GEnome-wide tool for Multi-scale Modeling
data Extraction and Representation
for Saccharomyces cerevisiae

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.

Standard name	Systematic name	Name description	Type	#Experiments	#Methods	#Publications	Evidence
MSG5	YNL053W	Dual-specificity protein phosphatase	physical	14	6	8	Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Reconstituted Complex, PCA, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Biochemical Activity
SWI4	YER111C	DNA binding component of the SBF complex (Swi4p-Swi6p)	genetic	12	4	10	Synthetic Lethality, Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Rescue, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PPZ1	YML016C	Serine/threonine protein phosphatase Z, isoform of Ppz2p	genetic	12	6	9	Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Dosage Rescue, Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MKK1	YOR231W	MAPKK involved in the protein kinase C signaling pathway	physical	10	6	9	Biochemical Activity, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, PCA, Reconstituted Complex, Affinity Capture-Western, Biochemical Activity, PCA, Affinity Capture-Western
GAS1	YMR307W	Beta-1,3-glucanosyltransferase required for cell wall assembly	genetic	10	3	8	Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Suppression, Negative Genetic, Negative Genetic
RVS167	YDR388W	Calmodulin-binding actin-associated protein	genetic	10	3	7	Synthetic Lethality, Dosage Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SMI1	YGR229C	Protein involved in the regulation of cell wall synthesis	genetic	10	2	7	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
FPS1	YLL043W	Aquaglyceroporin, plasma membrane channel	genetic	9	4	8	Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression, Negative Genetic
NBP2	YDR162C	Protein involved in the HOG (high osmolarity glycerol) pathway	genetic	9	3	8	Positive Genetic, Positive Genetic, Positive Genetic, Dosage Lethality, Synthetic Growth Defect, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
BNI1	YNL271C	Formin	genetic	9	3	7	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
FKS1	YLR342W	Catalytic subunit of 1,3-beta-D-glucan synthase	genetic	9	2	7	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
ROT2	YBR229C	Glucosidase II catalytic subunit	genetic	9	2	7	Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CHS5	YLR330W	Component of the exomer complex	genetic	9	3	6	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CNB1	YKL190W	Calcineurin B	genetic	8	4	7	Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Enhancement
RVS161	YCR009C	Amphiphysin-like lipid raft protein	genetic	8	3	7	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
SWI5	YDR146C	Transcription factor that recruits Mediator and Swi/Snf complexes	genetic	8	3	7	Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
PKC1	YBL105C	Protein serine/threonine kinase	genetic	8	3	7	Dosage Rescue, Dosage Rescue, Negative Genetic, Negative Genetic, Phenotypic Suppression, Negative Genetic, Negative Genetic, Negative Genetic
TPM1	YNL079C	Major isoform of tropomyosin	genetic	8	2	7	Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
AIM44	YPL158C	Regulator of Cdc42p and Rho1p	genetic	8	4	6	Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Synthetic Rescue, Negative Genetic, Negative Genetic
BCK1	YJL095W	MAPKKK acting in the protein kinase C signaling pathway	genetic	8	2	6	Dosage Rescue, Dosage Rescue, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
VAC14	YLR386W	Enzyme regulator	genetic	8	2	6	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CHS6	YJL099W	Member of the ChAPs (Chs5p-Arf1p-binding proteins) family	genetic	8	2	6	Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RUD3	YOR216C	Golgi matrix protein	genetic	8	2	6	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
EDE1	YBL047C	Scaffold protein involved in the formation of early endocytic sites	genetic	8	3	5	Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
TRS65	YGR166W	Component of transport protein particle (TRAPP) complex II	genetic	8	3	5	Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PTC1	YDL006W	Type 2C protein phosphatase (PP2C)	genetic	7	6	6	Synthetic Lethality, Dosage Rescue, Phenotypic Suppression, Phenotypic Enhancement, Positive Genetic, Synthetic Rescue, Phenotypic Suppression
RLM1	YPL089C	MADS-box transcription factor	physical	7	5	6	Two-hybrid, Biochemical Activity, Two-hybrid, Affinity Capture-MS, PCA, Co-localization, Biochemical Activity
SPA2	YLL021W	Component of the polarisome	genetic	7	3	6	Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BNI4	YNL233W	Targeting subunit for Glc7p protein phosphatase	genetic	7	3	6	Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
CLA4	YNL298W	Cdc42p-activated signal transducing kinase	genetic	7	3	6	Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
IRA2	YOL081W	GTPase-activating protein	genetic	7	2	6	Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ALG6	YOR002W	ER-luminal alpha 1,3 glucosyltransferase	genetic	7	2	6	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
OPI3	YJR073C	Methylene-fatty-acyl-phospholipid synthase	genetic	7	2	6	Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SKN7	YHR206W	Nuclear response regulator and transcription factor	genetic	7	1	6	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SDP1	YIL113W	Stress-inducible dual-specificity MAP kinase phosphatase	physical	7	6	5	Affinity Capture-MS, Two-hybrid, Biochemical Activity, Biochemical Activity, PCA, Affinity Capture-Western, Reconstituted Complex
SKT5	YBL061C	Activator of Chs3p (chitin synthase III) during vegetative growth	genetic	7	2	5	Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
OST3	YOR085W	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen	genetic	7	1	5	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CYK3	YDL117W	SH3-domain protein located in the bud neck and cytokinetic actin ring	genetic	7	3	4	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Dosage Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
YUR1	YJL139C	Mannosyltransferase involved in protein N-glycosylation	genetic	7	2	4	Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CWH41	YGL027C	Processing alpha glucosidase I	genetic	7	2	4	Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BST1	YFL025C	GPI inositol deacylase of the endoplasmic reticulum (ER)	genetic	7	2	4	Negative Genetic, Negative Genetic, Dosage Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SAC1	YKL212W	Phosphatidylinositol phosphate phosphatase	genetic	6	3	6	Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HOG1	YLR113W	Mitogen-activated protein kinase involved in osmoregulation	genetic	6	5	5	Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Dosage Rescue, Phenotypic Suppression, Synthetic Growth Defect
CDC28	YBR160W	Cyclin-dependent kinase (CDK) catalytic subunit	genetic	6	4	5	Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Positive Genetic, Positive Genetic, Dosage Lethality
ROM2	YLR371W	Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p	genetic	6	4	5	Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic, Positive Genetic, Negative Genetic
MKK2	YPL140C	MAPKK involved in the protein kinase C signaling pathway	physical	6	4	5	Affinity Capture-MS, Two-hybrid, Biochemical Activity, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS
BCK1	YJL095W	MAPKKK acting in the protein kinase C signaling pathway	physical	6	3	5	Affinity Capture-MS, Biochemical Activity, Affinity Capture-MS, PCA, PCA, PCA
TSC11	YER093C	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p)	genetic	6	3	5	Synthetic Lethality, Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MKK1	YOR231W	MAPKK involved in the protein kinase C signaling pathway	genetic	6	3	5	Synthetic Rescue, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
SSD1	YDR293C	Translational repressor	genetic	6	2	5	Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ECM33	YBR078W	GPI-anchored protein involved in efficient glucose uptake	genetic	6	2	5	Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GAB1	YLR459W	Subunit of the glycosylphosphatidylinositol transamidase complex	genetic	6	2	5	Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BEM3	YPL115C	Rho GTPase activating protein (RhoGAP)	genetic	6	1	5	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HSP82	YPL240C	Hsp90 chaperone	physical	6	2	4	Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
ELP4	YPL101W	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex	genetic	6	2	4	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HOC1	YJR075W	Alpha-1,6-mannosyltransferase	genetic	6	2	4	Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SLA1	YBL007C	Cytoskeletal protein binding protein	genetic	6	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ERG6	YML008C	Delta(24)-sterol C-methyltransferase	genetic	6	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CSF1	YLR087C	Protein with structural similarity to lipid transport protein Vps13p	genetic	6	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TOR1	YJR066W	PIK-related protein kinase and rapamycin target	genetic	5	4	5	Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Dosage Rescue, Phenotypic Suppression
CCW12	YLR110C	Cell wall mannoprotein	genetic	5	3	5	Negative Genetic, Synthetic Lethality, Dosage Rescue, Negative Genetic, Negative Genetic
SIS2	YKR072C	Negative regulatory subunit of protein phosphatase 1 (Ppz1p)	genetic	5	3	4	Dosage Lethality, Synthetic Rescue, Dosage Lethality, Dosage Lethality, Dosage Growth Defect
IKI3	YLR384C	Subunit of Elongator complex	genetic	5	2	4	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ACT1	YFL039C	Actin, structural protein in cytoskeleton	genetic	5	2	4	Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BEM2	YER155C	Rho GTPase activating protein (RhoGAP)	genetic	5	2	4	Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEC66	YBR171W	Non-essential subunit of Sec63 complex	genetic	5	2	4	Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PIN4	YBL051C	Protein involved in G2/M phase progression and response to DNA damage	genetic	5	2	4	Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TOR2	YKL203C	PIK-related protein kinase and rapamycin target	genetic	5	2	4	Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
YPS7	YDR349C	Putative GPI-anchored aspartic protease	genetic	5	2	4	Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS27	YNR006W	Endosomal protein that forms a complex with Hse1p	genetic	5	2	4	Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BUD6	YLR319C	Actin- and formin-interacting protein	genetic	5	2	4	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ELP2	YGR200C	Subunit of Elongator complex	genetic	5	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PTP3	YER075C	Phosphotyrosine-specific protein phosphatase	genetic	5	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ARV1	YLR242C	Cortical ER protein	genetic	5	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GUP1	YGL084C	Plasma membrane protein involved in remodeling GPI anchors	genetic	5	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
KRE5	YOR336W	Protein required for beta-1,6 glucan biosynthesis	genetic	5	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SWI4	YER111C	DNA binding component of the SBF complex (Swi4p-Swi6p)	physical	5	4	3	Affinity Capture-Western, Reconstituted Complex, Biochemical Activity, Affinity Capture-Western, Two-hybrid
PPZ2	YDR436W	Serine/threonine protein phosphatase Z, isoform of Ppz1p	genetic	5	3	3	Synthetic Growth Defect, Synthetic Growth Defect, Dosage Rescue, Synthetic Growth Defect, Synthetic Rescue
RPO21	YDL140C	RNA polymerase II largest subunit B220	physical	5	2	3	Biochemical Activity, Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
ALG5	YPL227C	UDP-glucose:dolichyl-phosphate glucosyltransferase	genetic	5	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LAS21	YJL062W	Mannose-ethanolamine phosphotransferase	genetic	5	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CNE1	YAL058W	Calnexin	genetic	5	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SMI1	YGR229C	Protein involved in the regulation of cell wall synthesis	physical	5	3	2	Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Two-hybrid
MNN10	YDR245W	Subunit of a Golgi mannosyltransferase complex	genetic	4	3	4	Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
ELP3	YPL086C	Subunit of Elongator complex	genetic	4	3	4	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Dosage Rescue
PCL1	YNL289W	Cyclin, interacts with cyclin-dependent kinase Pho85p	genetic	4	3	4	Dosage Rescue, Synthetic Growth Defect, Dosage Growth Defect, Dosage Rescue
CHS7	YHR142W	Protein of unknown function	genetic	4	3	4	Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect
PHO85	YPL031C	Cyclin-dependent kinase	genetic	4	2	4	Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality
VMS1	YDR049W	Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes,	genetic	4	2	4	Positive Genetic, Negative Genetic, Positive Genetic, Positive Genetic
SWP1	YMR149W	Delta subunit of the oligosaccharyl transferase glycoprotein complex	genetic	4	2	4	Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
BCK2	YER167W	Serine/threonine-rich protein involved in PKC1 signaling pathway	genetic	4	2	4	Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
KRE1	YNL322C	Cell wall glycoprotein involved in beta-glucan assembly	genetic	4	2	4	Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RXT2	YBR095C	Component of the histone deacetylase Rpd3L complex	genetic	4	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PBR1	YNL181W	Putative oxidoreductase	genetic	4	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SRO7	YPR032W	Effector of Rab GTPase Sec4p	genetic	4	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GLC7	YER133W	Type 1 S/T protein phosphatase (PP1) catalytic subunit	genetic	4	4	3	Dosage Rescue, Synthetic Lethality, Dosage Growth Defect, Negative Genetic
GFA1	YKL104C	Glutamine-fructose-6-phosphate amidotransferase	genetic	4	3	3	Phenotypic Enhancement, Negative Genetic, Negative Genetic, Dosage Rescue
RIM101	YHL027W	Cys2His2 zinc-finger transcriptional repressor	genetic	4	3	3	Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality
CHS3	YBR023C	Chitin synthase III	genetic	4	3	3	Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
PFY1	YOR122C	Profilin	genetic	4	3	3	Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
COP1	YDL145C	Alpha subunit of COPI vesicle coatomer complex	genetic	4	2	3	Dosage Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
MYO2	YOR326W	Type V myosin motor involved in actin-based transport of cargos	genetic	4	2	3	Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
VPS4	YPR173C	AAA-ATPase involved in multivesicular body (MVB) protein sorting	genetic	4	2	3	Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
SSO1	YPL232W	Plasma membrane t-SNARE	genetic	4	2	3	Negative Genetic, Dosage Growth Defect, Negative Genetic, Negative Genetic
GSH1	YJL101C	Gamma glutamylcysteine synthetase	genetic	4	2	3	Positive Genetic, Positive Genetic, Positive Genetic, Synthetic Growth Defect
GWT1	YJL091C	Protein involved in the inositol acylation of GlcN-PI	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ARC15	YIL062C	Subunit of the ARP2/3 complex	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ARC35	YNR035C	Subunit of the ARP2/3 complex	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LST8	YNL006W	Protein required for the transport of Gap1p	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CMD1	YBR109C	Calmodulin	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEC13	YLR208W	Structural component of 3 complexes	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ERG10	YPL028W	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase)	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
UBP14	YBR058C	Ubiquitin-specific protease	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS5	YOR069W	Nexin-1 homolog	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LHS1	YKL073W	Molecular chaperone of the endoplasmic reticulum lumen	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PGM1	YKL127W	Phosphoglucomutase, minor isoform	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
INO2	YDR123C	Transcription factor	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PAL1	YDR348C	Protein of unknown function thought to be involved in endocytosis	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
KTI12	YKL110C	Protein that plays a role in modification of tRNA wobble nucleosides	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PEF1	YGR058W	Penta-EF-hand protein	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PEX13	YLR191W	Peroxisomal importomer complex component	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
OST2	YOR103C	Epsilon subunit of the oligosaccharyltransferase complex	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
OST6	YML019W	Subunit of the oligosaccharyltransferase complex of the ER lumen	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PMT2	YAL023C	Protein O-mannosyltransferase of the ER membrane	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEC28	YIL076W	Epsilon-COP subunit of the coatomer	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RGL1	YPL066W	Regulator of Rho1p signaling, cofactor of Tus1p	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DEG1	YFL001W	tRNA:pseudouridine synthase	genetic	4	1	3	Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
CWH43	YCR017C	GPI lipid remodelase	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SHE4	YOR035C	Protein containing a UCS (UNC-45/CRO1/SHE4) domain	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ERS1	YCR075C	Protein involved in cystine transport	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HPT1	YDR399W	Dimeric hypoxanthine-guanine phosphoribosyltransferase	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LST4	YKL176C	Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ICE2	YIL090W	Integral ER membrane protein with type-III transmembrane domains	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CDC15	YAR019C	Hippo-like kinase of the Mitotic Exit Network	genetic	3	3	3	Synthetic Lethality, Dosage Growth Defect, Negative Genetic
SMY1	YKL079W	Kinesin-like myosin passenger-protein	genetic	3	3	3	Synthetic Growth Defect, Dosage Growth Defect, Negative Genetic
MSG5	YNL053W	Dual-specificity protein phosphatase	genetic	3	3	3	Dosage Rescue, Positive Genetic, Phenotypic Suppression
RIM20	YOR275C	Protein involved in proteolytic activation of Rim101p	genetic	3	3	3	Synthetic Lethality, Dosage Growth Defect, Negative Genetic
ROT1	YMR200W	Molecular chaperone involved in protein folding in ER	genetic	3	3	3	Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
MNN2	YBR015C	Alpha-1,2-mannosyltransferase	genetic	3	3	3	Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
ARP2	YDL029W	Essential component of the Arp2/3 complex	genetic	3	2	3	Synthetic Lethality, Synthetic Lethality, Negative Genetic
BRO1	YPL084W	Cytoplasmic class E vacuolar protein sorting (VPS) factor	genetic	3	2	3	Negative Genetic, Synthetic Lethality, Negative Genetic
KDX1	YKL161C	Protein kinase	genetic	3	2	3	Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement
VPS8	YAL002W	Membrane-binding component of the CORVET complex	genetic	3	2	3	Synthetic Growth Defect, Negative Genetic, Negative Genetic
PHO80	YOL001W	Cyclin	genetic	3	2	3	Negative Genetic, Dosage Growth Defect, Negative Genetic
ATG21	YPL100W	Phosphoinositide binding protein	genetic	3	2	3	Phenotypic Enhancement, Negative Genetic, Negative Genetic
SLG1	YOR008C	Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway	genetic	3	2	3	Dosage Rescue, Negative Genetic, Negative Genetic
ALG8	YOR067C	Glucosyl transferase	genetic	3	2	3	Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SIN4	YNL236W	Subunit of the RNA polymerase II mediator complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
CDC3	YLR314C	Component of the septin ring that is required for cytokinesis	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
COG3	YER157W	Essential component of the conserved oligomeric Golgi complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
NAB6	YML117W	Putative RNA-binding protein	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
PHO23	YNL097C	Component of the Rpd3L histone deacetylase complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
ANP1	YEL036C	Subunit of the alpha-1,6 mannosyltransferase complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
PRB1	YEL060C	Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
ACS2	YLR153C	Acetyl-coA synthetase isoform	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
SHP1	YBL058W	UBX domain-containing substrate adaptor for Cdc48p	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
SRN2	YLR119W	Component of the ESCRT-I complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
VMA1	YDL185W	Subunit A of the V1 peripheral membrane domain of V-ATPase	genetic	3	1	3	Positive Genetic, Positive Genetic, Positive Genetic
WBP1	YEL002C	Beta subunit of the oligosaccharyl transferase glycoprotein complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
SWI3	YJL176C	Subunit of the SWI/SNF chromatin remodeling complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
SNT309	YPR101W	Member of the NineTeen Complex (NTC)	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
MEH1	YKR007W	Subunit of the EGO/GSE complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
CDH1	YGL003C	Activator of anaphase-promoting complex/cyclosome (APC/C)	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
PEA2	YER149C	Coiled-coil 12S polarisome subunit	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
SEC9	YGR009C	t-SNARE protein required for secretory vesicle-plasma membrane fusion	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
ALG1	YBR110W	Mannosyltransferase	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
MSC2	YDR205W	Endoplasmic reticulum zinc transporter	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
ERI1	YPL096C-A	Endoplasmic reticulum membrane protein that binds and inhibits Ras2p	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
SEC11	YIR022W	18kDa catalytic subunit of the Signal Peptidase Complex (SPC)	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
SEH1	YGL100W	Subunit of the Nup84 nuclear pore and SEACAT subcomplexes	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
CAB1	YDR531W	Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
RPL14A	YKL006W	Ribosomal 60S subunit protein L14A	genetic	3	1	3	Positive Genetic, Positive Genetic, Positive Genetic
PER1	YCR044C	Protein of the endoplasmic reticulum	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
RPS21B	YJL136C	Protein component of the small (40S) ribosomal subunit	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
MET22	YOL064C	Bisphosphate-3'-nucleotidase	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
SWI6	YLR182W	Transcription cofactor	physical	3	3	2	Affinity Capture-Western, Reconstituted Complex, Biochemical Activity
SPA2	YLL021W	Component of the polarisome	physical	3	3	2	Co-localization, Two-hybrid, Affinity Capture-Western
SSK2	YNR031C	MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway	physical	3	3	2	Affinity Capture-MS, Affinity Capture-Western, PCA
RCN2	YOR220W	Protein of unknown function	physical	3	3	2	Affinity Capture-MS, Biochemical Activity, Reconstituted Complex
PEX19	YDL065C	Chaperone and import receptor for newly-synthesized class I PMPs	genetic	3	2	2	Negative Genetic, Dosage Growth Defect, Negative Genetic
ARL1	YBR164C	Soluble GTPase with a role in regulation of membrane traffic	genetic	3	2	2	Positive Genetic, Positive Genetic, Dosage Rescue
RNT1	YMR239C	Nuclear dsRNA-specific ribonuclease (RNase III)	genetic	3	2	2	Synthetic Lethality, Negative Genetic, Negative Genetic
CDC11	YJR076C	Component of the septin ring that is required for cytokinesis	genetic	3	2	2	Dosage Growth Defect, Negative Genetic, Negative Genetic
RPD3	YNL330C	Histone deacetylase, component of both the Rpd3S and Rpd3L complexes	genetic	3	2	2	Dosage Lethality, Dosage Lethality, Negative Genetic
ERG27	YLR100W	3-keto sterol reductase	genetic	3	2	2	Synthetic Lethality, Negative Genetic, Negative Genetic
MTC5	YDR128W	Subunit of SEACAT, a subcomplex of the SEA complex	genetic	3	2	2	Dosage Growth Defect, Negative Genetic, Negative Genetic
PTP3	YER075C	Phosphotyrosine-specific protein phosphatase	physical	3	2	2	Reconstituted Complex, Biochemical Activity, Biochemical Activity
KIC1	YHR102W	Protein kinase of the PAK/Ste20 family, required for cell integrity	physical	3	2	2	Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
PTP2	YOR208W	Phosphotyrosine-specific phosphatase	physical	3	2	2	Reconstituted Complex, Biochemical Activity, Biochemical Activity
SIR3	YLR442C	Silencing protein	physical	3	2	2	Reconstituted Complex, Biochemical Activity, Biochemical Activity
MID2	YLR332W	O-glycosylated plasma membrane protein	genetic	3	2	2	Dosage Rescue, Dosage Rescue, Phenotypic Suppression
AIM26	YKL037W	Protein of unknown function	genetic	3	2	2	Synthetic Lethality, Synthetic Lethality, Negative Genetic
ALG13	YGL047W	Catalytic component of UDP-GlcNAc transferase	genetic	3	2	2	Dosage Growth Defect, Negative Genetic, Negative Genetic
CDC1	YDR182W	Putative mannose-ethanolamine phosphate phosphodiesterase	genetic	3	2	2	Phenotypic Suppression, Negative Genetic, Negative Genetic
RPP2B	YDR382W	Ribosomal protein P2 beta	genetic	3	1	2	Positive Genetic, Positive Genetic, Positive Genetic
SAP30	YMR263W	Component of Rpd3L histone deacetylase complex	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
PMA2	YPL036W	Plasma membrane H+-ATPase	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
SNF5	YBR289W	Subunit of the SWI/SNF chromatin remodeling complex	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
PAN1	YIR006C	Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
GPI19	YDR437W	Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
ALG14	YBR070C	Component of UDP-GlcNAc transferase	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
PIR1	YKL164C	O-glycosylated protein required for cell wall stability	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
EMC3	YKL207W	Member of conserved ER transmembrane complex	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
RPO21	YDL140C	RNA polymerase II largest subunit B220	regulation	3	3	1	co-immunoprecipitation evidence, protein kinase assay evidence, qualitative western immunoblotting evidence
SSN8	YNL025C	Cyclin-like component of RNA polymerase II holoenzyme	physical	3	3	1	Reconstituted Complex, Affinity Capture-Western, Biochemical Activity
PAF1	YBR279W	Component of the Paf1p complex involved in transcription elongation	physical	3	2	1	Affinity Capture-Western, Affinity Capture-Western, Two-hybrid
BEM1	YBR200W	Protein containing SH3-domains	physical	3	2	1	Affinity Capture-Western, PCA, PCA
GRX4	YER174C	Glutathione-dependent oxidoreductase and glutathione S-transferase	physical	3	2	1	Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
GRX3	YDR098C	Glutathione-dependent oxidoreductase	physical	3	2	1	Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
CCR4	YAL021C	Component of the CCR4-NOT transcriptional complex	genetic	2	2	2	Dosage Growth Defect, Phenotypic Suppression
BEM1	YBR200W	Protein containing SH3-domains	genetic	2	2	2	Negative Genetic, Dosage Growth Defect
CDC28	YBR160W	Cyclin-dependent kinase (CDK) catalytic subunit	physical	2	2	2	Biochemical Activity, PCA
CDC10	YCR002C	Component of the septin ring, required for cytokinesis	genetic	2	2	2	Negative Genetic, Synthetic Growth Defect
CDC55	YGL190C	Regulatory subunit B of protein phosphatase 2A (PP2A)	genetic	2	2	2	Negative Genetic, Synthetic Growth Defect
ERO1	YML130C	Thiol oxidase required for oxidative protein folding in the ER	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
ACK1	YDL203C	Protein that functions in the cell wall integrity pathway	genetic	2	2	2	Phenotypic Suppression, Negative Genetic
PPH3	YDR075W	Catalytic subunit of protein phosphatase PP4 complex	genetic	2	2	2	Dosage Growth Defect, Positive Genetic
GCN5	YGR252W	Catalytic subunit of ADA and SAGA histone acetyltransferase complexes	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
ROM2	YLR371W	Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p	physical	2	2	2	Affinity Capture-MS, Biochemical Activity
RRD2	YPL152W	Peptidyl-prolyl cis/trans-isomerase	genetic	2	2	2	Synthetic Rescue, Negative Genetic
BCY1	YIL033C	Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA)	genetic	2	2	2	Dosage Rescue, Negative Genetic
BRE2	YLR015W	Subunit of COMPASS (Set1C) complex	genetic	2	2	2	Dosage Growth Defect, Positive Genetic
CDC13	YDL220C	Single stranded DNA-binding protein found at TG1-3 telomere G-tails	genetic	2	2	2	Negative Genetic, Dosage Growth Defect
PMA1	YGL008C	Plasma membrane P2-type H+-ATPase	genetic	2	2	2	Phenotypic Suppression, Negative Genetic
SEC18	YBR080C	AAA ATPase and SNARE disassembly chaperone	genetic	2	2	2	Dosage Growth Defect, Negative Genetic
SGS1	YMR190C	RecQ family nucleolar DNA helicase	genetic	2	2	2	Negative Genetic, Positive Genetic
KEL2	YGR238C	Protein that negatively regulates mitotic exit	genetic	2	2	2	Synthetic Growth Defect, Dosage Growth Defect
STE20	YHL007C	Cdc42p-activated signal transducing kinase	genetic	2	2	2	Negative Genetic, Dosage Growth Defect
TUS1	YLR425W	Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity	genetic	2	2	2	Synthetic Lethality, Negative Genetic
TOS7	YOL019W	Protein involved in secretion and cell wall organization	genetic	2	2	2	Phenotypic Enhancement, Dosage Growth Defect
VPS9	YML097C	Guanine nucleotide exchange factor (GEF) and ubiquitin receptor	genetic	2	2	2	Negative Genetic, Dosage Growth Defect
UBC1	YDR177W	Ubiquitin-conjugating enzyme	genetic	2	2	2	Phenotypic Suppression, Dosage Growth Defect
VPS74	YDR372C	Golgi PI4K effector, PtdIns4P sensor, and retention receptor	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
TAF1	YGR274C	TFIID subunit, involved in RNA pol II transcription initiation	genetic	2	2	2	Synthetic Lethality, Dosage Growth Defect
TTI1	YKL033W	Subunit of the ASTRA complex, involved in chromatin remodeling	genetic	2	2	2	Negative Genetic, Dosage Growth Defect
SMT3	YDR510W	Ubiquitin-like protein of the SUMO family	genetic	2	2	2	Synthetic Growth Defect, Dosage Growth Defect
TOS8	YGL096W	Homeodomain-containing protein and putative transcription factor	genetic	2	2	2	Dosage Growth Defect, Dosage Lethality
SUR7	YML052W	Plasma membrane protein, component of eisosomes	genetic	2	2	2	Dosage Growth Defect, Negative Genetic
YPR015C	YPR015C	Putative zinc finger transcription factor	genetic	2	2	2	Dosage Growth Defect, Dosage Lethality
MKK2	YPL140C	MAPKK involved in the protein kinase C signaling pathway	genetic	2	2	2	Phenotypic Enhancement, Synthetic Rescue
MIH1	YMR036C	Protein tyrosine phosphatase	genetic	2	2	2	Phenotypic Suppression, Synthetic Rescue
FKH2	YNL068C	Forkhead family transcription factor	genetic	2	2	2	Negative Genetic, Phenotypic Suppression
CLN2	YPL256C	G1 cyclin involved in regulation of the cell cycle	genetic	2	2	2	Synthetic Lethality, Positive Genetic
PMI40	YER003C	Mannose-6-phosphate isomerase	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
PRS1	YKL181W	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase	physical	2	2	2	Two-hybrid, Affinity Capture-Western
ATG1	YGL180W	Protein serine/threonine kinase	genetic	2	2	2	Phenotypic Enhancement, Dosage Growth Defect
PCL2	YDL127W	Cyclin, interacts with cyclin-dependent kinase Pho85p	genetic	2	2	2	Dosage Rescue, Synthetic Growth Defect
SEC2	YNL272C	Guanyl-nucleotide exchange factor for the small G-protein Sec4p	genetic	2	2	2	Synthetic Lethality, Negative Genetic
BNR1	YIL159W	Formin	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
PRP16	YKR086W	DEAH-box RNA helicase	genetic	2	2	2	Synthetic Lethality, Negative Genetic
RLM1	YPL089C	MADS-box transcription factor	genetic	2	2	2	Dosage Lethality, Phenotypic Suppression
BET4	YJL031C	Alpha subunit of Type II geranylgeranyltransferase	genetic	2	2	2	Dosage Growth Defect, Negative Genetic
MON2	YNL297C	Protein with a role in endocytosis and vacuole integrity	genetic	2	2	2	Dosage Growth Defect, Positive Genetic
RPN4	YDL020C	Transcription factor that stimulates expression of proteasome genes	genetic	2	2	2	Negative Genetic, Dosage Growth Defect
PDR12	YPL058C	Plasma membrane ATP-binding cassette (ABC) transporter	genetic	2	2	2	Negative Genetic, Dosage Growth Defect
DPM1	YPR183W	Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane	genetic	2	2	2	Synthetic Rescue, Negative Genetic
MRC1	YCL061C	S-phase checkpoint protein required for DNA replication	genetic	2	2	2	Dosage Rescue, Negative Genetic
MET4	YNL103W	Leucine-zipper transcriptional activator	genetic	2	2	2	Dosage Growth Defect, Dosage Lethality
MTC1	YJL123C	Protein of unknown function that may interact with ribosomes	genetic	2	2	2	Dosage Growth Defect, Negative Genetic
RIM21	YNL294C	pH sensor molecule, component of the RIM101 pathway	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
RGM1	YMR182C	Putative zinc finger DNA binding transcription factor	genetic	2	2	2	Dosage Growth Defect, Dosage Lethality
HUR1	YGL168W	Protein with a role in DNA repair	genetic	2	2	2	Synthetic Growth Defect, Positive Genetic
GSC2	YGR032W	Catalytic subunit of 1,3-beta-glucan synthase	genetic	2	2	2	Dosage Rescue, Dosage Growth Defect
RER2	YBR002C	Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1	genetic	2	2	2	Synthetic Lethality, Negative Genetic
CHO2	YGR157W	Phosphatidylethanolamine methyltransferase (PEMT)	genetic	2	2	2	Dosage Growth Defect, Negative Genetic
NCS6	YGL211W	Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
ERD1	YDR414C	Predicted membrane protein required for lumenal ER protein retention	genetic	2	2	2	Synthetic Lethality, Negative Genetic
GPI11	YDR302W	ER membrane protein involved in a late step of GPI anchor assembly	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
MNL2	YLR057W	Putative mannosidase involved in ER-associated protein degradation	genetic	2	2	2	Dosage Growth Defect, Negative Genetic
CDC42	YLR229C	Small rho-like GTPase	genetic	2	1	2	Negative Genetic, Negative Genetic
ARC18	YLR370C	Subunit of the ARP2/3 complex	genetic	2	1	2	Negative Genetic, Negative Genetic
ARC40	YBR234C	Subunit of the ARP2/3 complex	genetic	2	1	2	Synthetic Lethality, Synthetic Lethality
BET2	YPR176C	Beta subunit of Type II geranylgeranyltransferase	genetic	2	1	2	Negative Genetic, Negative Genetic
GGA2	YHR108W	Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking	genetic	2	1	2	Synthetic Growth Defect, Synthetic Growth Defect
FAB1	YFR019W	1-phosphatidylinositol-3-phosphate 5-kinase	genetic	2	1	2	Negative Genetic, Negative Genetic
MPH1	YIR002C	3'-5' DNA helicase involved in error-free bypass of DNA lesions	genetic	2	1	2	Negative Genetic, Negative Genetic
PRP6	YBR055C	Splicing factor	genetic	2	1	2	Negative Genetic, Negative Genetic
PTC3	YBL056W	Type 2C protein phosphatase (PP2C)	genetic	2	1	2	Dosage Rescue, Dosage Rescue
RPC53	YDL150W	RNA polymerase III subunit C53	genetic	2	1	2	Positive Genetic, Positive Genetic
SEC27	YGL137W	Essential beta'-coat protein of the COPI coatomer	genetic	2	1	2	Negative Genetic, Negative Genetic
SIN3	YOL004W	Component of both the Rpd3S and Rpd3L histone deacetylase complexes	genetic	2	1	2	Negative Genetic, Negative Genetic
GLC8	YMR311C	Regulatory subunit of protein phosphatase 1 (Glc7p)	genetic	2	1	2	Negative Genetic, Negative Genetic
RHO1	YPR165W	GTP-binding protein of the rho subfamily of Ras-like proteins	genetic	2	1	2	Dosage Rescue, Dosage Rescue
SGD1	YLR336C	Essential nuclear protein	genetic	2	1	2	Negative Genetic, Negative Genetic
KIN2	YLR096W	S/T protein kinase	physical	2	1	2	Affinity Capture-MS, Affinity Capture-MS
SLT2	YHR030C	Serine/threonine MAP kinase	physical	2	1	2	Affinity Capture-Western, Affinity Capture-Western
SSN8	YNL025C	Cyclin-like component of RNA polymerase II holoenzyme	genetic	2	1	2	Negative Genetic, Negative Genetic
SSY1	YDR160W	Component of the SPS plasma membrane amino acid sensor system	genetic	2	1	2	Negative Genetic, Negative Genetic
VPS24	YKL041W	One of four subunits of the ESCRT-III complex	genetic	2	1	2	Negative Genetic, Negative Genetic
SPC2	YML055W	Subunit of signal peptidase complex	genetic	2	1	2	Negative Genetic, Negative Genetic
YHC1	YLR298C	Component of the U1 snRNP complex required for pre-mRNA splicing	genetic	2	1	2	Negative Genetic, Negative Genetic
STT4	YLR305C	Phosphatidylinositol-4-kinase	genetic	2	1	2	Negative Genetic, Negative Genetic
SKG3	YLR187W	Protein of unknown function	physical	2	1	2	Affinity Capture-MS, Affinity Capture-MS
DEF1	YKL054C	RNAPII degradation factor	genetic	2	1	2	Negative Genetic, Negative Genetic
CDC43	YGL155W	Beta subunit of geranylgeranyltransferase type I	genetic	2	1	2	Negative Genetic, Negative Genetic
LST7	YGR057C	Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p	genetic	2	1	2	Negative Genetic, Negative Genetic
COG6	YNL041C	Component of the conserved oligomeric Golgi complex	genetic	2	1	2	Positive Genetic, Positive Genetic
RSC1	YGR056W	Component of the RSC chromatin remodeling complex	genetic	2	1	2	Negative Genetic, Negative Genetic
SEC22	YLR268W	R-SNARE protein	genetic	2	1	2	Negative Genetic, Negative Genetic
CCH1	YGR217W	Voltage-gated high-affinity calcium channel	genetic	2	1	2	Negative Genetic, Negative Genetic
MNN11	YJL183W	Subunit of a Golgi mannosyltransferase complex	genetic	2	1	2	Negative Genetic, Negative Genetic
PTR3	YFR029W	Component of the SPS plasma membrane amino acid sensor system	genetic	2	1	2	Negative Genetic, Negative Genetic
IZH3	YLR023C	Membrane protein involved in zinc ion homeostasis	genetic	2	1	2	Negative Genetic, Negative Genetic
RPL35A	YDL191W	Ribosomal 60S subunit protein L35A	genetic	2	1	2	Positive Genetic, Positive Genetic
CDC50	YCR094W	Endosomal protein that interacts with phospholipid flippase Drs2p	genetic	2	1	2	Negative Genetic, Negative Genetic
ERG4	YGL012W	C-24(28) sterol reductase	genetic	2	1	2	Negative Genetic, Negative Genetic
ILM1	YJR118C	Protein of unknown function	genetic	2	1	2	Negative Genetic, Negative Genetic
PEX22	YAL055W	Putative peroxisomal membrane protein	genetic	2	1	2	Negative Genetic, Negative Genetic
AVO2	YMR068W	Component of a complex containing the Tor2p kinase and other proteins	regulation	2	2	1	protein kinase assay evidence, qualitative western immunoblotting evidence
HOG1	YLR113W	Mitogen-activated protein kinase involved in osmoregulation	regulation	2	2	1	green fluorescent protein immunolocalization evidence, qualitative western immunoblotting evidence
CAF20	YOR276W	Phosphoprotein of the mRNA cap-binding complex	physical	2	2	1	Biochemical Activity, Reconstituted Complex
PRS3	YHL011C	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase	genetic	2	2	1	Dosage Rescue, Synthetic Lethality
STE12	YHR084W	Transcription factor that is activated by a MAPK signaling cascade	physical	2	2	1	Affinity Capture-MS, Affinity Capture-Western
VHS3	YOR054C	Negative regulatory subunit of protein phosphatase 1 Ppz1p	genetic	2	2	1	Dosage Growth Defect, Synthetic Rescue
ZDS1	YMR273C	Protein with a role in regulating Swe1p-dependent polarized growth	genetic	2	2	1	Synthetic Rescue, Dosage Lethality
WSC2	YNL283C	Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway	genetic	2	2	1	Dosage Rescue, Phenotypic Suppression
KSS1	YGR040W	Mitogen-activated protein kinase (MAPK)	genetic	2	2	1	Dosage Rescue, Synthetic Growth Defect
CLB5	YPR120C	B-type cyclin involved in DNA replication during S phase	genetic	2	2	1	Dosage Rescue, Synthetic Lethality
KAR1	YNL188W	Protein involved in karyogamy and spindle pole body duplication	genetic	2	2	1	Dosage Rescue, Synthetic Lethality
GGA1	YDR358W	Golgi-localized protein with homology to gamma-adaptin	physical	2	2	1	Biochemical Activity, Reconstituted Complex
INP51	YIL002C	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase	genetic	2	2	1	Phenotypic Suppression, Synthetic Rescue
MRC1	YCL061C	S-phase checkpoint protein required for DNA replication	physical	2	2	1	Biochemical Activity, Affinity Capture-Western
PTP1	YDL230W	Phosphotyrosine-specific protein phosphatase	physical	2	2	1	Affinity Capture-Western, Reconstituted Complex
SIC1	YLR079W	Cyclin-dependent kinase inhibitor (CKI)	physical	2	2	1	Biochemical Activity, Affinity Capture-Western
RPI1	YIL119C	Transcription factor, allelic differences between S288C and Sigma1278b	genetic	2	2	1	Dosage Rescue, Phenotypic Enhancement
HDA1	YNL021W	Catalytic subunit of class II HDA1 histone deacetylase complex	genetic	2	1	1	Dosage Lethality, Dosage Lethality
ERG13	YML126C	3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase	genetic	2	1	1	Negative Genetic, Negative Genetic
MVD1	YNR043W	Mevalonate pyrophosphate decarboxylase	genetic	2	1	1	Negative Genetic, Negative Genetic
MED8	YBR193C	Subunit of the RNA polymerase II mediator complex	genetic	2	1	1	Negative Genetic, Negative Genetic
SEC63	YOR254C	Essential subunit of Sec63 complex	genetic	2	1	1	Negative Genetic, Negative Genetic
GET2	YER083C	Subunit of the GET complex	genetic	2	1	1	Positive Genetic, Positive Genetic
CCT5	YJR064W	Subunit of the cytosolic chaperonin Cct ring complex	genetic	2	1	1	Negative Genetic, Negative Genetic
COF1	YLL050C	Cofilin, involved in pH-dependent actin filament depolarization	genetic	2	1	1	Negative Genetic, Negative Genetic
SMK1	YPR054W	Middle sporulation-specific mitogen-activated protein kinase (MAPK)	physical	2	1	1	Affinity Capture-MS, Affinity Capture-MS
TAF9	YMR236W	Subunit (17 kDa) of TFIID and SAGA complexes	genetic	2	1	1	Synthetic Lethality, Synthetic Lethality
SOV1	YMR066W	Mitochondrial protein of unknown function	genetic	2	1	1	Synthetic Growth Defect, Synthetic Growth Defect
TRS20	YBR254C	Core component of transport protein particle (TRAPP) complexes I-III	genetic	2	1	1	Negative Genetic, Negative Genetic
VTI1	YMR197C	Protein involved in cis-Golgi membrane traffic	genetic	2	1	1	Negative Genetic, Negative Genetic
SMP3	YOR149C	Alpha 1,2-mannosyltransferase	genetic	2	1	1	Negative Genetic, Negative Genetic
SXM1	YDR395W	Nuclear transport factor (karyopherin)	genetic	2	1	1	Negative Genetic, Negative Genetic
MOB2	YFL034C-B	Activator of Cbk1p kinase	genetic	2	1	1	Negative Genetic, Negative Genetic
SIW14	YNL032W	Inositol phosphatase involved in inositol pyrophosphate metabolism	genetic	2	1	1	Synthetic Lethality, Synthetic Lethality
KAR2	YJL034W	ATPase involved in protein import into the ER	genetic	2	1	1	Negative Genetic, Negative Genetic
BTS1	YPL069C	Geranylgeranyl diphosphate synthase (GGPPS)	genetic	2	1	1	Negative Genetic, Negative Genetic
GPI2	YPL076W	Protein involved in the synthesis of GlcNAc-PI	genetic	2	1	1	Negative Genetic, Negative Genetic
GAA1	YLR088W	Subunit of the GPI:protein transamidase complex	genetic	2	1	1	Negative Genetic, Negative Genetic
GPI17	YDR434W	Transmembrane protein	genetic	2	1	1	Negative Genetic, Negative Genetic
GPI13	YLL031C	ER membrane localized phosphoryltransferase	genetic	2	1	1	Negative Genetic, Negative Genetic
ALG2	YGL065C	Mannosyltransferase in the N-linked glycosylation pathway	genetic	2	1	1	Negative Genetic, Negative Genetic
QRI1	YDL103C	UDP-N-acetylglucosamine pyrophosphorylase	genetic	2	1	1	Negative Genetic, Negative Genetic
GPI10	YGL142C	Integral membrane protein involved in GPI anchor synthesis	genetic	2	1	1	Negative Genetic, Negative Genetic
GPI15	YNL038W	Protein involved in the synthesis of GlcNAc-PI	genetic	2	1	1	Negative Genetic, Negative Genetic
DFR1	YOR236W	Dihydrofolate reductase involved in tetrahydrofolate biosynthesis	genetic	2	1	1	Positive Genetic, Positive Genetic
FKH2	YNL068C	Forkhead family transcription factor	regulation	1	1	1	ChEC-Seq experiments
GCR1	YPL075W	Transcriptional activator of genes involved in glycolysis	regulation	1	1	1	DNA to cDNA expression microarray evidence
TFC7	YOR110W	RNA pol III transcription initiation factor complex (TFIIIC) subunit	regulation	1	1	1	chromatin immunoprecipitation-chip evidence
SUA7	YPR086W	Transcription factor TFIIB	regulation	1	1	1	chromatin immunoprecipitation-chip evidence
SIR3	YLR442C	Silencing protein	regulation	1	1	1	qualitative western immunoblotting evidence
TSC11	YER093C	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p)	regulation	1	1	1	protein kinase assay evidence
CDC73	YLR418C	Component of the Paf1p complex	physical	1	1	1	Affinity Capture-Western
CTR9	YOL145C	Component of the Paf1p complex involved in transcription elongation	physical	1	1	1	Affinity Capture-Western
CWC25	YNL245C	Splicing factor required for the first step of pre-mRNA splicing	genetic	1	1	1	Negative Genetic
LEO1	YOR123C	Component of the Paf1 complex	physical	1	1	1	Affinity Capture-Western
CBF5	YLR175W	Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs	physical	1	1	1	Affinity Capture-MS
RPB3	YIL021W	RNA polymerase II third largest subunit B44	physical	1	1	1	Affinity Capture-Western
RPB3	YIL021W	RNA polymerase II third largest subunit B44	genetic	1	1	1	Negative Genetic
RPO21	YDL140C	RNA polymerase II largest subunit B220	genetic	1	1	1	Dosage Growth Defect
RTF1	YGL244W	Subunit of RNAPII-associated chromatin remodeling Paf1 complex	physical	1	1	1	Affinity Capture-Western
MMS21	YEL019C	Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex	genetic	1	1	1	Negative Genetic
SDS22	YKL193C	Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p	genetic	1	1	1	Dosage Growth Defect
ARP4	YJL081C	Nuclear actin-related protein involved in chromatin remodeling	genetic	1	1	1	Positive Genetic
RVB2	YPL235W	ATP-dependent DNA helicase, also known as reptin	genetic	1	1	1	Dosage Growth Defect
DRS1	YLL008W	Nucleolar DEAD-box protein required for ribosome assembly and function	genetic	1	1	1	Negative Genetic
EBP2	YKL172W	Required for 25S rRNA maturation and 60S ribosomal subunit assembly	genetic	1	1	1	Negative Genetic
CAB3	YKL088W	Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis	physical	1	1	1	PCA
PFK27	YOL136C	6-phosphofructo-2-kinase	genetic	1	1	1	Dosage Growth Defect
POP4	YBR257W	Subunit of both RNase MRP and nuclear RNase P	genetic	1	1	1	Negative Genetic
NSE4	YDL105W	Component of the SMC5-SMC6 complex	genetic	1	1	1	Negative Genetic
NUG1	YER006W	GTPase that associates with nuclear 60S pre-ribosomes	genetic	1	1	1	Dosage Growth Defect
KES1	YPL145C	Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger	genetic	1	1	1	Dosage Growth Defect
GAR1	YHR089C	Protein component of the H/ACA snoRNP pseudouridylase complex	genetic	1	1	1	Dosage Growth Defect
MAK21	YDR060W	Constituent of 66S pre-ribosomal particles	genetic	1	1	1	Positive Genetic
RRP5	YMR229C	RNA binding protein involved in synthesis of 18S and 5.8S rRNAs	genetic	1	1	1	Dosage Growth Defect
RAT1	YOR048C	Nuclear 5' to 3' single-stranded RNA exonuclease	genetic	1	1	1	Negative Genetic
SAP155	YFR040W	Protein required for function of the Sit4p protein phosphatase	physical	1	1	1	PCA
DED1	YOR204W	ATP-dependent DEAD-box RNA helicase with strand-annealing activity	genetic	1	1	1	Positive Genetic
PAB1	YER165W	Poly(A) binding protein	genetic	1	1	1	Negative Genetic
CDC48	YDL126C	AAA ATPase with protein-unfoldase activity	genetic	1	1	1	Synthetic Growth Defect
NPL3	YDR432W	RNA-binding protein	genetic	1	1	1	Synthetic Growth Defect
LRP1	YHR081W	Nuclear exosome-associated nucleic acid binding protein	genetic	1	1	1	Synthetic Rescue
RRP40	YOL142W	Exosome non-catalytic core component	genetic	1	1	1	Synthetic Rescue
RRP6	YOR001W	Nuclear exosome exonuclease component	genetic	1	1	1	Synthetic Lethality
RPA34	YJL148W	RNA polymerase I subunit A34.5	physical	1	1	1	Reconstituted Complex
RPB5	YBR154C	RNA polymerase subunit ABC27	genetic	1	1	1	Positive Genetic
RPC25	YKL144C	RNA polymerase III subunit C25	genetic	1	1	1	Negative Genetic
RPA49	YNL248C	RNA polymerase I subunit A49	genetic	1	1	1	Positive Genetic
MFT1	YML062C	Subunit of the THO complex	genetic	1	1	1	Dosage Growth Defect
RSC3	YDR303C	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Dosage Lethality
RSC8	YFR037C	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Dosage Growth Defect
RGR1	YLR071C	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Dosage Growth Defect
PWP1	YLR196W	Protein with WD-40 repeats involved in rRNA processing	genetic	1	1	1	Positive Genetic
NAP1	YKR048C	Histone chaperone and assembly chaperone for Rps6a/b	genetic	1	1	1	Positive Genetic
RPN11	YFR004W	Metalloprotease subunit of 19S regulatory particle	physical	1	1	1	Affinity Capture-MS
RPN5	YDL147W	Subunit of the CSN and 26S proteasome lid complexes	genetic	1	1	1	Positive Genetic
RPN6	YDL097C	Essential, non-ATPase regulatory subunit of the 26S proteasome lid	physical	1	1	1	Affinity Capture-MS
RPN8	YOR261C	Essential non-ATPase regulatory subunit of the 26S proteasome	genetic	1	1	1	Negative Genetic
RPT3	YDR394W	ATPase of the 19S regulatory particle of the 26S proteasome	physical	1	1	1	Affinity Capture-MS
PRE10	YOR362C	Alpha 7 subunit of the 20S proteasome	genetic	1	1	1	Dosage Growth Defect
PRE3	YJL001W	Beta 1 subunit of the 20S proteasome	physical	1	1	1	Two-hybrid
CCR4	YAL021C	Component of the CCR4-NOT transcriptional complex	physical	1	1	1	Affinity Capture-RNA
CDC39	YCR093W	Subunit of the CCR4-NOT1 core complex	genetic	1	1	1	Negative Genetic
NAB2	YGL122C	Nuclear polyadenylated RNA-binding protein	physical	1	1	1	Biochemical Activity
NUP82	YJL061W	Linker nucleoporin component of the nuclear pore complex (NPC)	genetic	1	1	1	Negative Genetic
BMS1	YPL217C	GTPase required for ribosomal subunit synthesis and rRNA processing	genetic	1	1	1	Dosage Growth Defect
APC1	YNL172W	Largest subunit of the Anaphase-Promoting Complex/Cyclosome	genetic	1	1	1	Negative Genetic
ARD1	YHR013C	Subunit of protein N-terminal acetyltransferase NatA	genetic	1	1	1	Synthetic Growth Defect
ARP2	YDL029W	Essential component of the Arp2/3 complex	physical	1	1	1	Affinity Capture-MS
ARP3	YJR065C	Essential component of the Arp2/3 complex	genetic	1	1	1	Negative Genetic
ASF1	YJL115W	Nucleosome assembly factor	genetic	1	1	1	Negative Genetic
BET3	YKR068C	Core component of transport protein particle (TRAPP) complexes I-III	genetic	1	1	1	Negative Genetic
ASC1	YMR116C	G-protein beta subunit and guanine dissociation inhibitor for Gpa2p	physical	1	1	1	Affinity Capture-MS
BUD14	YAR014C	Protein involved in bud-site selection	genetic	1	1	1	Positive Genetic
CAF40	YNL288W	Component of the CCR4-NOT transcriptional complex	genetic	1	1	1	Negative Genetic
CDC24	YAL041W	Guanine nucleotide exchange factor (GEF) for Cdc42p	genetic	1	1	1	Negative Genetic
CDC12	YHR107C	Component of the septin ring that is required for cytokinesis	genetic	1	1	1	Synthetic Lethality
CDC36	YDL165W	Component of the CCR4-NOT core complex, involved in mRNA decapping	genetic	1	1	1	Negative Genetic
ERG26	YGL001C	C-3 sterol dehydrogenase	genetic	1	1	1	Negative Genetic
CEG1	YGL130W	Guanylyltransferase involved in mRNA 5' capping	genetic	1	1	1	Negative Genetic
AVO1	YOL078W	Component of the membrane-bound TORC2 complex	genetic	1	1	1	Negative Genetic
CKS1	YBR135W	Cyclin-dependent protein kinase regulatory subunit and adaptor	genetic	1	1	1	Positive Genetic
CTK1	YKL139W	Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I)	genetic	1	1	1	Negative Genetic
DOA1	YKL213C	WD-repeat protein involved in ubiquitin-mediated protein degradation	genetic	1	1	1	Negative Genetic
EAF3	YPR023C	Component of the Rpd3S histone deacetylase complex	genetic	1	1	1	Negative Genetic
EXO84	YBR102C	Exocyst subunit with dual roles in exocytosis and spliceosome assembly	physical	1	1	1	PCA
FTH1	YBR207W	Putative high affinity iron transporter	genetic	1	1	1	Negative Genetic
GCD7	YLR291C	Beta subunit of translation initiation factor eIF2B	genetic	1	1	1	Positive Genetic
GCN3	YKR026C	Alpha subunit of translation initiation factor eIF2B	physical	1	1	1	Affinity Capture-Western
GLO3	YER122C	ADP-ribosylation factor GTPase activating protein (ARF GAP)	genetic	1	1	1	Negative Genetic
DHH1	YDL160C	Cytoplasmic DEAD-box helicase and mRNA decapping activator	physical	1	1	1	Affinity Capture-RNA
DHH1	YDL160C	Cytoplasmic DEAD-box helicase and mRNA decapping activator	genetic	1	1	1	Dosage Growth Defect
HRP1	YOL123W	Subunit of cleavage factor I	physical	1	1	1	Affinity Capture-MS
HRP1	YOL123W	Subunit of cleavage factor I	genetic	1	1	1	Dosage Growth Defect
IPP1	YBR011C	Cytoplasmic inorganic pyrophosphatase (PPase)	physical	1	1	1	Affinity Capture-MS
IST1	YNL265C	Protein with positive role in the multivesicular body sorting pathway	genetic	1	1	1	Dosage Growth Defect
ISW1	YBR245C	ATPase subunit of imitation-switch (ISWI) class chromatin remodelers	genetic	1	1	1	Synthetic Rescue
KRR1	YCL059C	Nucleolar protein required for rRNA synthesis and ribosomal assembly	genetic	1	1	1	Negative Genetic
END3	YNL084C	EH domain-containing protein involved in endocytosis	genetic	1	1	1	Negative Genetic
LAS17	YOR181W	Actin assembly factor	genetic	1	1	1	Negative Genetic
LCB1	YMR296C	Component of serine palmitoyltransferase	genetic	1	1	1	Negative Genetic
LCB2	YDR062W	Component of serine palmitoyltransferase	genetic	1	1	1	Negative Genetic
KEL1	YHR158C	Protein required for proper cell fusion and cell morphology	genetic	1	1	1	Synthetic Growth Defect
MBP1	YDL056W	Transcription factor	genetic	1	1	1	Dosage Growth Defect
MCM6	YGL201C	Protein involved in DNA replication	genetic	1	1	1	Dosage Growth Defect
ADA2	YDR448W	Transcription coactivator	physical	1	1	1	Affinity Capture-Western
MOT1	YPL082C	Essential protein involved in regulation of transcription	genetic	1	1	1	Synthetic Lethality
MRPL19	YNL185C	Mitochondrial ribosomal protein of the large subunit	genetic	1	1	1	Negative Genetic
MRPL8	YJL063C	Mitochondrial ribosomal protein of the large subunit	genetic	1	1	1	Negative Genetic
FYV4	YHR059W	Protein of unknown function	physical	1	1	1	PCA
MSH2	YOL090W	Protein that binds to DNA mismatches	physical	1	1	1	PCA
LCD1	YDR499W	Essential protein required for the DNA integrity checkpoint pathways	genetic	1	1	1	Dosage Growth Defect
MGM101	YJR144W	Protein with a role in mitochondrial DNA recombinational repair	genetic	1	1	1	Negative Genetic
MPH1	YIR002C	3'-5' DNA helicase involved in error-free bypass of DNA lesions	physical	1	1	1	PCA
MSH3	YCR092C	Mismatch repair protein	physical	1	1	1	PCA
MTR10	YOR160W	Nuclear import receptor	genetic	1	1	1	Dosage Growth Defect
MYO1	YHR023W	Type II myosin heavy chain	genetic	1	1	1	Synthetic Lethality
MYO4	YAL029C	Type V myosin motor involved in actin-based transport of cargos	genetic	1	1	1	Synthetic Growth Defect
KAP114	YGL241W	Karyopherin, responsible for nuclear import of specific proteins	genetic	1	1	1	Dosage Growth Defect
LYS12	YIL094C	Homo-isocitrate dehydrogenase	physical	1	1	1	Affinity Capture-MS
ATG18	YFR021W	Phosphoinositide binding protein	genetic	1	1	1	Negative Genetic
AHA1	YDR214W	Co-chaperone that binds Hsp82p and activates its ATPase activity	physical	1	1	1	Affinity Capture-MS
NSP1	YJL041W	FG-nucleoporin component of central core of the nuclear pore complex	genetic	1	1	1	Positive Genetic
OST1	YJL002C	Alpha subunit of the oligosaccharyltransferase complex of the ER lumen	genetic	1	1	1	Negative Genetic
GIM3	YNL153C	Subunit of the heterohexameric cochaperone prefoldin complex	genetic	1	1	1	Synthetic Growth Defect
GIM5	YML094W	Subunit of the heterohexameric cochaperone prefoldin complex	genetic	1	1	1	Synthetic Growth Defect
DOA4	YDR069C	Ubiquitin hydrolase	genetic	1	1	1	Negative Genetic
LPD1	YFL018C	Dihydrolipoamide dehydrogenase	genetic	1	1	1	Negative Genetic
DIG1	YPL049C	MAP kinase-responsive inhibitor of the Ste12p transcription factor	physical	1	1	1	Affinity Capture-MS
PEP3	YLR148W	Component of CORVET membrane tethering complex	physical	1	1	1	PCA
LIN1	YHR156C	Non-essential component of U5 snRNP	genetic	1	1	1	Dosage Growth Defect
INO4	YOL108C	Transcription factor involved in phospholipid synthesis	genetic	1	1	1	Negative Genetic
PTC4	YBR125C	Cytoplasmic type 2C protein phosphatase (PP2C)	physical	1	1	1	Reconstituted Complex
PTC4	YBR125C	Cytoplasmic type 2C protein phosphatase (PP2C)	genetic	1	1	1	Dosage Rescue
NAB3	YPL190C	RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p)	genetic	1	1	1	Dosage Growth Defect
POL2	YNL262W	Catalytic subunit of DNA polymerase (II) epsilon	genetic	1	1	1	Synthetic Growth Defect
MET18	YIL128W	Component of cytosolic iron-sulfur protein assembly (CIA) machinery	genetic	1	1	1	Negative Genetic
ILV1	YER086W	Threonine deaminase, catalyzes first step in isoleucine biosynthesis	genetic	1	1	1	Negative Genetic
MKT1	YNL085W	Protein similar to nucleases that forms a complex with Pbp1p	physical	1	1	1	Affinity Capture-MS
RAM1	YDL090C	Beta subunit of the CAAX farnesyltransferase (FTase)	genetic	1	1	1	Positive Genetic
REF2	YDR195W	RNA-binding protein	genetic	1	1	1	Negative Genetic
PTI1	YGR156W	Essential component of CPF (cleavage and polyadenylation factor)	genetic	1	1	1	Negative Genetic
RET2	YFR051C	Delta subunit of the coatomer complex (COPI)	genetic	1	1	1	Positive Genetic
RAD52	YML032C	Protein involved in homologous recombination	genetic	1	1	1	Negative Genetic
ROX3	YBL093C	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Dosage Growth Defect
DEP1	YAL013W	Component of the Rpd3L histone deacetylase complex	genetic	1	1	1	Negative Genetic
CTI6	YPL181W	Component of the Rpd3L histone deacetylase complex	genetic	1	1	1	Negative Genetic
RTS1	YOR014W	B-type regulatory subunit of protein phosphatase 2A (PP2A)	genetic	1	1	1	Negative Genetic
OPI1	YHL020C	Transcriptional regulator of a variety of genes	genetic	1	1	1	Dosage Rescue
PIL1	YGR086C	Eisosome core component	physical	1	1	1	Affinity Capture-MS
NUP84	YDL116W	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC)	genetic	1	1	1	Positive Genetic
SEC62	YPL094C	Essential subunit of Sec63 complex	genetic	1	1	1	Negative Genetic
SET2	YJL168C	Histone methyltransferase with a role in transcriptional elongation	genetic	1	1	1	Dosage Rescue
SGN1	YIR001C	Cytoplasmic RNA-binding protein	genetic	1	1	1	Dosage Growth Defect
HOS2	YGL194C	Histone deacetylase and subunit of Set3 and Rpd3L complexes	genetic	1	1	1	Dosage Rescue
SDS3	YIL084C	Component of the Rpd3L histone deacetylase complex	genetic	1	1	1	Negative Genetic
CCT8	YJL008C	Subunit of the cytosolic chaperonin Cct ring complex	genetic	1	1	1	Negative Genetic
PRP9	YDL030W	Subunit of the SF3a splicing factor complex	genetic	1	1	1	Negative Genetic
GAL83	YER027C	One of three alternate beta-subunits of the Snf1 kinase complex	genetic	1	1	1	Dosage Growth Defect
NAT1	YDL040C	Subunit of protein N-terminal acetyltransferase NatA	genetic	1	1	1	Synthetic Growth Defect
SEN1	YLR430W	ATP-dependent 5' to 3' RNA/DNA and DNA helicase	genetic	1	1	1	Phenotypic Enhancement
IST2	YBR086C	Cortical ER protein involved in ER-plasma membrane (PM) tethering	genetic	1	1	1	Negative Genetic
CCT7	YJL111W	Subunit of the cytosolic chaperonin Cct ring complex	genetic	1	1	1	Dosage Rescue
MKS1	YNL076W	Pleiotropic negative transcriptional regulator	genetic	1	1	1	Negative Genetic
SKN1	YGR143W	Protein involved in sphingolipid biosynthesis	genetic	1	1	1	Dosage Growth Defect
SEC3	YER008C	Subunit of the exocyst complex	genetic	1	1	1	Synthetic Lethality
RPT4	YOR259C	ATPase of the 19S regulatory particle of the 26S proteasome	genetic	1	1	1	Positive Genetic
HSE1	YHL002W	Subunit of the endosomal Vps27p-Hse1p complex	physical	1	1	1	PCA
FLC2	YAL053W	Putative calcium channel involved in calcium release under hypotonic	genetic	1	1	1	Positive Genetic
HEK2	YBL032W	RNA binding protein involved in asymmetric localization of ASH1 mRNA	genetic	1	1	1	Phenotypic Suppression
FES1	YBR101C	Hsp70 (Ssa1p) nucleotide exchange factor	physical	1	1	1	Affinity Capture-Western
BOI1	YBL085W	Protein involved in polar growth, functionally redundant with Boi2p	physical	1	1	1	PCA
PUF3	YLL013C	Protein of the mitochondrial outer surface	physical	1	1	1	Affinity Capture-RNA
PUF3	YLL013C	Protein of the mitochondrial outer surface	genetic	1	1	1	Dosage Growth Defect
NTE1	YML059C	Serine esterase	genetic	1	1	1	Dosage Rescue
NOB1	YOR056C	Protein involved in proteasomal and 40S ribosomal subunit biogenesis	genetic	1	1	1	Positive Genetic
GET4	YOR164C	Protein involved in inserting tail-anchored proteins into ER membranes	genetic	1	1	1	Negative Genetic
EGD2	YHR193C	Alpha subunit of the nascent polypeptide-associated complex (NAC)	physical	1	1	1	Affinity Capture-MS
CRZ1	YNL027W	Transcription factor, activates transcription of stress response genes	physical	1	1	1	PCA
ADR1	YDR216W	Carbon source-responsive zinc-finger transcription factor	genetic	1	1	1	Dosage Growth Defect
GND1	YHR183W	6-phosphogluconate dehydrogenase (decarboxylating)	physical	1	1	1	Affinity Capture-MS
GRH1	YDR517W	Acetylated cis-Golgi protein, homolog of human GRASP65	physical	1	1	1	PCA
ASA1	YPR085C	Subunit of the ASTRA complex, involved in chromatin remodeling	genetic	1	1	1	Negative Genetic
FOL2	YGR267C	GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis	physical	1	1	1	Affinity Capture-MS
ARF1	YDL192W	ADP-ribosylation factor	genetic	1	1	1	Negative Genetic
IDH1	YNL037C	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase	physical	1	1	1	Affinity Capture-MS
CPR6	YLR216C	Peptidyl-prolyl cis-trans isomerase (cyclophilin)	physical	1	1	1	Affinity Capture-MS
RTK1	YDL025C	Putative protein kinase, potentially phosphorylated by Cdc28p	genetic	1	1	1	Dosage Growth Defect
SAC6	YDR129C	Fimbrin, actin-bundling protein	genetic	1	1	1	Negative Genetic
CNA1	YLR433C	Calcineurin A	genetic	1	1	1	Dosage Rescue
GSP1	YLR293C	Ran GTPase	genetic	1	1	1	Positive Genetic
CDC53	YDL132W	Cullin	genetic	1	1	1	Synthetic Lethality
PBS2	YJL128C	MAP kinase kinase of the HOG signaling pathway	physical	1	1	1	Affinity Capture-Western
RHO5	YNL180C	Non-essential small GTPase of the Rho/Rac family of Ras-like proteins	genetic	1	1	1	Synthetic Rescue
OYE2	YHR179W	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN)	physical	1	1	1	Affinity Capture-MS
POR1	YNL055C	Mitochondrial porin (voltage-dependent anion channel)	genetic	1	1	1	Negative Genetic
ILV5	YLR355C	Acetohydroxyacid reductoisomerase and mtDNA binding protein	physical	1	1	1	Affinity Capture-MS
OYE3	YPL171C	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN)	physical	1	1	1	PCA
PMA1	YGL008C	Plasma membrane P2-type H+-ATPase	physical	1	1	1	Affinity Capture-MS
APM3	YBR288C	Mu3-like subunit of the clathrin associated protein complex (AP-3)	genetic	1	1	1	Negative Genetic
PTC5	YOR090C	Mitochondrial type 2C protein phosphatase (PP2C)	physical	1	1	1	PCA
PTC5	YOR090C	Mitochondrial type 2C protein phosphatase (PP2C)	genetic	1	1	1	Dosage Growth Defect
RGP1	YDR137W	Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p)	genetic	1	1	1	Positive Genetic
CAF120	YNL278W	Part of the CCR4-NOT transcriptional regulatory complex	genetic	1	1	1	Dosage Growth Defect
QCR2	YPR191W	Subunit 2 of ubiquinol cytochrome-c reductase (Complex III)	physical	1	1	1	Affinity Capture-MS
CLN1	YMR199W	G1 cyclin involved in regulation of the cell cycle	genetic	1	1	1	Synthetic Lethality
PKH2	YOL100W	Serine/threonine protein kinase	genetic	1	1	1	Synthetic Growth Defect
PDC6	YGR087C	Minor isoform of pyruvate decarboxylase	physical	1	1	1	Affinity Capture-MS
PRS3	YHL011C	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase	physical	1	1	1	Two-hybrid
CYC8	YBR112C	General transcriptional co-repressor	genetic	1	1	1	Negative Genetic
KRE6	YPR159W	Glucosyl hydrolase required for beta-1,6-glucan biosynthesis	genetic	1	1	1	Dosage Growth Defect
MRS6	YOR370C	Rab escort protein	genetic	1	1	1	Dosage Rescue
CDC20	YGL116W	Activator of anaphase-promoting complex/cyclosome (APC/C)	genetic	1	1	1	Negative Genetic
ELM1	YKL048C	Serine/threonine protein kinase	genetic	1	1	1	Dosage Growth Defect
DAS1	YJL149W	Putative SCF ubiquitin ligase F-box protein	genetic	1	1	1	Negative Genetic
MOH1	YBL049W	Protein of unknown function, essential for stationary phase survival	genetic	1	1	1	Negative Genetic
PSK2	YOL045W	PAS-domain containing serine/threonine protein kinase	genetic	1	1	1	Negative Genetic
SFP1	YLR403W	Regulates transcription of ribosomal protein and biogenesis genes	genetic	1	1	1	Dosage Lethality
DSK2	YMR276W	Nuclear-enriched ubiquitin-like polyubiquitin-binding protein	physical	1	1	1	Affinity Capture-MS
FAR10	YLR238W	Protein involved in recovery from arrest in response to pheromone	physical	1	1	1	PCA
RSP5	YER125W	NEDD4 family E3 ubiquitin ligase	genetic	1	1	1	Negative Genetic
BUL1	YMR275C	Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex	genetic	1	1	1	Negative Genetic
OCA1	YNL099C	Putative protein tyrosine phosphatase	genetic	1	1	1	Positive Genetic
GPN3	YLR243W	Putative GTPase with a role in biogenesis of RNA pol II and polIII	genetic	1	1	1	Dosage Growth Defect
SAH1	YER043C	S-adenosyl-L-homocysteine hydrolase	genetic	1	1	1	Negative Genetic
PRM2	YIL037C	Pheromone-regulated protein	genetic	1	1	1	Dosage Growth Defect
CTF13	YMR094W	Subunit of the CBF3 complex	genetic	1	1	1	Positive Genetic
PEX6	YNL329C	AAA-peroxin	genetic	1	1	1	Negative Genetic
GAL7	YBR018C	Galactose-1-phosphate uridyl transferase	physical	1	1	1	Affinity Capture-MS
AIM46	YHR199C	Protein of unknown function	physical	1	1	1	PCA
LAS1	YKR063C	Endonuclease involved in pre-rRNA processing at both ends of ITS2	genetic	1	1	1	Negative Genetic
HOG1	YLR113W	Mitogen-activated protein kinase involved in osmoregulation	physical	1	1	1	Affinity Capture-Western
CWC21	YDR482C	Protein involved in RNA splicing by the spliceosome	physical	1	1	1	PCA
CHS1	YNL192W	Chitin synthase I	genetic	1	1	1	Negative Genetic
KSP1	YHR082C	Serine/threonine protein kinase	physical	1	1	1	Biochemical Activity
KSP1	YHR082C	Serine/threonine protein kinase	genetic	1	1	1	Dosage Growth Defect
DIA2	YOR080W	Origin-binding F-box protein	physical	1	1	1	Affinity Capture-MS
RAS2	YNL098C	GTP-binding protein	genetic	1	1	1	Negative Genetic
DPB11	YJL090C	DNA replication initiation protein	genetic	1	1	1	Positive Genetic
CAF4	YKR036C	WD40 repeat-containing protein associated with the CCR4-NOT complex	genetic	1	1	1	Dosage Growth Defect
TIF2	YJL138C	Translation initiation factor eIF4A	physical	1	1	1	Affinity Capture-MS
SWI6	YLR182W	Transcription cofactor	genetic	1	1	1	Synthetic Growth Defect
STE20	YHL007C	Cdc42p-activated signal transducing kinase	physical	1	1	1	Biochemical Activity
TOR1	YJR066W	PIK-related protein kinase and rapamycin target	physical	1	1	1	Co-fractionation
TOR2	YKL203C	PIK-related protein kinase and rapamycin target	physical	1	1	1	Co-fractionation
SSE1	YPL106C	ATPase component of heat shock protein Hsp90 chaperone complex	physical	1	1	1	Affinity Capture-Western
SOG2	YOR353C	Key component of the RAM signaling network	physical	1	1	1	Affinity Capture-MS
SOG2	YOR353C	Key component of the RAM signaling network	genetic	1	1	1	Negative Genetic
SRP54	YPR088C	Signal recognition particle (SRP) subunit (homolog of mammalian SRP54)	physical	1	1	1	Affinity Capture-MS
USE1	YGL098W	Essential SNARE protein localized to the ER	physical	1	1	1	Reconstituted Complex
YPL077C	YPL077C	Putative protein of unknown function	physical	1	1	1	Reconstituted Complex
SNF2	YOR290C	Catalytic subunit of the SWI/SNF chromatin remodeling complex	physical	1	1	1	Co-localization
SNF6	YHL025W	Subunit of the SWI/SNF chromatin remodeling complex	physical	1	1	1	Co-localization
SSB2	YNL209W	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone	physical	1	1	1	Co-purification
TSC11	YER093C	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p)	physical	1	1	1	Biochemical Activity
UBS1	YBR165W	Ubiquitin-conjugating enzyme suppressor that regulates Cdc34p	physical	1	1	1	PCA
TEP1	YNL128W	PTEN homolog with no demonstrated inositol lipid phosphatase activity	physical	1	1	1	PCA
TUS1	YLR425W	Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity	physical	1	1	1	PCA
WSS1	YHR134W	SUMO-ligase and SUMO-targeted metalloprotease	physical	1	1	1	PCA
UBP16	YPL072W	Deubiquitinating enzyme anchored to the outer mitochondrial membrane	physical	1	1	1	PCA
ULA1	YPL003W	Protein that activates Rub1p (NEDD8) before neddylation	physical	1	1	1	PCA
VTH1	YIL173W	Putative membrane glycoprotein	physical	1	1	1	PCA
STE5	YDR103W	Pheromone-responsive MAPK scaffold protein	physical	1	1	1	PCA
YAP7	YOL028C	Transcriptional repressor of nitric oxide oxidase	physical	1	1	1	PCA
VHS3	YOR054C	Negative regulatory subunit of protein phosphatase 1 Ppz1p	physical	1	1	1	PCA
SSK1	YLR006C	Cytoplasmic phosphorelay intermediate osmosensor and regulator	physical	1	1	1	PCA
SSK1	YLR006C	Cytoplasmic phosphorelay intermediate osmosensor and regulator	genetic	1	1	1	Synthetic Growth Defect
TRS85	YDR108W	Component of transport protein particle (TRAPP) complex III	physical	1	1	1	PCA
SRN2	YLR119W	Component of the ESCRT-I complex	physical	1	1	1	PCA
SRX1	YKL086W	Sulfiredoxin	physical	1	1	1	PCA
STB1	YNL309W	Protein with role in regulation of MBF-specific transcription at Start	physical	1	1	1	PCA
SSN3	YPL042C	Component of the RNA polymerase II mediator complex	physical	1	1	1	PCA
SYG1	YIL047C	Plasma membrane protein of unknown function	physical	1	1	1	PCA
YBP1	YBR216C	Protein involved in cellular response to oxidative stress	physical	1	1	1	PCA
VRP1	YLR337C	Verprolin, proline-rich actin-associated protein	physical	1	1	1	PCA
VRP1	YLR337C	Verprolin, proline-rich actin-associated protein	genetic	1	1	1	Negative Genetic
TIP41	YPR040W	Tap42p-interacting protein	physical	1	1	1	PCA
UFD4	YKL010C	Ubiquitin-protein ligase (E3)	physical	1	1	1	PCA
URM1	YIL008W	Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs	physical	1	1	1	PCA
URM1	YIL008W	Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs	genetic	1	1	1	Synthetic Growth Defect
TPK1	YJL164C	cAMP-dependent protein kinase catalytic subunit	physical	1	1	1	PCA
TPK3	YKL166C	cAMP-dependent protein kinase catalytic subunit	physical	1	1	1	PCA
SSD1	YDR293C	Translational repressor	physical	1	1	1	PCA
UTP15	YMR093W	Nucleolar protein	physical	1	1	1	PCA
UTP15	YMR093W	Nucleolar protein	genetic	1	1	1	Dosage Growth Defect
SST2	YLR452C	GTPase-activating protein for Gpa1p	physical	1	1	1	PCA
SYP1	YCR030C	Negative regulator of WASP-Arp23 complex	genetic	1	1	1	Phenotypic Enhancement
STM1	YLR150W	Protein required for optimal translation under nutrient stress	genetic	1	1	1	Dosage Rescue
TCO89	YPL180W	Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p)	genetic	1	1	1	Synthetic Lethality
UBP3	YER151C	Ubiquitin-specific protease that cleaves Ub-protein fusions	genetic	1	1	1	Phenotypic Suppression
YPD1	YDL235C	Osmotic stress-responsive phosphorelay intermediate sensor protein	genetic	1	1	1	Negative Genetic
TPS2	YDR074W	Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex	genetic	1	1	1	Negative Genetic
WHI3	YNL197C	RNA binding protein that modulates mRNA stability	genetic	1	1	1	Synthetic Lethality
YKE2	YLR200W	Subunit of the heterohexameric Gim/prefoldin protein complex	genetic	1	1	1	Synthetic Growth Defect
TAF10	YDR167W	Subunit (145 kDa) of TFIID and SAGA complexes	genetic	1	1	1	Synthetic Lethality
SWA2	YDR320C	Auxilin-like protein involved in vesicular transport	genetic	1	1	1	Positive Genetic
YPT31	YER031C	Rab family GTPase	genetic	1	1	1	Negative Genetic
VPS21	YOR089C	Endosomal Rab family GTPase	genetic	1	1	1	Negative Genetic
SNC2	YOR327C	Vesicle membrane receptor protein (v-SNARE)	genetic	1	1	1	Negative Genetic
VPS64	YDR200C	Protein required for cytoplasm to vacuole targeting of proteins	genetic	1	1	1	Negative Genetic
VIP1	YLR410W	Bifunctional inositol pyrophosphate kinase and phosphatase	genetic	1	1	1	Negative Genetic
UME6	YDR207C	Rpd3L histone deacetylase complex subunit	genetic	1	1	1	Negative Genetic
SLX5	YDL013W	Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex	genetic	1	1	1	Negative Genetic
SPT23	YKL020C	ER membrane protein involved in regulation of OLE1 transcription	genetic	1	1	1	Negative Genetic
YPK2	YMR104C	AGC-type S/T protein kinase	genetic	1	1	1	Negative Genetic
TEL1	YBL088C	Protein kinase primarily involved in telomere length regulation	genetic	1	1	1	Negative Genetic
YPT6	YLR262C	Rab family GTPase	genetic	1	1	1	Positive Genetic
YDJ1	YNL064C	Type I HSP40 co-chaperone	genetic	1	1	1	Negative Genetic
SWE1	YJL187C	Protein kinase that regulates the G2/M transition	genetic	1	1	1	Phenotypic Suppression
STE11	YLR362W	Signal transducing MEK kinase	genetic	1	1	1	Phenotypic Suppression
YMR295C	YMR295C	Protein of unknown function that associates with ribosomes	genetic	1	1	1	Dosage Growth Defect
THO1	YER063W	Conserved nuclear RNA-binding protein	genetic	1	1	1	Dosage Growth Defect
YER085C	YER085C	Putative protein of unknown function	genetic	1	1	1	Dosage Growth Defect
SNF8	YPL002C	Component of the ESCRT-II complex	genetic	1	1	1	Dosage Growth Defect
YPT53	YNL093W	Stress-induced Rab family GTPase	genetic	1	1	1	Dosage Growth Defect
VTA1	YLR181C	Multivesicular body (MVB) protein	genetic	1	1	1	Dosage Growth Defect
ZAP1	YJL056C	Zinc-regulated transcription factor	genetic	1	1	1	Dosage Growth Defect
YND1	YER005W	Apyrase with wide substrate specificity	genetic	1	1	1	Dosage Growth Defect
SPS22	YCL048W	Protein of unknown function	genetic	1	1	1	Dosage Growth Defect
SNF7	YLR025W	One of four subunits of the ESCRT-III complex	genetic	1	1	1	Dosage Growth Defect
YML082W	YML082W	Putative protein predicted to have carbon-sulfur lyase activity	genetic	1	1	1	Dosage Growth Defect
YOL057W	YOL057W	Dipeptidyl-peptidase III	genetic	1	1	1	Dosage Growth Defect
YNL108C	YNL108C	Protein phosphatase	genetic	1	1	1	Dosage Growth Defect
YTA6	YPL074W	Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family	genetic	1	1	1	Dosage Growth Defect
TAF5	YBR198C	Subunit (90 kDa) of TFIID and SAGA complexes	genetic	1	1	1	Dosage Growth Defect
YSP2	YDR326C	Sterol-binding protein	genetic	1	1	1	Dosage Growth Defect
SPS18	YNL204C	Protein of unknown function, contains a putative zinc-binding domain	genetic	1	1	1	Dosage Growth Defect
UBP7	YIL156W	Ubiquitin-specific protease that cleaves ubiquitin-protein fusions	genetic	1	1	1	Dosage Growth Defect
TVP38	YKR088C	Integral membrane protein	genetic	1	1	1	Dosage Growth Defect
SWP82	YFL049W	Member of the SWI/SNF chromatin remodeling complex	genetic	1	1	1	Dosage Growth Defect
UTP18	YJL069C	Small-subunit processome protein involved in pre-18S rRNA maturation	genetic	1	1	1	Dosage Growth Defect
UMP1	YBR173C	Chaperone required for correct maturation of the 20S proteasome	genetic	1	1	1	Dosage Growth Defect
SNG1	YGR197C	Protein involved in resistance to nitrosoguanidine and 6-azauracil	genetic	1	1	1	Dosage Growth Defect
VHS2	YIL135C	Regulator of septin dynamics	genetic	1	1	1	Dosage Growth Defect
UGP1	YKL035W	UDP-glucose pyrophosphorylase (UGPase)	genetic	1	1	1	Dosage Growth Defect
TYW1	YPL207W	Iron-sulfur protein required for synthesis of wybutosine modified tRNA	genetic	1	1	1	Dosage Growth Defect
ULS1	YOR191W	Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL)	genetic	1	1	1	Dosage Growth Defect
YNL194C	YNL194C	Integral membrane protein	genetic	1	1	1	Dosage Growth Defect
UBP11	YKR098C	Ubiquitin-specific protease	genetic	1	1	1	Dosage Growth Defect
YKR075C	YKR075C	Protein of unknown function	genetic	1	1	1	Dosage Growth Defect
YNG2	YHR090C	Subunit of NuA4, an essential histone acetyltransferase complex	genetic	1	1	1	Dosage Growth Defect
UFO1	YML088W	F-box receptor protein	genetic	1	1	1	Dosage Growth Defect
YAP1801	YHR161C	Protein of the AP180 family, involved in clathrin cage assembly	genetic	1	1	1	Dosage Growth Defect
SNQ2	YDR011W	Plasma membrane ATP-binding cassette (ABC) transporter	genetic	1	1	1	Dosage Growth Defect
SNF1	YDR477W	AMP-activated S/T protein kinase	genetic	1	1	1	Synthetic Growth Defect
SUR1	YPL057C	Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit	genetic	1	1	1	Synthetic Growth Defect
SRM1	YGL097W	Nucleotide exchange factor for Gsp1p	genetic	1	1	1	Positive Genetic
STU1	YBL034C	Microtubule plus-end-tracking non-motor protein	genetic	1	1	1	Positive Genetic
SMC3	YJL074C	Subunit of the multiprotein cohesin complex	genetic	1	1	1	Positive Genetic
VPS52	YDR484W	Component of the GARP (Golgi-associated retrograde protein) complex	genetic	1	1	1	Positive Genetic
VAC8	YEL013W	Vacuole-specific Myo2p receptor	genetic	1	1	1	Positive Genetic
VMA8	YEL051W	Subunit D of the V1 peripheral membrane domain of V-ATPase	genetic	1	1	1	Positive Genetic
UBR2	YLR024C	Cytoplasmic ubiquitin-protein ligase (E3)	genetic	1	1	1	Positive Genetic
SYS1	YJL004C	Integral membrane protein of the Golgi	genetic	1	1	1	Positive Genetic
VPS51	YKR020W	Component of the GARP (Golgi-associated retrograde protein) complex	genetic	1	1	1	Positive Genetic
VMA13	YPR036W	Subunit H of the V1 peripheral membrane domain of V-ATPase	genetic	1	1	1	Positive Genetic
TCP1	YDR212W	Alpha subunit of chaperonin-containing T-complex	genetic	1	1	1	Negative Genetic
YPI1	YFR003C	Regulatory subunit of the type I protein phosphatase (PP1) Glc7p	genetic	1	1	1	Negative Genetic
VRG4	YGL225W	Golgi GDP-mannose transporter	genetic	1	1	1	Negative Genetic
ZPR1	YGR211W	Essential protein with two zinc fingers	genetic	1	1	1	Negative Genetic
TAO3	YIL129C	Component of the RAM signaling network	genetic	1	1	1	Negative Genetic
SSL2	YIL143C	Component of RNA polymerase transcription factor TFIIH holoenzyme	genetic	1	1	1	Negative Genetic
URA6	YKL024C	Uridylate kinase	genetic	1	1	1	Negative Genetic
SPC42	YKL042W	Central plaque component of spindle pole body (SPB)	genetic	1	1	1	Negative Genetic
SRP102	YKL154W	Signal recognition particle (SRP) receptor beta subunit	genetic	1	1	1	Negative Genetic
YKT6	YKL196C	Vesicle membrane protein (v-SNARE) with acyltransferase activity	genetic	1	1	1	Negative Genetic
TEM1	YML064C	GTPase involved in initiation of Mitotic Exit Network (MEN)	genetic	1	1	1	Negative Genetic
TRS130	YMR218C	Component of transport protein particle (TRAPP) complex II	genetic	1	1	1	Negative Genetic
WRS1	YOL097C	Cytoplasmic tryptophanyl-tRNA synthetase	genetic	1	1	1	Negative Genetic
TIM22	YDL217C	Essential core component of mitochondrial TIM22 complex	genetic	1	1	1	Negative Genetic
STN1	YDR082W	Telomere end-binding and capping protein	genetic	1	1	1	Negative Genetic
SUP35	YDR172W	Translation termination factor eRF3	genetic	1	1	1	Negative Genetic
SRP101	YDR292C	Signal recognition particle (SRP) receptor alpha subunit	genetic	1	1	1	Negative Genetic
TFB1	YDR311W	Subunit of TFIIH and nucleotide excision repair factor 3 complexes	genetic	1	1	1	Negative Genetic
SRV2	YNL138W	CAP (cyclase-associated protein)	genetic	1	1	1	Negative Genetic
YAL064W	YAL064W	Protein of unknown function	genetic	1	1	1	Negative Genetic
YBL028C	YBL028C	Protein of unknown function that may interact with ribosomes	genetic	1	1	1	Negative Genetic
YBR196C-A	YBR196C-A	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YDR003W-A	YDR003W-A	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YDR249C	YDR249C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YDR524C-B	YDR524C-B	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YDR524W-C	YDR524W-C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
UBC6	YER100W	Ubiquitin-conjugating enzyme involved in ERAD	genetic	1	1	1	Negative Genetic
XKS1	YGR194C	Xylulokinase	genetic	1	1	1	Negative Genetic
STE50	YCL032W	Adaptor protein for various signaling pathways	genetic	1	1	1	Negative Genetic
TED1	YIL039W	GPI-glycan remodelase	genetic	1	1	1	Negative Genetic
YIL055C	YIL055C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YIL102C	YIL102C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YIR021W-A	YIR021W-A	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YKL096C-B	YKL096C-B	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YKL183C-A	YKL183C-A	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YRM1	YOR172W	Zinc finger transcription factor involved in multidrug resistance	genetic	1	1	1	Dosage Lethality
TYE7	YOR344C	Serine-rich protein that contains a bHLH DNA binding motif	genetic	1	1	1	Dosage Lethality
USV1	YPL230W	Putative transcription factor containing a C2H2 zinc finger	genetic	1	1	1	Dosage Lethality
YLR053C	YLR053C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
SSP120	YLR250W	Protein packaged into COPII vesicles for ER to Golgi trafficking	genetic	1	1	1	Negative Genetic
YTA12	YMR089C	Mitochondrial inner membrane m-AAA protease component	genetic	1	1	1	Negative Genetic
VAC7	YNL054W	Integral vacuolar membrane protein	genetic	1	1	1	Negative Genetic
SPH1	YLR313C	Protein involved in shmoo formation and bipolar bud site selection	genetic	1	1	1	Dosage Rescue
YOR186W	YOR186W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
TFB6	YOR352W	Subunit of TFIIH complex	genetic	1	1	1	Negative Genetic
VTS1	YOR359W	Flap-structured DNA-binding and RNA-binding protein	genetic	1	1	1	Negative Genetic
YPL034W	YPL034W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
SPE2	YOL052C	S-adenosylmethionine decarboxylase	genetic	1	1	1	Positive Genetic
VPS53	YJL029C	Component of the GARP (Golgi-associated retrograde protein) complex	genetic	1	1	1	Positive Genetic
SPE1	YKL184W	Ornithine decarboxylase	genetic	1	1	1	Positive Genetic
SYT1	YPR095C	Guanine nucleotide exchange factor (GEF) for Arf proteins	genetic	1	1	1	Negative Genetic
VAM7	YGL212W	Vacuolar SNARE protein	genetic	1	1	1	Positive Genetic
UBP8	YMR223W	Ubiquitin-specific protease component of the SAGA acetylation complex	genetic	1	1	1	Negative Genetic
SPN1	YPR133C	Protein involved in RNA polymerase II transcription	genetic	1	1	1	Positive Genetic
SPC105	YGL093W	Subunit of a kinetochore-microtubule binding complex	genetic	1	1	1	Negative Genetic
STE6	YKL209C	Plasma membrane ATP-binding cassette (ABC) transporter	genetic	1	1	1	Negative Genetic
TUB4	YLR212C	Gamma-tubulin	genetic	1	1	1	Synthetic Growth Defect
RAD50	YNL250W	Subunit of MRX complex with Mre11p and Xrs2p	genetic	1	1	1	Synthetic Lethality
LHS1	YKL073W	Molecular chaperone of the endoplasmic reticulum lumen	physical	1	1	1	Affinity Capture-MS
SIS1	YNL007C	Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p	physical	1	1	1	Affinity Capture-MS
NUS1	YDL193W	Forms dehydrodolichyl diphosphate synthase complex with RER2 or SRT1	genetic	1	1	1	Negative Genetic
OPY1	YBR129C	Protein of unknown function	genetic	1	1	1	Negative Genetic
CCE1	YKL011C	Mitochondrial cruciform cutting endonuclease	genetic	1	1	1	Negative Genetic
SEC4	YFL005W	Rab family GTPase	genetic	1	1	1	Negative Genetic
OMS1	YDR316W	Protein integral to the mitochondrial membrane	physical	1	1	1	PCA
PCL6	YER059W	Pho85p cyclin of the Pho80p subfamily	genetic	1	1	1	Dosage Growth Defect
PTP2	YOR208W	Phosphotyrosine-specific phosphatase	genetic	1	1	1	Phenotypic Suppression
SKI2	YLR398C	Ski complex component and putative RNA helicase	genetic	1	1	1	Dosage Growth Defect
CLB2	YPR119W	B-type cyclin involved in cell cycle progression	physical	1	1	1	PCA
HAP3	YBL021C	Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex	genetic	1	1	1	Positive Genetic
SKM1	YOL113W	Member of the PAK family of serine/threonine protein kinases	genetic	1	1	1	Phenotypic Enhancement
GTO1	YGR154C	Omega-class glutathione transferase	genetic	1	1	1	Negative Genetic
LSM8	YJR022W	Lsm (Like Sm) protein	physical	1	1	1	PCA
LSM8	YJR022W	Lsm (Like Sm) protein	genetic	1	1	1	Negative Genetic
PTC2	YER089C	Type 2C protein phosphatase (PP2C)	physical	1	1	1	Reconstituted Complex
PTC2	YER089C	Type 2C protein phosphatase (PP2C)	genetic	1	1	1	Dosage Rescue
RAD53	YPL153C	DNA damage response kinase	genetic	1	1	1	Dosage Rescue
GCR2	YNL199C	Transcriptional activator of genes involved in glycolysis	genetic	1	1	1	Negative Genetic
PRS2	YER099C	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase	physical	1	1	1	Two-hybrid
PHO86	YJL117W	Endoplasmic reticulum (ER) resident protein	genetic	1	1	1	Negative Genetic
EXO70	YJL085W	Subunit of the exocyst complex	genetic	1	1	1	Positive Genetic
QCR7	YDR529C	Subunit 7 of ubiquinol cytochrome-c reductase (Complex III)	genetic	1	1	1	Negative Genetic
BIR1	YJR089W	Subunit of chromosomal passenger complex (CPC)	genetic	1	1	1	Negative Genetic
ERG11	YHR007C	Lanosterol 14-alpha-demethylase	genetic	1	1	1	Synthetic Lethality
RNR3	YIL066C	Minor isoform of large subunit of ribonucleotide-diphosphate reductase	physical	1	1	1	PCA
PKH1	YDR490C	Serine/threonine protein kinase	genetic	1	1	1	Synthetic Growth Defect
RED1	YLR263W	Protein component of the synaptonemal complex axial elements	genetic	1	1	1	Dosage Growth Defect
MMS22	YLR320W	Subunit of E3 ubiquitin ligase complex involved in replication repair	genetic	1	1	1	Negative Genetic
APL4	YPR029C	Gamma-adaptin	genetic	1	1	1	Dosage Growth Defect
ESS1	YJR017C	Peptidylprolyl-cis/trans-isomerase (PPIase)	genetic	1	1	1	Negative Genetic
CTK3	YML112W	Gamma subunit of C-terminal domain kinase I	genetic	1	1	1	Negative Genetic
DCK1	YLR422W	Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1	genetic	1	1	1	Negative Genetic
DAD2	YKR083C	Essential subunit of the Dam1 complex (aka DASH complex)	genetic	1	1	1	Negative Genetic
DUO1	YGL061C	Essential subunit of the Dam1 complex (aka DASH complex)	genetic	1	1	1	Negative Genetic
BIT2	YBR270C	Subunit of TORC2 membrane-associated complex	physical	1	1	1	PCA
DDI1	YER143W	Aspartic-type endopeptidase	genetic	1	1	1	Dosage Growth Defect
BUD27	YFL023W	Unconventional prefoldin protein involved in translation initiation	genetic	1	1	1	Dosage Growth Defect
ARP1	YHR129C	Actin-related protein of the dynactin complex	genetic	1	1	1	Synthetic Lethality
DID4	YKL002W	Class E Vps protein of the ESCRT-III complex	genetic	1	1	1	Negative Genetic
MCM10	YIL150C	Essential chromatin-associated protein	physical	1	1	1	PCA
BIM1	YER016W	Microtubule plus end-tracking protein	physical	1	1	1	PCA
EBS1	YDR206W	Protein involved in translation inhibition and nonsense-mediated decay	physical	1	1	1	Affinity Capture-MS
EBS1	YDR206W	Protein involved in translation inhibition and nonsense-mediated decay	genetic	1	1	1	Dosage Growth Defect
BNI4	YNL233W	Targeting subunit for Glc7p protein phosphatase	physical	1	1	1	Affinity Capture-Western
AFT1	YGL071W	Transcription factor involved in iron utilization and homeostasis	physical	1	1	1	Affinity Capture-Western
AFT1	YGL071W	Transcription factor involved in iron utilization and homeostasis	genetic	1	1	1	Synthetic Rescue
GTR1	YML121W	Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex	genetic	1	1	1	Phenotypic Suppression
GDS1	YOR355W	Protein involved in histone H4 acetylation at ribosomal protein genes	genetic	1	1	1	Dosage Growth Defect
CWC24	YLR323C	General splicing factor	genetic	1	1	1	Negative Genetic
IRE1	YHR079C	Serine-threonine kinase and endoribonuclease	genetic	1	1	1	Negative Genetic
LST7	YGR057C	Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p	physical	1	1	1	PCA
MCM16	YPR046W	Component of the Ctf19 complex and the COMA subcomplex	physical	1	1	1	PCA
ASM4	YDL088C	FG-nucleoporin component of central core of nuclear pore complex (NPC)	physical	1	1	1	PCA
NDC1	YML031W	Subunit of the transmembrane ring of the nuclear pore complex (NPC)	genetic	1	1	1	Dosage Growth Defect
HUA2	YOR284W	Cytoplasmic protein of unknown function	genetic	1	1	1	Negative Genetic
PCL8	YPL219W	Cyclin	genetic	1	1	1	Dosage Growth Defect
PPG1	YNR032W	Serine protein phosphatase involved in formation of FAR complex	genetic	1	1	1	Dosage Growth Defect
RIM101	YHL027W	Cys2His2 zinc-finger transcriptional repressor	physical	1	1	1	PCA
PDR8	YLR266C	Transcription factor	genetic	1	1	1	Negative Genetic
RPS26A	YGL189C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Dosage Growth Defect
CDC34	YDR054C	Ubiquitin-conjugating enzyme (E2)	genetic	1	1	1	Synthetic Lethality
BAS1	YKR099W	Myb-related transcription factor	genetic	1	1	1	Dosage Growth Defect
CAK1	YFL029C	Cyclin-dependent kinase-activating kinase	genetic	1	1	1	Positive Genetic
PEX14	YGL153W	Central component of the peroxisomal importomer complex	genetic	1	1	1	Negative Genetic
LDB17	YDL146W	Protein involved in the regulation of endocytosis	genetic	1	1	1	Negative Genetic
KEG1	YFR042W	Integral membrane protein of the ER	genetic	1	1	1	Negative Genetic
GPI16	YHR188C	Subunit of the glycosylphosphatidylinositol transamidase complex	genetic	1	1	1	Synthetic Lethality
ASK10	YGR097W	Regulator of the Fps1p glycerol channel	genetic	1	1	1	Negative Genetic
PRR1	YKL116C	Serine/threonine protein kinase	genetic	1	1	1	Dosage Growth Defect
ASK1	YKL052C	Essential subunit of the Dam1 complex (aka DASH complex)	genetic	1	1	1	Negative Genetic
AVO2	YMR068W	Component of a complex containing the Tor2p kinase and other proteins	physical	1	1	1	Biochemical Activity
MDY2	YOL111C	Protein involved in inserting tail-anchored proteins into ER membranes	genetic	1	1	1	Negative Genetic
NST1	YNL091W	Translational inhibitor and suppressor of proteasome-assembly defects	physical	1	1	1	Affinity Capture-Western
COG4	YPR105C	Essential component of the conserved oligomeric Golgi complex	genetic	1	1	1	Negative Genetic
AIM4	YBR194W	Protein proposed to be associated with the nuclear pore complex	genetic	1	1	1	Negative Genetic
BOS1	YLR078C	v-SNARE (vesicle specific SNAP receptor)	genetic	1	1	1	Negative Genetic
GMH1	YKR030W	Golgi membrane protein of unknown function	genetic	1	1	1	Dosage Growth Defect
COG5	YNL051W	Component of the conserved oligomeric Golgi complex	genetic	1	1	1	Positive Genetic
DOC1	YGL240W	Processivity factor	genetic	1	1	1	Positive Genetic
HTL1	YCR020W-B	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Phenotypic Suppression
PEX12	YMR026C	C3HC4-type RING-finger peroxin and E3 ubiquitin ligase	genetic	1	1	1	Negative Genetic
PEX17	YNL214W	Membrane peroxin of the peroxisomal importomer complex	genetic	1	1	1	Negative Genetic
PEX5	YDR244W	Peroxisomal membrane signal receptor for peroxisomal matrix proteins	genetic	1	1	1	Dosage Growth Defect
CHL1	YPL008W	Probable DNA helicase	physical	1	1	1	PCA
RFT1	YBL020W	Membrane protein required for translocation of Man5GlcNac2-PP-Dol	genetic	1	1	1	Negative Genetic
RSC30	YHR056C	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Dosage Growth Defect
CET1	YPL228W	RNA 5'-triphosphatase involved in mRNA 5' capping	genetic	1	1	1	Positive Genetic
RPC10	YHR143W-A	RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III	genetic	1	1	1	Synthetic Lethality
ARP6	YLR085C	Actin-related protein that binds nucleosomes	physical	1	1	1	PCA
LEU3	YLR451W	Zinc-knuckle transcription factor, repressor and activator	genetic	1	1	1	Dosage Growth Defect
MSN2	YMR037C	Stress-responsive transcriptional activator	genetic	1	1	1	Dosage Growth Defect
SKO1	YNL167C	Basic leucine zipper transcription factor of the ATF/CREB family	physical	1	1	1	PCA
SKO1	YNL167C	Basic leucine zipper transcription factor of the ATF/CREB family	genetic	1	1	1	Negative Genetic
IES3	YLR052W	Subunit of the INO80 chromatin remodeling complex	genetic	1	1	1	Dosage Growth Defect
SAS3	YBL052C	Histone acetyltransferase catalytic subunit of NuA3 complex	genetic	1	1	1	Dosage Growth Defect
MCM1	YMR043W	Transcription factor	genetic	1	1	1	Phenotypic Suppression
CBF1	YJR060W	Basic helix-loop-helix (bHLH) protein	genetic	1	1	1	Negative Genetic
MIF2	YKL089W	Centromeric CDEIII region binding protein	genetic	1	1	1	Negative Genetic
RAD9	YDR217C	DNA damage-dependent checkpoint protein	genetic	1	1	1	Synthetic Lethality
BUR6	YER159C	Subunit of a heterodimeric NC2 transcription regulator complex	genetic	1	1	1	Negative Genetic
BUB1	YGR188C	Protein kinase involved in the cell cycle checkpoint into anaphase	genetic	1	1	1	Negative Genetic
CTF8	YHR191C	Subunit of a complex with Ctf18p	genetic	1	1	1	Negative Genetic
CTK2	YJL006C	Beta subunit of C-terminal domain kinase I (CTDK-I)	genetic	1	1	1	Negative Genetic
EPS1	YIL005W	ER protein with chaperone and co-chaperone activity	genetic	1	1	1	Negative Genetic
BNI5	YNL166C	Linker protein responsible for recruitment of myosin to the bud neck	genetic	1	1	1	Dosage Growth Defect
HSP150	YJL159W	O-mannosylated heat shock protein	genetic	1	1	1	Dosage Rescue
NIS1	YNL078W	Protein involved in axial bud site selection	genetic	1	1	1	Negative Genetic
BIK1	YCL029C	Microtubule-associated protein	physical	1	1	1	PCA
RTG2	YGL252C	Sensor of mitochondrial dysfunction	genetic	1	1	1	Negative Genetic
SEC1	YDR164C	Sm-like protein involved in docking and fusion of exocytic vesicles	genetic	1	1	1	Negative Genetic
SEC15	YGL233W	Essential 113 kDa subunit of the exocyst complex	genetic	1	1	1	Synthetic Growth Defect
SEC20	YDR498C	Membrane glycoprotein v-SNARE	genetic	1	1	1	Negative Genetic
SEC6	YIL068C	Essential 88kDa subunit of the exocyst complex	physical	1	1	1	PCA
RRD1	YIL153W	Peptidyl-prolyl cis/trans-isomerase	genetic	1	1	1	Synthetic Rescue
NMD2	YHR077C	Protein involved in the nonsense-mediated mRNA decay (NMD) pathway	physical	1	1	1	PCA
PEP7	YDR323C	Adaptor protein involved in vesicle-mediated vacuolar protein sorting	genetic	1	1	1	Dosage Growth Defect
FIG4	YNL325C	Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase	genetic	1	1	1	Negative Genetic
BBP1	YPL255W	Protein required for the spindle pole body (SPB) duplication	genetic	1	1	1	Dosage Growth Defect
KTI11	YBL071W-A	Zn-ribbon protein that co-purifies with Dph1 and Dph2	genetic	1	1	1	Negative Genetic
JNM1	YMR294W	Component of the yeast dynactin complex	genetic	1	1	1	Synthetic Lethality
PHO2	YDL106C	Homeobox transcription factor	physical	1	1	1	PCA
SEC5	YDR166C	Essential 107kDa subunit of the exocyst complex	genetic	1	1	1	Synthetic Lethality
GOS1	YHL031C	v-SNARE protein involved in Golgi transport	genetic	1	1	1	Dosage Growth Defect
HSF1	YGL073W	Trimeric heat shock transcription factor	genetic	1	1	1	Dosage Rescue
OST4	YDL232W	Subunit of the oligosaccharyltransferase complex of the ER lumen	genetic	1	1	1	Negative Genetic
BUD8	YLR353W	Protein involved in bud-site selection	genetic	1	1	1	Dosage Growth Defect
HAP4	YKL109W	Transcription factor	genetic	1	1	1	Negative Genetic
MOB1	YIL106W	Component of the mitotic exit network	genetic	1	1	1	Synthetic Lethality
MPT5	YGL178W	mRNA-binding protein of the PUF family	genetic	1	1	1	Dosage Rescue
CSG2	YBR036C	Endoplasmic reticulum membrane protein	genetic	1	1	1	Negative Genetic
GYP1	YOR070C	Cis-golgi GTPase-activating protein (GAP) for yeast Rabs	genetic	1	1	1	Positive Genetic
SLN1	YIL147C	Transmembrane histidine phosphotransfer kinase and osmosensor	genetic	1	1	1	Positive Genetic
EMC1	YCL045C	Member of conserved endoplasmic reticulum membrane complex	genetic	1	1	1	Negative Genetic
SLA2	YNL243W	Adaptor protein that links actin to clathrin and endocytosis	genetic	1	1	1	Negative Genetic
ABF1	YKL112W	DNA binding protein with possible chromatin-reorganizing activity	genetic	1	1	1	Negative Genetic
BNR1	YIL159W	Formin	physical	1	1	1	PCA
FCP1	YMR277W	Carboxy-terminal domain (CTD) phosphatase	genetic	1	1	1	Positive Genetic
CAT8	YMR280C	Zinc cluster transcriptional activator	genetic	1	1	1	Positive Genetic
GTS1	YGL181W	Protein involved in Arf3p regulation and in transcription regulation	genetic	1	1	1	Dosage Growth Defect
AKR1	YDR264C	Palmitoyl transferase involved in protein palmitoylation	genetic	1	1	1	Negative Genetic
DOT1	YDR440W	Nucleosomal histone H3-Lys79 methylase	genetic	1	1	1	Dosage Growth Defect
ATC1	YDR184C	Nuclear protein	physical	1	1	1	PCA
COQ1	YBR003W	Hexaprenyl pyrophosphate synthetase	genetic	1	1	1	Dosage Growth Defect
HMT1	YBR034C	Nuclear SAM-dependent mono- and asymmetric methyltransferase	genetic	1	1	1	Dosage Growth Defect
BPT1	YLL015W	ABC type transmembrane transporter of MRP/CFTR family	genetic	1	1	1	Dosage Growth Defect
MID2	YLR332W	O-glycosylated plasma membrane protein	physical	1	1	1	PCA
GIC2	YDR309C	Rho-family GTPase interacting protein and Cdc42p effector	genetic	1	1	1	Dosage Growth Defect
PET309	YLR067C	Specific translational activator for the COX1 mRNA	genetic	1	1	1	Negative Genetic
RGD1	YBR260C	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p	genetic	1	1	1	Dosage Rescue
NNF2	YGR089W	Protein that exhibits physical and genetic interactions with Rpb8p	genetic	1	1	1	Negative Genetic
GYL1	YMR192W	Putative GTPase activating protein (GAP) with a role in exocytosis	genetic	1	1	1	Negative Genetic
HRI1	YLR301W	Protein of unknown function that interacts with Sec72p and Hrr25p	genetic	1	1	1	Negative Genetic
SHO1	YER118C	Transmembrane osmosensor for filamentous growth and HOG pathways	genetic	1	1	1	Synthetic Growth Defect
AZF1	YOR113W	Zinc-finger transcription factor	genetic	1	1	1	Dosage Lethality
MRF1	YGL143C	Mitochondrial translation release factor	physical	1	1	1	PCA
SCW4	YGR279C	Cell wall protein with similarity to glucanases	genetic	1	1	1	Dosage Growth Defect
ADY4	YLR227C	Structural component of the meiotic outer plaque	genetic	1	1	1	Dosage Growth Defect
MSB3	YNL293W	Rab GTPase-activating protein	genetic	1	1	1	Dosage Growth Defect
ENT2	YLR206W	Epsin-like protein required for endocytosis and actin patch assembly	genetic	1	1	1	Dosage Growth Defect
FUS1	YCL027W	Membrane protein localized to the shmoo tip	physical	1	1	1	PCA
NCP1	YHR042W	NADP-cytochrome P450 reductase	genetic	1	1	1	Synthetic Lethality
HMS1	YOR032C	bHLH protein with similarity to myc-family transcription factors	genetic	1	1	1	Positive Genetic
ERT1	YBR239C	Transcriptional regulator	physical	1	1	1	PCA
GGA1	YDR358W	Golgi-localized protein with homology to gamma-adaptin	genetic	1	1	1	Synthetic Growth Defect
HAC1	YFL031W	Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog)	genetic	1	1	1	Negative Genetic
DID2	YKR035W-A	Class E protein of the vacuolar protein-sorting (Vps) pathway	genetic	1	1	1	Dosage Growth Defect
PRS4	YBL068W	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP	physical	1	1	1	Two-hybrid
ARL3	YPL051W	ARF-like small GTPase of the RAS superfamily	genetic	1	1	1	Positive Genetic
FLO8	YER109C	Transcription factor	genetic	1	1	1	Dosage Rescue
MIP1	YOR330C	Mitochondrial DNA polymerase gamma	genetic	1	1	1	Negative Genetic
EAF7	YNL136W	Subunit of the NuA4 histone acetyltransferase complex	genetic	1	1	1	Negative Genetic
INN1	YNL152W	Essential protein that associates with contractile actomyosin ring	genetic	1	1	1	Negative Genetic
IXR1	YKL032C	Transcriptional repressor that regulates hypoxic genes during normoxia	genetic	1	1	1	Negative Genetic
ERG5	YMR015C	C-22 sterol desaturase	genetic	1	1	1	Dosage Growth Defect
ORM2	YLR350W	Protein that mediates sphingolipid homeostasis	genetic	1	1	1	Phenotypic Suppression
SBE22	YHR103W	Protein involved in bud growth	genetic	1	1	1	Dosage Growth Defect
PDS5	YMR076C	Cohesion maintenance factor	physical	1	1	1	PCA
CRG1	YHR209W	S-AdoMet-dependent methyltransferase involved in lipid homeostasis	genetic	1	1	1	Synthetic Growth Defect
SAC7	YDR389W	GTPase activating protein (GAP) for Rho1p	genetic	1	1	1	Dosage Growth Defect
EMC6	YLL014W	Member of conserved ER transmembrane complex	genetic	1	1	1	Negative Genetic
EPO1	YMR124W	Protein involved in septin-ER tethering	genetic	1	1	1	Negative Genetic
PTR3	YFR029W	Component of the SPS plasma membrane amino acid sensor system	physical	1	1	1	PCA
PBN1	YCL052C	Component of glycosylphosphatidylinositol-mannosyltransferase I	genetic	1	1	1	Dosage Growth Defect
CAT2	YML042W	Carnitine acetyl-CoA transferase	physical	1	1	1	PCA
ASF2	YDL197C	Anti-silencing protein	genetic	1	1	1	Dosage Growth Defect
COQ9	YLR201C	Protein required for ubiquinone biosynthesis and respiratory growth	genetic	1	1	1	Negative Genetic
GEF1	YJR040W	Voltage-gated chloride channel	genetic	1	1	1	Positive Genetic
BCH2	YKR027W	Member of the ChAPs (Chs5p-Arf1p-binding proteins) family	genetic	1	1	1	Dosage Growth Defect
GAT2	YMR136W	Protein containing GATA family zinc finger motifs	genetic	1	1	1	Positive Genetic
INP1	YMR204C	Peripheral membrane protein of peroxisomes	genetic	1	1	1	Dosage Growth Defect
DAL5	YJR152W	Allantoate permease	physical	1	1	1	PCA
CFD1	YIL003W	Highly conserved iron-sulfur cluster binding protein	genetic	1	1	1	Negative Genetic
SEC8	YPR055W	Essential 121 kDa subunit of the exocyst complex	genetic	1	1	1	Synthetic Lethality
FMP32	YFL046W	Regulator of mitochondrial proline metabolism	physical	1	1	1	PCA
RPL40A	YIL148W	Ubiquitin-ribosomal 60S subunit protein L40A fusion protein	genetic	1	1	1	Negative Genetic
PEX1	YKL197C	AAA-peroxin	genetic	1	1	1	Negative Genetic
ERG7	YHR072W	Lanosterol synthase	genetic	1	1	1	Synthetic Lethality
FAT1	YBR041W	Very long chain fatty acyl-CoA synthetase and fatty acid transporter	genetic	1	1	1	Negative Genetic
DCC1	YCL016C	Subunit of a complex with Ctf8p and Ctf18p	genetic	1	1	1	Negative Genetic
NFS1	YCL017C	Cysteine desulfurase involved in iron-sulfur cluster biogenesis	genetic	1	1	1	Negative Genetic
SAT4	YCR008W	Ser/Thr protein kinase involved in salt tolerance, nutrient response	genetic	1	1	1	Dosage Growth Defect
HRQ1	YDR291W	3'-5' DNA helicase of the conserved RecQ family	genetic	1	1	1	Positive Genetic
SCM3	YDL139C	Nonhistone component of centromeric chromatin	physical	1	1	1	PCA
PMT5	YDL093W	Protein O-mannosyltransferase	genetic	1	1	1	Negative Genetic
PAM1	YDR251W	Essential protein of unknown function	genetic	1	1	1	Dosage Growth Defect
PUF4	YGL014W	Member of the PUF protein family	genetic	1	1	1	Dosage Growth Defect
GID11	YLR149C	Substrate receptor of the glucose-induced degradation-deficient (GID)	genetic	1	1	1	Negative Genetic
KXD1	YGL079W	Subunit of the BLOC-1 complex involved in endosomal maturation	genetic	1	1	1	Negative Genetic
GRX4	YER174C	Glutathione-dependent oxidoreductase and glutathione S-transferase	genetic	1	1	1	Dosage Rescue
RIM8	YGL045W	Protein involved in proteolytic activation of Rim101p	genetic	1	1	1	Synthetic Lethality
PMR1	YGL167C	High affinity Ca2+/Mn2+ P-type ATPase	genetic	1	1	1	Positive Genetic
ACB1	YGR037C	Acyl-CoA-binding protein	genetic	1	1	1	Negative Genetic
MPP6	YNR024W	Nuclear exosome-associated RNA binding protein	genetic	1	1	1	Synthetic Rescue
IMP21	YIL154C	Transcriptional activator involved in maintenance of ion homeostasis	genetic	1	1	1	Dosage Growth Defect
GRE3	YHR104W	Aldose reductase	genetic	1	1	1	Dosage Growth Defect
HOB2	YPR117W	Protein with structural similarity to lipid transport protein Vps13p	genetic	1	1	1	Negative Genetic
GCD14	YJL125C	Subunit of tRNA (1-methyladenosine) methyltransferase	genetic	1	1	1	Negative Genetic
RPP1A	YDL081C	Ribosomal stalk protein P1 alpha	genetic	1	1	1	Dosage Growth Defect
BYE1	YKL005C	Negative regulator of transcription elongation	genetic	1	1	1	Negative Genetic
KIN4	YOR233W	Serine/threonine protein kinase	genetic	1	1	1	Positive Genetic
SBA1	YKL117W	Co-chaperone that binds and regulates Hsp90 family chaperones	genetic	1	1	1	Negative Genetic
DTR1	YBR180W	Putative dityrosine transporter of the major facilitator superfamily	genetic	1	1	1	Dosage Growth Defect
INA17	YPL099C	F1F0 ATPase synthase peripheral stalk assembly factor	physical	1	1	1	PCA
CYK3	YDL117W	SH3-domain protein located in the bud neck and cytokinetic actin ring	physical	1	1	1	PCA
RTT109	YLL002W	Histone acetyltransferase	genetic	1	1	1	Negative Genetic
NAM2	YLR382C	Mitochondrial leucyl-tRNA synthetase	genetic	1	1	1	Negative Genetic
CSH1	YBR161W	Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit	genetic	1	1	1	Synthetic Growth Defect
GIP4	YAL031C	Cytoplasmic protein that regulates protein phosphatase 1 Glc7p	genetic	1	1	1	Dosage Growth Defect
MSF1	YPR047W	Mitochondrial phenylalanyl-tRNA synthetase	physical	1	1	1	Affinity Capture-MS
PFK26	YIL107C	6-phosphofructo-2-kinase	genetic	1	1	1	Negative Genetic
RMA1	YKL132C	Putative dihydrofolate synthetase	physical	1	1	1	PCA
SDD2	YMR074C	Protein with homology to human PDCD5	genetic	1	1	1	Dosage Growth Defect
RPS14B	YJL191W	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Negative Genetic
MRPL27	YBR282W	Mitochondrial ribosomal protein of the large subunit	genetic	1	1	1	Negative Genetic
CSA1	YPR174C	Protein of unknown function	genetic	1	1	1	Dosage Growth Defect
CLB4	YLR210W	B-type cyclin involved in cell cycle progression	genetic	1	1	1	Dosage Growth Defect
PAL2	YHR097C	Protein involved in clathrin-mediated endocytosis	genetic	1	1	1	Dosage Growth Defect
CMK2	YOL016C	Calmodulin-dependent protein kinase	genetic	1	1	1	Positive Genetic
FPS1	YLL043W	Aquaglyceroporin, plasma membrane channel	physical	1	1	1	Affinity Capture-Western
CYC3	YAL039C	Cytochrome c heme lyase (holocytochrome c synthase)	genetic	1	1	1	Dosage Growth Defect
IRC5	YFR038W	Putative ATPase containing the DEAD/H helicase-related sequence motif	physical	1	1	1	Reconstituted Complex
INP54	YOL065C	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase	genetic	1	1	1	Phenotypic Enhancement
PDX3	YBR035C	Pyridoxine (pyridoxamine) phosphate oxidase	genetic	1	1	1	Negative Genetic
ORM1	YGR038W	Protein that mediates sphingolipid homeostasis	genetic	1	1	1	Phenotypic Suppression
NMT1	YLR195C	N-myristoyl transferase	genetic	1	1	1	Negative Genetic
PIB2	YGL023C	Phosphatidylinositol 3-phosphate binding protein	physical	1	1	1	PCA
SCH9	YHR205W	AGC family protein kinase	genetic	1	1	1	Synthetic Rescue
ECM22	YLR228C	Sterol regulatory element binding protein	genetic	1	1	1	Dosage Growth Defect
RKM4	YDR257C	Ribosomal lysine methyltransferase	physical	1	1	1	PCA
ERG24	YNL280C	C-14 sterol reductase	genetic	1	1	1	Negative Genetic
PYP1	YNL010W	Sugar alcohol phosphatase	genetic	1	1	1	Negative Genetic
DER1	YBR201W	ER membrane protein that promotes export of misfolded polypeptides	genetic	1	1	1	Negative Genetic
PEX3	YDR329C	Peroxisomal membrane protein (PMP)	genetic	1	1	1	Dosage Growth Defect
RRT2	YBR246W	Methylesterase performing penultimate step of diphthamide biosynthesis	physical	1	1	1	PCA
PHD1	YKL043W	Transcriptional activator that enhances pseudohyphal growth	genetic	1	1	1	Dosage Lethality
RIM13	YMR154C	Calpain-like cysteine protease	genetic	1	1	1	Synthetic Growth Defect
RBA50	YDR527W	Protein involved in transcription	physical	1	1	1	PCA
CHS2	YBR038W	Chitin synthase II	genetic	1	1	1	Negative Genetic
PDR3	YBL005W	Transcriptional activator of the pleiotropic drug resistance network	physical	1	1	1	PCA
NCB2	YDR397C	Subunit of a heterodimeric NC2 transcription regulator complex	genetic	1	1	1	Negative Genetic
PTR2	YKR093W	Integral membrane peptide transporter	genetic	1	1	1	Dosage Growth Defect
ENA2	YDR039C	P-type ATPase sodium pump	genetic	1	1	1	Dosage Growth Defect
COM2	YER130C	Transcription factor that binds IME1 Upstream Activation Signal (UAS)	genetic	1	1	1	Negative Genetic
SFT2	YBL102W	Tetra-spanning membrane protein found mostly in the late Golgi	physical	1	1	1	PCA
GOT1	YMR292W	Homodimeric protein that is packaged into COPII vesicles	physical	1	1	1	PCA
GRX3	YDR098C	Glutathione-dependent oxidoreductase	genetic	1	1	1	Dosage Rescue
COS1	YNL336W	Endosomal protein involved in turnover of plasma membrane proteins	genetic	1	1	1	Negative Genetic
SCS7	YMR272C	Sphingolipid alpha-hydroxylase	genetic	1	1	1	Negative Genetic
PCH2	YBR186W	Hexameric ring ATPase that remodels chromosome axis protein Hop1p	physical	1	1	1	PCA
ALG7	YBR243C	UDP-N-acetyl-glucosamine-1-P transferase	genetic	1	1	1	Synthetic Lethality
MDM32	YOR147W	Mitochondrial inner membrane protein with similarity to Mdm31p	genetic	1	1	1	Negative Genetic
GPM2	YDL021W	Nonfunctional homolog of Gpm1p phosphoglycerate mutase	genetic	1	1	1	Negative Genetic
RBS1	YDL189W	Protein involved in assembly of the RNA Pol III complex	physical	1	1	1	PCA
SIC1	YLR079W	Cyclin-dependent kinase inhibitor (CKI)	genetic	1	1	1	Negative Genetic
INO1	YJL153C	Inositol-3-phosphate synthase	genetic	1	1	1	Dosage Rescue
HER2	YMR293C	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex	genetic	1	1	1	Negative Genetic
KRE9	YJL174W	Glycoprotein involved in cell wall beta-glucan assembly	genetic	1	1	1	Negative Genetic
HUG1	YML058W-A	Ribonucleotide reductase inhibitor	physical	1	1	1	PCA
PEX22	YAL055W	Putative peroxisomal membrane protein	physical	1	1	1	PCA
PEX34	YCL056C	Protein that regulates peroxisome populations	genetic	1	1	1	Dosage Growth Defect
MSN1	YOL116W	Transcriptional activator	genetic	1	1	1	Dosage Growth Defect
PXP1	YEL020C	Peroxisomal matrix protein	genetic	1	1	1	Negative Genetic
GPI14	YJR013W	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I	genetic	1	1	1	Negative Genetic
RAM2	YKL019W	Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I	genetic	1	1	1	Negative Genetic
MTC2	YKL098W	Protein of unknown function	genetic	1	1	1	Negative Genetic
ISC1	YER019W	Inositol phosphosphingolipid phospholipase C	genetic	1	1	1	Synthetic Lethality
ALG9	YNL219C	Mannosyltransferase, involved in N-linked glycosylation	genetic	1	1	1	Dosage Growth Defect
PIG1	YLR273C	Putative targeting subunit for type-1 protein phosphatase Glc7p	genetic	1	1	1	Dosage Growth Defect
PFA4	YOL003C	Palmitoyltransferase with autoacylation activity	genetic	1	1	1	Negative Genetic
DFG10	YIL049W	Probable polyprenol reductase	genetic	1	1	1	Negative Genetic
FCY22	YER060W-A	Putative purine-cytosine permease	genetic	1	1	1	Negative Genetic
DIE2	YGR227W	Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase	genetic	1	1	1	Synthetic Growth Defect
BOR1	YNL275W	Boron efflux transporter of the plasma membrane	genetic	1	1	1	Negative Genetic
SED4	YCR067C	Integral ER membrane protein that stimulates Sar1p GTPase activity	physical	1	1	1	PCA
RPH1	YER169W	JmjC domain-containing histone demethylase	genetic	1	1	1	Dosage Lethality
RQC2	YPL009C	Component of the Ribosome Quality Control (RQC) complex	genetic	1	1	1	Negative Genetic
MIC60	YKR016W	Component of the MICOS complex	genetic	1	1	1	Negative Genetic
ERG9	YHR190W	Farnesyl-diphosphate farnesyl transferase (squalene synthase)	genetic	1	1	1	Synthetic Growth Defect
NBL1	YHR199C-A	Subunit of the conserved chromosomal passenger complex (CPC)	genetic	1	1	1	Negative Genetic
MRX14	YDR115W	Putative mitochondrial ribosomal protein of the large subunit	genetic	1	1	1	Negative Genetic
EMC10	YDR056C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
GLD1	YPR109W	Component of Dsc E3 ligase complex in Golgi and endosomes	genetic	1	1	1	Negative Genetic
CRD1	YDL142C	Cardiolipin synthase	genetic	1	1	1	Negative Genetic
ERG12	YMR208W	Mevalonate kinase	genetic	1	1	1	Negative Genetic
AFG1	YEL052W	Protein that may act as a chaperone for cytochrome c oxidase subunits	genetic	1	1	1	Dosage Growth Defect
KNH1	YDL049C	Protein with similarity to Kre9p	genetic	1	1	1	Dosage Growth Defect
MCD4	YKL165C	Protein involved in GPI anchor synthesis	genetic	1	1	1	Synthetic Lethality
DPI34	YOR114W	Putative mitochondrial protein of unknown function	genetic	1	1	1	Negative Genetic
PRM1	YNL279W	Pheromone-regulated multispanning membrane protein	genetic	1	1	1	Dosage Growth Defect
ATG22	YCL038C	Vacuolar integral membrane protein required for efflux of amino acids	genetic	1	1	1	Negative Genetic
PSD1	YNL169C	Phosphatidylserine decarboxylase of the mitochondrial inner membrane	genetic	1	1	1	Negative Genetic
HXT15	YDL245C	Putative transmembrane polyol transporter	physical	1	1	1	PCA
GPI8	YDR331W	Catalytic subunit of the ER membrane GPI transamidase complex	genetic	1	1	1	Negative Genetic
ERD2	YBL040C	HDEL receptor	genetic	1	1	1	Negative Genetic
GPI1	YGR216C	Membrane protein involved in the synthesis of GlcNAc-PI	genetic	1	1	1	Synthetic Lethality
ITR2	YOL103W	Myo-inositol transporter	physical	1	1	1	PCA
ALK2	YBL009W	Atypical protein kinase	physical	1	1	1	PCA
MPM1	YJL066C	Mitochondrial intermembrane space protein of unknown function	physical	1	1	1	Affinity Capture-MS
PHO5	YBR093C	Repressible acid phosphatase	genetic	1	1	1	Dosage Growth Defect
ROM1	YGR070W	Guanine nucleotide exchange factor (GEF) for Rho1p	physical	1	1	1	Affinity Capture-MS
GCV1	YDR019C	T subunit of the mitochondrial glycine decarboxylase complex	genetic	1	1	1	Positive Genetic
EMC2	YJR088C	Member of conserved ER transmembrane complex	genetic	1	1	1	Negative Genetic
PXP2	YJR111C	Peroxisomal matrix protein with naturally active promoter	genetic	1	1	1	Dosage Growth Defect
RRG9	YNL213C	Protein of unknown function	genetic	1	1	1	Negative Genetic
QRI5	YLR204W	Mitochondrial inner membrane protein	physical	1	1	1	PCA
RPS28B	YLR264W	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
LRE1	YCL051W	Protein involved in control of cell wall structure and stress response	genetic	1	1	1	Negative Genetic
PPM1	YDR435C	Carboxyl methyltransferase	genetic	1	1	1	Negative Genetic
ALP1	YNL270C	Arginine transporter	genetic	1	1	1	Negative Genetic
MLO50	YLR049C	Mitochondrial protein of unknown function	genetic	1	1	1	Dosage Growth Defect
RSF2	YJR127C	Zinc-finger protein	physical	1	1	1	PCA
FLO10	YKR102W	Member of the FLO family of cell wall flocculation proteins	genetic	1	1	1	Dosage Growth Defect
KCH1	YJR054W	Potassium transporter that mediates K+ influx	genetic	1	1	1	Dosage Growth Defect
CAX4	YGR036C	Dolichyl pyrophosphate (Dol-P-P) phosphatase	genetic	1	1	1	Negative Genetic
GRE1	YPL223C	Hydrophilin essential in desiccation-rehydration process	physical	1	1	1	PCA
RTS2	YOR077W	Basic zinc-finger protein	physical	1	1	1	PCA
MNE1	YOR350C	Protein involved in splicing Group I aI5-beta intron from COX1 mRNA	physical	1	1	1	PCA
PAU23	YLR037C	Cell wall mannoprotein	physical	1	1	1	PCA
SEC59	YMR013C	Dolichol kinase	genetic	1	1	1	Negative Genetic
ECM8	YBR076W	Non-essential protein of unknown function	genetic	1	1	1	Negative Genetic
PAU21	YOR394W	Protein of unknown function	genetic	1	1	1	Dosage Growth Defect
SHH3	YMR118C	Putative mitochondrial inner membrane protein of unknown function	genetic	1	1	1	Negative Genetic