2 YGL065C Mannosyltransferase in the N-linked glycosylation pathway genetic 2 1 1 Negative Genetic, Negative Genetic
EMI1 YDR512C Non-essential protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
HSP78 YDR258C Oligomeric mitochondrial matrix chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
RPS25A YGR027C Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Negative Genetic, Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 2 1 1 Negative Genetic, Negative Genetic
THR4 YCR053W Threonine synthase genetic 2 1 1 Negative Genetic, Negative Genetic
RIM9 YMR063W Plasma membrane protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TOA2 YKL058W TFIIA small subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Negative Genetic
CHL4 YDR254W Outer kinetochore protein required for chromosome stability genetic 1 1 1 Positive Genetic
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
DED81 YHR019C Cytosolic asparaginyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
DED81 YHR019C Cytosolic asparaginyl-tRNA synthetase genetic 1 1 1 Negative Genetic
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Negative Genetic
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 1 1 1 Affinity Capture-Western
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Dosage Growth Defect
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit physical 1 1 1 Co-purification
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit genetic 1 1 1 Negative Genetic
IKI3 YLR384C Subunit of Elongator complex physical 1 1 1 Affinity Capture-MS
HSP60 YLR259C Tetradecameric mitochondrial chaperonin physical 1 1 1 Affinity Capture-MS
BRX1 YOL077C Nucleolar protein physical 1 1 1 Affinity Capture-MS
EBP2 YKL172W Required for 25S rRNA maturation and 60S ribosomal subunit assembly physical 1 1 1 Affinity Capture-MS
ERB1 YMR049C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
HAS1 YMR290C ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
HAS1 YMR290C ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
NIP7 YPL211W Nucleolar protein required for 60S ribosome subunit biogenesis physical 1 1 1 Affinity Capture-MS
NOG1 YPL093W Putative GTPase physical 1 1 1 Affinity Capture-MS
NOP2 YNL061W rRNA m5C methyltransferase physical 1 1 1 Affinity Capture-MS
NOP4 YPL043W Nucleolar protein physical 1 1 1 Affinity Capture-MS
NOP7 YGR103W Component of several different pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
RPL10 YLR075W Ribosomal 60S subunit protein L10 physical 1 1 1 Affinity Capture-MS
RPL17A YKL180W Ribosomal 60S subunit protein L17A physical 1 1 1 Affinity Capture-MS
RPL27A YHR010W Ribosomal 60S subunit protein L27A physical 1 1 1 Affinity Capture-MS
RPL30 YGL030W Ribosomal 60S subunit protein L30 physical 1 1 1 Affinity Capture-MS
RPL32 YBL092W Ribosomal 60S subunit protein L32 physical 1 1 1 Affinity Capture-MS
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins physical 1 1 1 Affinity Capture-MS
GCD6 YDR211W Catalytic epsilon subunit of the translation initiation factor eIF2B physical 1 1 1 Affinity Capture-MS
ADH1 YOL086C Alcohol dehydrogenase physical 1 1 1 Affinity Capture-MS
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Negative Genetic
POP3 YNL282W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
PRP43 YGL120C RNA helicase in the DEAH-box family physical 1 1 1 Affinity Capture-MS
PRP45 YAL032C Protein required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
SMB1 YER029C Core Sm protein Sm B physical 1 1 1 Affinity Capture-MS
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Positive Genetic
SNT309 YPR101W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Negative Genetic
NOC2 YOR206W Protein involved in ribosome biogenesis physical 1 1 1 Affinity Capture-MS
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes physical 1 1 1 Affinity Capture-MS
NUG1 YER006W GTPase that associates with nuclear 60S pre-ribosomes physical 1 1 1 Affinity Capture-MS
HAP5 YOR358W Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 1 1 1 Negative Genetic
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 1 1 1 Negative Genetic
NAN1 YPL126W U3 snoRNP protein physical 1 1 1 Affinity Capture-MS
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger genetic 1 1 1 Synthetic Rescue
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly physical 1 1 1 Affinity Capture-MS
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
NOP15 YNL110C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
CIC1 YHR052W Essential protein that interacts with proteasome components physical 1 1 1 Affinity Capture-MS
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases physical 1 1 1 Affinity Capture-MS
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) physical 1 1 1 Affinity Capture-MS
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) genetic 1 1 1 Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform physical 1 1 1 Affinity Capture-MS
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family physical 1 1 1 Affinity Capture-MS
NSR1 YGR159C Nucleolin, nucleolar protein that binds nuclear localization sequences physical 1 1 1 Affinity Capture-MS
NHP2 YDL208W Protein related to mammalian high mobility group (HMG) proteins physical 1 1 1 Affinity Capture-MS
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein physical 1 1 1 Affinity Capture-MS
FUN12 YAL035W Translation initiation factor eIF5B physical 1 1 1 Affinity Capture-MS
MAK21 YDR060W Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs physical 1 1 1 Affinity Capture-MS
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Negative Genetic
NAT3 YPR131C Catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Phenotypic Suppression
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Affinity Capture-MS
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus physical 1 1 1 Affinity Capture-MS
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity physical 1 1 1 Affinity Capture-MS
RPS4B YHR203C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CDC33 YOL139C Translation initiation factor eIF4E physical 1 1 1 Affinity Capture-MS
TIF2 YJL138C Translation initiation factor eIF4A physical 1 1 1 Affinity Capture-MS
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
RRP9 YPR137W Protein involved in pre-rRNA processing physical 1 1 1 Affinity Capture-MS
RPC40 YPR110C RNA polymerase subunit AC40 physical 1 1 1 Affinity Capture-MS
RPA34 YJL148W RNA polymerase I subunit A34.5 physical 1 1 1 Affinity Capture-MS
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Negative Genetic
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
RPC19 YNL113W RNA polymerase subunit AC19 physical 1 1 1 Affinity Capture-MS
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Negative Genetic
RPA190 YOR341W RNA polymerase I largest subunit A190 physical 1 1 1 Affinity Capture-MS
RPA49 YNL248C RNA polymerase I subunit A49 physical 1 1 1 Affinity Capture-MS
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Negative Genetic
RPA43 YOR340C RNA polymerase I subunit A43 genetic 1 1 1 Positive Genetic
RPL3 YOR063W Ribosomal 60S subunit protein L3 physical 1 1 1 Affinity Capture-MS
THO2 YNL139C Subunit of the THO complex genetic 1 1 1 Phenotypic Enhancement
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 physical 1 1 1 Affinity Capture-MS
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MUD1 YBR119W U1 snRNP A protein physical 1 1 1 Affinity Capture-MS
DST1 YGL043W General transcription elongation factor TFIIS physical 1 1 1 Affinity Capture-MS
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing physical 1 1 1 Affinity Capture-MS
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing physical 1 1 1 Affinity Capture-MS
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 1 1 1 Negative Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Positive Genetic
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 1 1 1 Positive Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes physical 1 1 1 Affinity Capture-MS
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Synthetic Growth Defect
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-Western
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
NIP1 YMR309C eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
NIP1 YMR309C eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
PRT1 YOR361C eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
RPG1 YBR079C eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
TIF34 YMR146C eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
TIF35 YDR429C eIF3g subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
PTA1 YAL043C Subunit of holo-CPF genetic 1 1 1 Negative Genetic
IMD3 YLR432W Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex physical 1 1 1 Affinity Capture-MS
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-MS
PUF6 YDR496C Pumilio-homology domain protein physical 1 1 1 Affinity Capture-MS
THS1 YIL078W Threonyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
THS1 YIL078W Threonyl-tRNA synthetase genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 physical 1 1 1 Affinity Capture-MS
TRM3 YDL112W 2'-O-ribose methyltransferase genetic 1 1 1 Negative Genetic
OLA1 YBR025C P-loop ATPase with similarity to human OLA1 and bacterial YchF physical 1 1 1 Affinity Capture-MS
EFT2 YDR385W Elongation factor 2 (EF-2), also encoded by EFT1 physical 1 1 1 Affinity Capture-MS
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme physical 1 1 1 Affinity Capture-MS
ADE4 YMR300C Phosphoribosylpyrophosphate amidotransferase (PRPPAT) physical 1 1 1 Affinity Capture-MS
APL2 YKL135C Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex genetic 1 1 1 Negative Genetic
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA physical 1 1 1 Affinity Capture-MS
ARO1 YDR127W Pentafunctional arom protein physical 1 1 1 Affinity Capture-MS
ARP2 YDL029W Essential component of the Arp2/3 complex physical 1 1 1 Affinity Capture-MS
ASF1 YJL115W Nucleosome assembly factor physical 1 1 1 Affinity Capture-MS
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
BMH2 YDR099W 14-3-3 protein, minor isoform physical 1 1 1 Affinity Capture-MS
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 1 1 1 Synthetic Growth Defect
BEM2 YER155C Rho GTPase activating protein (RhoGAP) physical 1 1 1 Affinity Capture-MS
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 1 1 1 Affinity Capture-MS
BOI2 YER114C Protein involved in polar growth genetic 1 1 1 Negative Genetic
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
TIF6 YPR016C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
CHC1 YGL206C Clathrin heavy chain physical 1 1 1 Affinity Capture-MS
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 Affinity Capture-MS
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation physical 1 1 1 Affinity Capture-Western
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
ENO1 YGR254W Enolase I, a phosphopyruvate hydratase physical 1 1 1 Affinity Capture-MS
EMG1 YLR186W Methyltransferase for rRNA genetic 1 1 1 Synthetic Growth Defect
ERG13 YML126C 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase physical 1 1 1 Affinity Capture-MS
EMP24 YGL200C Component of the p24 complex genetic 1 1 1 Synthetic Growth Defect
FRS1 YLR060W Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity genetic 1 1 1 Negative Genetic
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
HAP2 YGL237C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) genetic 1 1 1 Positive Genetic
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 1 1 1 Negative Genetic
CLU1 YMR012W Subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
KGD2 YDR148C Dihydrolipoyl transsuccinylase genetic 1 1 1 Positive Genetic
KRE33 YNL132W Acetyltransferase required for biogenesis of small ribosomal subunit physical 1 1 1 Affinity Capture-MS
KRS1 YDR037W Lysyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Negative Genetic
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
GFA1 YKL104C Glutamine-fructose-6-phosphate amidotransferase physical 1 1 1 Affinity Capture-MS
LSM4 YER112W Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-MS
ENO2 YHR174W Enolase II, a phosphopyruvate hydratase physical 1 1 1 Affinity Capture-MS
MBP1 YDL056W Transcription factor genetic 1 1 1 Negative Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Positive Genetic
GLT1 YDL171C NAD(+)-dependent glutamate synthase (GOGAT) physical 1 1 1 Affinity Capture-MS
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED2 YDL005C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
FBA1 YKL060C Fructose 1,6-bisphosphate aldolase physical 1 1 1 Affinity Capture-MS
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Negative Genetic
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
FYV4 YHR059W Protein of unknown function genetic 1 1 1 Negative Genetic
MGM101 YJR144W Protein with a role in mitochondrial DNA recombinational repair physical 1 1 1 Affinity Capture-MS
MTR10 YOR160W Nuclear import receptor genetic 1 1 1 Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos physical 1 1 1 Affinity Capture-MS
MYO4 YAL029C Type V myosin motor involved in actin-based transport of cargos physical 1 1 1 Affinity Capture-MS
NAM8 YHR086W RNA binding protein, component of the U1 snRNP protein physical 1 1 1 Affinity Capture-MS
MIS1 YBR084W Mitochondrial C1-tetrahydrofolate synthase physical 1 1 1 Affinity Capture-MS
NCL1 YBL024W S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase physical 1 1 1 Affinity Capture-MS
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex genetic 1 1 1 Negative Genetic
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
FPR4 YLR449W Peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Affinity Capture-MS
FAS2 YPL231W Alpha subunit of fatty acid synthetase physical 1 1 1 Affinity Capture-MS
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Negative Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Synthetic Rescue
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Positive Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
PGK1 YCR012W 3-phosphoglycerate kinase physical 1 1 1 Affinity Capture-MS
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Synthetic Rescue
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation physical 1 1 1 Affinity Capture-MS
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
BLM10 YFL007W Proteasome activator genetic 1 1 1 Phenotypic Suppression
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
HTA1 YDR225W Histone H2A physical 1 1 1 Affinity Capture-MS
PRP4 YPR178W Splicing factor genetic 1 1 1 Positive Genetic
LEA1 YPL213W Component of U2 snRNP complex physical 1 1 1 Affinity Capture-MS
LIN1 YHR156C Non-essential component of U5 snRNP genetic 1 1 1 Negative Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
PAA1 YDR071C Polyamine acetyltransferase physical 1 1 1 Affinity Capture-MS
PTC4 YBR125C Cytoplasmic type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome physical 1 1 1 Affinity Capture-MS
HTA2 YBL003C Histone H2A physical 1 1 1 Affinity Capture-MS
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes physical 1 1 1 Affinity Capture-MS
RAD16 YBR114W Nucleotide excision repair (NER) protein genetic 1 1 1 Synthetic Rescue
RAD23 YEL037C Protein with ubiquitin-like N terminus genetic 1 1 1 Synthetic Rescue
GCN20 YFR009W Positive regulator of the Gcn2p kinase activity physical 1 1 1 Affinity Capture-MS
RAD3 YER171W 5' to 3' DNA helicase genetic 1 1 1 Negative Genetic
GPM1 YKL152C Tetrameric phosphoglycerate mutase physical 1 1 1 Affinity Capture-MS
RAM1 YDL090C Beta subunit of the CAAX farnesyltransferase (FTase) genetic 1 1 1 Negative Genetic
RET2 YFR051C Delta subunit of the coatomer complex (COPI) physical 1 1 1 Affinity Capture-MS
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 1 1 1 Affinity Capture-MS
RFC3 YNL290W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-MS
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPA12 YJR063W RNA polymerase I subunit A12.2 physical 1 1 1 Affinity Capture-MS
RPL23A YBL087C Ribosomal 60S subunit protein L23A physical 1 1 1 Affinity Capture-MS
DBP2 YNL112W ATP-dependent RNA helicase of the DEAD-box protein family physical 1 1 1 Affinity Capture-MS
RPL2A YFR031C-A Ribosomal 60S subunit protein L2A physical 1 1 1 Affinity Capture-MS
MLH2 YLR035C Protein involved in mismatch repair and meiotic recombination genetic 1 1 1 Negative Genetic
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Positive Genetic
NUM1 YDR150W Protein required for nuclear migration physical 1 1 1 Affinity Capture-MS
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 1 1 1 Negative Genetic
PIL1 YGR086C Eisosome core component physical 1 1 1 Affinity Capture-MS
PGI1 YBR196C Glycolytic enzyme phosphoglucose isomerase physical 1 1 1 Affinity Capture-MS
SEC13 YLR208W Structural component of 3 complexes physical 1 1 1 Affinity Capture-MS
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer physical 1 1 1 Affinity Capture-MS
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer physical 1 1 1 Affinity Capture-MS
RPP2B YDR382W Ribosomal protein P2 beta physical 1 1 1 Affinity Capture-MS
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SAM1 YLR180W S-adenosylmethionine synthetase physical 1 1 1 Affinity Capture-MS
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Negative Genetic
BGL2 YGR282C Endo-beta-1,3-glucanase physical 1 1 1 Affinity Capture-MS
NET1 YJL076W Core subunit of the RENT complex physical 1 1 1 Affinity Capture-MS
CCT2 YIL142W Subunit beta of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
BZZ1 YHR114W SH3 domain protein implicated in regulating actin polymerization genetic 1 1 1 Negative Genetic
ECM25 YJL201W Endocytic site protein required for stress-induced cell elongation genetic 1 1 1 Negative Genetic
INP52 YNL106C Polyphosphatidylinositol phosphatase genetic 1 1 1 Synthetic Growth Defect
SLA1 YBL007C Cytoskeletal protein binding protein physical 1 1 1 Two-hybrid
SLY1 YDR189W Hydrophilic protein involved in ER/Golgi vesicle trafficking genetic 1 1 1 Negative Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 1 1 1 Positive Genetic
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Positive Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Positive Genetic
PRP11 YDL043C Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SPE3 YPR069C Spermidine synthase physical 1 1 1 Affinity Capture-MS
NEM1 YHR004C Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 1 1 1 Positive Genetic
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 1 1 1 Negative Genetic
NGG1 YDR176W Subunit of chromatin modifying histone acetyltransferase complexes genetic 1 1 1 Synthetic Growth Defect
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-MS
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 1 1 1 Positive Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex physical 1 1 1 Affinity Capture-MS
SUA7 YPR086W Transcription factor TFIIB genetic 1 1 1 Negative Genetic
SUI3 YPL237W Beta subunit of the translation initiation factor eIF2 physical 1 1 1 Affinity Capture-MS
SUI3 YPL237W Beta subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
CRN1 YLR429W Coronin genetic 1 1 1 Synthetic Growth Defect
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Positive Genetic
SUP45 YBR143C Polypeptide release factor (eRF1) in translation termination physical 1 1 1 Affinity Capture-MS
TAF13 YML098W TFIID subunit (19 kDa) physical 1 1 1 Affinity Capture-MS
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
CCT7 YJL111W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
CCT7 YJL111W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
EFB1 YAL003W Translation elongation factor 1 beta physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
TEF2 YBR118W Translational elongation factor EF-1 alpha physical 1 1 1 Affinity Capture-MS
TEF2 YBR118W Translational elongation factor EF-1 alpha genetic 1 1 1 Negative Genetic
NEW1 YPL226W Translation termination and ribosome biogenesis factor physical 1 1 1 Affinity Capture-MS
TFA1 YKL028W TFIIE large subunit genetic 1 1 1 Negative Genetic
RBG1 YAL036C Member of the DRG family of GTP-binding proteins physical 1 1 1 Affinity Capture-MS
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 Co-purification
GLN1 YPR035W Glutamine synthetase (GS) physical 1 1 1 Affinity Capture-MS
TIF1 YKR059W Translation initiation factor eIF4A physical 1 1 1 Affinity Capture-MS
BET5 YML077W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Phenotypic Suppression
RGC1 YPR115W Putative regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Positive Genetic
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) physical 1 1 1 Affinity Capture-MS
RRP12 YPL012W Protein required for export of the ribosomal subunits physical 1 1 1 Affinity Capture-MS
DOT6 YER088C Protein involved in rRNA and ribosome biogenesis physical 1 1 1 Affinity Capture-MS
TMA20 YER007C-A Protein of unknown function that associates with ribosomes physical 1 1 1 Affinity Capture-MS
SYF1 YDR416W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
GET4 YOR164C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Positive Genetic
SKI3 YPR189W Ski complex component and TPR protein genetic 1 1 1 Positive Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Rescue
FPR3 YML074C Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Affinity Capture-MS
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Positive Genetic
CRZ1 YNL027W Transcription factor, activates transcription of stress response genes genetic 1 1 1 Negative Genetic
CAR2 YLR438W L-ornithine transaminase (OTAse) physical 1 1 1 Affinity Capture-MS
FIN1 YDR130C Spindle pole body-related intermediate filament protein genetic 1 1 1 Negative Genetic
GND1 YHR183W 6-phosphogluconate dehydrogenase (decarboxylating) physical 1 1 1 Affinity Capture-MS
IRA2 YOL081W GTPase-activating protein physical 1 1 1 Affinity Capture-Western
HYP2 YEL034W Translation elongation factor eIF-5A physical 1 1 1 Affinity Capture-MS
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Synthetic Growth Defect
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
RIM15 YFL033C Protein kinase involved in cell proliferation in response to nutrients physical 1 1 1 Biochemical Activity
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex physical 1 1 1 Affinity Capture-MS
ATG17 YLR423C Scaffold protein responsible for phagophore assembly site organization genetic 1 1 1 Negative Genetic
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
GPP1 YIL053W Constitutively expressed DL-glycerol-3-phosphate phosphatase physical 1 1 1 Affinity Capture-MS
GPP1 YIL053W Constitutively expressed DL-glycerol-3-phosphate phosphatase genetic 1 1 1 Negative Genetic
DCS1 YLR270W Non-essential hydrolase involved in mRNA decapping genetic 1 1 1 Negative Genetic
SER1 YOR184W 3-phosphoserine aminotransferase physical 1 1 1 Affinity Capture-MS
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 1 1 1 Synthetic Growth Defect
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 1 1 1 Synthetic Growth Defect
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-MS
AHP1 YLR109W Thiol-specific peroxiredoxin physical 1 1 1 Affinity Capture-MS
DPS1 YLL018C Aspartyl-tRNA synthetase, primarily cytoplasmic physical 1 1 1 Affinity Capture-MS
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 1 1 1 Negative Genetic
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) physical 1 1 1 Affinity Capture-MS
ILV5 YLR355C Acetohydroxyacid reductoisomerase and mtDNA binding protein physical 1 1 1 Affinity Capture-MS
NOP6 YDL213C rRNA-binding protein required for 40S ribosomal subunit biogenesis physical 1 1 1 Affinity Capture-MS
PMA1 YGL008C Plasma membrane P2-type H+-ATPase physical 1 1 1 Affinity Capture-MS
PRO1 YDR300C Gamma-glutamyl kinase physical 1 1 1 Affinity Capture-MS
PRO1 YDR300C Gamma-glutamyl kinase genetic 1 1 1 Synthetic Growth Defect
SEC53 YFL045C Phosphomannomutase physical 1 1 1 Affinity Capture-MS
ESL2 YKR096W hEST1A/B (SMG5/6)-like protein genetic 1 1 1 Negative Genetic
GLC8 YMR311C Regulatory subunit of protein phosphatase 1 (Glc7p) genetic 1 1 1 Positive Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 1 1 1 Negative Genetic
CCT5 YJR064W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 1 1 1 Negative Genetic
PCL7 YIL050W Pho85p cyclin of the Pho80p subfamily genetic 1 1 1 Negative Genetic
PGM2 YMR105C Phosphoglucomutase physical 1 1 1 Affinity Capture-MS
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization physical 1 1 1 Affinity Capture-MS
PRS3 YHL011C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 1 1 1 Affinity Capture-MS
TOP2 YNL088W Topoisomerase II genetic 1 1 1 Negative Genetic
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
SES1 YDR023W Cytosolic seryl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
KDX1 YKL161C Protein kinase genetic 1 1 1 Negative Genetic
PET9 YBL030C Major ADP/ATP carrier of the mitochondrial inner membrane physical 1 1 1 Affinity Capture-MS
PET9 YBL030C Major ADP/ATP carrier of the mitochondrial inner membrane genetic 1 1 1 Dosage Rescue
MAE1 YKL029C Mitochondrial malic enzyme physical 1 1 1 Affinity Capture-MS
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
PRO3 YER023W Delta 1-pyrroline-5-carboxylate reductase physical 1 1 1 Affinity Capture-MS
PAC11 YDR488C Dynein intermediate chain, microtubule motor protein genetic 1 1 1 Negative Genetic
DLD3 YEL071W 2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase physical 1 1 1 Affinity Capture-MS
ACS2 YLR153C Acetyl-coA synthetase isoform physical 1 1 1 Affinity Capture-MS
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 1 1 1 Negative Genetic
ILV3 YJR016C Dihydroxyacid dehydratase genetic 1 1 1 Negative Genetic
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) physical 1 1 1 Affinity Capture-MS
MLH3 YPL164C Protein involved in DNA mismatch repair and meiotic recombination genetic 1 1 1 Positive Genetic
CCT3 YJL014W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
PDS1 YDR113C Securin physical 1 1 1 Biochemical Activity
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 1 1 1 Negative Genetic
RNQ1 YCL028W [PIN(+)] prion physical 1 1 1 Affinity Capture-MS
SMC6 YLR383W Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-MS
IMD4 YML056C Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Negative Genetic
UBI4 YLL039C Ubiquitin genetic 1 1 1 Positive Genetic
FAR10 YLR238W Protein involved in recovery from arrest in response to pheromone genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Affinity Capture-Western
CDC60 YPL160W Cytosolic leucyl tRNA synthetase physical 1 1 1 Affinity Capture-MS
GRS1 YBR121C Cytoplasmic and mitochondrial glycyl-tRNA synthase physical 1 1 1 Affinity Capture-MS
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Negative Genetic
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Positive Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p physical 1 1 1 Affinity Capture-MS
SAH1 YER043C S-adenosyl-L-homocysteine hydrolase physical 1 1 1 Affinity Capture-MS
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Positive Genetic
GRX1 YCL035C Glutathione-dependent disulfide oxidoreductase genetic 1 1 1 Negative Genetic
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk physical 1 1 1 Affinity Capture-MS
MNP1 YGL068W Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
TMA19 YKL056C Protein that associates with ribosomes physical 1 1 1 Affinity Capture-MS
TMA19 YKL056C Protein that associates with ribosomes genetic 1 1 1 Positive Genetic
SAR1 YPL218W ARF family GTPase physical 1 1 1 Affinity Capture-MS
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis physical 1 1 1 Affinity Capture-MS
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis genetic 1 1 1 Negative Genetic
KEL2 YGR238C Protein that negatively regulates mitotic exit genetic 1 1 1 Negative Genetic
KSP1 YHR082C Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 1 1 1 Synthetic Growth Defect
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation physical 1 1 1 Affinity Capture-MS
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Negative Genetic
SEG1 YMR086W Component of eisosome required for proper eisosome assembly genetic 1 1 1 Negative Genetic
TMA108 YIL137C Ribosome-associated, nascent chain binding factor physical 1 1 1 Affinity Capture-MS
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Positive Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Phenotypic Suppression
RCK1 YGL158W Protein kinase involved in oxidative stress response genetic 1 1 1 Phenotypic Suppression
ILV2 YMR108W Acetolactate synthase physical 1 1 1 Affinity Capture-MS
HAL5 YJL165C Snf1p-related nutrient-responsive protein kinase genetic 1 1 1 Negative Genetic
NOP13 YNL175C Nucleolar protein found in preribosomal complexes physical 1 1 1 Affinity Capture-MS
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Negative Genetic
PTP2 YOR208W Phosphotyrosine-specific phosphatase genetic 1 1 1 Positive Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression physical 1 1 1 Affinity Capture-MS
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Positive Genetic
AHC1 YOR023C Subunit of the Ada histone acetyltransferase complex genetic 1 1 1 Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Negative Genetic
SKM1 YOL113W Member of the PAK family of serine/threonine protein kinases genetic 1 1 1 Negative Genetic
FKH2 YNL068C Forkhead family transcription factor genetic 1 1 1 Negative Genetic
THI22 YPR121W Protein with similarity to hydroxymethylpyrimidine phosphate kinases genetic 1 1 1 Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Growth Defect
MAS2 YHR024C Alpha subunit of the mitochondrial processing protease (MPP) genetic 1 1 1 Negative Genetic
ASR1 YPR093C Ubiquitin ligase that modifies and regulates RNA Pol II genetic 1 1 1 Phenotypic Suppression
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B physical 1 1 1 Affinity Capture-MS
NUP53 YMR153W FG-nucleoporin component of central core of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 1 1 1 Synthetic Rescue
PRS5 YOL061W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 1 1 1 Affinity Capture-MS
CIN5 YOR028C Basic leucine zipper (bZIP) transcription factor of the yAP-1 family genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
EXG1 YLR300W Major exo-1,3-beta-glucanase of the cell wall genetic 1 1 1 Negative Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex physical 1 1 1 Affinity Capture-MS
DHR2 YKL078W Predominantly nucleolar DEAH-box ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
RPL5 YPL131W Ribosomal 60S subunit protein L5 physical 1 1 1 Affinity Capture-MS
APM4 YOL062C Cargo-binding mu subunit of AP-2 genetic 1 1 1 Negative Genetic
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains physical 1 1 1 Affinity Capture-Western
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains genetic 1 1 1 Phenotypic Suppression
TAL1 YLR354C Transaldolase, enzyme in the non-oxidative pentose phosphate pathway physical 1 1 1 Affinity Capture-MS
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis genetic 1 1 1 Negative Genetic
MTQ2 YDR140W S-adenosylmethionine-dependent methyltransferase physical 1 1 1 Affinity Capture-MS
PRS1 YKL181W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 1 1 1 Affinity Capture-MS
DSL1 YNL258C Peripheral membrane protein needed for Golgi-to-ER retrograde traffic genetic 1 1 1 Negative Genetic
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 1 1 1 Negative Genetic
ADE8 YDR408C Phosphoribosyl-glycinamide transformylase physical 1 1 1 Affinity Capture-MS
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
ENT3 YJR125C Protein containing an N-terminal epsin-like domain genetic 1 1 1 Negative Genetic
GDH1 YOR375C NADP(+)-dependent glutamate dehydrogenase physical 1 1 1 Affinity Capture-MS
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Negative Genetic
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 1 1 1 Negative Genetic
IRE1 YHR079C Serine-threonine kinase and endoribonuclease genetic 1 1 1 Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 1 1 1 Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase physical 1 1 1 Affinity Capture-Western
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Phenotypic Suppression
ACA1 YER045C ATF/CREB family basic leucine zipper (bZIP) transcription factor genetic 1 1 1 Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 1 1 1 Synthetic Growth Defect
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
PDR8 YLR266C Transcription factor genetic 1 1 1 Negative Genetic
RPS26A YGL189C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS26B YER131W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site genetic 1 1 1 Phenotypic Suppression
MRX16 YDR132C Protein that associates with the large mitoribosomal subunit genetic 1 1 1 Negative Genetic
ISY1 YJR050W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
STB2 YMR053C Protein that interacts with Sin3p in a two-hybrid assay genetic 1 1 1 Negative Genetic
PUT3 YKL015W Transcriptional activator genetic 1 1 1 Negative Genetic
PEF1 YGR058W Penta-EF-hand protein genetic 1 1 1 Positive Genetic
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
RIB4 YOL143C Lumazine synthase (DMRL synthase) physical 1 1 1 Affinity Capture-MS
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 physical 1 1 1 Affinity Capture-MS
NPR2 YEL062W Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex physical 1 1 1 Affinity Capture-MS
CDC26 YFR036W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 1 1 1 Synthetic Growth Defect
MDR1 YGR100W Cytoplasmic GTPase-activating protein genetic 1 1 1 Negative Genetic
RPL4A YBR031W Ribosomal 60S subunit protein L4A physical 1 1 1 Affinity Capture-MS
RLP24 YLR009W Essential protein required for ribosomal large subunit biogenesis physical 1 1 1 Affinity Capture-MS
RPS4A YJR145C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS5 YJR123W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
NFI1 YOR156C SUMO E3 ligase genetic 1 1 1 Negative Genetic
RPL23B YER117W Ribosomal 60S subunit protein L23B physical 1 1 1 Affinity Capture-MS
RPL9A YGL147C Ribosomal 60S subunit protein L9A physical 1 1 1 Affinity Capture-MS
RPS24A YER074W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS24B YIL069C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
CRP1 YHR146W Protein that binds to cruciform DNA structures genetic 1 1 1 Negative Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
SWC7 YLR385C Protein of unknown function genetic 1 1 1 Negative Genetic
MSN2 YMR037C Stress-responsive transcriptional activator genetic 1 1 1 Negative Genetic
TAF7 YMR227C TFIID subunit (67 kDa) genetic 1 1 1 Negative Genetic
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
IES4 YOR189W Component of the INO80 chromatiin remodeling complex genetic 1 1 1 Negative Genetic
SAS3 YBL052C Histone acetyltransferase catalytic subunit of NuA3 complex genetic 1 1 1 Negative Genetic
HOS3 YPL116W Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) genetic 1 1 1 Positive Genetic
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Negative Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Positive Genetic
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family genetic 1 1 1 Negative Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 1 1 1 Positive Genetic
RPS8B YER102W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL20B YOR312C Ribosomal 60S subunit protein L20B physical 1 1 1 Affinity Capture-MS
RPS11A YDR025W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17B YDR447C Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS1B YML063W Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS11B YBR048W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS9B YBR189W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL22A YLR061W Ribosomal 60S subunit protein L22A physical 1 1 1 Affinity Capture-MS
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Synthetic Growth Defect
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
ATG8 YBL078C Ub-like protein genetic 1 1 1 Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Negative Genetic
HXK2 YGL253W Hexokinase isoenzyme 2 physical 1 1 1 Affinity Capture-MS
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Negative Genetic
MYO5 YMR109W One of two type I myosin motors genetic 1 1 1 Negative Genetic
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Synthetic Growth Defect
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Negative Genetic
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 1 1 1 Negative Genetic
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Negative Genetic
RCY1 YJL204C F-box protein involved in recycling endocytosed proteins genetic 1 1 1 Negative Genetic
RAV2 YDR202C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Negative Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Positive Genetic
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 1 1 1 Affinity Capture-MS
TIM18 YOR297C Component of the mitochondrial TIM22 complex genetic 1 1 1 Positive Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
TIP20 YGL145W Peripheral membrane protein required for COPI vesicle fusion to the ER genetic 1 1 1 Negative Genetic
PEP8 YJL053W Vacuolar protein component of the retromer genetic 1 1 1 Positive Genetic
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes genetic 1 1 1 Synthetic Growth Defect
CST9 YLR394W SUMO E3 ligase genetic 1 1 1 Negative Genetic
CIN1 YOR349W Tubulin folding factor D involved in beta-tubulin (Tub2p) folding genetic 1 1 1 Negative Genetic
PHO2 YDL106C Homeobox transcription factor genetic 1 1 1 Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Negative Genetic
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat physical 1 1 1 Affinity Capture-Western
SEC31 YDL195W Component of the Sec13p-Sec31p complex of the COPII vesicle coat genetic 1 1 1 Negative Genetic
SIL1 YOL031C Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Positive Genetic
SSA3 YBL075C ATPase involved in protein folding and the response to stress genetic 1 1 1 Phenotypic Suppression
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Synthetic Growth Defect
MUD2 YKL074C Protein involved in early pre-mRNA splicing physical 1 1 1 Affinity Capture-MS
MUD2 YKL074C Protein involved in early pre-mRNA splicing genetic 1 1 1 Negative Genetic
RRI2 YOL117W Subunit of the COP9 signalosome (CSN) complex physical 1 1 1 Affinity Capture-MS
DAL80 YKR034W Negative regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
HCH1 YNL281W Heat shock protein regulator physical 1 1 1 Affinity Capture-MS
LRG1 YDL240W GTPase-activating protein (GAP) genetic 1 1 1 Negative Genetic
MET28 YIR017C bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex genetic 1 1 1 Negative Genetic
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector genetic 1 1 1 Negative Genetic
PRP16 YKR086W DEAH-box RNA helicase physical 1 1 1 Affinity Capture-MS
PRP16 YKR086W DEAH-box RNA helicase genetic 1 1 1 Negative Genetic
NNF2 YGR089W Protein that exhibits physical and genetic interactions with Rpb8p genetic 1 1 1 Negative Genetic
PRP22 YER013W DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
TEA1 YOR337W Ty1 enhancer activator involved in Ty enhancer-mediated transcription genetic 1 1 1 Negative Genetic
SAM2 YDR502C S-adenosylmethionine synthetase physical 1 1 1 Affinity Capture-MS
RPL1A YPL220W Ribosomal 60S subunit protein L1A physical 1 1 1 Affinity Capture-MS
RPL1B YGL135W Ribosomal 60S subunit protein L1B physical 1 1 1 Affinity Capture-MS
PBP1 YGR178C Component of glucose deprivation induced stress granules physical 1 1 1 Affinity Capture-MS
ATP1 YBL099W Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-MS
ATP1 YBL099W Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Dosage Rescue
CHS5 YLR330W Component of the exomer complex genetic 1 1 1 Positive Genetic
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
OAF1 YAL051W Oleate-activated transcription factor genetic 1 1 1 Negative Genetic
RDI1 YDL135C Rho GDP dissociation inhibitor genetic 1 1 1 Negative Genetic
ERT1 YBR239C Transcriptional regulator genetic 1 1 1 Negative Genetic
SHG1 YBR258C Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Positive Genetic
MSL5 YLR116W Component of commitment complex physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit genetic 1 1 1 Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
MDL1 YLR188W Mitochondrial inner membrane half-type ABC transporter genetic 1 1 1 Negative Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
RPL11A YPR102C Ribosomal 60S subunit protein L11A physical 1 1 1 Affinity Capture-MS
RPL11B YGR085C Ribosomal 60S subunit protein L11B physical 1 1 1 Affinity Capture-MS
CLB3 YDL155W B-type cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Negative Genetic
PDR12 YPL058C Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
RPL28 YGL103W Ribosomal 60S subunit protein L28 physical 1 1 1 Affinity Capture-MS
EFT1 YOR133W Elongation factor 2 (EF-2), also encoded by EFT2 physical 1 1 1 Affinity Capture-MS
TEF1 YPR080W Translational elongation factor EF-1 alpha physical 1 1 1 Affinity Capture-MS
TFB4 YPR056W Subunit of TFIIH complex genetic 1 1 1 Negative Genetic
RPL18A YOL120C Ribosomal 60S subunit protein L18A physical 1 1 1 Affinity Capture-MS
RPL18B YNL301C Ribosomal 60S subunit protein L18B physical 1 1 1 Affinity Capture-MS
RPS23A YGR118W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS23B YPR132W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
TEC1 YBR083W Transcription factor targeting filamentation genes and Ty1 expression genetic 1 1 1 Phenotypic Suppression
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
CRF1 YDR223W Transcriptional corepressor genetic 1 1 1 Negative Genetic
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL14B YHL001W Ribosomal 60S subunit protein L14B physical 1 1 1 Affinity Capture-MS
SNU13 YEL026W RNA binding protein physical 1 1 1 Affinity Capture-MS
RPL7A YGL076C Ribosomal 60S subunit protein L7A physical 1 1 1 Affinity Capture-MS
RPL15A YLR029C Ribosomal 60S subunit protein L15A physical 1 1 1 Affinity Capture-MS
RPL19B YBL027W Ribosomal 60S subunit protein L19B physical 1 1 1 Affinity Capture-MS
RPL21A YBR191W Ribosomal 60S subunit protein L21A physical 1 1 1 Affinity Capture-MS
RPL27B YDR471W Ribosomal 60S subunit protein L27B physical 1 1 1 Affinity Capture-MS
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Positive Genetic
ILV6 YCL009C Regulatory subunit of acetolactate synthase physical 1 1 1 Affinity Capture-MS
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 1 1 1 Positive Genetic
RPL16B YNL069C Ribosomal 60S subunit protein L16B physical 1 1 1 Affinity Capture-MS
RPL36B YPL249C-A Ribosomal 60S subunit protein L36B physical 1 1 1 Affinity Capture-MS
PDP3 YLR455W Component of the NuA3b histone acetyltransferase complex physical 1 1 1 Affinity Capture-MS
ASG7 YJL170C Protein that regulates signaling from G protein beta subunit Ste4p genetic 1 1 1 Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Synthetic Growth Defect
GTB1 YDR221W Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p genetic 1 1 1 Negative Genetic
JHD2 YJR119C JmjC domain family histone demethylase genetic 1 1 1 Negative Genetic
RUP1 YOR138C Protein that regulates ubiquitination of Rsp5p genetic 1 1 1 Negative Genetic
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Negative Genetic
STE7 YDL159W Signal transducing MAP kinase kinase physical 1 1 1 Biochemical Activity
STE7 YDL159W Signal transducing MAP kinase kinase genetic 1 1 1 Phenotypic Suppression
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein physical 1 1 1 Biochemical Activity
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 1 1 1 Positive Genetic
RPS31 YLR167W Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin physical 1 1 1 Biochemical Activity
DIC1 YLR348C Mitochondrial dicarboxylate carrier genetic 1 1 1 Negative Genetic
MRH1 YDR033W Protein that localizes primarily to the plasma membrane physical 1 1 1 Affinity Capture-MS
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance physical 1 1 1 Affinity Capture-MS
NTO1 YPR031W Subunit of the NuA3 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
TIP1 YBR067C Major cell wall mannoprotein with possible lipase activity physical 1 1 1 Affinity Capture-MS
IFA38 YBR159W Microsomal beta-keto-reductase physical 1 1 1 Affinity Capture-MS
RPL43B YJR094W-A Ribosomal 60S subunit protein L43B physical 1 1 1 Affinity Capture-MS
PBP4 YDL053C Pbp1p binding protein physical 1 1 1 Affinity Capture-MS
SOL2 YCR073W-A Protein with a possible role in tRNA export physical 1 1 1 Affinity Capture-MS
SRP14 YDL092W Signal recognition particle (SRP) subunit physical 1 1 1 Affinity Capture-MS
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
HXK1 YFR053C Hexokinase isoenzyme 1 genetic 1 1 1 Negative Genetic
RPS10B YMR230W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
TRS23 YDR246W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
NAT5 YOR253W Subunit of protein N-terminal acetyltransferase NatA physical 1 1 1 Affinity Capture-MS
PUF4 YGL014W Member of the PUF protein family genetic 1 1 1 Negative Genetic
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component physical 1 1 1 Affinity Capture-MS
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 1 1 1 Negative Genetic
GID11 YLR149C Substrate receptor of the glucose-induced degradation-deficient (GID) genetic 1 1 1 Negative Genetic
SRP40 YKR092C Nucleolar serine-rich protein physical 1 1 1 Affinity Capture-MS
SRP40 YKR092C Nucleolar serine-rich protein genetic 1 1 1 Phenotypic Suppression
TSA1 YML028W Thioredoxin peroxidase physical 1 1 1 Affinity Capture-MS
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Growth Defect
GUK1 YDR454C Guanylate kinase genetic 1 1 1 Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Positive Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
DDR48 YMR173W DNA damage-responsive protein physical 1 1 1 Affinity Capture-MS
ZEO1 YOL109W Peripheral membrane protein of the plasma membrane physical 1 1 1 Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-MS
URA2 YJL130C Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase physical 1 1 1 Affinity Capture-MS
YEF3 YLR249W Translation elongation factor 3 physical 1 1 1 Affinity Capture-MS
YHR214C-B YHR214C-B Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
YPR158W-B YPR158W-B Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
YML045W YML045W Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
URB1 YKL014C Protein required for the normal accumulation of 25S and 5.8S rRNAs physical 1 1 1 Affinity Capture-MS
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease physical 1 1 1 Affinity Capture-MS
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Negative Genetic
UTP4 YDR324C Subunit of U3-containing 90S preribosome and SSU processome complexes physical 1 1 1 Affinity Capture-MS
YHR020W YHR020W Prolyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
URA7 YBL039C Major CTP synthase isozyme (see also URA8) physical 1 1 1 Affinity Capture-MS
UTP9 YHR196W Nucleolar protein physical 1 1 1 Affinity Capture-MS
VMA2 YBR127C Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase physical 1 1 1 Affinity Capture-MS
YTM1 YOR272W Ribosomal assembly factor and 66S pre-ribosomal particle constituent physical 1 1 1 Affinity Capture-MS
UGP1 YKL035W UDP-glucose pyrophosphorylase (UGPase) physical 1 1 1 Affinity Capture-MS
YNL040W YNL040W Protein of unknown function physical 1 1 1 Affinity Capture-MS
YMR045C YMR045C Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
YBL005W-B YBL005W-B Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
VMA6 YLR447C Subunit d of the V0 integral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
YCR016W YCR016W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
URA1 YKL216W Dihydroorotate dehydrogenase physical 1 1 1 Affinity Capture-MS
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
URN1 YPR152C Protein of unknown function containing WW and FF domains physical 1 1 1 Affinity Capture-MS
YAK1 YJL141C Serine-threonine protein kinase physical 1 1 1 Reconstituted Complex
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 1 1 1 Affinity Capture-MS
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins genetic 1 1 1 Dosage Rescue
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Negative Genetic
VPS75 YNL246W NAP family histone chaperone genetic 1 1 1 Positive Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Synthetic Growth Defect
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Positive Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Positive Genetic
ZAP1 YJL056C Zinc-regulated transcription factor genetic 1 1 1 Negative Genetic
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor genetic 1 1 1 Positive Genetic
URC2 YDR520C Putative Zn(II)2Cys6 motif containing transcription factor genetic 1 1 1 Negative Genetic
WTM2 YOR229W Transcriptional modulator genetic 1 1 1 Positive Genetic
ZNF1 YFL052W Zinc cluster transcription factor that regulates respiratory growth genetic 1 1 1 Negative Genetic
WAR1 YML076C Homodimeric Zn2Cys6 zinc finger transcription factor genetic 1 1 1 Negative Genetic
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 1 1 1 Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
VPS68 YOL129W Vacuolar membrane protein of unknown function genetic 1 1 1 Negative Genetic
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 1 1 1 Positive Genetic
YPI1 YFR003C Regulatory subunit of the type I protein phosphatase (PP1) Glc7p genetic 1 1 1 Negative Genetic
YAL064W YAL064W Protein of unknown function genetic 1 1 1 Negative Genetic
VID24 YBR105C GID Complex regulatory subunit genetic 1 1 1 Negative Genetic
YSY6 YBR162W-A Protein of unknown function genetic 1 1 1 Negative Genetic
YPT10 YBR264C Rab family GTP-binding protein genetic 1 1 1 Negative Genetic
YDL157C YDL157C Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
YDR061W YDR061W Protein with similarity to ABC transporter family members genetic 1 1 1 Negative Genetic
YDR131C YDR131C F-box protein subunit of SCF ubiquitin ligase complex genetic 1 1 1 Negative Genetic
WHI4 YDL224C Putative RNA binding protein genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
YNL140C YNL140C Protein of unknown function genetic 1 1 1 Negative Genetic
YGR035C YGR035C Putative protein of unknown function, potential Cdc28p substrate genetic 1 1 1 Negative Genetic
YHR045W YHR045W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YIL152W YIL152W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YJL077W-B YJL077W-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
YLL056C YLL056C NADH-dependent aldehyde reductase genetic 1 1 1 Negative Genetic
UCC1 YLR224W F-box protein and component of SCF ubiquitin ligase complexes genetic 1 1 1 Negative Genetic
YML053C YML053C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YNL108C YNL108C Protein phosphatase genetic 1 1 1 Negative Genetic
YNL115C YNL115C Putative protein of unknown function genetic 1 1 1 Negative Genetic
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 1 1 1 Negative Genetic
YOL057W YOL057W Dipeptidyl-peptidase III genetic 1 1 1 Negative Genetic
YOL164W-A YOL164W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Dosage Rescue
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 1 1 1 Negative Genetic
TOD6 YBL054W PAC motif binding protein involved in rRNA and ribosome biogenesis genetic 1 1 1 Negative Genetic
MET12 YPL023C Protein with MTHFR activity in vitro genetic 1 1 1 Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Synthetic Growth Defect
CAB4 YGR277C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Positive Genetic
LYS14 YDR034C Transcriptional activator involved in regulating lysine biosynthesis genetic 1 1 1 Negative Genetic
MMF1 YIL051C Mitochondrial protein required for transamination of isoleucine physical 1 1 1 Affinity Capture-MS
SEC28 YIL076W Epsilon-COP subunit of the coatomer physical 1 1 1 Affinity Capture-MS
ALD6 YPL061W Cytosolic aldehyde dehydrogenase physical 1 1 1 Affinity Capture-MS
MEF2 YJL102W Mitochondrial elongation factor involved in translational elongation genetic 1 1 1 Positive Genetic
CTP1 YBR291C Mitochondrial inner membrane citrate transporter genetic 1 1 1 Negative Genetic
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Negative Genetic
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) genetic 1 1 1 Negative Genetic
RPS25B YLR333C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS25B YLR333C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
AIM26 YKL037W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein genetic 1 1 1 Synthetic Growth Defect
MGR1 YCL044C Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 1 1 1 Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Negative Genetic
UBP14 YBR058C Ubiquitin-specific protease genetic 1 1 1 Positive Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-MS
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites genetic 1 1 1 Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
SOL1 YNR034W Protein with a possible role in tRNA export physical 1 1 1 Affinity Capture-MS
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone genetic 1 1 1 Negative Genetic
SHM2 YLR058C Cytosolic serine hydroxymethyltransferase physical 1 1 1 Affinity Capture-MS
GLN4 YOR168W Glutamine tRNA synthetase genetic 1 1 1 Negative Genetic
SAS5 YOR213C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 1 1 1 Negative Genetic
MRS2 YOR334W Mitochondrial inner membrane Mg(2+) channel genetic 1 1 1 Negative Genetic
FAS1 YKL182W Beta subunit of fatty acid synthetase physical 1 1 1 Affinity Capture-MS
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 1 1 1 Negative Genetic
JID1 YPR061C Probable Hsp40p co-chaperone genetic 1 1 1 Negative Genetic
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 1 1 1 Negative Genetic
PFK26 YIL107C 6-phosphofructo-2-kinase genetic 1 1 1 Negative Genetic
PHO13 YDL236W Conserved phosphatase acting as a metabolite repair enzyme genetic 1 1 1 Negative Genetic
IDP3 YNL009W Peroxisomal NADP-dependent isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
RPL12A YEL054C Ribosomal 60S subunit protein L12A physical 1 1 1 Affinity Capture-MS
PML39 YML107C Protein required for nuclear retention of unspliced pre-mRNAs genetic 1 1 1 Negative Genetic
NVJ3 YDR179W-A Protein with a potential role in tethering ER and vacuoles genetic 1 1 1 Negative Genetic
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SRP68 YPL243W Core component of the signal recognition particle (SRP) complex physical 1 1 1 Affinity Capture-MS
MSS18 YPR134W Nuclear encoded protein needed for splicing of mitochondrial intron genetic 1 1 1 Negative Genetic
PSA1 YDL055C GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) physical 1 1 1 Affinity Capture-MS
RPL24A YGL031C Ribosomal 60S subunit protein L24A physical 1 1 1 Affinity Capture-MS
RPL20A YMR242C Ribosomal 60S subunit protein L20A physical 1 1 1 Affinity Capture-MS
TUB2 YFL037W Beta-tubulin physical 1 1 1 Affinity Capture-MS
RPS22B YLR367W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 1 1 1 Positive Genetic
RPL4B YDR012W Ribosomal 60S subunit protein L4B genetic 1 1 1 Positive Genetic
RPL13B YMR142C Ribosomal 60S subunit protein L13B physical 1 1 1 Affinity Capture-MS
RPS16A YMR143W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL7B YPL198W Ribosomal 60S subunit protein L7B physical 1 1 1 Affinity Capture-MS
RPL8B YLL045C Ribosomal 60S subunit protein L8A physical 1 1 1 Affinity Capture-MS
RPS7B YNL096C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL17B YJL177W Ribosomal 60S subunit protein L17B physical 1 1 1 Affinity Capture-MS
RPS14B YJL191W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL19A YBR084C-A Ribosomal 60S subunit protein L19A physical 1 1 1 Affinity Capture-MS
RPL35A YDL191W Ribosomal 60S subunit protein L35A physical 1 1 1 Affinity Capture-MS
RPL6B YLR448W Ribosomal 60S subunit protein L6B physical 1 1 1 Affinity Capture-MS
RPL8A YHL033C Ribosomal 60S subunit protein L8A physical 1 1 1 Affinity Capture-MS
RPL33B YOR234C Ribosomal 60S subunit protein L33B physical 1 1 1 Affinity Capture-MS
RPL43A YPR043W Ribosomal 60S subunit protein L43A physical 1 1 1 Affinity Capture-MS
RPL6A YML073C Ribosomal 60S subunit protein L6A physical 1 1 1 Affinity Capture-MS
TSC13 YDL015C Enoyl reductase genetic 1 1 1 Negative Genetic
ISR1 YPR106W Predicted protein kinase genetic 1 1 1 Positive Genetic
RPP2A YOL039W Ribosomal protein P2 alpha physical 1 1 1 Affinity Capture-MS
OPY2 YPR075C Integral membrane protein that acts as a membrane anchor for Ste50p genetic 1 1 1 Negative Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase physical 1 1 1 Affinity Capture-MS
RPL35B YDL136W Ribosomal 60S subunit protein L35B physical 1 1 1 Affinity Capture-MS
RPL34A YER056C-A Ribosomal 60S subunit protein L34A physical 1 1 1 Affinity Capture-MS
RPL34B YIL052C Ribosomal 60S subunit protein L34B physical 1 1 1 Affinity Capture-MS
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 1 1 1 Positive Genetic
FRE8 YLR047C Protein with sequence similarity to iron/copper reductases genetic 1 1 1 Negative Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
PSP1 YDR505C Asn and gln rich protein of unknown function genetic 1 1 1 Negative Genetic
RNH70 YGR276C 3'-5' exoribonuclease genetic 1 1 1 Negative Genetic
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
TMA22 YJR014W Protein of unknown function physical 1 1 1 Affinity Capture-MS
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
LCL1 YPL056C Putative protein of unknown function genetic 1 1 1 Negative Genetic
TOS4 YLR183C Putative transcription factor, contains Forkhead Associated domain genetic 1 1 1 Negative Genetic
SMF1 YOL122C Divalent metal ion transporter genetic 1 1 1 Negative Genetic
PYP1 YNL010W Sugar alcohol phosphatase physical 1 1 1 Affinity Capture-MS
RPS18B YML026C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
NCR1 YPL006W Vacuolar membrane protein involved with Npc2p in sterol trafficking genetic 1 1 1 Negative Genetic
NRM1 YNR009W Transcriptional co-repressor of MBF-regulated gene expression genetic 1 1 1 Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL14A YKL006W Ribosomal 60S subunit protein L14A physical 1 1 1 Affinity Capture-MS
TOM70 YNL121C Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Dosage Rescue
RPL2B YIL018W Ribosomal 60S subunit protein L2B physical 1 1 1 Affinity Capture-MS
ASP1 YDR321W Cytosolic L-asparaginase, involved in asparagine catabolism physical 1 1 1 Affinity Capture-MS
THR1 YHR025W Homoserine kinase physical 1 1 1 Affinity Capture-MS
TED1 YIL039W GPI-glycan remodelase genetic 1 1 1 Dosage Rescue
RPP1B YDL130W Ribosomal protein P1 beta physical 1 1 1 Affinity Capture-MS
RIB3 YDR487C 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase) physical 1 1 1 Affinity Capture-MS
RPL31B YLR406C Ribosomal 60S subunit protein L31B physical 1 1 1 Affinity Capture-MS
RPS16B YDL083C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
HXT3 YDR345C Low affinity glucose transporter of the major facilitator superfamily physical 1 1 1 Affinity Capture-MS
SDD4 YPR022C Putative transcription factor, as suggested by computational analysis genetic 1 1 1 Phenotypic Enhancement
ERG4 YGL012W C-24(28) sterol reductase genetic 1 1 1 Negative Genetic
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
SCY1 YGL083W Putative kinase genetic 1 1 1 Negative Genetic
LDB18 YLL049W Component of the dynactin complex genetic 1 1 1 Negative Genetic
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering physical 1 1 1 Affinity Capture-MS
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
HLJ1 YMR161W Co-chaperone for Hsp40p genetic 1 1 1 Positive Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 1 1 1 Negative Genetic
SFB3 YHR098C Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
CCW12 YLR110C Cell wall mannoprotein genetic 1 1 1 Negative Genetic
TPI1 YDR050C Triose phosphate isomerase, abundant glycolytic enzyme physical 1 1 1 Affinity Capture-MS
TYR1 YBR166C Prephenate dehydrogenase involved in tyrosine biosynthesis genetic 1 1 1 Negative Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 1 1 1 Positive Genetic
RPI1 YIL119C Transcription factor, allelic differences between S288C and Sigma1278b genetic 1 1 1 Negative Genetic
MLO127 YJR039W Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
HAL9 YOL089C Putative transcription factor containing a zinc finger genetic 1 1 1 Negative Genetic
GRX2 YDR513W Cytoplasmic glutaredoxin genetic 1 1 1 Negative Genetic
ATG41 YPL250C Protein of unknown function genetic 1 1 1 Positive Genetic
BSC4 YNL269W Protein of unknown function genetic 1 1 1 Negative Genetic
TRS65 YGR166W Component of transport protein particle (TRAPP) complex II genetic 1 1 1 Positive Genetic
STP2 YHR006W Transcription factor genetic 1 1 1 Negative Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Positive Genetic
RQC2 YPL009C Component of the Ribosome Quality Control (RQC) complex physical 1 1 1 Affinity Capture-MS
RPS25A YGR027C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Positive Genetic
MIC60 YKR016W Component of the MICOS complex genetic 1 1 1 Negative Genetic
HTS1 YPR033C Cytoplasmic and mitochondrial histidine tRNA synthetase physical 1 1 1 Affinity Capture-MS
RPL33A YPL143W Ribosomal 60S subunit protein L33A physical 1 1 1 Affinity Capture-MS
RPL12B YDR418W Ribosomal 60S subunit protein L12B physical 1 1 1 Affinity Capture-MS
RPS6B YBR181C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
TDH3 YGR192C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3 physical 1 1 1 Affinity Capture-MS
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 1 1 1 Positive Genetic
FMC1 YIL098C Mitochondrial matrix protein genetic 1 1 1 Negative Genetic
MCP1 YOR228C Mitochondrial protein of unknown function involved in lipid homeostas genetic 1 1 1 Negative Genetic
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Negative Genetic
GPI15 YNL038W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Positive Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
APS3 YJL024C Small subunit of the clathrin-associated adaptor complex AP-3 physical 1 1 1 Affinity Capture-MS
APS3 YJL024C Small subunit of the clathrin-associated adaptor complex AP-3 genetic 1 1 1 Negative Genetic
RPL24B YGR148C Ribosomal 60S subunit protein L24B physical 1 1 1 Affinity Capture-MS
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 1 1 1 Positive Genetic
ROM1 YGR070W Guanine nucleotide exchange factor (GEF) for Rho1p genetic 1 1 1 Phenotypic Enhancement
SHM1 YBR263W Mitochondrial serine hydroxymethyltransferase physical 1 1 1 Affinity Capture-MS
TIF11 YMR260C Translation initiation factor eIF1A physical 1 1 1 Affinity Capture-MS
UBC1 YDR177W Ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
MGR2 YPL098C Subunit of the TIM23 translocase complex genetic 1 1 1 Dosage Rescue
NGL1 YOL042W Putative endonuclease genetic 1 1 1 Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Negative Genetic
RKR1 YMR247C RING domain E3 ubiquitin ligase genetic 1 1 1 Synthetic Rescue
ECM38 YLR299W Gamma-glutamyltranspeptidase genetic 1 1 1 Negative Genetic
NCE101 YJL205C Protein of unknown function genetic 1 1 1 Negative Genetic
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Negative Genetic
MRX11 YPL041C Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
ODC2 YOR222W Mitochondrial inner membrane transporter genetic 1 1 1 Negative Genetic
RBH1 YJL181W Putative protein of unknown function genetic 1 1 1 Positive Genetic
TOM7 YNL070W Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Negative Genetic
PET20 YPL159C Mitochondrial protein genetic 1 1 1 Positive Genetic
MTC4 YBR255W Protein of unknown function genetic 1 1 1 Negative Genetic
SDH9 YJL045W Minor succinate dehydrogenase isozyme genetic 1 1 1 Negative Genetic
IZH1 YDR492W Membrane protein involved in zinc ion homeostasis genetic 1 1 1 Negative Genetic
PHM7 YOL084W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Negative Genetic
LDB16 YCL005W Protein involved in lipid droplet (LD) assembly genetic 1 1 1 Negative Genetic
IRS4 YKR019C EH domain-containing protein genetic 1 1 1 Negative Genetic
SPS2 YDR522C Protein expressed during sporulation genetic 1 1 1 Negative Genetic
SSP2 YOR242C Sporulation specific protein that localizes to the spore wall genetic 1 1 1 Negative Genetic
TSC3 YBR058C-A Protein that stimulates the activity of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
STP4 YDL048C Protein containing a Kruppel-type zinc-finger domain genetic 1 1 1 Negative Genetic
NPP2 YEL016C Nucleotide pyrophosphatase/phosphodiesterase genetic 1 1 1 Negative Genetic
TEP1 YNL128W PTEN homolog with no demonstrated inositol lipid phosphatase activity genetic 1 1 1 Negative Genetic
TMS1 YDR105C Vacuolar membrane protein of unknown function genetic 1 1 1 Negative Genetic
SPO23 YBR250W Protein of unknown function genetic 1 1 1 Negative Genetic
SUT2 YPR009W Zn2Cys6 family transcription factor genetic 1 1 1 Negative Genetic
TTI2 YJR136C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic