Standard name Systematic name Name description Description
PKC1 YBL105C Protein serine/threonine kinase Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
Visualize the interactome of PKC1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G2 112

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.195 NaN 0.245
Budsite 0.129 0.12 0.109
Cell Periphery 0.120 0.12 NaN
Cort. Patches 0.290 0.08 0.291
Cytoplasm 0.483 0.64 0.455
SpindlePole 0.057 NaN NaN
Mito NaN 0.12 0.273

GFP localization & abundance

GFP localization GFP abundance
ambiguous, bud neck, cytoplasm, bud no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PKC1 2 0 1 2 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins physical 12 3 11 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 11 4 9 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Dosage Rescue, Dosage Rescue, Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 10 4 9 Synthetic Rescue, Dosage Rescue, Synthetic Lethality, Negative Genetic, Synthetic Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Rescue
SLT2 YHR030C Serine/threonine MAP kinase genetic 8 3 7 Dosage Rescue, Dosage Rescue, Negative Genetic, Negative Genetic, Phenotypic Suppression, Negative Genetic, Negative Genetic, Negative Genetic
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins genetic 7 4 6 Dosage Rescue, Dosage Rescue, Synthetic Rescue, Phenotypic Suppression, Negative Genetic, Dosage Rescue, Phenotypic Suppression
ACK1 YDL203C Protein that functions in the cell wall integrity pathway genetic 7 4 5 Synthetic Lethality, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 6 3 5 Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue, Phenotypic Suppression, Synthetic Growth Defect
OST3 YOR085W Gamma subunit of the oligosaccharyltransferase complex of the ER lumen genetic 6 2 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
OCA6 YDR067C Cytoplasmic protein required for replication of Brome mosaic virus genetic 5 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Dosage Rescue, Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 5 4 4 Synthetic Rescue, Phenotypic Suppression, Positive Genetic, Positive Genetic, Dosage Rescue
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 5 3 4 Dosage Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 5 2 4 Synthetic Rescue, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 5 3 3 Dosage Rescue, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 5 2 3 Negative Genetic, Positive Genetic, Positive Genetic, Negative Genetic, Positive Genetic
MIG1 YGL035C Transcription factor involved in glucose repression genetic 4 3 4 Synthetic Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 4 2 4 Negative Genetic, Negative Genetic, Positive Genetic, Positive Genetic
CNB1 YKL190W Calcineurin B genetic 4 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Dosage Rescue
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 4 2 4 Dosage Lethality, Dosage Lethality, Positive Genetic, Positive Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family genetic 4 2 4 Dosage Rescue, Dosage Rescue, Dosage Rescue, Negative Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 4 1 4 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
OCA4 YCR095C Cytoplasmic protein required for replication of Brome mosaic virus genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 4 3 3 Negative Genetic, Synthetic Rescue, Synthetic Growth Defect, Negative Genetic
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 4 3 3 Phenotypic Enhancement, Negative Genetic, Dosage Rescue, Negative Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 4 2 3 Dosage Rescue, Dosage Rescue, Negative Genetic, Negative Genetic
PMT2 YAL023C Protein O-mannosyltransferase of the ER membrane genetic 4 2 3 Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 4 2 3 Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p genetic 4 2 3 Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 4 2 3 Negative Genetic, Phenotypic Suppression, Negative Genetic, Negative Genetic
CWH43 YCR017C GPI lipid remodelase genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
FYV8 YGR196C Protein of unknown function genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 4 1 3 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
ROT2 YBR229C Glucosidase II catalytic subunit genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 4 1 3 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
TRS65 YGR166W Component of transport protein particle (TRAPP) complex II genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BST1 YFL025C GPI inositol deacylase of the endoplasmic reticulum (ER) genetic 4 1 3 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex genetic 4 3 2 Dosage Rescue, Dosage Rescue, Synthetic Lethality, Phenotypic Suppression
MTC5 YDR128W Subunit of SEACAT, a subcomplex of the SEA complex genetic 4 2 2 Negative Genetic, Positive Genetic, Negative Genetic, Negative Genetic
BNI1 YNL271C Formin genetic 3 3 3 Dosage Rescue, Synthetic Lethality, Negative Genetic
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 3 3 3 Synthetic Rescue, Phenotypic Suppression, Dosage Growth Defect
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
MKK1 YOR231W MAPKK involved in the protein kinase C signaling pathway genetic 3 3 3 Synthetic Rescue, Dosage Rescue, Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 3 2 3 Dosage Rescue, Dosage Rescue, Positive Genetic
MKK2 YPL140C MAPKK involved in the protein kinase C signaling pathway genetic 3 2 3 Dosage Rescue, Negative Genetic, Negative Genetic
SPA2 YLL021W Component of the polarisome genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
YPK1 YKL126W S/T protein kinase genetic 3 2 3 Dosage Rescue, Dosage Rescue, Phenotypic Suppression
RHO2 YNL090W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 3 2 3 Negative Genetic, Phenotypic Suppression, Negative Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 3 2 3 Phenotypic Suppression, Negative Genetic, Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 3 2 3 Synthetic Lethality, Positive Genetic, Positive Genetic
PER1 YCR044C Protein of the endoplasmic reticulum genetic 3 2 3 Synthetic Lethality, Positive Genetic, Positive Genetic
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ZDS2 YML109W Protein with a role in regulating Swe1p-dependent polarized growth physical 3 1 3 Two-hybrid, Two-hybrid, Two-hybrid
URA7 YBL039C Major CTP synthase isozyme (see also URA8) physical 3 1 3 Biochemical Activity, Biochemical Activity, Biochemical Activity
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CCH1 YGR217W Voltage-gated high-affinity calcium channel genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PAH1 YMR165C Mg2+-dependent phosphatidate (PA) phosphatase physical 3 1 3 Biochemical Activity, Biochemical Activity, Biochemical Activity
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 3 3 2 Dosage Rescue, Synthetic Growth Defect, Negative Genetic
CRD1 YDL142C Cardiolipin synthase genetic 3 3 2 Dosage Rescue, Phenotypic Suppression, Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 3 2 2 Negative Genetic, Negative Genetic, Positive Genetic
CMD1 YBR109C Calmodulin genetic 3 2 2 Dosage Rescue, Negative Genetic, Negative Genetic
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 3 2 2 Dosage Rescue, Negative Genetic, Negative Genetic
ROT1 YMR200W Molecular chaperone involved in protein folding in ER genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 3 2 2 Synthetic Rescue, Synthetic Rescue, Positive Genetic
ELP3 YPL086C Subunit of Elongator complex genetic 3 2 2 Negative Genetic, Negative Genetic, Dosage Rescue
HSP150 YJL159W O-mannosylated heat shock protein genetic 3 2 2 Phenotypic Suppression, Negative Genetic, Negative Genetic
MID2 YLR332W O-glycosylated plasma membrane protein genetic 3 2 2 Dosage Rescue, Negative Genetic, Negative Genetic
KEX1 YGL203C Cell death protease essential for hypochlorite-induced apoptosis genetic 3 2 2 Positive Genetic, Negative Genetic, Positive Genetic
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 3 2 2 Negative Genetic, Negative Genetic, Phenotypic Enhancement
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
MDM10 YAL010C Subunit of both the ERMES and the SAM complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NAB6 YML117W Putative RNA-binding protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PGM1 YKL127W Phosphoglucomutase, minor isoform genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC43 YGL155W Beta subunit of geranylgeranyltransferase type I genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SBE2 YDR351W Protein required for bud growth genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YGR017W YGR017W Putative protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YUR1 YJL139C Mannosyltransferase involved in protein N-glycosylation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RIM13 YMR154C Calpain-like cysteine protease genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PRS5 YOL061W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NBA1 YOL070C Protein involved in axial bud site selection genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ASK1 YKL052C Essential subunit of the Dam1 complex (aka DASH complex) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PEA2 YER149C Coiled-coil 12S polarisome subunit genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
OST6 YML019W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
EMC1 YCL045C Member of conserved endoplasmic reticulum membrane complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ALG5 YPL227C UDP-glucose:dolichyl-phosphate glucosyltransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CWH41 YGL027C Processing alpha glucosidase I genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
EMC4 YGL231C Member of conserved ER transmembrane complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ECM7 YLR443W Putative integral membrane protein with a role in calcium uptake genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ALG6 YOR002W ER-luminal alpha 1,3 glucosyltransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
LDB18 YLL049W Component of the dynactin complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PIR1 YKL164C O-glycosylated protein required for cell wall stability genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CNE1 YAL058W Calnexin genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
EMC2 YJR088C Member of conserved ER transmembrane complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
KRE5 YOR336W Protein required for beta-1,6 glucan biosynthesis genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 3 2 1 Positive Genetic, Negative Genetic, Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 3 2 1 Positive Genetic, Negative Genetic, Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) physical 2 2 2 Affinity Capture-Western, Biochemical Activity
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 2 2 2 Phenotypic Suppression, Dosage Growth Defect
AVO1 YOL078W Component of the membrane-bound TORC2 complex genetic 2 2 2 Dosage Rescue, Negative Genetic
DYN1 YKR054C Cytoplasmic heavy chain dynein genetic 2 2 2 Synthetic Lethality, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
MBP1 YDL056W Transcription factor genetic 2 2 2 Synthetic Lethality, Phenotypic Suppression
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 2 2 2 Dosage Rescue, Negative Genetic
BGL2 YGR282C Endo-beta-1,3-glucanase genetic 2 2 2 Synthetic Rescue, Negative Genetic
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 2 2 2 Dosage Rescue, Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
MIH1 YMR036C Protein tyrosine phosphatase genetic 2 2 2 Positive Genetic, Dosage Rescue
APL4 YPR029C Gamma-adaptin genetic 2 2 2 Positive Genetic, Negative Genetic
SWP1 YMR149W Delta subunit of the oligosaccharyl transferase glycoprotein complex genetic 2 2 2 Dosage Rescue, Negative Genetic
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex genetic 2 2 2 Dosage Rescue, Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein physical 2 2 2 Two-hybrid, Affinity Capture-MS
SYP1 YCR030C Negative regulator of WASP-Arp23 complex physical 2 2 2 Affinity Capture-MS, Biochemical Activity
PKC1 YBL105C Protein serine/threonine kinase physical 2 2 2 Two-hybrid, Biochemical Activity
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 2 2 2 Positive Genetic, Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 2 2 2 Dosage Rescue, Negative Genetic
VPS45 YGL095C Protein of the Sec1p/Munc-18 family genetic 2 2 2 Dosage Rescue, Negative Genetic
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 2 2 2 Phenotypic Suppression, Negative Genetic
SSD1 YDR293C Translational repressor genetic 2 2 2 Dosage Rescue, Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 2 2 2 Phenotypic Enhancement, Positive Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 2 Synthetic Lethality, Positive Genetic
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 2 2 2 Dosage Rescue, Positive Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 2 2 2 Negative Genetic, Synthetic Rescue
ISR1 YPR106W Predicted protein kinase genetic 2 2 2 Synthetic Lethality, Negative Genetic
ATG15 YCR068W Phospholipase genetic 2 2 2 Synthetic Lethality, Negative Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 2 2 2 Synthetic Lethality, Negative Genetic
CDC42 YLR229C Small rho-like GTPase genetic 2 1 2 Negative Genetic, Negative Genetic
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family genetic 2 1 2 Negative Genetic, Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 2 1 2 Dosage Rescue, Dosage Rescue
HGH1 YGR187C Chaperone protein for translation factor eEF2 genetic 2 1 2 Negative Genetic, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
NEM1 YHR004C Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme physical 2 1 2 Biochemical Activity, Biochemical Activity
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 2 1 2 Negative Genetic, Negative Genetic
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
PDI1 YCL043C Protein disulfide isomerase genetic 2 1 2 Negative Genetic, Negative Genetic
HAL5 YJL165C Snf1p-related nutrient-responsive protein kinase genetic 2 1 2 Positive Genetic, Positive Genetic
MEH1 YKR007W Subunit of the EGO/GSE complex genetic 2 1 2 Negative Genetic, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 2 1 2 Negative Genetic, Negative Genetic
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase genetic 2 1 2 Negative Genetic, Negative Genetic
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex genetic 2 1 2 Negative Genetic, Negative Genetic
SPO7 YAL009W Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme physical 2 1 2 Biochemical Activity, Biochemical Activity
SPC110 YDR356W Inner plaque spindle pole body (SPB) component genetic 2 1 2 Dosage Rescue, Dosage Rescue
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 1 2 Dosage Rescue, Dosage Rescue
SLM2 YNL047C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p genetic 2 1 2 Dosage Rescue, Dosage Rescue
SLM1 YIL105C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p genetic 2 1 2 Dosage Rescue, Dosage Rescue
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 2 1 2 Negative Genetic, Negative Genetic
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 2 1 2 Positive Genetic, Positive Genetic
SAC3 YDR159W mRNA export factor genetic 2 1 2 Positive Genetic, Positive Genetic
YPS7 YDR349C Putative GPI-anchored aspartic protease genetic 2 1 2 Negative Genetic, Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
PKH1 YDR490C Serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
TIF1 YKR059W Translation initiation factor eIF4A genetic 2 1 2 Negative Genetic, Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
VAC14 YLR386W Enzyme regulator genetic 2 1 2 Negative Genetic, Negative Genetic
RCE1 YMR274C Type II CAAX prenyl protease genetic 2 1 2 Negative Genetic, Negative Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 2 1 2 Negative Genetic, Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 2 1 2 Negative Genetic, Negative Genetic
PUB1 YNL016W Poly (A)+ RNA-binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone genetic 2 1 2 Negative Genetic, Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 2 1 2 Negative Genetic, Negative Genetic
RGL1 YPL066W Regulator of Rho1p signaling, cofactor of Tus1p genetic 2 1 2 Negative Genetic, Negative Genetic
YPR089W YPR089W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 2 1 2 Negative Genetic, Negative Genetic
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 2 1 2 Positive Genetic, Positive Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 2 1 2 Positive Genetic, Positive Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 2 1 2 Positive Genetic, Positive Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 2 1 2 Negative Genetic, Negative Genetic
PAL1 YDR348C Protein of unknown function thought to be involved in endocytosis genetic 2 1 2 Negative Genetic, Negative Genetic
PEF1 YGR058W Penta-EF-hand protein genetic 2 1 2 Negative Genetic, Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 2 1 2 Positive Genetic, Positive Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 2 1 2 Negative Genetic, Negative Genetic
PHO80 YOL001W Cyclin genetic 2 1 2 Negative Genetic, Negative Genetic
ERV41 YML067C Protein localized to COPII-coated vesicles genetic 2 1 2 Negative Genetic, Negative Genetic
ASG1 YIL130W Zinc cluster protein proposed to be a transcriptional regulator genetic 2 1 2 Negative Genetic, Negative Genetic
CUE4 YML101C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
AIM22 YJL046W Lipoate-protein ligase genetic 2 1 2 Negative Genetic, Negative Genetic
CWP2 YKL096W-A Covalently linked cell wall mannoprotein genetic 2 1 2 Negative Genetic, Negative Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 2 1 2 Negative Genetic, Negative Genetic
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 2 1 2 Negative Genetic, Negative Genetic
PHD1 YKL043W Transcriptional activator that enhances pseudohyphal growth genetic 2 1 2 Negative Genetic, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 2 1 2 Positive Genetic, Positive Genetic
ATG41 YPL250C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
EMC3 YKL207W Member of conserved ER transmembrane complex genetic 2 1 2 Negative Genetic, Negative Genetic
ALG8 YOR067C Glucosyl transferase genetic 2 1 2 Negative Genetic, Negative Genetic
FAR1 YJL157C CDK inhibitor and nuclear anchor regulation 2 2 1 physical interaction evidence, protein kinase assay evidence
STE5 YDR103W Pheromone-responsive MAPK scaffold protein regulation 2 2 1 physical interaction evidence, protein kinase assay evidence
MAK21 YDR060W Constituent of 66S pre-ribosomal particles genetic 2 2 1 Positive Genetic, Negative Genetic
ABD1 YBR236C Methyltransferase genetic 2 2 1 Positive Genetic, Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 2 2 1 Positive Genetic, Negative Genetic
LEM3 YNL323W Membrane protein of the plasma membrane and ER genetic 2 2 1 Positive Genetic, Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l physical 2 2 1 Affinity Capture-Western, Two-hybrid
SWP1 YMR149W Delta subunit of the oligosaccharyl transferase glycoprotein complex physical 2 2 1 Affinity Capture-Western, Two-hybrid
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex physical 2 2 1 Affinity Capture-Western, Two-hybrid
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 2 2 1 Positive Genetic, Negative Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 2 2 1 Positive Genetic, Negative Genetic
STE5 YDR103W Pheromone-responsive MAPK scaffold protein physical 2 2 1 Biochemical Activity, PCA
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 2 2 1 Positive Genetic, Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 2 2 1 Positive Genetic, Negative Genetic
PPQ1 YPL179W Protein phosphatase that regulates the mating response genetic 2 2 1 Positive Genetic, Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 2 2 1 Positive Genetic, Negative Genetic
POM34 YLR018C Subunit of the transmembrane ring of the nuclear pore complex (NPC) genetic 2 2 1 Negative Genetic, Positive Genetic
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 2 2 1 Dosage Rescue, Synthetic Lethality
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 2 2 1 Negative Genetic, Positive Genetic
PBN1 YCL052C Component of glycosylphosphatidylinositol-mannosyltransferase I genetic 2 2 1 Positive Genetic, Negative Genetic
CGR1 YGL029W Protein involved in nucleolar integrity and processing of pre-rRNA genetic 2 2 1 Positive Genetic, Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 2 2 1 Positive Genetic, Negative Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 2 2 1 Positive Genetic, Negative Genetic
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 2 1 1 Negative Genetic, Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 2 1 1 Negative Genetic, Negative Genetic
IKI3 YLR384C Subunit of Elongator complex genetic 2 1 1 Negative Genetic, Negative Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 2 1 1 Negative Genetic, Negative Genetic
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 2 1 1 Negative Genetic, Negative Genetic
ARC15 YIL062C Subunit of the ARP2/3 complex genetic 2 1 1 Negative Genetic, Negative Genetic
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 2 1 1 Negative Genetic, Negative Genetic
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 2 1 1 Negative Genetic, Negative Genetic
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 2 1 1 Negative Genetic, Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 2 1 1 Negative Genetic, Negative Genetic
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 2 1 1 Negative Genetic, Negative Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 2 1 1 Negative Genetic, Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 2 1 1 Negative Genetic, Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 2 1 1 Negative Genetic, Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 2 1 1 Negative Genetic, Negative Genetic
ERG13 YML126C 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase genetic 2 1 1 Negative Genetic, Negative Genetic
GFA1 YKL104C Glutamine-fructose-6-phosphate amidotransferase genetic 2 1 1 Negative Genetic, Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 2 1 1 Negative Genetic, Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 2 1 1 Negative Genetic, Negative Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 2 1 1 Negative Genetic, Negative Genetic
MYO1 YHR023W Type II myosin heavy chain physical 2 1 1 Two-hybrid, Two-hybrid
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 2 1 1 Negative Genetic, Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 2 1 1 Negative Genetic, Negative Genetic
HTB1 YDR224C Histone H2B genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
ERG27 YLR100W 3-keto sterol reductase genetic 2 1 1 Negative Genetic, Negative Genetic
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) genetic 2 1 1 Negative Genetic, Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Positive Genetic, Positive Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 2 1 1 Positive Genetic, Positive Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 2 1 1 Positive Genetic, Positive Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 2 1 1 Negative Genetic, Negative Genetic
MSG5 YNL053W Dual-specificity protein phosphatase genetic 2 1 1 Positive Genetic, Positive Genetic
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein genetic 2 1 1 Negative Genetic, Negative Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 2 1 1 Negative Genetic, Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 2 1 1 Negative Genetic, Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 2 1 1 Positive Genetic, Positive Genetic
UTP6 YDR449C Nucleolar protein genetic 2 1 1 Negative Genetic, Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 2 1 1 Negative Genetic, Negative Genetic
RRN3 YKL125W Protein required for transcription of rDNA by RNA polymerase I genetic 2 1 1 Negative Genetic, Negative Genetic
RPC34 YNR003C RNA polymerase III subunit C34 genetic 2 1 1 Negative Genetic, Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 2 1 1 Negative Genetic, Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 2 1 1 Negative Genetic, Negative Genetic
URA6 YKL024C Uridylate kinase genetic 2 1 1 Negative Genetic, Negative Genetic
SEC13 YLR208W Structural component of 3 complexes genetic 2 1 1 Negative Genetic, Negative Genetic
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) genetic 2 1 1 Negative Genetic, Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 2 1 1 Negative Genetic, Negative Genetic
SMP3 YOR149C Alpha 1,2-mannosyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
PRT1 YOR361C eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 2 1 1 Negative Genetic, Negative Genetic
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 2 1 1 Negative Genetic, Negative Genetic
YML119W YML119W Putative protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
TMC1 YOR052C AN1-type zinc finger protein, effector of proteotoxic stress response genetic 2 1 1 Negative Genetic, Negative Genetic
PYC1 YGL062W Pyruvate carboxylase isoform genetic 2 1 1 Negative Genetic, Negative Genetic
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 2 1 1 Negative Genetic, Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 2 1 1 Negative Genetic, Negative Genetic
SNC2 YOR327C Vesicle membrane receptor protein (v-SNARE) genetic 2 1 1 Negative Genetic, Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 2 1 1 Negative Genetic, Negative Genetic
SYT1 YPR095C Guanine nucleotide exchange factor (GEF) for Arf proteins genetic 2 1 1 Negative Genetic, Negative Genetic
TIF2 YJL138C Translation initiation factor eIF4A genetic 2 1 1 Negative Genetic, Negative Genetic
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 2 1 1 Negative Genetic, Negative Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 2 1 1 Negative Genetic, Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 2 1 1 Negative Genetic, Negative Genetic
PEX13 YLR191W Peroxisomal importomer complex component genetic 2 1 1 Negative Genetic, Negative Genetic
HOS3 YPL116W Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) genetic 2 1 1 Dosage Lethality, Dosage Lethality
MIF2 YKL089W Centromeric CDEIII region binding protein genetic 2 1 1 Negative Genetic, Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 2 1 1 Negative Genetic, Negative Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 2 1 1 Negative Genetic, Negative Genetic
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 2 1 1 Negative Genetic, Negative Genetic
BUD6 YLR319C Actin- and formin-interacting protein genetic 2 1 1 Negative Genetic, Negative Genetic
DFG5 YMR238W Putative mannosidase genetic 2 1 1 Positive Genetic, Positive Genetic
ERV14 YGL054C COPII-coated vesicle protein genetic 2 1 1 Positive Genetic, Positive Genetic
EMC6 YLL014W Member of conserved ER transmembrane complex genetic 2 1 1 Negative Genetic, Negative Genetic
EPO1 YMR124W Protein involved in septin-ER tethering genetic 2 1 1 Negative Genetic, Negative Genetic
PAC1 YOR269W Regulator of dynein, involved in intracellular transport physical 2 1 1 Two-hybrid, Two-hybrid
MXR1 YER042W Methionine-S-sulfoxide reductase genetic 2 1 1 Negative Genetic, Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 2 1 1 Negative Genetic, Negative Genetic
GLN4 YOR168W Glutamine tRNA synthetase genetic 2 1 1 Negative Genetic, Negative Genetic
MSB1 YOR188W Protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
GAA1 YLR088W Subunit of the GPI:protein transamidase complex genetic 2 1 1 Negative Genetic, Negative Genetic
GPI17 YDR434W Transmembrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
CAB1 YDR531W Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase genetic 2 1 1 Negative Genetic, Negative Genetic
ARV1 YLR242C Cortical ER protein genetic 2 1 1 Negative Genetic, Negative Genetic
NMT1 YLR195C N-myristoyl transferase genetic 2 1 1 Negative Genetic, Negative Genetic
ALG13 YGL047W Catalytic component of UDP-GlcNAc transferase genetic 2 1 1 Negative Genetic, Negative Genetic
MUP1 YGR055W High affinity methionine permease genetic 2 1 1 Negative Genetic, Negative Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
BIG1 YHR101C Integral membrane protein of the endoplasmic reticulum genetic 2 1 1 Negative Genetic, Negative Genetic
ALG2 YGL065C Mannosyltransferase in the N-linked glycosylation pathway genetic 2 1 1 Negative Genetic, Negative Genetic
PFA4 YOL003C Palmitoyltransferase with autoacylation activity genetic 2 1 1 Negative Genetic, Negative Genetic
ERG9 YHR190W Farnesyl-diphosphate farnesyl transferase (squalene synthase) genetic 2 1 1 Negative Genetic, Negative Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 2 1 1 Negative Genetic, Negative Genetic
GPI15 YNL038W Protein involved in the synthesis of GlcNAc-PI genetic 2 1 1 Negative Genetic, Negative Genetic
ERG8 YMR220W Phosphomevalonate kinase genetic 2 1 1 Negative Genetic, Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 2 1 1 Negative Genetic, Negative Genetic
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 2 1 1 Negative Genetic, Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 DNA to cDNA expression microarray evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STE18 YJR086W G protein gamma subunit regulation 1 1 1 qualitative western immunoblotting evidence
URA7 YBL039C Major CTP synthase isozyme (see also URA8) regulation 1 1 1 enzymatic activity assay evidence
PAH1 YMR165C Mg2+-dependent phosphatidate (PA) phosphatase regulation 1 1 1 quantitative western immunoblotting evidence
URA8 YJR103W Minor CTP synthase isozyme (see also URA7) regulation 1 1 1 enzymatic activity assay evidence
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation regulation 1 1 1 green fluorescent protein immunolocalization evidence
NEM1 YHR004C Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme regulation 1 1 1 sodium dodecyl sulfate polyacrylamide gel electrophoresis evidence
RPS5 YJR123W Protein component of the small (40S) ribosomal subunit regulation 1 1 1 protein kinase assay evidence
SPO7 YAL009W Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme regulation 1 1 1 sodium dodecyl sulfate polyacrylamide gel electrophoresis evidence
AME1 YBR211C Essential kinetochore protein associated with microtubules and SPBs genetic 1 1 1 Positive Genetic
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 1 1 1 Synthetic Lethality
NSL1 YPL233W Essential component of the MIND kinetochore complex genetic 1 1 1 Negative Genetic
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Positive Genetic
ESF1 YDR365C Nucleolar protein involved in pre-rRNA processing genetic 1 1 1 Negative Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 1 1 1 Dosage Rescue
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Positive Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex physical 1 1 1 Two-hybrid
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Positive Genetic
EBP2 YKL172W Required for 25S rRNA maturation and 60S ribosomal subunit assembly genetic 1 1 1 Negative Genetic
HAS1 YMR290C ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
NOP2 YNL061W rRNA m5C methyltransferase genetic 1 1 1 Negative Genetic
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
LTO1 YNL260C Substrate-specific adaptor protein involved in apo-Rli1p maturation genetic 1 1 1 Negative Genetic
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger genetic 1 1 1 Negative Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Dosage Rescue
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
PAB1 YER165W Poly(A) binding protein physical 1 1 1 Two-hybrid
CSL4 YNL232W Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
NIP1 YMR309C eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Positive Genetic
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 1 1 1 Negative Genetic
ALA1 YOR335C Cytoplasmic and mitochondrial alanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 1 1 1 Negative Genetic
APL3 YBL037W Alpha-adaptin physical 1 1 1 Affinity Capture-MS
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Positive Genetic
BDF1 YLR399C BET family transcriptional regulator genetic 1 1 1 Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Negative Genetic
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Affinity Capture-MS
BUD20 YLR074C C2H2-type zinc finger protein required for ribosome assembly genetic 1 1 1 Positive Genetic
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Positive Genetic
CUS1 YMR240C Protein required for assembly of U2 snRNP into the spliceosome genetic 1 1 1 Negative Genetic
CYR1 YJL005W Adenylate cyclase genetic 1 1 1 Negative Genetic
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Negative Genetic
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites physical 1 1 1 Affinity Capture-MS
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
ENO1 YGR254W Enolase I, a phosphopyruvate hydratase physical 1 1 1 Affinity Capture-MS
ERO1 YML130C Thiol oxidase required for oxidative protein folding in the ER genetic 1 1 1 Negative Genetic
FRS1 YLR060W Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
GCN2 YDR283C Protein kinase genetic 1 1 1 Negative Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity genetic 1 1 1 Negative Genetic
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
GCN3 YKR026C Alpha subunit of translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
GDI1 YER136W GDP dissociation inhibitor genetic 1 1 1 Positive Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Positive Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Positive Genetic
DYN1 YKR054C Cytoplasmic heavy chain dynein physical 1 1 1 Two-hybrid
AEP2 YMR282C Mitochondrial protein genetic 1 1 1 Negative Genetic
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
KIN3 YAR018C Nonessential serine/threonine protein kinase physical 1 1 1 Two-hybrid
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly genetic 1 1 1 Negative Genetic
END3 YNL084C EH domain-containing protein involved in endocytosis physical 1 1 1 Two-hybrid
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Negative Genetic
CRM1 YGR218W Nuclear export factor, exportin genetic 1 1 1 Negative Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
KEL1 YHR158C Protein required for proper cell fusion and cell morphology genetic 1 1 1 Phenotypic Suppression
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Negative Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Synthetic Rescue
MRP7 YNL005C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRPL44 YMR225C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
MYO1 YHR023W Type II myosin heavy chain genetic 1 1 1 Dosage Rescue
MAM33 YIL070C Acidic protein of the mitochondrial matrix genetic 1 1 1 Negative Genetic
ATG18 YFR021W Phosphoinositide binding protein genetic 1 1 1 Negative Genetic
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Positive Genetic
OST1 YJL002C Alpha subunit of the oligosaccharyltransferase complex of the ER lumen physical 1 1 1 Affinity Capture-Western
OST1 YJL002C Alpha subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
PAN2 YGL094C Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex genetic 1 1 1 Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Negative Genetic
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
MRPL38 YKL170W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Negative Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Positive Genetic
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome genetic 1 1 1 Negative Genetic
MVD1 YNR043W Mevalonate pyrophosphate decarboxylase genetic 1 1 1 Negative Genetic
NOP14 YDL148C Nucleolar protein genetic 1 1 1 Negative Genetic
PEP4 YPL154C Vacuolar aspartyl protease (proteinase A) genetic 1 1 1 Negative Genetic
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
NUP145 YGL092W Essential protein with distinct roles in two nuclear pore subcomplexes genetic 1 1 1 Positive Genetic
ABF2 YMR072W Mitochondrial DNA-binding protein genetic 1 1 1 Negative Genetic
INP52 YNL106C Polyphosphatidylinositol phosphatase genetic 1 1 1 Dosage Rescue
LSB3 YFR024C-A Protein containing a C-terminal SH3 domain physical 1 1 1 Affinity Capture-MS
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Negative Genetic
NEM1 YHR004C Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 1 1 1 Positive Genetic
IST2 YBR086C Cortical ER protein involved in ER-plasma membrane (PM) tethering genetic 1 1 1 Negative Genetic
CRN1 YLR429W Coronin genetic 1 1 1 Positive Genetic
MNN4 YKL201C Putative positive regulator of mannosylphosphate transferase Mnn6p genetic 1 1 1 Negative Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Negative Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Positive Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway physical 1 1 1 Biochemical Activity
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Negative Genetic
FLC2 YAL053W Putative calcium channel involved in calcium release under hypotonic genetic 1 1 1 Positive Genetic
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 1 1 1 Positive Genetic
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA genetic 1 1 1 Dosage Rescue
GET4 YOR164C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
BBC1 YJL020C Protein possibly involved in assembly of actin patches physical 1 1 1 Two-hybrid
BBC1 YJL020C Protein possibly involved in assembly of actin patches genetic 1 1 1 Negative Genetic
AKL1 YBR059C Ser/Thr protein kinase physical 1 1 1 Affinity Capture-MS
FIN1 YDR130C Spindle pole body-related intermediate filament protein genetic 1 1 1 Negative Genetic
NGL2 YMR285C Protein involved in 5.8S rRNA processing genetic 1 1 1 Negative Genetic
CSR2 YPR030W Nuclear ubiquitin protein ligase binding protein genetic 1 1 1 Negative Genetic
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
GPP1 YIL053W Constitutively expressed DL-glycerol-3-phosphate phosphatase genetic 1 1 1 Dosage Rescue
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 1 1 1 Synthetic Rescue
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Negative Genetic
MGE1 YOR232W Mitochondrial matrix cochaperone genetic 1 1 1 Negative Genetic
HIR3 YJR140C Subunit of the HIR complex genetic 1 1 1 Positive Genetic
CNA1 YLR433C Calcineurin A genetic 1 1 1 Dosage Rescue
CDC53 YDL132W Cullin genetic 1 1 1 Negative Genetic
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 1 1 1 Negative Genetic
HSH49 YOR319W U2-snRNP associated splicing factor genetic 1 1 1 Negative Genetic
KOG1 YHR186C Subunit of TORC1 genetic 1 1 1 Negative Genetic
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 1 1 1 Positive Genetic
EGD1 YPL037C Subunit beta1 of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Synthetic Lethality
ADK1 YDR226W Adenylate kinase, required for purine metabolism genetic 1 1 1 Negative Genetic
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Dosage Lethality
FAR1 YJL157C CDK inhibitor and nuclear anchor physical 1 1 1 Biochemical Activity
CYC8 YBR112C General transcriptional co-repressor genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
KRE6 YPR159W Glucosyl hydrolase required for beta-1,6-glucan biosynthesis genetic 1 1 1 Dosage Rescue
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 1 1 1 Negative Genetic
DMA1 YHR115C Ubiquitin-protein ligase (E3) genetic 1 1 1 Synthetic Rescue
GUF1 YLR289W Mitochondrial matrix GTPase genetic 1 1 1 Negative Genetic
GPP2 YER062C DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis genetic 1 1 1 Dosage Rescue
ATG7 YHR171W Autophagy-related protein and dual specificity member of the E1 family genetic 1 1 1 Negative Genetic
BUD32 YGR262C Protein kinase genetic 1 1 1 Dosage Growth Defect
GRS1 YBR121C Cytoplasmic and mitochondrial glycyl-tRNA synthase genetic 1 1 1 Negative Genetic
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Positive Genetic
LTP1 YPR073C Protein phosphotyrosine phosphatase of unknown cellular role genetic 1 1 1 Dosage Rescue
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Negative Genetic
PDX1 YGR193C E3-binding protein of the mitochondrial pyruvate dehydrogenase complex genetic 1 1 1 Negative Genetic
INA1 YLR413W Protein of unknown function genetic 1 1 1 Negative Genetic
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 genetic 1 1 1 Negative Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Positive Genetic
KEL2 YGR238C Protein that negatively regulates mitotic exit genetic 1 1 1 Phenotypic Suppression
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 1 1 1 Negative Genetic
ADE17 YMR120C Enzyme of 'de novo' purine biosynthesis genetic 1 1 1 Negative Genetic
HHT1 YBR010W Histone H3 physical 1 1 1 Biochemical Activity
CDC123 YLR215C Assembly factor for the eIF2 translation initiation factor complex genetic 1 1 1 Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Synthetic Lethality
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Negative Genetic
BCK2 YER167W Serine/threonine-rich protein involved in PKC1 signaling pathway genetic 1 1 1 Phenotypic Enhancement
NUS1 YDL193W Forms dehydrodolichyl diphosphate synthase complex with RER2 or SRT1 genetic 1 1 1 Negative Genetic
NTG1 YAL015C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Negative Genetic
LSC1 YOR142W Alpha subunit of succinyl-CoA ligase genetic 1 1 1 Negative Genetic
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake genetic 1 1 1 Negative Genetic
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport genetic 1 1 1 Positive Genetic
FKH2 YNL068C Forkhead family transcription factor physical 1 1 1 Biochemical Activity
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Negative Genetic
LSM8 YJR022W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
FAL1 YDR021W Nucleolar protein required for maturation of 18S rRNA genetic 1 1 1 Negative Genetic
DEF1 YKL054C RNAPII degradation factor genetic 1 1 1 Negative Genetic
FCF1 YDR339C PINc domain endonuclease genetic 1 1 1 Negative Genetic
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 1 1 1 Negative Genetic
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Negative Genetic
CKI1 YLR133W Choline kinase physical 1 1 1 Biochemical Activity
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Positive Genetic
APM4 YOL062C Cargo-binding mu subunit of AP-2 physical 1 1 1 Two-hybrid
KKQ8 YKL168C Putative serine/threonine protein kinase with unknown cellular role genetic 1 1 1 Negative Genetic
ADH5 YBR145W Alcohol dehydrogenase isoenzyme V genetic 1 1 1 Negative Genetic
DAD2 YKR083C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Positive Genetic
CDD1 YLR245C Cytidine deaminase genetic 1 1 1 Negative Genetic
CIN4 YMR138W GTP-binding protein involved in beta-tubulin (Tub2p) folding genetic 1 1 1 Positive Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Dosage Rescue
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Negative Genetic
INO2 YDR123C Transcription factor genetic 1 1 1 Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Positive Genetic
LEU4 YNL104C Alpha-isopropylmalate synthase (2-isopropylmalate synthase) genetic 1 1 1 Negative Genetic
LST7 YGR057C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Negative Genetic
MPD2 YOL088C Member of the protein disulfide isomerase (PDI) family genetic 1 1 1 Negative Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 1 1 1 Negative Genetic
MSN5 YDR335W Karyopherin genetic 1 1 1 Negative Genetic
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
NDL1 YLR254C Homolog of nuclear distribution factor NudE physical 1 1 1 Two-hybrid
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 1 1 1 Negative Genetic
PEX21 YGR239C Peroxin required for peroxisomal matrix protein targeting genetic 1 1 1 Negative Genetic
PCL8 YPL219W Cyclin genetic 1 1 1 Negative Genetic
ZDS2 YML109W Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Negative Genetic
TOS2 YGR221C Protein involved in localization of Cdc24p to the site of bud growth physical 1 1 1 Two-hybrid
PRP45 YAL032C Protein required for pre-mRNA splicing physical 1 1 1 Two-hybrid
PRP46 YPL151C Member of the NineTeen Complex (NTC) physical 1 1 1 Two-hybrid
SHO1 YER118C Transmembrane osmosensor for filamentous growth and HOG pathways physical 1 1 1 Two-hybrid
PKH2 YOL100W Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
TYR1 YBR166C Prephenate dehydrogenase involved in tyrosine biosynthesis physical 1 1 1 Affinity Capture-MS
TRM5 YHR070W tRNA(m(1)G37)methyltransferase physical 1 1 1 Affinity Capture-MS
SSL2 YIL143C Component of RNA polymerase transcription factor TFIIH holoenzyme physical 1 1 1 Affinity Capture-MS
SSL2 YIL143C Component of RNA polymerase transcription factor TFIIH holoenzyme genetic 1 1 1 Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis physical 1 1 1 Two-hybrid
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
TOP3 YLR234W DNA Topoisomerase III physical 1 1 1 Two-hybrid
TOP2 YNL088W Topoisomerase II physical 1 1 1 Two-hybrid
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-Western
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Phenotypic Suppression
SPC72 YAL047C Gamma-tubulin small complex (gamma-TuSC) receptor physical 1 1 1 Two-hybrid
SWC3 YAL011W Protein of unknown function physical 1 1 1 Two-hybrid
STV1 YMR054W Subunit a of the vacuolar-ATPase V0 domain physical 1 1 1 Two-hybrid
VPS20 YMR077C Myristoylated subunit of the ESCRT-III complex physical 1 1 1 Two-hybrid
VPS20 YMR077C Myristoylated subunit of the ESCRT-III complex genetic 1 1 1 Negative Genetic
VPS5 YOR069W Nexin-1 homolog physical 1 1 1 Two-hybrid
RGA1 YOR127W GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) physical 1 1 1 Two-hybrid
RGA1 YOR127W GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) genetic 1 1 1 Positive Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex physical 1 1 1 Two-hybrid
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis physical 1 1 1 Two-hybrid
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone genetic 1 1 1 Negative Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 1 1 1 Two-hybrid
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
TOR2 YKL203C PIK-related protein kinase and rapamycin target physical 1 1 1 Biochemical Activity
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
RTT109 YLL002W Histone acetyltransferase physical 1 1 1 Biochemical Activity
RPS5 YJR123W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Biochemical Activity
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
RPS0A YGR214W Ribosomal 40S subunit protein S0A genetic 1 1 1 Positive Genetic
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PMT4 YJR143C Protein O-mannosyltransferase genetic 1 1 1 Dosage Rescue
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Dosage Rescue
WSC3 YOL105C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Dosage Rescue
STM1 YLR150W Protein required for optimal translation under nutrient stress genetic 1 1 1 Dosage Rescue
YMR1 YJR110W Phosphatidylinositol 3-phosphate (PI3P) phosphatase genetic 1 1 1 Dosage Rescue
STE4 YOR212W G protein beta subunit genetic 1 1 1 Phenotypic Suppression
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Synthetic Lethality
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Synthetic Lethality
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Dosage Rescue
RPL35A YDL191W Ribosomal 60S subunit protein L35A genetic 1 1 1 Positive Genetic
PMT1 YDL095W Protein O-mannosyltransferase of the ER membrane genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Negative Genetic
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
YKL091C YKL091C Putative phosphatidylinositol/phosphatidylcholine transfer protein genetic 1 1 1 Negative Genetic
TCD2 YKL027W tRNA threonylcarbamoyladenosine dehydratase genetic 1 1 1 Positive Genetic
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 1 1 1 Negative Genetic
URA5 YML106W Major orotate phosphoribosyltransferase (OPRTase) isozyme genetic 1 1 1 Positive Genetic
PRM6 YML047C Potassium transporter that mediates K+ influx genetic 1 1 1 Negative Genetic
SKY1 YMR216C SR protein kinase (SRPK) genetic 1 1 1 Positive Genetic
SWS2 YNL081C Putative mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
STD1 YOR047C Protein involved in control of glucose-regulated gene expression genetic 1 1 1 Negative Genetic
SSP2 YOR242C Sporulation specific protein that localizes to the spore wall genetic 1 1 1 Positive Genetic
YOR385W YOR385W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Negative Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Negative Genetic
PMA2 YPL036W Plasma membrane H+-ATPase genetic 1 1 1 Negative Genetic
PPZ2 YDR436W Serine/threonine protein phosphatase Z, isoform of Ppz1p genetic 1 1 1 Dosage Rescue
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Synthetic Lethality
YPK2 YMR104C AGC-type S/T protein kinase genetic 1 1 1 Dosage Rescue
WSC2 YNL283C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Phenotypic Suppression
ROM1 YGR070W Guanine nucleotide exchange factor (GEF) for Rho1p genetic 1 1 1 Phenotypic Suppression
SEC6 YIL068C Essential 88kDa subunit of the exocyst complex genetic 1 1 1 Phenotypic Suppression
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Phenotypic Suppression
RAD51 YER095W Strand exchange protein genetic 1 1 1 Phenotypic Suppression
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Phenotypic Suppression
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 1 1 1 Synthetic Lethality
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
TTI2 YJR136C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
SLN1 YIL147C Transmembrane histidine phosphotransfer kinase and osmosensor genetic 1 1 1 Positive Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Positive Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Positive Genetic
SRP1 YNL189W Karyopherin alpha homolog genetic 1 1 1 Positive Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Positive Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Positive Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Positive Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Positive Genetic
UTH1 YKR042W Mitochondrial inner membrane protein genetic 1 1 1 Positive Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Positive Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Positive Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Positive Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
YIA6 YIL006W Mitochondrial NAD+ transporter genetic 1 1 1 Positive Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Positive Genetic
YRA2 YKL214C Member of the REF (RNA and export factor binding proteins) family genetic 1 1 1 Positive Genetic
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Positive Genetic
SDH1 YKL148C Flavoprotein subunit of succinate dehydrogenase genetic 1 1 1 Positive Genetic
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) genetic 1 1 1 Positive Genetic
SSK1 YLR006C Cytoplasmic phosphorelay intermediate osmosensor and regulator genetic 1 1 1 Positive Genetic
TMA23 YMR269W Nucleolar protein implicated in ribosome biogenesis genetic 1 1 1 Positive Genetic
VPS68 YOL129W Vacuolar membrane protein of unknown function genetic 1 1 1 Positive Genetic
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 1 1 1 Positive Genetic
RPL21B YPL079W Ribosomal 60S subunit protein L21B genetic 1 1 1 Positive Genetic
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Positive Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 1 1 1 Positive Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Positive Genetic
SRL1 YOR247W Mannoprotein that exhibits a tight association with the cell wall genetic 1 1 1 Positive Genetic
SLI15 YBR156C Subunit of the conserved chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
TOS1 YBR162C Covalently-bound cell wall protein of unknown function genetic 1 1 1 Positive Genetic
RPS6B YBR181C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Positive Genetic
VAC8 YEL013W Vacuole-specific Myo2p receptor genetic 1 1 1 Positive Genetic
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Positive Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Positive Genetic
RPL23B YER117W Ribosomal 60S subunit protein L23B genetic 1 1 1 Positive Genetic
RPL29 YFR032C-A Ribosomal 60S subunit protein L29 genetic 1 1 1 Positive Genetic
YHL042W YHL042W Endoplasmic reticulum protein genetic 1 1 1 Positive Genetic
SNX4 YJL036W Sorting nexin genetic 1 1 1 Positive Genetic
REC107 YJR021C Protein involved in early stages of meiotic recombination genetic 1 1 1 Positive Genetic
YLR154C-H YLR154C-H Putative protein of unknown function genetic 1 1 1 Positive Genetic
TDA5 YLR426W Putative protein of unknown function genetic 1 1 1 Positive Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Positive Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Negative Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Negative Genetic
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Negative Genetic
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase genetic 1 1 1 Negative Genetic
UTP13 YLR222C Nucleolar protein genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 1 1 1 Negative Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
UTP5 YDR398W Subunit of U3-containing Small Subunit (SSU) processome complex genetic 1 1 1 Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Negative Genetic
SED5 YLR026C cis-Golgi t-SNARE syntaxin genetic 1 1 1 Negative Genetic
SMC4 YLR086W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
RSE1 YML049C Protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Negative Genetic
PRP4 YPR178W Splicing factor genetic 1 1 1 Negative Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
SLU7 YDR088C RNA splicing factor genetic 1 1 1 Negative Genetic
SNU56 YDR240C Component of U1 snRNP required for mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
SRP101 YDR292C Signal recognition particle (SRP) receptor alpha subunit genetic 1 1 1 Negative Genetic
SYF1 YDR416W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 1 1 1 Negative Genetic
TFC4 YGR047C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Negative Genetic
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Negative Genetic
RIB5 YBR256C Riboflavin synthase genetic 1 1 1 Negative Genetic
TSC10 YBR265W 3-ketosphinganine reductase genetic 1 1 1 Negative Genetic
PWP2 YCR057C Conserved 90S pre-ribosomal component genetic 1 1 1 Negative Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
SEC31 YDL195W Component of the Sec13p-Sec31p complex of the COPII vesicle coat genetic 1 1 1 Negative Genetic
UTP4 YDR324C Subunit of U3-containing 90S preribosome and SSU processome complexes genetic 1 1 1 Negative Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
PRP3 YDR473C Splicing factor genetic 1 1 1 Negative Genetic
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 1 1 1 Negative Genetic
SMC2 YFR031C Subunit of the condensin complex genetic 1 1 1 Negative Genetic
SEC9 YGR009C t-SNARE protein required for secretory vesicle-plasma membrane fusion genetic 1 1 1 Negative Genetic
PRP31 YGR091W Splicing factor genetic 1 1 1 Negative Genetic
UTP8 YGR128C Nucleolar protein required for export of tRNAs from the nucleus genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
SDA1 YGR245C Protein required for actin organization and passage through Start genetic 1 1 1 Negative Genetic
QNS1 YHR074W Glutamine-dependent NAD(+) synthetase genetic 1 1 1 Negative Genetic
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 1 1 1 Negative Genetic
THS1 YIL078W Threonyl-tRNA synthetase genetic 1 1 1 Negative Genetic
UTP25 YIL091C Nucleolar protein genetic 1 1 1 Negative Genetic
SEC11 YIR022W 18kDa catalytic subunit of the Signal Peptidase Complex (SPC) genetic 1 1 1 Negative Genetic
TIM54 YJL054W Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
SPC42 YKL042W Central plaque component of spindle pole body (SPB) genetic 1 1 1 Negative Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Negative Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Negative Genetic
PRP16 YKR086W DEAH-box RNA helicase genetic 1 1 1 Negative Genetic
YEF3 YLR249W Translation elongation factor 3 genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 1 1 1 Negative Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 1 1 1 Negative Genetic
SEC59 YMR013C Dolichol kinase genetic 1 1 1 Negative Genetic
TRS130 YMR218C Component of transport protein particle (TRAPP) complex II genetic 1 1 1 Negative Genetic
TIF11 YMR260C Translation initiation factor eIF1A genetic 1 1 1 Negative Genetic
TFB2 YPL122C Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Negative Genetic
RPS29B YDL061C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 1 1 1 Negative Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Negative Genetic
SNG1 YGR197C Protein involved in resistance to nitrosoguanidine and 6-azauracil genetic 1 1 1 Negative Genetic
RPS27B YHR021C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 1 1 1 Negative Genetic
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS30A YLR287C-A Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YLR287C YLR287C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YLR345W YLR345W Similar to 6-phosphofructo-2-kinase enzymes genetic 1 1 1 Negative Genetic
YMR244W YMR244W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Negative Genetic
YPL225W YPL225W Protein of unknown function genetic 1 1 1 Negative Genetic
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport genetic 1 1 1 Negative Genetic
TAH1 YCR060W Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Negative Genetic
RBS1 YDL189W Protein involved in assembly of the RNA Pol III complex genetic 1 1 1 Negative Genetic
RAV2 YDR202C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Negative Genetic
STP1 YDR463W Transcription factor genetic 1 1 1 Negative Genetic
YFL051C YFL051C Putative protein of unknown function genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
YHR045W YHR045W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RBH1 YJL181W Putative protein of unknown function genetic 1 1 1 Negative Genetic
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B genetic 1 1 1 Negative Genetic
PRY2 YKR013W Sterol binding protein involved in the export of acetylated sterols genetic 1 1 1 Negative Genetic
RPS21A YKR057W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
PUS5 YLR165C Pseudouridine synthase genetic 1 1 1 Negative Genetic
SEI1 YLR404W Seipin involved in lipid droplet (LD) assembly genetic 1 1 1 Negative Genetic
RPL31B YLR406C Ribosomal 60S subunit protein L31B genetic 1 1 1 Negative Genetic
THI3 YDL080C Regulatory protein that binds Pdc2p and Thi2p transcription factors genetic 1 1 1 Negative Genetic
TRM11 YOL124C Catalytic subunit of adoMet-dependent tRNA methyltransferase complex genetic 1 1 1 Negative Genetic
PUS7 YOR243C Pseudouridine synthase genetic 1 1 1 Negative Genetic
RBL2 YOR265W Protein involved in microtubule morphogenesis genetic 1 1 1 Negative Genetic
RTT10 YPL183C WD40 domain-containing protein involved in endosomal recycling genetic 1 1 1 Negative Genetic
YAR029W YAR029W Member of DUP240 gene family but contains no transmembrane domains genetic 1 1 1 Negative Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Negative Genetic
YCR016W YCR016W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RPS16B YDL083C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SXM1 YDR395W Nuclear transport factor (karyopherin) genetic 1 1 1 Negative Genetic
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YIP4 YGL198W Protein that interacts with Rab GTPases genetic 1 1 1 Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
SOD2 YHR008C Mitochondrial manganese superoxide dismutase genetic 1 1 1 Negative Genetic
SBE22 YHR103W Protein involved in bud growth genetic 1 1 1 Negative Genetic
RPS4B YHR203C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
TGL1 YKL140W Steryl ester hydrolase genetic 1 1 1 Negative Genetic
TPO1 YLL028W Polyamine transporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic
YLR036C YLR036C Putative protein predicted to have transmembrane domains genetic 1 1 1 Negative Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Negative Genetic
RPS29A YLR388W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RIM9 YMR063W Plasma membrane protein of unknown function genetic 1 1 1 Negative Genetic
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex genetic 1 1 1 Negative Genetic
TGL3 YMR313C Bifunctional triacylglycerol lipase and LPE acyltransferase genetic 1 1 1 Negative Genetic
PYP1 YNL010W Sugar alcohol phosphatase genetic 1 1 1 Negative Genetic
YNL058C YNL058C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SAL1 YNL083W ADP/ATP transporter genetic 1 1 1 Negative Genetic
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone genetic 1 1 1 Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Negative Genetic
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 1 1 1 Negative Genetic
YDC1 YPL087W Alkaline dihydroceramidase, involved in sphingolipid metabolism genetic 1 1 1 Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Negative Genetic
YPL229W YPL229W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Negative Genetic
YLH47 YPR125W Mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
RPS23A YGR118W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YHI9 YHR029C Protein of unknown function genetic 1 1 1 Negative Genetic
PRM2 YIL037C Pheromone-regulated protein genetic 1 1 1 Negative Genetic
YIR042C YIR042C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SKA1 YKL023W SKI complex-associated protein genetic 1 1 1 Negative Genetic
SKS1 YPL026C Putative serine/threonine protein kinase genetic 1 1 1 Negative Genetic
SMN1 YHR202W Putative AMP hydrolase genetic 1 1 1 Negative Genetic
YOL057W YOL057W Dipeptidyl-peptidase III genetic 1 1 1 Negative Genetic
SYC1 YOR179C Subunit of the APT subcomplex of cleavage and polyadenylation factor genetic 1 1 1 Negative Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Negative Genetic
YAT1 YAR035W Outer mitochondrial carnitine acetyltransferase genetic 1 1 1 Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
YBR182C-A YBR182C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YBR184W YBR184W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YBR196C-A YBR196C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YBR221W-A YBR221W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YCL001W-A YCL001W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
SLM5 YCR024C Mitochondrial asparaginyl-tRNA synthetase genetic 1 1 1 Negative Genetic
YDL057W YDL057W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RGT2 YDL138W Plasma membrane high glucose sensor that regulates glucose transport genetic 1 1 1 Negative Genetic
VTC5 YDR089W Novel subunit of the vacuolar transporter chaperone complex genetic 1 1 1 Negative Genetic
SAC6 YDR129C Fimbrin, actin-bundling protein genetic 1 1 1 Negative Genetic
PMT7 YDR307W Putative protein mannosyltransferase similar to Pmt1p genetic 1 1 1 Negative Genetic
YPQ2 YDR352W Putative vacuolar membrane transporter for cationic amino acids genetic 1 1 1 Negative Genetic
RPL12B YDR418W Ribosomal 60S subunit protein L12B genetic 1 1 1 Negative Genetic
YDR524C-B YDR524C-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
YDR524W-C YDR524W-C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SDD1 YEL057C Protein of unknown function genetic 1 1 1 Negative Genetic
YEL076C YEL076C Putative protein of unknown function genetic 1 1 1 Negative Genetic
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD genetic 1 1 1 Negative Genetic
YER175W-A YER175W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SLO1 YER180C-A Protein interacting with Arl3p genetic 1 1 1 Negative Genetic
YFR006W YFR006W Putative X-Pro aminopeptidase genetic 1 1 1 Negative Genetic
VID30 YGL227W Central component of GID Complex, involved in FBPase degradation genetic 1 1 1 Negative Genetic
TAD1 YGL243W tRNA-specific adenosine deaminase genetic 1 1 1 Negative Genetic
RMR1 YGL250W Protein required for meiotic recombination and gene conversion genetic 1 1 1 Negative Genetic
RPL11B YGR085C Ribosomal 60S subunit protein L11B genetic 1 1 1 Negative Genetic
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Negative Genetic
SAY1 YGR263C Sterol deacetylase genetic 1 1 1 Negative Genetic
YGR283C YGR283C Putative methyltransferase genetic 1 1 1 Negative Genetic
YHL012W YHL012W Putative UTP glucose-1-phosphate uridylyltransferase genetic 1 1 1 Negative Genetic
YHL015W-A YHL015W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
YHL048C-A YHL048C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
RRF1 YHR038W Mitochondrial ribosome recycling factor genetic 1 1 1 Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Negative Genetic
URM1 YIL008W Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs genetic 1 1 1 Negative Genetic
RPL40A YIL148W Ubiquitin-ribosomal 60S subunit protein L40A fusion protein genetic 1 1 1 Negative Genetic
VLD1 YIR014W Component of Dsc E3 ligase complex in vacuolar membranes genetic 1 1 1 Negative Genetic
SAG1 YJR004C Alpha-agglutinin of alpha-cells genetic 1 1 1 Negative Genetic
TDA4 YJR116W Protein distantly similar to ceramide synthases, Lag1p and Lac1p genetic 1 1 1 Negative Genetic
YJR142W YJR142W 8-oxo-dGTP diphosphatase of the Nudix hydrolase family genetic 1 1 1 Negative Genetic
THI11 YJR156C Protein involved in synthesis of the thiamine precursor HMP genetic 1 1 1 Negative Genetic
SOR1 YJR159W Sorbitol dehydrogenase genetic 1 1 1 Negative Genetic
YKL096C-B YKL096C-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
SEG2 YKL105C Eisosome component genetic 1 1 1 Negative Genetic
PMU1 YKL128C Putative phosphomutase genetic 1 1 1 Negative Genetic
STE6 YKL209C Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
YKR045C YKR045C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YLL032C YLL032C Protein of unknown function genetic 1 1 1 Negative Genetic
YPS1 YLR120C Aspartic protease genetic 1 1 1 Negative Genetic
YPS3 YLR121C Aspartic protease genetic 1 1 1 Negative Genetic
TDA9 YML081W Transcription factor that regulates acetate production genetic 1 1 1 Negative Genetic
YML100W-A YML100W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
TVP18 YMR071C Integral membrane protein genetic 1 1 1 Negative Genetic
YMR084W YMR084W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
SCW10 YMR305C Cell wall protein with similarity to glucanases genetic 1 1 1 Negative Genetic
SFB2 YNL049C Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
SKO1 YNL167C Basic leucine zipper transcription factor of the ATF/CREB family genetic 1 1 1 Negative Genetic
YNL190W YNL190W Hydrophilin essential in desiccation-rehydration process genetic 1 1 1 Negative Genetic
YNL193W YNL193W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
YPT11 YNL304W Rab GTPase genetic 1 1 1 Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Negative Genetic
SNO2 YNL334C Protein of unknown function genetic 1 1 1 Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Negative Genetic
YOL166W-A YOL166W-A Protein of unknown function genetic 1 1 1 Negative Genetic
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 1 1 1 Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Negative Genetic
YOR394C-A YOR394C-A Protein of unknown function genetic 1 1 1 Negative Genetic
SNF8 YPL002C Component of the ESCRT-II complex genetic 1 1 1 Negative Genetic
RTC6 YPL183W-A Protein involved in translation genetic 1 1 1 Negative Genetic
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 1 1 1 Negative Genetic
SAH1 YER043C S-adenosyl-L-homocysteine hydrolase genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Positive Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Positive Genetic
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Dosage Rescue
RTS3 YGR161C Putative component of the protein phosphatase type 2A complex genetic 1 1 1 Dosage Rescue
PPT1 YGR123C Protein serine/threonine phosphatase genetic 1 1 1 Dosage Rescue
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Dosage Rescue
PTC4 YBR125C Cytoplasmic type 2C protein phosphatase (PP2C) genetic 1 1 1 Dosage Rescue
PTP1 YDL230W Phosphotyrosine-specific protein phosphatase genetic 1 1 1 Dosage Rescue
YVH1 YIR026C Dual specificity protein phosphatase genetic 1 1 1 Dosage Rescue
TEP1 YNL128W PTEN homolog with no demonstrated inositol lipid phosphatase activity genetic 1 1 1 Dosage Rescue
PSR1 YLL010C Plasma membrane-associated protein phosphatase genetic 1 1 1 Dosage Rescue
PTP3 YER075C Phosphotyrosine-specific protein phosphatase genetic 1 1 1 Negative Genetic
YNR066C YNR066C Putative membrane-localized protein of unknown function genetic 1 1 1 Negative Genetic
TCM62 YBR044C Protein involved in assembly of the succinate dehydrogenase complex genetic 1 1 1 Negative Genetic
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response genetic 1 1 1 Positive Genetic
SEC72 YLR292C Non-essential subunit of Sec63 complex genetic 1 1 1 Positive Genetic
POM152 YMR129W Glycoprotein subunit of transmembrane ring of nuclear pore complex genetic 1 1 1 Positive Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Positive Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 1 1 1 Positive Genetic
SDS22 YKL193C Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p genetic 1 1 1 Positive Genetic
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
REC8 YPR007C Meiosis-specific component of the sister chromatid cohesion complex genetic 1 1 1 Negative Genetic
PRR1 YKL116C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
PML39 YML107C Protein required for nuclear retention of unspliced pre-mRNAs genetic 1 1 1 Negative Genetic
MCO14 YHL018W Putative 4a-hydroxytetrahydrobiopterin dehydratase genetic 1 1 1 Negative Genetic
ATG34 YOL083W Receptor protein involved in selective autophagy during starvation physical 1 1 1 Affinity Capture-MS
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Negative Genetic
COQ5 YML110C 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase genetic 1 1 1 Negative Genetic
NTC20 YBR188C Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
MNS1 YJR131W Alpha-1,2-mannosidase genetic 1 1 1 Negative Genetic
PEX14 YGL153W Central component of the peroxisomal importomer complex genetic 1 1 1 Negative Genetic
KEG1 YFR042W Integral membrane protein of the ER genetic 1 1 1 Negative Genetic
IRC6 YFR043C Clathrin coat accessory factor genetic 1 1 1 Negative Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
BLI1 YKL061W Subunit of the BLOC-1 complex involved in endosomal maturation physical 1 1 1 Two-hybrid
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
GMH1 YKR030W Golgi membrane protein of unknown function genetic 1 1 1 Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Positive Genetic
CEP3 YMR168C Essential kinetochore protein physical 1 1 1 Two-hybrid
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
IKI1 YHR187W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
NNF1 YJR112W Essential component of the outer kinetochore MIND complex physical 1 1 1 Two-hybrid
HTL1 YCR020W-B Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
PEX2 YJL210W RING-finger peroxin and E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
GRC3 YLL035W Polynucleotide kinase present on rDNA genetic 1 1 1 Negative Genetic
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Positive Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Positive Genetic
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Positive Genetic
CDC31 YOR257W Calcium-binding component of the spindle pole body (SPB) half-bridge genetic 1 1 1 Dosage Rescue
HPC2 YBR215W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
MCM1 YMR043W Transcription factor genetic 1 1 1 Negative Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Positive Genetic
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Positive Genetic
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Positive Genetic
EPS1 YIL005W ER protein with chaperone and co-chaperone activity genetic 1 1 1 Negative Genetic
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 1 1 1 Negative Genetic
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Positive Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex genetic 1 1 1 Negative Genetic
PEP8 YJL053W Vacuolar protein component of the retromer genetic 1 1 1 Positive Genetic
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
CST9 YLR394W SUMO E3 ligase genetic 1 1 1 Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex physical 1 1 1 Two-hybrid
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Synthetic Lethality
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 1 1 1 Positive Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Negative Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
EMP46 YLR080W Integral membrane component of ER-derived COPII-coated vesicles genetic 1 1 1 Negative Genetic
FUS2 YMR232W Cell fusion regulator genetic 1 1 1 Phenotypic Enhancement
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Negative Genetic
MBF1 YOR298C-A Transcriptional coactivator genetic 1 1 1 Negative Genetic
MST28 YAR033W Putative integral membrane protein, involved in vesicle formation genetic 1 1 1 Negative Genetic
ERV46 YAL042W Protein localized to COPII-coated vesicles genetic 1 1 1 Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 1 1 1 Positive Genetic
GAL80 YML051W Transcriptional regulator involved in the repression of GAL genes genetic 1 1 1 Negative Genetic
GIC1 YHR061C Rho-family GTPase interacting protein and Cdc42p effector genetic 1 1 1 Dosage Rescue
EMC5 YIL027C Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
ARG80 YMR042W Transcription factor involved in regulating arginine-responsive genes genetic 1 1 1 Negative Genetic
AFI1 YOR129C Arf3p polarization-specific docking factor genetic 1 1 1 Negative Genetic
ERG25 YGR060W C-4 methyl sterol oxidase genetic 1 1 1 Negative Genetic
ESC1 YMR219W Protein involved in telomeric silencing physical 1 1 1 Affinity Capture-MS
ESC2 YDR363W Sumo-like domain protein genetic 1 1 1 Negative Genetic
MAC1 YMR021C Copper-sensing transcription factor genetic 1 1 1 Positive Genetic
NRT1 YOR071C High-affinity nicotinamide riboside transporter genetic 1 1 1 Negative Genetic
PEX25 YPL112C Peripheral peroxisomal membrane peroxin genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
FIR1 YER032W Protein involved in 3' mRNA processing genetic 1 1 1 Negative Genetic
NNK1 YKL171W Protein kinase genetic 1 1 1 Negative Genetic
MKK1 YOR231W MAPKK involved in the protein kinase C signaling pathway physical 1 1 1 Two-hybrid
PEX30 YLR324W ER-resident protein involved in peroxisomal biogenesis genetic 1 1 1 Negative Genetic
ADY4 YLR227C Structural component of the meiotic outer plaque genetic 1 1 1 Negative Genetic
MSB4 YOL112W GTPase-activating protein of the Ras superfamily genetic 1 1 1 Negative Genetic
PFY1 YOR122C Profilin genetic 1 1 1 Negative Genetic
MCA1 YOR197W Ca2+-dependent cysteine protease genetic 1 1 1 Negative Genetic
FUS1 YCL027W Membrane protein localized to the shmoo tip physical 1 1 1 Two-hybrid
KAR1 YNL188W Protein involved in karyogamy and spindle pole body duplication genetic 1 1 1 Dosage Rescue
HHT2 YNL031C Histone H3 physical 1 1 1 Biochemical Activity
ERT1 YBR239C Transcriptional regulator genetic 1 1 1 Negative Genetic
HPA2 YPR193C Tetrameric histone acetyltransferase genetic 1 1 1 Negative Genetic
PAM16 YJL104W Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
PAN3 YKL025C Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex genetic 1 1 1 Negative Genetic
MID1 YNL291C Stretch-activated Ca2+-permeable cation channel genetic 1 1 1 Synthetic Lethality
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily genetic 1 1 1 Positive Genetic
DBP6 YNR038W Essential protein involved in ribosome biogenesis genetic 1 1 1 Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Positive Genetic
INN1 YNL152W Essential protein that associates with contractile actomyosin ring genetic 1 1 1 Negative Genetic
PER33 YLR064W Protein that localizes to the endoplasmic reticulum genetic 1 1 1 Positive Genetic
PIN3 YPR154W Negative regulator of actin nucleation-promoting factor activity physical 1 1 1 Two-hybrid
MCR1 YKL150W Mitochondrial NADH-cytochrome b5 reductase genetic 1 1 1 Negative Genetic
ABZ1 YNR033W Para-aminobenzoate (PABA) synthase genetic 1 1 1 Negative Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 1 1 1 Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
IDS2 YJL146W Protein involved in modulation of Ime2p activity during meiosis genetic 1 1 1 Negative Genetic
MDM1 YML104C PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs physical 1 1 1 Two-hybrid
COY1 YKL179C Golgi membrane protein with similarity to mammalian CASP physical 1 1 1 Two-hybrid
FMP27 YLR454W Protein with structural similarity to lipid transport protein Vps13p physical 1 1 1 Two-hybrid
PAC1 YOR269W Regulator of dynein, involved in intracellular transport genetic 1 1 1 Negative Genetic
AUA1 YFL010W-A Protein required for the negative regulation by ammonia of Gap1p genetic 1 1 1 Negative Genetic
HMG1 YML075C HMG-CoA reductase genetic 1 1 1 Negative Genetic
ATP18 YML081C-A Subunit of the mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Negative Genetic
ARR3 YPR201W Plasma membrane metalloid/H+ antiporter genetic 1 1 1 Positive Genetic
FRA1 YLL029W Protein involved in negative regulation of iron regulon transcription genetic 1 1 1 Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Synthetic Lethality
DUS3 YLR401C Dihydrouridine synthase genetic 1 1 1 Negative Genetic
BCH2 YKR027W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 1 1 1 Positive Genetic
PDR11 YIL013C ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
CFD1 YIL003W Highly conserved iron-sulfur cluster binding protein genetic 1 1 1 Negative Genetic
ERI1 YPL096C-A Endoplasmic reticulum membrane protein that binds and inhibits Ras2p genetic 1 1 1 Negative Genetic
DIC1 YLR348C Mitochondrial dicarboxylate carrier genetic 1 1 1 Negative Genetic
KRE2 YDR483W Alpha1,2-mannosyltransferase of the Golgi genetic 1 1 1 Negative Genetic
ERG7 YHR072W Lanosterol synthase genetic 1 1 1 Negative Genetic
HSK3 YKL138C-A Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Two-hybrid
IRC7 YFR055W Cysteine desulphydrase, enables growth on cysteine as nitrogen source genetic 1 1 1 Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Positive Genetic
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Synthetic Rescue
MSS4 YDR208W Phosphatidylinositol-4-phosphate 5-kinase genetic 1 1 1 Negative Genetic
FCF2 YLR051C Nucleolar protein involved in the early steps of 35S rRNA processing genetic 1 1 1 Negative Genetic
BLS1 YLR408C Subunit of the BLOC-1 complex involved in endosomal maturation genetic 1 1 1 Negative Genetic
AHK1 YDL073W Scaffold protein in the HKR1 sub-branch of the Hog1p-signaling pathway genetic 1 1 1 Negative Genetic
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Negative Genetic
MTG1 YMR097C Putative GTPase peripheral to the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
GLG1 YKR058W Glycogenin glucosyltransferase genetic 1 1 1 Negative Genetic
MET10 YFR030W Subunit alpha of assimilatory sulfite reductase genetic 1 1 1 Negative Genetic
GEP7 YGL057C Protein of unknown function genetic 1 1 1 Positive Genetic
LCB5 YLR260W Minor sphingoid long-chain base kinase genetic 1 1 1 Negative Genetic
MSC7 YHR039C Protein of unknown function genetic 1 1 1 Negative Genetic
MEF2 YJL102W Mitochondrial elongation factor involved in translational elongation genetic 1 1 1 Negative Genetic
CTP1 YBR291C Mitochondrial inner membrane citrate transporter genetic 1 1 1 Negative Genetic
LAM1 YHR155W Putative sterol transfer protein genetic 1 1 1 Positive Genetic
INA17 YPL099C F1F0 ATPase synthase peripheral stalk assembly factor genetic 1 1 1 Negative Genetic
MSS51 YLR203C Specific translational activator for the mitochondrial COX1 mRNA genetic 1 1 1 Negative Genetic
CAJ1 YER048C Nuclear type II J heat shock protein of the E. coli dnaJ family genetic 1 1 1 Negative Genetic
AIM26 YKL037W Protein of unknown function genetic 1 1 1 Negative Genetic
CSH1 YBR161W Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
HFD1 YMR110C Dehydrogenase involved in ubiquinone and sphingolipid metabolism genetic 1 1 1 Negative Genetic
DNF1 YER166W Aminophospholipid translocase (flippase) genetic 1 1 1 Positive Genetic
LIP5 YOR196C Protein involved in biosynthesis of the coenzyme lipoic acid genetic 1 1 1 Negative Genetic
MRS2 YOR334W Mitochondrial inner membrane Mg(2+) channel genetic 1 1 1 Negative Genetic
PEX32 YBR168W Peroxisomal integral membrane protein genetic 1 1 1 Negative Genetic
JJJ2 YJL162C Protein of unknown function genetic 1 1 1 Negative Genetic
OGG1 YML060W Nuclear and mitochondrial glycosylase/lyase genetic 1 1 1 Negative Genetic
FOL3 YMR113W Dihydrofolate synthetase, involved in folic acid biosynthesis physical 1 1 1 Affinity Capture-MS
GEM1 YAL048C Outer mitochondrial membrane GTPase, subunit of the ERMES complex genetic 1 1 1 Negative Genetic
CSA1 YPR174C Protein of unknown function genetic 1 1 1 Negative Genetic
CHS6 YJL099W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 1 1 1 Negative Genetic
DPH5 YLR172C Methyltransferase required for synthesis of diphthamide genetic 1 1 1 Negative Genetic
PAL2 YHR097C Protein involved in clathrin-mediated endocytosis genetic 1 1 1 Negative Genetic
AVT3 YKL146W Vacuolar transporter genetic 1 1 1 Negative Genetic
DUS1 YML080W Dihydrouridine synthase genetic 1 1 1 Negative Genetic
OSH7 YHR001W Oxysterol-binding phosphatidylserine transferase genetic 1 1 1 Negative Genetic
PIK1 YNL267W Phosphatidylinositol 4-kinase genetic 1 1 1 Negative Genetic
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 1 1 1 Negative Genetic
CHS7 YHR142W Protein of unknown function genetic 1 1 1 Negative Genetic
DDP1 YOR163W Diadenosine and diphosphoinositol polyphosphate phosphatase genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Positive Genetic
LIP1 YMR298W Ceramide synthase subunit genetic 1 1 1 Positive Genetic
ATR1 YML116W Multidrug efflux pump of the major facilitator superfamily genetic 1 1 1 Negative Genetic
DNF2 YDR093W Aminophospholipid translocase (flippase) genetic 1 1 1 Positive Genetic
DCR2 YLR361C Protein phosphatase genetic 1 1 1 Negative Genetic
PEX3 YDR329C Peroxisomal membrane protein (PMP) genetic 1 1 1 Negative Genetic
PEX31 YGR004W Peroxisomal integral membrane protein genetic 1 1 1 Negative Genetic
CRH1 YGR189C Chitin transglycosylase genetic 1 1 1 Negative Genetic
APE4 YHR113W Cytoplasmic aspartyl aminopeptidase with possible vacuole function genetic 1 1 1 Negative Genetic
BXI1 YNL305C Protein involved in apoptosis genetic 1 1 1 Negative Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Negative Genetic
ARF3 YOR094W Glucose-repressible ADP-ribosylation factor genetic 1 1 1 Negative Genetic
DFG16 YOR030W Probable multiple transmembrane protein genetic 1 1 1 Negative Genetic
CIS3 YJL158C Mannose-containing glycoprotein constituent of the cell wall genetic 1 1 1 Negative Genetic
HSP30 YCR021C Negative regulator of the H(+)-ATPase Pma1p genetic 1 1 1 Negative Genetic
NEO1 YIL048W Phospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
COS1 YNL336W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
COS7 YDL248W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
ARO10 YDR380W Phenylpyruvate decarboxylase genetic 1 1 1 Negative Genetic
KRE9 YJL174W Glycoprotein involved in cell wall beta-glucan assembly genetic 1 1 1 Negative Genetic
ALG12 YNR030W Alpha-1,6-mannosyltransferase localized to the ER genetic 1 1 1 Positive Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 1 1 1 Negative Genetic
GPC1 YGR149W Glycerophosphocholine acyltransferase (GPCAT) genetic 1 1 1 Negative Genetic
PHS1 YJL097W Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane genetic 1 1 1 Positive Genetic
GPI14 YJR013W Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I genetic 1 1 1 Negative Genetic
NFU1 YKL040C Protein involved in Fe-S cluster transfer to mitochondrial clients genetic 1 1 1 Negative Genetic
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 1 1 1 Negative Genetic
CHO1 YER026C Phosphatidylserine synthase genetic 1 1 1 Dosage Rescue
CCW14 YLR390W-A Covalently linked cell wall glycoprotein genetic 1 1 1 Negative Genetic
AGA2 YGL032C Adhesion subunit of a-agglutinin of a-cells genetic 1 1 1 Negative Genetic
CSI2 YOL007C Protein of unknown function genetic 1 1 1 Negative Genetic
NDD1 YOR372C Transcriptional activator essential for nuclear division physical 1 1 1 Biochemical Activity
GIS3 YLR094C Protein of unknown function genetic 1 1 1 Negative Genetic
HSP78 YDR258C Oligomeric mitochondrial matrix chaperone genetic 1 1 1 Negative Genetic
LAM4 YHR080C Sterol-binding protein that localizes to puncta in the cortical ER physical 1 1 1 Two-hybrid
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Negative Genetic
CBP4 YGR174C Mitochondrial protein required for assembly of cytochrome bc1 complex genetic 1 1 1 Positive Genetic
MRPL31 YKL138C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
IGO2 YHR132W-A Protein required for initiation of G0 program physical 1 1 1 Biochemical Activity
EMC10 YDR056C Putative protein of unknown function genetic 1 1 1 Negative Genetic
FMP33 YJL161W Putative protein of unknown function genetic 1 1 1 Negative Genetic
IZH2 YOL002C Plasma membrane receptor for plant antifungal osmotin genetic 1 1 1 Negative Genetic
ERG12 YMR208W Mevalonate kinase genetic 1 1 1 Negative Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Positive Genetic
CPR8 YNR028W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
MIC10 YCL057C-A Conserved component of the MICOS complex genetic 1 1 1 Positive Genetic
GSH2 YOL049W Glutathione synthetase genetic 1 1 1 Negative Genetic
DIT2 YDR402C N-formyltyrosine oxidase genetic 1 1 1 Negative Genetic
LEE1 YPL054W Zinc-finger protein of unknown function genetic 1 1 1 Negative Genetic
LNP1 YHR192W Lunapark family member involved in ER network formation physical 1 1 1 Two-hybrid
CTR86 YCR054C Essential protein of unknown function genetic 1 1 1 Positive Genetic
ALG11 YNL048W Alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
PIC2 YER053C Mitochondrial copper and phosphate carrier genetic 1 1 1 Negative Genetic
FLX1 YIL134W Mitochondrial flavin adenine dinucleotide transporter genetic 1 1 1 Negative Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 1 1 1 Negative Genetic
GPI1 YGR216C Membrane protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
ATX2 YOR079C Golgi membrane protein involved in manganese homeostasis genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
BIO4 YNR057C Dethiobiotin synthetase genetic 1 1 1 Negative Genetic
PET100 YDR079W Chaperone that facilitates the assembly of cytochrome c oxidase genetic 1 1 1 Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Negative Genetic
AIF1 YNR074C Mitochondrial cell death effector genetic 1 1 1 Negative Genetic
HMS2 YJR147W Protein with similarity to heat shock transcription factors genetic 1 1 1 Negative Genetic
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Negative Genetic
PCP1 YGR101W Mitochondrial serine protease genetic 1 1 1 Negative Genetic
PHM7 YOL084W Protein of unknown function genetic 1 1 1 Positive Genetic
CAX4 YGR036C Dolichyl pyrophosphate (Dol-P-P) phosphatase genetic 1 1 1 Negative Genetic
PAU13 YHL046C Protein of unknown function genetic 1 1 1 Negative Genetic
MNL2 YLR057W Putative mannosidase involved in ER-associated protein degradation genetic 1 1 1 Negative Genetic
FYV12 YOR183W Protein of unknown function genetic 1 1 1 Negative Genetic
MIN3 YMR182W-A Mitochondrial protein of unknown function genetic 1 1 1 Positive Genetic