Standard name Systematic name Name description Description
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of replication fork, such as fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; Rtt101p-Mms22p ligase associates with replisome complex during S phase via Ctf4p; required for accurate meiotic chromosome segregation
Visualize the interactome of MMS22
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MMS22 2 1 0 0 1

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage physical 11 5 7 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Co-crystal Structure, Protein-peptide, Two-hybrid, Affinity Capture-Western
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 9 4 6 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex physical 8 3 5 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-Western
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 8 3 5 Positive Genetic, Positive Genetic, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Dosage Growth Defect, Positive Genetic, Positive Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 7 4 7 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality, Negative Genetic, Synthetic Growth Defect
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 7 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 7 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 7 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
CTF4 YPR135W Chromatin-associated protein physical 6 3 4 Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 6 3 4 Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 6 2 4 Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 6 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 6 2 4 Positive Genetic, Positive Genetic, Positive Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 6 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 5 2 5 Positive Genetic, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Positive Genetic
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 5 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 5 2 3 Positive Genetic, Positive Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RIF1 YBR275C Protein involved in control of DNA replication genetic 4 2 3 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 4 2 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
UBP6 YFR010W Ubiquitin-specific protease genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 3 2 3 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
DST1 YGL043W General transcription elongation factor TFIIS genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BUB2 YMR055C Mitotic exit network regulator genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 3 3 2 Negative Genetic, Synthetic Growth Defect, Dosage Rescue
ASF1 YJL115W Nucleosome assembly factor genetic 3 2 2 Positive Genetic, Synthetic Growth Defect, Synthetic Growth Defect
GET1 YGL020C Subunit of the GET complex genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MDM10 YAL010C Subunit of both the ERMES and the SAM complex genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
HTA1 YDR225W Histone H2A genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FAR11 YNL127W Protein involved in recovery from cell cycle arrest genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PPM1 YDR435C Carboxyl methyltransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SSK2 YNR031C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SAE2 YGL175C Endonuclease required for telomere elongation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DEG1 YFL001W tRNA:pseudouridine synthase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
IRC5 YFR038W Putative ATPase containing the DEAD/H helicase-related sequence motif genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MCH5 YOR306C Plasma membrane riboflavin transporter genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC73 YLR418C Component of the Paf1p complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
CIK1 YMR198W Kinesin-associated protein genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 2 2 2 Negative Genetic, Positive Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RTT109 YLL002W Histone acetyltransferase genetic 2 2 2 Positive Genetic, Phenotypic Suppression
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
SLX4 YLR135W Endonuclease involved in processing DNA genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SUT1 YGL162W Zn(II)2Cys6 family transcription factor genetic 2 2 2 Positive Genetic, Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 2 2 2 Synthetic Lethality, Negative Genetic
IMD3 YLR432W Inosine monophosphate dehydrogenase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
HHF1 YBR009C Histone H4 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HTB2 YBL002W Histone H2B physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 2 1 2 Negative Genetic, Negative Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HHT1 YBR010W Histone H3 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 2 1 2 Negative Genetic, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 2 1 2 Negative Genetic, Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 2 1 2 Negative Genetic, Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 2 1 2 Negative Genetic, Negative Genetic
UFD2 YDL190C Ubiquitin (Ub) chain assembly factor (E4) genetic 2 1 2 Negative Genetic, Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 2 1 2 Negative Genetic, Negative Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 2 1 2 Negative Genetic, Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 2 1 2 Negative Genetic, Negative Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 2 1 2 Negative Genetic, Negative Genetic
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 2 1 2 Negative Genetic, Negative Genetic
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 2 1 2 Negative Genetic, Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 2 1 2 Negative Genetic, Negative Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 2 1 2 Positive Genetic, Positive Genetic
RNH202 YDR279W Ribonuclease H2 subunit genetic 2 1 2 Negative Genetic, Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 2 1 2 Negative Genetic, Negative Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 2 Positive Genetic, Positive Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 2 1 2 Negative Genetic, Negative Genetic
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
ERG3 YLR056W C-5 sterol desaturase genetic 2 1 2 Negative Genetic, Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
CDC45 YLR103C DNA replication initiation factor physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
MCM6 YGL201C Protein involved in DNA replication physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
MCM2 YBL023C Protein involved in DNA replication physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion physical 2 2 1 Two-hybrid, Reconstituted Complex
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion genetic 2 2 1 Synthetic Lethality, Dosage Rescue
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 1 Negative Genetic, Negative Genetic
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 1 1 Negative Genetic, Negative Genetic
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 2 1 1 Negative Genetic, Negative Genetic
HHT1 YBR010W Histone H3 genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 2 1 1 Negative Genetic, Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 2 1 1 Negative Genetic, Negative Genetic
PAC11 YDR488C Dynein intermediate chain, microtubule motor protein genetic 2 1 1 Negative Genetic, Negative Genetic
YLL058W YLL058W Putative protein of unknown function with similarity to Str2p genetic 2 1 1 Negative Genetic, Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 2 1 1 Negative Genetic, Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD55 YDR076W Protein that stimulates strand exchange genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD51 YER095W Strand exchange protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD57 YDR004W Protein that stimulates strand exchange genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 2 1 1 Negative Genetic, Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 2 1 1 Negative Genetic, Negative Genetic
NUP145 YGL092W Essential protein with distinct roles in two nuclear pore subcomplexes genetic 2 1 1 Negative Genetic, Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 2 1 1 Negative Genetic, Negative Genetic
DPC29 YGR021W Putative mitochondrial protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
ILV6 YCL009C Regulatory subunit of acetolactate synthase genetic 2 1 1 Negative Genetic, Negative Genetic
CYB5 YNL111C Cytochrome b5 genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
INO2 YDR123C Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription physical 1 1 1 Affinity Capture-MS
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation physical 1 1 1 Affinity Capture-MS
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation physical 1 1 1 Two-hybrid
DED81 YHR019C Cytosolic asparaginyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
LEO1 YOR123C Component of the Paf1 complex physical 1 1 1 Affinity Capture-MS
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs physical 1 1 1 Affinity Capture-MS
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
BFR2 YDR299W Component of the SSU and 90S preribosomes physical 1 1 1 Affinity Capture-MS
ESF1 YDR365C Nucleolar protein involved in pre-rRNA processing physical 1 1 1 Affinity Capture-MS
ENP2 YGR145W Component of the SSU physical 1 1 1 Affinity Capture-MS
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit physical 1 1 1 Affinity Capture-MS
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 1 1 1 Negative Genetic
IKI3 YLR384C Subunit of Elongator complex physical 1 1 1 Affinity Capture-MS
HSP60 YLR259C Tetradecameric mitochondrial chaperonin physical 1 1 1 Affinity Capture-MS
BRX1 YOL077C Nucleolar protein physical 1 1 1 Affinity Capture-MS
DBP9 YLR276C DEAD-box protein required for 27S rRNA processing physical 1 1 1 Affinity Capture-MS
DRS1 YLL008W Nucleolar DEAD-box protein required for ribosome assembly and function physical 1 1 1 Affinity Capture-MS
EBP2 YKL172W Required for 25S rRNA maturation and 60S ribosomal subunit assembly physical 1 1 1 Affinity Capture-MS
ERB1 YMR049C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
HAS1 YMR290C ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
MAK16 YAL025C Essential nuclear protein physical 1 1 1 Affinity Capture-MS
IPI1 YHR085W Component of the Rix1 complex and possibly pre-replicative complexes genetic 1 1 1 Positive Genetic
GCD6 YDR211W Catalytic epsilon subunit of the translation initiation factor eIF2B physical 1 1 1 Affinity Capture-MS
GCD6 YDR211W Catalytic epsilon subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
ADH1 YOL086C Alcohol dehydrogenase physical 1 1 1 Affinity Capture-MS
COR1 YBL045C Core subunit of the ubiquinol-cytochrome c reductase complex physical 1 1 1 Affinity Capture-MS
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) physical 1 1 1 Affinity Capture-MS
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 1 1 1 Negative Genetic
KRE29 YER038C Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
CIC1 YHR052W Essential protein that interacts with proteasome components physical 1 1 1 Affinity Capture-MS
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases physical 1 1 1 Affinity Capture-MS
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) physical 1 1 1 Affinity Capture-MS
BMH1 YER177W 14-3-3 protein, major isoform physical 1 1 1 Affinity Capture-MS
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family physical 1 1 1 Affinity Capture-MS
GAR1 YHR089C Protein component of the H/ACA snoRNP pseudouridylase complex physical 1 1 1 Affinity Capture-MS
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Negative Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity physical 1 1 1 Affinity Capture-MS
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 1 1 1 Affinity Capture-MS
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 physical 1 1 1 Affinity Capture-MS
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
ARP9 YMR033W Component of both the SWI/SNF and RSC chromatin remodeling complexes physical 1 1 1 Affinity Capture-MS
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
ILS1 YBL076C Cytoplasmic isoleucine-tRNA synthetase physical 1 1 1 Affinity Capture-MS
ARX1 YDR101C Nuclear export factor for the ribosomal pre-60S subunit physical 1 1 1 Affinity Capture-MS
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B physical 1 1 1 Affinity Capture-MS
BCP1 YDR361C Essential nuclear chaperone for ribosomal protein Rpl23p physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Negative Genetic
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
ADE13 YLR359W Adenylosuccinate lyase physical 1 1 1 Affinity Capture-MS
AOS1 YPR180W Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p genetic 1 1 1 Negative Genetic
APL6 YGR261C Beta3-like subunit of the yeast AP-3 complex physical 1 1 1 Affinity Capture-MS
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ARO1 YDR127W Pentafunctional arom protein physical 1 1 1 Affinity Capture-MS
BAT1 YHR208W Mitochondrial branched-chain amino acid (BCAA) aminotransferase physical 1 1 1 Affinity Capture-MS
BDF1 YLR399C BET family transcriptional regulator physical 1 1 1 Affinity Capture-MS
BMH2 YDR099W 14-3-3 protein, minor isoform physical 1 1 1 Affinity Capture-MS
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Affinity Capture-MS
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Synthetic Growth Defect
BUD20 YLR074C C2H2-type zinc finger protein required for ribosome assembly physical 1 1 1 Affinity Capture-MS
CAR1 YPL111W Arginase, catabolizes arginine to ornithine and urea physical 1 1 1 Affinity Capture-MS
CAR1 YPL111W Arginase, catabolizes arginine to ornithine and urea genetic 1 1 1 Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 1 1 1 Affinity Capture-MS
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping physical 1 1 1 Affinity Capture-MS
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Negative Genetic
ERG26 YGL001C C-3 sterol dehydrogenase physical 1 1 1 Affinity Capture-MS
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) physical 1 1 1 Affinity Capture-MS
IPI3 YNL182C Component of the Rix1 complex and pre-replicative complexes (pre-RCs) physical 1 1 1 Affinity Capture-MS
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
CHC1 YGL206C Clathrin heavy chain physical 1 1 1 Affinity Capture-MS
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
CNS1 YBR155W TPR-containing co-chaperone physical 1 1 1 Affinity Capture-MS
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex physical 1 1 1 Affinity Capture-MS
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 Affinity Capture-MS
CYS4 YGR155W Cystathionine beta-synthase physical 1 1 1 Affinity Capture-MS
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Positive Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Synthetic Lethality
DPB2 YPR175W Second largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 1 1 1 Affinity Capture-MS
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Negative Genetic
ELP2 YGR200C Subunit of Elongator complex physical 1 1 1 Affinity Capture-MS
ENO1 YGR254W Enolase I, a phosphopyruvate hydratase physical 1 1 1 Affinity Capture-MS
ENP1 YBR247C Protein associated with U3 and U14 snoRNAs physical 1 1 1 Affinity Capture-MS
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex physical 1 1 1 Affinity Capture-MS
ERG13 YML126C 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase physical 1 1 1 Affinity Capture-MS
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) physical 1 1 1 Affinity Capture-MS
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Affinity Capture-MS
GCN2 YDR283C Protein kinase genetic 1 1 1 Negative Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity physical 1 1 1 Affinity Capture-MS
DYN1 YKR054C Cytoplasmic heavy chain dynein genetic 1 1 1 Negative Genetic
GLY1 YEL046C Threonine aldolase physical 1 1 1 Affinity Capture-MS
HIS4 YCL030C Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase physical 1 1 1 Affinity Capture-MS
HRP1 YOL123W Subunit of cleavage factor I physical 1 1 1 Affinity Capture-MS
HRT1 YOL133W RING-H2 domain core subunit of multiple ubiquitin ligase complexes physical 1 1 1 Affinity Capture-MS
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex genetic 1 1 1 Synthetic Rescue
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) physical 1 1 1 Affinity Capture-MS
ACK1 YDL203C Protein that functions in the cell wall integrity pathway genetic 1 1 1 Positive Genetic
IST1 YNL265C Protein with positive role in the multivesicular body sorting pathway physical 1 1 1 Affinity Capture-MS
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
ESC8 YOL017W Protein involved in telomeric and mating-type locus silencing genetic 1 1 1 Negative Genetic
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling physical 1 1 1 Affinity Capture-MS
CLU1 YMR012W Subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
ARB1 YER036C ATPase of the ATP-binding cassette (ABC) family physical 1 1 1 Affinity Capture-MS
KRE33 YNL132W Acetyltransferase required for biogenesis of small ribosomal subunit physical 1 1 1 Affinity Capture-MS
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly physical 1 1 1 Affinity Capture-MS
KRS1 YDR037W Lysyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
GFA1 YKL104C Glutamine-fructose-6-phosphate amidotransferase physical 1 1 1 Affinity Capture-MS
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Synthetic Lethality
GLT1 YDL171C NAD(+)-dependent glutamate synthase (GOGAT) physical 1 1 1 Affinity Capture-MS
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex physical 1 1 1 Affinity Capture-MS
MCM6 YGL201C Protein involved in DNA replication genetic 1 1 1 Synthetic Rescue
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 1 1 1 Affinity Capture-MS
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
MHR1 YDR296W Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
CCM1 YGR150C Mitochondrial 15S rRNA-binding protein genetic 1 1 1 Synthetic Lethality
MGM101 YJR144W Protein with a role in mitochondrial DNA recombinational repair physical 1 1 1 Affinity Capture-MS
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Negative Genetic
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring physical 1 1 1 Affinity Capture-MS
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Synthetic Growth Defect
KAP114 YGL241W Karyopherin, responsible for nuclear import of specific proteins genetic 1 1 1 Negative Genetic
LYS12 YIL094C Homo-isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
MIS1 YBR084W Mitochondrial C1-tetrahydrofolate synthase physical 1 1 1 Affinity Capture-MS
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Synthetic Growth Defect
INO80 YGL150C Nucleosome spacing factor physical 1 1 1 Affinity Capture-MS
FAS2 YPL231W Alpha subunit of fatty acid synthetase genetic 1 1 1 Negative Genetic
HSP42 YDR171W Small heat shock protein (sHSP) with chaperone activity physical 1 1 1 Affinity Capture-MS
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Synthetic Growth Defect
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC physical 1 1 1 Affinity Capture-MS
DIG1 YPL049C MAP kinase-responsive inhibitor of the Ste12p transcription factor genetic 1 1 1 Synthetic Growth Defect
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Lethality
HTA1 YDR225W Histone H2A physical 1 1 1 Affinity Capture-MS
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome physical 1 1 1 Affinity Capture-MS
IMP4 YNL075W Component of the SSU processome physical 1 1 1 Affinity Capture-MS
CPA2 YJR109C Large subunit of carbamoyl phosphate synthetase physical 1 1 1 Affinity Capture-MS
MKT1 YNL085W Protein similar to nucleases that forms a complex with Pbp1p physical 1 1 1 Affinity Capture-MS
ADE57 YGL234W Bifunctional enzyme of 'de novo' purine nucleotide pathway physical 1 1 1 Affinity Capture-MS
ADE3 YGR204W Cytoplasmic trifunctional enzyme physical 1 1 1 Affinity Capture-MS
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III physical 1 1 1 Affinity Capture-MS
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Synthetic Lethality
BGL2 YGR282C Endo-beta-1,3-glucanase physical 1 1 1 Affinity Capture-MS
CCT2 YIL142W Subunit beta of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor physical 1 1 1 Affinity Capture-MS
INP52 YNL106C Polyphosphatidylinositol phosphatase genetic 1 1 1 Negative Genetic
LSB3 YFR024C-A Protein containing a C-terminal SH3 domain physical 1 1 1 Affinity Capture-MS
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
IST2 YBR086C Cortical ER protein involved in ER-plasma membrane (PM) tethering physical 1 1 1 Affinity Capture-MS
HEM13 YDR044W Coproporphyrinogen III oxidase genetic 1 1 1 Negative Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
CCT7 YJL111W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
CAM1 YPL048W One of two isoforms of the gamma subunit of eEF1B physical 1 1 1 Affinity Capture-MS
EFB1 YAL003W Translation elongation factor 1 beta physical 1 1 1 Affinity Capture-MS
GLN1 YPR035W Glutamine synthetase (GS) physical 1 1 1 Affinity Capture-MS
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex genetic 1 1 1 Negative Genetic
BOI1 YBL085W Protein involved in polar growth, functionally redundant with Boi2p physical 1 1 1 Affinity Capture-MS
LTV1 YKL143W Subunit of the EGO/GSE complex physical 1 1 1 Affinity Capture-MS
DOT6 YER088C Protein involved in rRNA and ribosome biogenesis physical 1 1 1 Affinity Capture-MS
LSM12 YHR121W Protein of unknown function that may function in RNA processing physical 1 1 1 Affinity Capture-MS
LYS9 YNR050C Saccharopine dehydrogenase (NADP+, L-glutamate-forming) physical 1 1 1 Affinity Capture-MS
FPR3 YML074C Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Affinity Capture-MS
EDC3 YEL015W Non-essential conserved protein with a role in mRNA decapping physical 1 1 1 Affinity Capture-MS
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) physical 1 1 1 Affinity Capture-MS
ACO1 YLR304C Aconitase physical 1 1 1 Affinity Capture-MS
LSP1 YPL004C Eisosome core component physical 1 1 1 Affinity Capture-MS
MDH1 YKL085W Mitochondrial malate dehydrogenase physical 1 1 1 Affinity Capture-MS
HYP2 YEL034W Translation elongation factor eIF-5A physical 1 1 1 Affinity Capture-MS
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
ADO1 YJR105W Adenosine kinase physical 1 1 1 Affinity Capture-MS
GPP1 YIL053W Constitutively expressed DL-glycerol-3-phosphate phosphatase physical 1 1 1 Affinity Capture-MS
ARF1 YDL192W ADP-ribosylation factor physical 1 1 1 Affinity Capture-MS
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
CPR6 YLR216C Peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 Affinity Capture-MS
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 1 1 1 Negative Genetic
AHP1 YLR109W Thiol-specific peroxiredoxin physical 1 1 1 Affinity Capture-MS
CMP2 YML057W Calcineurin A genetic 1 1 1 Positive Genetic
DPS1 YLL018C Aspartyl-tRNA synthetase, primarily cytoplasmic physical 1 1 1 Affinity Capture-MS
GSP1 YLR293C Ran GTPase physical 1 1 1 Affinity Capture-MS
FAA4 YMR246W Long chain fatty acyl-CoA synthetase physical 1 1 1 Affinity Capture-MS
ARO4 YBR249C 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase physical 1 1 1 Affinity Capture-MS
ILV5 YLR355C Acetohydroxyacid reductoisomerase and mtDNA binding protein physical 1 1 1 Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor physical 1 1 1 Affinity Capture-MS
HXT6 YDR343C High-affinity glucose transporter physical 1 1 1 Affinity Capture-MS
APM3 YBR288C Mu3-like subunit of the clathrin associated protein complex (AP-3) physical 1 1 1 Affinity Capture-MS
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism physical 1 1 1 Affinity Capture-MS
LCP5 YER127W Essential protein involved in maturation of 18S rRNA physical 1 1 1 Affinity Capture-MS
ESL2 YKR096W hEST1A/B (SMG5/6)-like protein physical 1 1 1 Affinity Capture-MS
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Negative Genetic
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 1 1 1 Negative Genetic
ADK1 YDR226W Adenylate kinase, required for purine metabolism physical 1 1 1 Affinity Capture-MS
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Synthetic Growth Defect
GPD2 YOL059W NAD-dependent glycerol 3-phosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
GPD1 YDL022W NAD-dependent glycerol-3-phosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
ECM10 YEL030W Heat shock protein of the Hsp70 family genetic 1 1 1 Negative Genetic
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
ARG4 YHR018C Argininosuccinate lyase physical 1 1 1 Affinity Capture-MS
LIA1 YJR070C Deoxyhypusine hydroxylase physical 1 1 1 Affinity Capture-MS
DLD3 YEL071W 2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase physical 1 1 1 Affinity Capture-MS
ACS2 YLR153C Acetyl-coA synthetase isoform physical 1 1 1 Affinity Capture-MS
ILV3 YJR016C Dihydroxyacid dehydratase physical 1 1 1 Affinity Capture-MS
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) physical 1 1 1 Affinity Capture-MS
CCT3 YJL014W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
KAP122 YGL016W Karyopherin beta genetic 1 1 1 Negative Genetic
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription genetic 1 1 1 Synthetic Growth Defect
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
ADH3 YMR083W Mitochondrial alcohol dehydrogenase isozyme III physical 1 1 1 Affinity Capture-MS
IMD4 YML056C Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
APE1 YKL103C Vacuolar aminopeptidase yscI physical 1 1 1 Affinity Capture-MS
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein physical 1 1 1 Affinity Capture-MS
HSL7 YBR133C Protein arginine N-methyltransferase genetic 1 1 1 Negative Genetic
CDC60 YPL160W Cytosolic leucyl tRNA synthetase physical 1 1 1 Affinity Capture-MS
GRS1 YBR121C Cytoplasmic and mitochondrial glycyl-tRNA synthase physical 1 1 1 Affinity Capture-MS
ERG20 YJL167W Farnesyl pyrophosphate synthetase physical 1 1 1 Affinity Capture-MS
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Negative Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
GPN3 YLR243W Putative GTPase with a role in biogenesis of RNA pol II and polIII physical 1 1 1 Affinity Capture-MS
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) physical 1 1 1 Affinity Capture-MS
MAK11 YKL021C Protein involved in an early step of 60S ribosomal subunit biogenesis physical 1 1 1 Affinity Capture-MS
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Negative Genetic
MET6 YER091C Cobalamin-independent methionine synthase physical 1 1 1 Affinity Capture-MS
LRO1 YNR008W Acyltransferase that converts diacylglycerol to triacylglycerol (TGA) genetic 1 1 1 Negative Genetic
FRS2 YFL022C Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
MCX1 YBR227C Non-proteolytic ATPase of the AAA family physical 1 1 1 Affinity Capture-MS
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 1 1 1 Positive Genetic
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis physical 1 1 1 Affinity Capture-MS
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis genetic 1 1 1 Negative Genetic
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 1 1 1 Negative Genetic
ACS1 YAL054C Acetyl-coA synthetase isoform physical 1 1 1 Affinity Capture-MS
ILV2 YMR108W Acetolactate synthase physical 1 1 1 Affinity Capture-MS
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake physical 1 1 1 Affinity Capture-MS
MAP2 YBL091C Methionine aminopeptidase physical 1 1 1 Affinity Capture-MS
MDH2 YOL126C Cytoplasmic malate dehydrogenase physical 1 1 1 Affinity Capture-MS
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
FKH2 YNL068C Forkhead family transcription factor physical 1 1 1 Affinity Capture-MS
FKH2 YNL068C Forkhead family transcription factor genetic 1 1 1 Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 1 1 1 Affinity Capture-MS
APA1 YCL050C AP4A phosphorylase physical 1 1 1 Affinity Capture-MS
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes physical 1 1 1 Affinity Capture-MS
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Negative Genetic
CIA1 YDR267C Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating physical 1 1 1 Affinity Capture-MS
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Negative Genetic
MIC19 YFR011C Component of the MICOS complex genetic 1 1 1 Negative Genetic
GBP2 YCL011C Poly(A+) RNA-binding protein physical 1 1 1 Affinity Capture-MS
MDJ1 YFL016C Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity physical 1 1 1 Affinity Capture-MS
ARG1 YOL058W Arginosuccinate synthetase physical 1 1 1 Affinity Capture-MS
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase physical 1 1 1 Affinity Capture-MS
CYS3 YAL012W Cystathionine gamma-lyase physical 1 1 1 Affinity Capture-MS
APE3 YBR286W Vacuolar aminopeptidase Y physical 1 1 1 Affinity Capture-MS
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Synthetic Growth Defect
PRP45 YAL032C Protein required for pre-mRNA splicing physical 1 1 1 Two-hybrid
SSA3 YBL075C ATPase involved in protein folding and the response to stress physical 1 1 1 Affinity Capture-MS
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus physical 1 1 1 Affinity Capture-MS
TDH1 YJL052W Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1 physical 1 1 1 Affinity Capture-MS
YMR187C YMR187C Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
YIL082W-A YIL082W-A Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
RPP2B YDR382W Ribosomal protein P2 beta physical 1 1 1 Affinity Capture-MS
RPP2A YOL039W Ribosomal protein P2 alpha physical 1 1 1 Affinity Capture-MS
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL43A YPR043W Ribosomal 60S subunit protein L43A physical 1 1 1 Affinity Capture-MS
NSR1 YGR159C Nucleolin, nucleolar protein that binds nuclear localization sequences physical 1 1 1 Affinity Capture-MS
TEF1 YPR080W Translational elongation factor EF-1 alpha physical 1 1 1 Affinity Capture-MS
RPP1B YDL130W Ribosomal protein P1 beta physical 1 1 1 Affinity Capture-MS
RPL22A YLR061W Ribosomal 60S subunit protein L22A physical 1 1 1 Affinity Capture-MS
RPS29B YDL061C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
RPL31B YLR406C Ribosomal 60S subunit protein L31B physical 1 1 1 Affinity Capture-MS
RPS23A YGR118W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS10B YMR230W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS30A YLR287C-A Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MRPL19 YNL185C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
RPS28B YLR264W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PET130 YJL023C Protein of unknown function physical 1 1 1 Affinity Capture-MS
PET130 YJL023C Protein of unknown function genetic 1 1 1 Synthetic Lethality
TUB3 YML124C Alpha-tubulin physical 1 1 1 Affinity Capture-MS
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing physical 1 1 1 Affinity Capture-MS
TAL1 YLR354C Transaldolase, enzyme in the non-oxidative pentose phosphate pathway physical 1 1 1 Affinity Capture-MS
TIF1 YKR059W Translation initiation factor eIF4A physical 1 1 1 Affinity Capture-MS
RPL18A YOL120C Ribosomal 60S subunit protein L18A physical 1 1 1 Affinity Capture-MS
RPL40A YIL148W Ubiquitin-ribosomal 60S subunit protein L40A fusion protein physical 1 1 1 Affinity Capture-MS
RPS31 YLR167W Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin physical 1 1 1 Affinity Capture-MS
RPG1 YBR079C eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
RPL38 YLR325C Ribosomal 60S subunit protein L38 physical 1 1 1 Affinity Capture-MS
RPL37A YLR185W Ribosomal 60S subunit protein L37A physical 1 1 1 Affinity Capture-MS
RPL15A YLR029C Ribosomal 60S subunit protein L15A physical 1 1 1 Affinity Capture-MS
RPS26A YGL189C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS29A YLR388W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SAR1 YPL218W ARF family GTPase physical 1 1 1 Affinity Capture-MS
RPL1A YPL220W Ribosomal 60S subunit protein L1A physical 1 1 1 Affinity Capture-MS
NOP6 YDL213C rRNA-binding protein required for 40S ribosomal subunit biogenesis physical 1 1 1 Affinity Capture-MS
RRG8 YPR116W Protein of unknown function physical 1 1 1 Affinity Capture-MS
RPC10 YHR143W-A RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III physical 1 1 1 Affinity Capture-MS
TSA1 YML028W Thioredoxin peroxidase physical 1 1 1 Affinity Capture-MS
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly physical 1 1 1 Affinity Capture-MS
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
NOP13 YNL175C Nucleolar protein found in preribosomal complexes physical 1 1 1 Affinity Capture-MS
RPL33A YPL143W Ribosomal 60S subunit protein L33A physical 1 1 1 Affinity Capture-MS
THG1 YGR024C tRNAHis guanylyltransferase physical 1 1 1 Affinity Capture-MS
RPA49 YNL248C RNA polymerase I subunit A49 physical 1 1 1 Affinity Capture-MS
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Negative Genetic
RPL33B YOR234C Ribosomal 60S subunit protein L33B physical 1 1 1 Affinity Capture-MS
RPL19A YBR084C-A Ribosomal 60S subunit protein L19A physical 1 1 1 Affinity Capture-MS
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins physical 1 1 1 Affinity Capture-MS
YEF3 YLR249W Translation elongation factor 3 physical 1 1 1 Affinity Capture-MS
YCR016W YCR016W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs physical 1 1 1 Affinity Capture-MS
YPT1 YFL038C Rab family GTPase physical 1 1 1 Affinity Capture-MS
RPL24A YGL031C Ribosomal 60S subunit protein L24A physical 1 1 1 Affinity Capture-MS
RPL24B YGR148C Ribosomal 60S subunit protein L24B physical 1 1 1 Affinity Capture-MS
RPC40 YPR110C RNA polymerase subunit AC40 physical 1 1 1 Affinity Capture-MS
TIF11 YMR260C Translation initiation factor eIF1A physical 1 1 1 Affinity Capture-MS
SEC4 YFL005W Rab family GTPase physical 1 1 1 Affinity Capture-MS
YHB1 YGR234W Nitric oxide oxidoreductase physical 1 1 1 Affinity Capture-MS
YDJ1 YNL064C Type I HSP40 co-chaperone physical 1 1 1 Affinity Capture-MS
PNO1 YOR145C Essential nucleolar protein required for pre-18S rRNA processing physical 1 1 1 Affinity Capture-MS
SER3 YER081W 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase physical 1 1 1 Affinity Capture-MS
TUB1 YML085C Alpha-tubulin physical 1 1 1 Affinity Capture-MS
RPL39 YJL189W Ribosomal 60S subunit protein L39 physical 1 1 1 Affinity Capture-MS
PSA1 YDL055C GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) physical 1 1 1 Affinity Capture-MS
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B physical 1 1 1 Affinity Capture-MS
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) physical 1 1 1 Affinity Capture-MS
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex physical 1 1 1 Affinity Capture-MS
NPL3 YDR432W RNA-binding protein physical 1 1 1 Affinity Capture-MS
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
RRP3 YHR065C Protein involved in rRNA processing physical 1 1 1 Affinity Capture-MS
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly physical 1 1 1 Affinity Capture-MS
NOP4 YPL043W Nucleolar protein physical 1 1 1 Affinity Capture-MS
RPA190 YOR341W RNA polymerase I largest subunit A190 physical 1 1 1 Affinity Capture-MS
PUF6 YDR496C Pumilio-homology domain protein physical 1 1 1 Affinity Capture-MS
RSM23 YGL129C Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
NOP10 YHR072W-A Subunit of box H/ACA snoRNP complex physical 1 1 1 Affinity Capture-MS
RFC3 YNL290W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-MS
MRPS35 YGR165W Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
RIO2 YNL207W Essential serine kinase involved in the processing of 20S pre-rRNA physical 1 1 1 Affinity Capture-MS
TIF6 YPR016C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
PUS6 YGR169C tRNA:pseudouridine synthase physical 1 1 1 Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
RPL34B YIL052C Ribosomal 60S subunit protein L34B physical 1 1 1 Affinity Capture-MS
ZUO1 YGR285C Ribosome-associated chaperone physical 1 1 1 Affinity Capture-MS
ZUO1 YGR285C Ribosome-associated chaperone genetic 1 1 1 Synthetic Lethality
RNR2 YJL026W Ribonucleotide-diphosphate reductase (RNR), small subunit physical 1 1 1 Affinity Capture-MS
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-MS
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A physical 1 1 1 Affinity Capture-MS
URA3 YEL021W Orotidine-5'-phosphate (OMP) decarboxylase physical 1 1 1 Affinity Capture-MS
NOG1 YPL093W Putative GTPase physical 1 1 1 Affinity Capture-MS
UTP23 YOR004W Component of the small subunit processome physical 1 1 1 Affinity Capture-MS
YPT32 YGL210W Rab family GTPase involved in the exocytic pathway physical 1 1 1 Affinity Capture-MS
RUB1 YDR139C Ubiquitin-like protein with similarity to mammalian NEDD8 physical 1 1 1 Affinity Capture-MS
RPA43 YOR340C RNA polymerase I subunit A43 physical 1 1 1 Affinity Capture-MS
RPA43 YOR340C RNA polymerase I subunit A43 genetic 1 1 1 Negative Genetic
PRB1 YEL060C Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity physical 1 1 1 Affinity Capture-MS
SHM2 YLR058C Cytosolic serine hydroxymethyltransferase physical 1 1 1 Affinity Capture-MS
YMR226C YMR226C NADP(+)-dependent serine dehydrogenase and carbonyl reductase physical 1 1 1 Affinity Capture-MS
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
NAM9 YNL137C Mitochondrial ribosomal component of the small subunit physical 1 1 1 Affinity Capture-MS
MRC1 YCL061C S-phase checkpoint protein required for DNA replication physical 1 1 1 Affinity Capture-MS
RLP24 YLR009W Essential protein required for ribosomal large subunit biogenesis physical 1 1 1 Affinity Capture-MS
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b physical 1 1 1 Affinity Capture-MS
SEC21 YNL287W Gamma subunit of coatomer physical 1 1 1 Affinity Capture-MS
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein physical 1 1 1 Affinity Capture-MS
TOD6 YBL054W PAC motif binding protein involved in rRNA and ribosome biogenesis physical 1 1 1 Affinity Capture-MS
MRP51 YPL118W Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
NUG1 YER006W GTPase that associates with nuclear 60S pre-ribosomes physical 1 1 1 Affinity Capture-MS
PAB1 YER165W Poly(A) binding protein physical 1 1 1 Affinity Capture-MS
NOG2 YNR053C Putative GTPase physical 1 1 1 Affinity Capture-MS
RET2 YFR051C Delta subunit of the coatomer complex (COPI) physical 1 1 1 Affinity Capture-MS
YTM1 YOR272W Ribosomal assembly factor and 66S pre-ribosomal particle constituent physical 1 1 1 Affinity Capture-MS
NOP15 YNL110C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer physical 1 1 1 Affinity Capture-MS
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
RRP15 YPR143W Nucleolar protein physical 1 1 1 Affinity Capture-MS
SUP45 YBR143C Polypeptide release factor (eRF1) in translation termination physical 1 1 1 Affinity Capture-MS
RPA135 YPR010C RNA polymerase I second largest subunit A135 physical 1 1 1 Affinity Capture-MS
VMA4 YOR332W Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase) physical 1 1 1 Affinity Capture-MS
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) physical 1 1 1 Affinity Capture-MS
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
RPB11 YOL005C RNA polymerase II subunit B12.5 physical 1 1 1 Affinity Capture-MS
PRS5 YOL061W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 1 1 1 Affinity Capture-MS
SEC53 YFL045C Phosphomannomutase physical 1 1 1 Affinity Capture-MS
RPB8 YOR224C RNA polymerase subunit ABC14.5 physical 1 1 1 Affinity Capture-MS
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 1 1 1 Affinity Capture-MS
MRP4 YHL004W Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
MRP1 YDR347W Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
RPF1 YHR088W Protein involved in assembly and export of the large ribosomal subunit physical 1 1 1 Affinity Capture-MS
SES1 YDR023W Cytosolic seryl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
RPC19 YNL113W RNA polymerase subunit AC19 physical 1 1 1 Affinity Capture-MS
RPC19 YNL113W RNA polymerase subunit AC19 genetic 1 1 1 Negative Genetic
SSF1 YHR066W Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
PSF3 YOL146W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 1 1 1 Affinity Capture-MS
PST2 YDR032C FMN-dependent NAD(P)H:quinone oxidoreductase physical 1 1 1 Affinity Capture-MS
RPL42A YNL162W Ribosomal 60S subunit protein L42A physical 1 1 1 Affinity Capture-MS
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit physical 1 1 1 Affinity Capture-MS
SRP14 YDL092W Signal recognition particle (SRP) subunit physical 1 1 1 Affinity Capture-MS
NET1 YJL076W Core subunit of the RENT complex physical 1 1 1 Affinity Capture-MS
TIF35 YDR429C eIF3g subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
THR1 YHR025W Homoserine kinase physical 1 1 1 Affinity Capture-MS
SKP1 YDR328C Evolutionarily conserved kinetochore protein physical 1 1 1 Affinity Capture-MS
MRPS12 YNR036C Mitochondrial protein physical 1 1 1 Affinity Capture-MS
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
WTM1 YOR230W Transcriptional modulator physical 1 1 1 Affinity Capture-MS
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein physical 1 1 1 Affinity Capture-MS
SCJ1 YMR214W One of several homologs of bacterial chaperone DnaJ physical 1 1 1 Affinity Capture-MS
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SNP1 YIL061C Component of U1 snRNP required for mRNA splicing via spliceosome physical 1 1 1 Affinity Capture-MS
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes physical 1 1 1 Affinity Capture-MS
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex physical 1 1 1 Affinity Capture-MS
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-MS
WRS1 YOL097C Cytoplasmic tryptophanyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
MRPS8 YMR158W Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
SOD2 YHR008C Mitochondrial manganese superoxide dismutase physical 1 1 1 Affinity Capture-MS
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
PDX1 YGR193C E3-binding protein of the mitochondrial pyruvate dehydrogenase complex physical 1 1 1 Affinity Capture-MS
REH1 YLR387C Cytoplasmic 60S subunit biogenesis factor physical 1 1 1 Affinity Capture-MS
MRP17 YKL003C Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
PCK1 YKR097W Phosphoenolpyruvate carboxykinase physical 1 1 1 Affinity Capture-MS
YCR087C-A YCR087C-A Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
PRT1 YOR361C eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
YMR315W YMR315W Protein with NADP(H) oxidoreductase activity physical 1 1 1 Affinity Capture-MS
POL4 YCR014C DNA polymerase IV physical 1 1 1 Affinity Capture-MS
MNP1 YGL068W Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
UGP1 YKL035W UDP-glucose pyrophosphorylase (UGPase) physical 1 1 1 Affinity Capture-MS
SNU13 YEL026W RNA binding protein physical 1 1 1 Affinity Capture-MS
SMY2 YBR172C GYF domain protein physical 1 1 1 Affinity Capture-MS
TIF3 YPR163C Translation initiation factor eIF-4B physical 1 1 1 Affinity Capture-MS
PBP4 YDL053C Pbp1p binding protein physical 1 1 1 Affinity Capture-MS
TMA19 YKL056C Protein that associates with ribosomes physical 1 1 1 Affinity Capture-MS
TRP5 YGL026C Tryptophan synthase physical 1 1 1 Affinity Capture-MS
PRC1 YMR297W Vacuolar carboxypeptidase Y (proteinase C, CPY) physical 1 1 1 Affinity Capture-MS
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome physical 1 1 1 Affinity Capture-MS
YPI1 YFR003C Regulatory subunit of the type I protein phosphatase (PP1) Glc7p physical 1 1 1 Affinity Capture-MS
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
MRPL15 YLR312W-A Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
NHP2 YDL208W Protein related to mammalian high mobility group (HMG) proteins physical 1 1 1 Affinity Capture-MS
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
MRPL35 YDR322W Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
MRPL35 YDR322W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-MS
MRPL11 YDL202W Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RCL1 YOL010W Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis physical 1 1 1 Affinity Capture-MS
SST2 YLR452C GTPase-activating protein for Gpa1p physical 1 1 1 Affinity Capture-MS
SNF7 YLR025W One of four subunits of the ESCRT-III complex physical 1 1 1 Affinity Capture-MS
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
SDH2 YLL041C Iron-sulfur protein subunit of succinate dehydrogenase physical 1 1 1 Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Negative Genetic
RNQ1 YCL028W [PIN(+)] prion physical 1 1 1 Affinity Capture-MS
SEC28 YIL076W Epsilon-COP subunit of the coatomer physical 1 1 1 Affinity Capture-MS
SRP72 YPL210C Core component of the signal recognition particle (SRP) physical 1 1 1 Affinity Capture-MS
REI1 YBR267W Cytoplasmic pre-60S factor physical 1 1 1 Affinity Capture-MS
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Positive Genetic
NAF1 YNL124W RNA-binding protein required for the assembly of box H/ACA snoRNPs physical 1 1 1 Affinity Capture-MS
NMD3 YHR170W Protein involved in nuclear export of the large ribosomal subunit physical 1 1 1 Affinity Capture-MS
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex physical 1 1 1 Affinity Capture-MS
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
YPR148C YPR148C Protein of unknown function physical 1 1 1 Affinity Capture-MS
RSC8 YFR037C Component of the RSC chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-MS
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
YKL075C YKL075C Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
PRS1 YKL181W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 1 1 1 Affinity Capture-MS
PBP1 YGR178C Component of glucose deprivation induced stress granules physical 1 1 1 Affinity Capture-MS
SHE1 YBL031W Mitotic spindle protein physical 1 1 1 Affinity Capture-MS
NSA2 YER126C Protein constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
RPN9 YDR427W Non-ATPase regulatory subunit of the 26S proteasome physical 1 1 1 Affinity Capture-MS
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex physical 1 1 1 Affinity Capture-MS
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Positive Genetic
NIC96 YFR002W Linker nucleoporin component of the nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
TKL1 YPR074C Transketolase physical 1 1 1 Affinity Capture-MS
MRPS9 YBR146W Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
MRPS5 YBR251W Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex physical 1 1 1 Affinity Capture-MS
MPM1 YJL066C Mitochondrial intermembrane space protein of unknown function physical 1 1 1 Affinity Capture-MS
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing physical 1 1 1 Affinity Capture-MS
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone physical 1 1 1 Affinity Capture-MS
YPT52 YKR014C Endosomal Rab family GTPase physical 1 1 1 Affinity Capture-MS
PCS60 YBR222C Oxalyl-CoA synthetase physical 1 1 1 Affinity Capture-MS
VLD1 YIR014W Component of Dsc E3 ligase complex in vacuolar membranes physical 1 1 1 Affinity Capture-MS
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) physical 1 1 1 Affinity Capture-MS
TUP1 YCR084C General repressor of transcription in complex with Cyc8p physical 1 1 1 Affinity Capture-MS
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase physical 1 1 1 Affinity Capture-MS
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer physical 1 1 1 Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-MS
RTN1 YDR233C Reticulon protein physical 1 1 1 Affinity Capture-MS
MSS116 YDR194C Mitochondrial transcription elongation factor physical 1 1 1 Affinity Capture-MS
TRM1 YDR120C tRNA methyltransferase physical 1 1 1 Affinity Capture-MS
YDR341C YDR341C Arginyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
YKL107W YKL107W NADH-dependent aldehyde reductase physical 1 1 1 Affinity Capture-MS
RSA4 YCR072C Ribosomal large subunit (60S) assembly factor physical 1 1 1 Affinity Capture-MS
STE50 YCL032W Adaptor protein for various signaling pathways physical 1 1 1 Affinity Capture-MS
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p physical 1 1 1 Affinity Capture-MS
PET123 YOR158W Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
RCK2 YLR248W Protein kinase involved in response to oxidative and osmotic stress physical 1 1 1 Affinity Capture-MS
PRE2 YPR103W Beta 5 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
UTP22 YGR090W Component of the small-subunit processome physical 1 1 1 Affinity Capture-MS
RPP1 YHR062C Subunit of both RNase MRP and nuclear RNase P physical 1 1 1 Affinity Capture-MS
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
SRP40 YKR092C Nucleolar serine-rich protein physical 1 1 1 Affinity Capture-MS
MSN4 YKL062W Stress-responsive transcriptional activator physical 1 1 1 Affinity Capture-MS
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine physical 1 1 1 Affinity Capture-MS
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors physical 1 1 1 Affinity Capture-MS
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase physical 1 1 1 Affinity Capture-MS
NSA1 YGL111W Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
YGR130C YGR130C Component of the eisosome with unknown function physical 1 1 1 Affinity Capture-MS
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
VAR1 Q0140 Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
SVF1 YDR346C Protein with a potential role in cell survival pathways physical 1 1 1 Affinity Capture-MS
ROK1 YGL171W RNA-dependent ATPase physical 1 1 1 Affinity Capture-MS
SRV2 YNL138W CAP (cyclase-associated protein) physical 1 1 1 Affinity Capture-MS
VAS1 YGR094W Mitochondrial and cytoplasmic valyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
RRP7 YCL031C Essential protein involved in rRNA processing and ribosome biogenesis physical 1 1 1 Affinity Capture-MS
UTR2 YEL040W Chitin transglycosylase physical 1 1 1 Affinity Capture-MS
SNZ1 YMR096W Subunit of a two-component pyridoxal-5'-phosphate synthase physical 1 1 1 Affinity Capture-MS
YGR017W YGR017W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
SOF1 YLL011W Protein required for biogenesis of 40S (small) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SHM1 YBR263W Mitochondrial serine hydroxymethyltransferase physical 1 1 1 Affinity Capture-MS
SBE22 YHR103W Protein involved in bud growth physical 1 1 1 Affinity Capture-MS
UFD4 YKL010C Ubiquitin-protein ligase (E3) physical 1 1 1 Affinity Capture-MS
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 1 1 1 Affinity Capture-MS
SDH9 YJL045W Minor succinate dehydrogenase isozyme physical 1 1 1 Affinity Capture-MS
PRM5 YIL117C Pheromone-regulated protein, predicted to have 1 transmembrane segment physical 1 1 1 Affinity Capture-MS
UTP15 YMR093W Nucleolar protein physical 1 1 1 Affinity Capture-MS
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
PGM2 YMR105C Phosphoglucomutase physical 1 1 1 Affinity Capture-MS
MRPS28 YDR337W Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
PWP2 YCR057C Conserved 90S pre-ribosomal component physical 1 1 1 Affinity Capture-MS
THS1 YIL078W Threonyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
ROD1 YOR018W Alpha-arrestin involved in ubiquitin-dependent endocytosis physical 1 1 1 Affinity Capture-MS
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping physical 1 1 1 Affinity Capture-MS
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Negative Genetic
UTP21 YLR409C Subunit of U3-containing 90S preribosome and SSU processome complexes physical 1 1 1 Affinity Capture-MS
SPB4 YFL002C Putative ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
NAB6 YML117W Putative RNA-binding protein physical 1 1 1 Affinity Capture-MS
NAB6 YML117W Putative RNA-binding protein genetic 1 1 1 Negative Genetic
RQC2 YPL009C Component of the Ribosome Quality Control (RQC) complex physical 1 1 1 Affinity Capture-MS
YMR310C YMR310C Putative methyltransferase physical 1 1 1 Affinity Capture-MS
TRP3 YKL211C Indole-3-glycerol-phosphate synthase physical 1 1 1 Affinity Capture-MS
PMI40 YER003C Mannose-6-phosphate isomerase physical 1 1 1 Affinity Capture-MS
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes physical 1 1 1 Affinity Capture-MS
UTP7 YER082C Nucleolar protein physical 1 1 1 Affinity Capture-MS
NPR1 YNL183C Protein kinase physical 1 1 1 Affinity Capture-MS
NPR1 YNL183C Protein kinase genetic 1 1 1 Negative Genetic
TOP2 YNL088W Topoisomerase II physical 1 1 1 Affinity Capture-MS
TOP2 YNL088W Topoisomerase II genetic 1 1 1 Negative Genetic
PTC5 YOR090C Mitochondrial type 2C protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade physical 1 1 1 Affinity Capture-MS
PRI1 YIR008C Subunit of DNA primase physical 1 1 1 Affinity Capture-MS
MOD5 YOR274W Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase physical 1 1 1 Affinity Capture-MS
SRP68 YPL243W Core component of the signal recognition particle (SRP) complex physical 1 1 1 Affinity Capture-MS
UTP14 YML093W Subunit of U3-containing Small Subunit (SSU) processome complex physical 1 1 1 Affinity Capture-MS
NOP7 YGR103W Component of several different pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
UTP6 YDR449C Nucleolar protein physical 1 1 1 Affinity Capture-MS
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation physical 1 1 1 Affinity Capture-MS
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export physical 1 1 1 Affinity Capture-MS
RPB2 YOR151C RNA polymerase II second largest subunit B150 physical 1 1 1 Affinity Capture-MS
MPP10 YJR002W Component of the SSU processome and 90S preribosome physical 1 1 1 Affinity Capture-MS
SRP1 YNL189W Karyopherin alpha homolog physical 1 1 1 Affinity Capture-MS
NOP2 YNL061W rRNA m5C methyltransferase physical 1 1 1 Affinity Capture-MS
NPR2 YEL062W Subunit of the Iml1p/SEACIT complex physical 1 1 1 Affinity Capture-MS
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression physical 1 1 1 Affinity Capture-MS
NAN1 YPL126W U3 snoRNP protein physical 1 1 1 Affinity Capture-MS
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 Affinity Capture-MS
STE11 YLR362W Signal transducing MEK kinase physical 1 1 1 Affinity Capture-MS
RSC9 YML127W Component of the RSC chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition physical 1 1 1 Affinity Capture-MS
MSC3 YLR219W Protein of unknown function physical 1 1 1 Affinity Capture-MS
PRP8 YHR165C Component of U4/U6-U5 snRNP complex physical 1 1 1 Affinity Capture-MS
NUP1 YOR098C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
PYC1 YGL062W Pyruvate carboxylase isoform physical 1 1 1 Affinity Capture-MS
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex physical 1 1 1 Affinity Capture-MS
VID30 YGL227W Central component of GID Complex, involved in FBPase degradation physical 1 1 1 Affinity Capture-MS
UTP9 YHR196W Nucleolar protein physical 1 1 1 Affinity Capture-MS
UTP9 YHR196W Nucleolar protein genetic 1 1 1 Positive Genetic
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex physical 1 1 1 Affinity Capture-MS
RKM4 YDR257C Ribosomal lysine methyltransferase physical 1 1 1 Affinity Capture-MS
TOM70 YNL121C Component of the TOM (translocase of outer membrane) complex physical 1 1 1 Affinity Capture-MS
UTP8 YGR128C Nucleolar protein required for export of tRNAs from the nucleus physical 1 1 1 Affinity Capture-MS
UTP8 YGR128C Nucleolar protein required for export of tRNAs from the nucleus genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Affinity Capture-MS
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex physical 1 1 1 Affinity Capture-MS
TIF4632 YGL049C Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat physical 1 1 1 Affinity Capture-MS
UBA1 YKL210W Ubiquitin activating enzyme (E1) physical 1 1 1 Affinity Capture-MS
MSM1 YGR171C Mitochondrial methionyl-tRNA synthetase (MetRS) physical 1 1 1 Affinity Capture-MS
SGD1 YLR336C Essential nuclear protein physical 1 1 1 Affinity Capture-MS
SCH9 YHR205W AGC family protein kinase physical 1 1 1 Affinity Capture-MS
YHR219W YHR219W Putative protein of unknown function with similarity to helicases physical 1 1 1 Affinity Capture-MS
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p physical 1 1 1 Affinity Capture-MS
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain physical 1 1 1 Affinity Capture-MS
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis physical 1 1 1 Affinity Capture-MS
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase physical 1 1 1 Affinity Capture-MS
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 1 1 1 Synthetic Lethality
TPS3 YMR261C Regulatory subunit of trehalose-6-phosphate synthase/phosphatase physical 1 1 1 Affinity Capture-MS
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes physical 1 1 1 Affinity Capture-MS
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Synthetic Growth Defect
USO1 YDL058W Essential protein involved in vesicle-mediated ER to Golgi transport physical 1 1 1 Affinity Capture-MS
USO1 YDL058W Essential protein involved in vesicle-mediated ER to Golgi transport genetic 1 1 1 Negative Genetic
SPT6 YGR116W Nucleosome remodeling protein physical 1 1 1 Affinity Capture-MS
RRP12 YPL012W Protein required for export of the ribosomal subunits physical 1 1 1 Affinity Capture-MS
YLR419W YLR419W Putative helicase with limited sequence similarity to human Rb protein physical 1 1 1 Affinity Capture-MS
SLH1 YGR271W Subunit of ribosome-associated quality control trigger complex (RQT) physical 1 1 1 Affinity Capture-MS
REA1 YLR106C Huge dynein-related AAA-type ATPase (midasin) physical 1 1 1 Affinity Capture-MS
UTP20 YBL004W Component of the small-subunit (SSU) processome physical 1 1 1 Affinity Capture-MS
PSF2 YJL072C Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 1 1 1 Affinity Capture-Western
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family genetic 1 1 1 Negative Genetic
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein physical 1 1 1 Affinity Capture-RNA
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Negative Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
THP2 YHR167W Subunit of the THO and TREX complexes genetic 1 1 1 Negative Genetic
VPS64 YDR200C Protein required for cytoplasm to vacuole targeting of proteins genetic 1 1 1 Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Negative Genetic
URA5 YML106W Major orotate phosphoribosyltransferase (OPRTase) isozyme genetic 1 1 1 Negative Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 1 1 1 Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
PAC2 YER007W Microtubule effector required for tubulin heterodimer formation genetic 1 1 1 Positive Genetic
YML119W YML119W Putative protein of unknown function genetic 1 1 1 Positive Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Positive Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Positive Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 1 1 1 Synthetic Growth Defect
PRP4 YPR178W Splicing factor genetic 1 1 1 Positive Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Lethality
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Synthetic Growth Defect
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 1 1 1 Synthetic Growth Defect
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 1 1 1 Synthetic Growth Defect
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 1 1 1 Synthetic Growth Defect
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 1 1 1 Synthetic Growth Defect
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Synthetic Growth Defect
PMA2 YPL036W Plasma membrane H+-ATPase genetic 1 1 1 Synthetic Growth Defect
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Synthetic Growth Defect
VPS45 YGL095C Protein of the Sec1p/Munc-18 family genetic 1 1 1 Synthetic Growth Defect
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Synthetic Growth Defect
PEP5 YMR231W Histone E3 ligase, component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Growth Defect
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Synthetic Growth Defect
VPS36 YLR417W Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
YDR061W YDR061W Protein with similarity to ABC transporter family members genetic 1 1 1 Synthetic Growth Defect
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Synthetic Lethality
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Synthetic Lethality
PEP3 YLR148W Component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Lethality
SNF8 YPL002C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Lethality
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Synthetic Lethality
VPS25 YJR102C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Lethality
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
PPZ2 YDR436W Serine/threonine protein phosphatase Z, isoform of Ppz1p genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Negative Genetic
WTM2 YOR229W Transcriptional modulator genetic 1 1 1 Positive Genetic
PKH1 YDR490C Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
OTU1 YFL044C Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p genetic 1 1 1 Positive Genetic
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 1 1 1 Positive Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Positive Genetic
SNT2 YGL131C Subunit of Snt2C complex, RING finger ubiquitin ligase (E3) genetic 1 1 1 Positive Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
YGK3 YOL128C Protein kinase related to mammalian GSK-3 glycogen synthase kinases genetic 1 1 1 Positive Genetic
PRR1 YKL116C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
NDT80 YHR124W Meiosis-specific transcription factor genetic 1 1 1 Negative Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Negative Genetic
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Negative Genetic
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
STB1 YNL309W Protein with role in regulation of MBF-specific transcription at Start genetic 1 1 1 Negative Genetic
PML1 YLR016C Subunit of the RES complex genetic 1 1 1 Negative Genetic
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform genetic 1 1 1 Negative Genetic
PIK1 YNL267W Phosphatidylinositol 4-kinase genetic 1 1 1 Synthetic Lethality
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Growth Defect
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Positive Genetic
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Positive Genetic
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Positive Genetic
TYW3 YGL050W tRNA methyltransferase required for synthesis of wybutosine genetic 1 1 1 Positive Genetic
VMA22 YHR060W Protein that is required for vacuolar H+-ATPase (V-ATPase) function genetic 1 1 1 Positive Genetic
MTG2 YHR168W Putative GTPase genetic 1 1 1 Positive Genetic
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
RPB5 YBR154C RNA polymerase subunit ABC27 genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
POP4 YBR257W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Negative Genetic
UBC1 YDR177W Ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
YCG1 YDR325W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 1 1 1 Negative Genetic
PRE1 YER012W Beta 4 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
RPL28 YGL103W Ribosomal 60S subunit protein L28 genetic 1 1 1 Negative Genetic
NOP19 YGR251W Ribosome biogenesis factor genetic 1 1 1 Negative Genetic
RFA3 YJL173C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
PRP21 YJL203W Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Negative Genetic
NSE1 YLR007W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
PDS5 YMR076C Cohesion maintenance factor genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Negative Genetic
POP3 YNL282W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
SPC29 YPL124W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
SMC4 YLR086W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Negative Genetic
YBL081W YBL081W Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
MNN2 YBR015C Alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
UBP14 YBR058C Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Negative Genetic
NGR1 YBR212W RNA binding protein that negatively regulates growth rate genetic 1 1 1 Negative Genetic
YBR221W-A YBR221W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YDL177C YDL177C Putative protein of unknown function genetic 1 1 1 Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
YDR169C-A YDR169C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SIZ1 YDR409W SUMO E3 ligase genetic 1 1 1 Negative Genetic
YDR541C YDR541C Aldehyde reductase genetic 1 1 1 Negative Genetic
UTR4 YEL038W Protein with sequence similarity to acireductone synthases genetic 1 1 1 Negative Genetic
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
PEX14 YGL153W Central component of the peroxisomal importomer complex genetic 1 1 1 Negative Genetic
MUP1 YGR055W High affinity methionine permease genetic 1 1 1 Negative Genetic
YGR121W-A YGR121W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
TNA1 YGR260W High affinity nicotinic acid plasma membrane permease genetic 1 1 1 Negative Genetic
RTT102 YGR275W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
YSC83 YHR017W Non-essential mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
YHR022C-A YHR022C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
NEL1 YHR035W Activator of Sar1p GTPase activity genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Negative Genetic
VID28 YIL017C GID Complex subunit, serves as adaptor for regulatory subunit Vid24p genetic 1 1 1 Negative Genetic
PAN6 YIL145C Pantothenate synthase genetic 1 1 1 Negative Genetic
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Negative Genetic
YJL070C YJL070C Putative metallo-dependent hydrolase superfamily protein genetic 1 1 1 Negative Genetic
TMH11 YJR085C Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
YJR124C YJR124C Putative protein of unknown function genetic 1 1 1 Negative Genetic
XPT1 YJR133W Xanthine-guanine phosphoribosyl transferase genetic 1 1 1 Negative Genetic
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Negative Genetic
YKR005C YKR005C Putative protein of unknown function genetic 1 1 1 Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Negative Genetic
UBP11 YKR098C Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
PPR1 YLR014C Zinc finger transcription factor genetic 1 1 1 Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs genetic 1 1 1 Negative Genetic
RCF1 YML030W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
YML037C YML037C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YML131W YML131W Protein of unknown function genetic 1 1 1 Negative Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 1 1 1 Negative Genetic
YMR158C-A YMR158C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
NGL2 YMR285C Protein involved in 5.8S rRNA processing genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
PLB3 YOL011W Phospholipase B (lysophospholipase) involved in lipid metabolism genetic 1 1 1 Negative Genetic
YOL164W-A YOL164W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SFM1 YOR021C SPOUT methyltransferase genetic 1 1 1 Negative Genetic
TFB6 YOR352W Subunit of TFIIH complex genetic 1 1 1 Negative Genetic
YOR385W YOR385W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Negative Genetic
PRM3 YPL192C Protein required for nuclear envelope fusion during karyogamy genetic 1 1 1 Negative Genetic
YPL229W YPL229W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YAR1 YPL239W Nucleocytoplasmic shuttling assembly chaperone genetic 1 1 1 Negative Genetic
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
SVP26 YHR181W ER exit adaptor for Golgi mannosyltransferases genetic 1 1 1 Positive Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Negative Genetic
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Positive Genetic
SHR5 YOL110W Palmitoyltransferase subunit genetic 1 1 1 Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 1 1 1 Negative Genetic
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Positive Genetic
RTT106 YNL206C Histone chaperone genetic 1 1 1 Phenotypic Suppression
SMC5 YOL034W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Synthetic Lethality
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
GDH2 YDL215C NAD(+)-dependent glutamate dehydrogenase physical 1 1 1 Affinity Capture-MS
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-MS
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Synthetic Lethality
ARG3 YJL088W Ornithine carbamoyltransferase physical 1 1 1 Affinity Capture-MS
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Negative Genetic
LEU4 YNL104C Alpha-isopropylmalate synthase (2-isopropylmalate synthase) physical 1 1 1 Affinity Capture-MS
MAD3 YJL013C Subunit of spindle-assembly checkpoint complex genetic 1 1 1 Positive Genetic
HSP10 YOR020C Mitochondrial matrix co-chaperonin physical 1 1 1 Affinity Capture-MS
IKS1 YJL057C Protein kinase of unknown cellular role genetic 1 1 1 Negative Genetic
CSM3 YMR048W Replication fork associated factor physical 1 1 1 Affinity Capture-Western
CSM3 YMR048W Replication fork associated factor genetic 1 1 1 Positive Genetic
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 1 1 1 Negative Genetic
JSN1 YJR091C Member of the Puf family of RNA-binding proteins physical 1 1 1 Affinity Capture-MS
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site genetic 1 1 1 Synthetic Rescue
ESL1 YIL151C hEST1A/B (SMG5/6)-like protein physical 1 1 1 Affinity Capture-MS
ASK10 YGR097W Regulator of the Fps1p glycerol channel physical 1 1 1 Affinity Capture-MS
CUB1 YPL260W Conserved fungal gene linked to DNA repair and proteasome function physical 1 1 1 Affinity Capture-MS
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
APC9 YLR102C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Negative Genetic
COG6 YNL041C Component of the conserved oligomeric Golgi complex physical 1 1 1 Affinity Capture-MS
DOC1 YGL240W Processivity factor genetic 1 1 1 Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Negative Genetic
AMD1 YML035C AMP deaminase genetic 1 1 1 Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Negative Genetic
LEU3 YLR451W Zinc-knuckle transcription factor, repressor and activator genetic 1 1 1 Positive Genetic
HPC2 YBR215W Subunit of the HIR complex physical 1 1 1 Affinity Capture-MS
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Positive Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Negative Genetic
MIF2 YKL089W Centromeric CDEIII region binding protein physical 1 1 1 Two-hybrid
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Negative Genetic
CLC1 YGR167W Clathrin light chain genetic 1 1 1 Negative Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Synthetic Growth Defect
GCD10 YNL062C Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p physical 1 1 1 Affinity Capture-MS
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
BNI5 YNL166C Linker protein responsible for recruitment of myosin to the bud neck genetic 1 1 1 Negative Genetic
HXK2 YGL253W Hexokinase isoenzyme 2 physical 1 1 1 Affinity Capture-MS
MCM3 YEL032W Protein involved in DNA replication physical 1 1 1 Affinity Capture-MS
FIG4 YNL325C Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase genetic 1 1 1 Negative Genetic
ATG2 YNL242W Peripheral membrane protein required for autophagic vesicle formation genetic 1 1 1 Negative Genetic
HRB1 YNL004W Poly(A+) RNA-binding protein physical 1 1 1 Affinity Capture-MS
MBF1 YOR298C-A Transcriptional coactivator physical 1 1 1 Affinity Capture-MS
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex physical 1 1 1 Affinity Capture-MS
ESC1 YMR219W Protein involved in telomeric silencing physical 1 1 1 Affinity Capture-MS
ESC2 YDR363W Sumo-like domain protein genetic 1 1 1 Negative Genetic
DBP1 YPL119C ATP-dependent RNA helicase of the DEAD-box protein family genetic 1 1 1 Negative Genetic
ALY1 YKR021W Alpha arrestin, substrate of calcineurin physical 1 1 1 Affinity Capture-MS
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector physical 1 1 1 Affinity Capture-MS
CMR2 YOR093C Putative protein of unknown function genetic 1 1 1 Negative Genetic
FIR1 YER032W Protein involved in 3' mRNA processing genetic 1 1 1 Negative Genetic
GYL1 YMR192W Putative GTPase activating protein (GAP) with a role in exocytosis physical 1 1 1 Affinity Capture-MS
IVY1 YDR229W Phospholipid-binding protein that interacts with both Ypt7p and Vps33p physical 1 1 1 Affinity Capture-MS
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Growth Defect
ACF2 YLR144C Intracellular beta-1,3-endoglucanase genetic 1 1 1 Negative Genetic
CQD1 YPL109C UbiB family mitochondrial protein genetic 1 1 1 Negative Genetic
GAT1 YFL021W Transcriptional activator of nitrogen catabolite repression genes physical 1 1 1 Affinity Capture-MS
ETT1 YOR051C Nuclear protein that inhibits replication of Brome mosaic virus physical 1 1 1 Affinity Capture-MS
EIS1 YMR031C Component of the eisosome required for proper eisosome assembly physical 1 1 1 Affinity Capture-MS
DBP6 YNR038W Essential protein involved in ribosome biogenesis physical 1 1 1 Affinity Capture-MS
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
LEU1 YGL009C Isopropylmalate isomerase physical 1 1 1 Affinity Capture-MS
MET1 YKR069W S-adenosyl-L-methionine uroporphyrinogen III transmethylase physical 1 1 1 Affinity Capture-MS
MDM31 YHR194W Mitochondrial protein that may have a role in phospholipid metabolism genetic 1 1 1 Synthetic Lethality
ASN2 YGR124W Asparagine synthetase physical 1 1 1 Affinity Capture-MS
EUC1 YMR111C Sequence-specific DNA binding protein physical 1 1 1 Affinity Capture-MS
ILV6 YCL009C Regulatory subunit of acetolactate synthase physical 1 1 1 Affinity Capture-MS
EPO1 YMR124W Protein involved in septin-ER tethering physical 1 1 1 Affinity Capture-MS
GLR1 YPL091W Cytosolic and mitochondrial glutathione oxidoreductase physical 1 1 1 Affinity Capture-MS
HSP26 YBR072W Small heat shock protein (sHSP) with chaperone activity physical 1 1 1 Affinity Capture-MS
CIT1 YNR001C Mitochondrial citrate synthase physical 1 1 1 Affinity Capture-MS
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Positive Genetic
ARR3 YPR201W Plasma membrane metalloid/H+ antiporter genetic 1 1 1 Negative Genetic
BUD22 YMR014W Protein required for rRNA maturation and ribosomal subunit biogenesis physical 1 1 1 Affinity Capture-MS
EGT2 YNL327W Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase genetic 1 1 1 Negative Genetic
HEM14 YER014W Protoporphyrinogen oxidase genetic 1 1 1 Synthetic Growth Defect
KTR2 YKR061W Mannosyltransferase involved in N-linked protein glycosylation genetic 1 1 1 Synthetic Growth Defect
GTB1 YDR221W Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Synthetic Growth Defect
ERI1 YPL096C-A Endoplasmic reticulum membrane protein that binds and inhibits Ras2p genetic 1 1 1 Positive Genetic
ATP16 YDL004W Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-MS
BOL3 YAL046C Protein involved in Fe-S cluster transfer to mitochondrial clients physical 1 1 1 Affinity Capture-MS
MET17 YLR303W O-acetyl homoserine-O-acetyl serine sulfhydrylase physical 1 1 1 Affinity Capture-MS
HSP12 YFL014W Plasma membrane protein involved in maintaining membrane organization physical 1 1 1 Affinity Capture-MS
GLK1 YCL040W Glucokinase physical 1 1 1 Affinity Capture-MS
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Synthetic Growth Defect
AYT1 YLL063C Acetyltransferase physical 1 1 1 Affinity Capture-MS
BUL2 YML111W Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 1 1 1 Negative Genetic
ICL1 YER065C Isocitrate lyase physical 1 1 1 Affinity Capture-MS
GID11 YLR149C Substrate receptor of the glucose-induced degradation-deficient (GID) genetic 1 1 1 Negative Genetic
ACP1 YKL192C Mitochondrial matrix acyl carrier protein physical 1 1 1 Affinity Capture-MS
ARG56 YER069W Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase physical 1 1 1 Affinity Capture-MS
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Positive Genetic
CRS1 YNL247W Cysteinyl-tRNA synthetase genetic 1 1 1 Negative Genetic
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase physical 1 1 1 Affinity Capture-MS
DTR1 YBR180W Putative dityrosine transporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain physical 1 1 1 Affinity Capture-MS
DIN7 YDR263C Mitochondrial nuclease functioning in DNA repair and replication physical 1 1 1 Affinity Capture-MS
IDP1 YDL066W Mitochondrial NADP-specific isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
ALD4 YOR374W Mitochondrial aldehyde dehydrogenase physical 1 1 1 Affinity Capture-MS
IRC19 YLL033W Protein of unknown function physical 1 1 1 Affinity Capture-MS
IRC19 YLL033W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
GEP5 YLR091W Protein of unknown function physical 1 1 1 Affinity Capture-MS
GEP5 YLR091W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
GAA1 YLR088W Subunit of the GPI:protein transamidase complex physical 1 1 1 Affinity Capture-MS
GVP36 YIL041W BAR domain protein that localizes to early and late Golgi vesicles physical 1 1 1 Affinity Capture-MS
IDI1 YPL117C Isopentenyl diphosphate:dimethylallyl diphosphate isomerase genetic 1 1 1 Negative Genetic
GUA1 YMR217W GMP synthase physical 1 1 1 Affinity Capture-MS
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
ERG24 YNL280C C-14 sterol reductase genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Negative Genetic
KTR1 YOR099W Alpha-1,2-mannosyltransferase physical 1 1 1 Affinity Capture-MS
MAM1 YER106W Monopolin physical 1 1 1 Two-hybrid
LDB18 YLL049W Component of the dynactin complex genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Positive Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Synthetic Lethality
COS7 YDL248W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
INO1 YJL153C Inositol-3-phosphate synthase physical 1 1 1 Affinity Capture-MS
ALG2 YGL065C Mannosyltransferase in the N-linked glycosylation pathway genetic 1 1 1 Negative Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 1 1 1 Negative Genetic
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 1 1 1 Synthetic Growth Defect
BUD16 YEL029C Putative pyridoxal kinase genetic 1 1 1 Synthetic Lethality
FCY22 YER060W-A Putative purine-cytosine permease genetic 1 1 1 Negative Genetic
AFT2 YPL202C Iron-regulated transcriptional activator genetic 1 1 1 Synthetic Growth Defect
GLO1 YML004C Monomeric glyoxalase I physical 1 1 1 Affinity Capture-MS
EFM5 YGR001C S-adenosylmethionine-dependent lysine methyltransferase physical 1 1 1 Affinity Capture-MS
HIS1 YER055C ATP phosphoribosyltransferase physical 1 1 1 Affinity Capture-MS
GTF1 YGR102C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Synthetic Lethality
MIN8 YPR010C-A Protein of unknown function physical 1 1 1 Affinity Capture-MS
ECM4 YKR076W S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR) genetic 1 1 1 Negative Genetic
MAL31 YBR298C Maltose permease physical 1 1 1 Affinity Capture-MS
DSC2 YOL073C Multi-transmembrane subunit of the DSC ubiquitin ligase complex genetic 1 1 1 Negative Genetic
LMO1 YLL007C Homolog of mammalian ELMO (Engulfment and celL MOtility) genetic 1 1 1 Negative Genetic
MAL33 YBR297W MAL-activator protein genetic 1 1 1 Negative Genetic
EGO2 YCR075W-A Subunit of the EGO/GSE complex genetic 1 1 1 Negative Genetic
AIM10 YER087W Protein with similarity to tRNA synthetases genetic 1 1 1 Synthetic Lethality
AI2 Q0055 Reverse transcriptase required for splicing of the COX1 pre-mRNA physical 1 1 1 Affinity Capture-MS
MET22 YOL064C Bisphosphate-3'-nucleotidase physical 1 1 1 Affinity Capture-MS
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Positive Genetic
IRC21 YMR073C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
BUD25 YER014C-A Protein involved in bud-site selection genetic 1 1 1 Negative Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Negative Genetic