GEnome-wide tool for Multi-scale Modeling
data Extraction and Representation
for Saccharomyces cerevisiae

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.

Standard name	Systematic name	Name description	Type	#Experiments	#Methods	#Publications	Evidence
SRS2	YJL092W	DNA helicase and DNA-dependent ATPase	genetic	44	6	38	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Dosage Rescue, Negative Genetic, Negative Genetic, Synthetic Lethality, Dosage Rescue, Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Negative Genetic, Negative Genetic
EXO1	YOR033C	5'-3' exonuclease and flap-endonuclease	genetic	37	7	34	Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
SAE2	YGL175C	Endonuclease required for telomere elongation	genetic	32	6	25	Synthetic Lethality, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
RAD51	YER095W	Strand exchange protein	genetic	31	5	30	Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Positive Genetic, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Positive Genetic, Positive Genetic
MUS81	YDR386W	Subunit of structure-specific Mms4p-Mus81p endonuclease	genetic	30	5	24	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic
MMS4	YBR098W	Subunit of structure-specific Mms4p-Mus81p endonuclease	genetic	29	4	25	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement
SLX4	YLR135W	Endonuclease involved in processing DNA	genetic	28	4	23	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality
TOP3	YLR234W	DNA Topoisomerase III	genetic	27	7	24	Dosage Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Growth Defect, Synthetic Rescue, Phenotypic Suppression, Dosage Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Positive Genetic
RAD52	YML032C	Protein involved in homologous recombination	genetic	23	6	18	Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Phenotypic Suppression, Positive Genetic, Phenotypic Suppression, Positive Genetic
POL32	YJR043C	Third subunit of DNA polymerase delta	genetic	21	5	16	Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Negative Genetic
TOP3	YLR234W	DNA Topoisomerase III	physical	21	5	15	Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-fractionation, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
MRE11	YMR224C	Nuclease subunit of the MRX complex with Rad50p and Xrs2p	genetic	20	6	18	Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic
TOP1	YOL006C	Topoisomerase I	genetic	20	4	16	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RRM3	YHR031C	DNA helicase involved in rDNA replication and Ty1 transposition	genetic	20	4	16	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RTT107	YHR154W	BRCA1 C-terminal domain protein needed for recovery from DNA damage	genetic	19	4	14	Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
SLX5	YDL013W	Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex	genetic	18	3	17	Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic
ELG1	YOR144C	Subunit of an alternative replication factor C complex	genetic	17	6	13	Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Suppression, Negative Genetic
WSS1	YHR134W	SUMO-ligase and SUMO-targeted metalloprotease	genetic	16	6	13	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic
ESC2	YDR363W	Sumo-like domain protein	genetic	16	4	12	Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic
RAD27	YKL113C	5' to 3' exonuclease, 5' flap endonuclease	genetic	16	4	10	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
SLX8	YER116C	Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex	genetic	15	2	13	Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
MRC1	YCL061C	S-phase checkpoint protein required for DNA replication	genetic	15	4	12	Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic
SLX1	YBR228W	Endonuclease involved in DNA recombination and repair	genetic	15	3	12	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
RAD9	YDR217C	DNA damage-dependent checkpoint protein	genetic	15	4	10	Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect
RNH202	YDR279W	Ribonuclease H2 subunit	genetic	14	4	11	Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic
CSM3	YMR048W	Replication fork associated factor	genetic	14	3	11	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DIA2	YOR080W	Origin-binding F-box protein	genetic	13	5	9	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
HST3	YOR025W	Sirtuin, histone H3 deacetylase	genetic	13	4	9	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
ASF1	YJL115W	Nucleosome assembly factor	genetic	12	5	10	Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Positive Genetic
MPH1	YIR002C	3'-5' DNA helicase involved in error-free bypass of DNA lesions	genetic	11	4	10	Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement
RMI1	YPL024W	Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex	genetic	11	4	10	Synthetic Rescue, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Positive Genetic
TSA1	YML028W	Thioredoxin peroxidase	genetic	11	3	9	Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic
VID22	YLR373C	G-quadruplex (G4) DNA binding protein	genetic	11	3	9	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
RNH203	YLR154C	Ribonuclease H2 subunit	genetic	11	3	8	Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic
RAD5	YLR032W	DNA helicase/Ubiquitin ligase	genetic	10	5	10	Synthetic Growth Defect, Phenotypic Suppression, Positive Genetic, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Dosage Lethality, Positive Genetic
SHU1	YHL006C	Component of Shu complex (aka PCSS complex)	genetic	10	4	9	Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic, Synthetic Rescue, Positive Genetic, Phenotypic Suppression, Positive Genetic, Positive Genetic
RAD57	YDR004W	Protein that stimulates strand exchange	genetic	10	4	9	Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Phenotypic Suppression, Phenotypic Enhancement, Positive Genetic, Positive Genetic, Positive Genetic
RAD24	YER173W	Checkpoint protein	genetic	10	3	9	Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression
YKU70	YMR284W	Subunit of the telomeric Ku complex (Yku70p-Yku80p)	genetic	10	6	8	Synthetic Lethality, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression
RAD54	YGL163C	DNA-dependent ATPase that stimulates strand exchange	genetic	10	4	8	Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Positive Genetic, Positive Genetic, Positive Genetic
RNH201	YNL072W	Ribonuclease H2 catalytic subunit	genetic	10	4	8	Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Positive Genetic, Negative Genetic
SMC6	YLR383W	Subunit of the SMC5-SMC6 complex	genetic	9	4	8	Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DNA2	YHR164C	ATP-dependent 5'-flap endonuclease and DNA helicase	genetic	9	3	8	Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic
DUN1	YDL101C	Cell-cycle checkpoint S/T protein kinase	genetic	9	3	8	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
RAD50	YNL250W	Subunit of MRX complex with Mre11p and Xrs2p	genetic	9	3	8	Synthetic Lethality, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
TEL1	YBL088C	Protein kinase primarily involved in telomere length regulation	genetic	9	5	6	Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Positive Genetic, Negative Genetic
RAD1	YPL022W	Single-stranded DNA endonuclease (with Rad10p)	genetic	8	4	8	Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic
SEN1	YLR430W	ATP-dependent 5' to 3' RNA/DNA and DNA helicase	genetic	8	4	7	Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
SMT3	YDR510W	Ubiquitin-like protein of the SUMO family	genetic	8	4	7	Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic
RAD55	YDR076W	Protein that stimulates strand exchange	genetic	8	3	7	Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Phenotypic Enhancement, Positive Genetic, Positive Genetic
PIF1	YML061C	DNA helicase, potent G-quadruplex DNA binder/unwinder	genetic	8	6	6	Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Dosage Lethality, Phenotypic Enhancement, Dosage Growth Defect, Phenotypic Suppression
RMI1	YPL024W	Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex	physical	8	4	4	Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Co-fractionation, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
MGS1	YNL218W	Protein with DNA-dependent ATPase and ssDNA annealing activities	genetic	7	4	7	Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
MMS1	YPR164W	Subunit of E3 ubiquitin ligase complex involved in replication repair	genetic	7	4	7	Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic
SHU2	YDR078C	Component of Shu complex (aka PCSS complex)	genetic	7	3	7	Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Positive Genetic
CSM2	YIL132C	Subunit of the Shu complex (aka PCSS complex)	genetic	7	3	7	Synthetic Rescue, Phenotypic Suppression, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Positive Genetic
PSY3	YLR376C	Component of Shu complex (aka PCSS complex)	genetic	7	3	7	Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Positive Genetic, Positive Genetic
MMS2	YGL087C	Ubiquitin-conjugating enzyme variant	genetic	7	4	6	Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Positive Genetic
UBC4	YBR082C	Ubiquitin-conjugating enzyme (E2)	genetic	7	3	6	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Negative Genetic
CDC7	YDL017W	S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase)	genetic	7	3	6	Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic
CDC48	YDL126C	AAA ATPase with protein-unfoldase activity	genetic	7	4	5	Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Positive Genetic
ULS1	YOR191W	Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL)	genetic	7	4	5	Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Dosage Growth Defect, Synthetic Rescue, Negative Genetic
CTF18	YMR078C	Subunit of a complex with Ctf8p	genetic	7	5	4	Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Positive Genetic, Negative Genetic
RFA1	YAR007C	Subunit of heterotrimeric Replication Protein A (RPA)	physical	7	3	4	Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western
MEC1	YBR136W	Genome integrity checkpoint protein and PI kinase superfamily member	genetic	6	3	6	Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect
MEC3	YLR288C	DNA damage and meiotic pachytene checkpoint protein	genetic	6	3	6	Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression
RAD17	YOR368W	Checkpoint protein	genetic	6	2	6	Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement
CDC13	YDL220C	Single stranded DNA-binding protein found at TG1-3 telomere G-tails	genetic	6	5	5	Dosage Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Positive Genetic
RAD18	YCR066W	E3 ubiquitin ligase	genetic	6	4	5	Phenotypic Enhancement, Phenotypic Enhancement, Positive Genetic, Phenotypic Suppression, Negative Genetic, Positive Genetic
ESA1	YOR244W	Catalytic subunit of the histone acetyltransferase complex (NuA4)	genetic	6	3	5	Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
TOF1	YNL273W	Subunit of a replication-pausing checkpoint complex	genetic	6	3	5	Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
CDC8	YJR057W	Nucleoside monophosphate and nucleoside diphosphate kinase	genetic	6	3	5	Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
POL1	YNL102W	Catalytic subunit of the DNA polymerase I alpha-primase complex	genetic	6	4	4	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Positive Genetic
NSE4	YDL105W	Component of the SMC5-SMC6 complex	genetic	6	3	4	Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Positive Genetic
MLH1	YMR167W	Protein required for mismatch repair in mitosis and meiosis	physical	6	3	4	Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Protein-peptide
SLX9	YGR081C	Protein required for pre-rRNA processing	genetic	6	3	4	Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Rescue, Negative Genetic, Positive Genetic
RAD53	YPL153C	DNA damage response kinase	genetic	5	5	5	Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression, Synthetic Rescue
CDC5	YMR001C	Polo-like kinase required for mitotic exit	genetic	5	4	5	Negative Genetic, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
DPB11	YJL090C	DNA replication initiation protein	genetic	5	4	5	Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Positive Genetic, Synthetic Rescue
FUN30	YAL019W	Snf2p family member with ATP-dependent chromatin remodeling activity	genetic	5	3	5	Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
SMC5	YOL034W	Subunit of the SMC5-SMC6 complex	genetic	5	3	5	Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression
MMS21	YEL019C	Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex	genetic	5	4	4	Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect
NSE1	YLR007W	Component of the SMC5-SMC6 complex	genetic	5	3	4	Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic
DBF4	YDR052C	Regulatory subunit of Cdc7p-Dbf4p kinase complex	genetic	5	3	4	Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic
POB3	YML069W	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p)	genetic	5	2	4	Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
XRS2	YDR369C	FHA domain-containing component of the Mre11 complex	genetic	5	2	4	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
CDC37	YDR168W	Essential Hsp90p co-chaperone	genetic	5	2	4	Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
CTF4	YPR135W	Chromatin-associated protein	genetic	5	2	4	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
POL3	YDL102W	Catalytic subunit of DNA polymerase delta	genetic	5	2	4	Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic
DCC1	YCL016C	Subunit of a complex with Ctf8p and Ctf18p	genetic	5	2	4	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
HRQ1	YDR291W	3'-5' DNA helicase of the conserved RecQ family	genetic	5	5	3	Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality, Synthetic Rescue, Negative Genetic
RAD53	YPL153C	DNA damage response kinase	physical	5	3	3	Co-localization, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western
MSH2	YOL090W	Protein that binds to DNA mismatches	genetic	4	4	4	Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic
SIZ1	YDR409W	SUMO E3 ligase	genetic	4	4	4	Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
DPM1	YPR183W	Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane	genetic	4	4	4	Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Positive Genetic
RAD59	YDL059C	Protein involved DNA double-strand break repair	genetic	4	3	4	Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic
NUP133	YKR082W	Subunit of Nup84p subcomplex of nuclear pore complex (NPC)	genetic	4	3	4	Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
FOB1	YDR110W	Nucleolar protein that binds the rDNA replication fork barrier site	genetic	4	3	4	Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Negative Genetic
CST9	YLR394W	SUMO E3 ligase	genetic	4	2	4	Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Negative Genetic
PRI1	YIR008C	Subunit of DNA primase	genetic	4	2	4	Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic
EST2	YLR318W	Reverse transcriptase subunit of the telomerase holoenzyme	genetic	4	2	4	Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement
SOD1	YJR104C	Cytosolic copper-zinc superoxide dismutase	genetic	4	1	4	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
APC5	YOR249C	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C)	genetic	4	4	3	Synthetic Lethality, Phenotypic Enhancement, Positive Genetic, Negative Genetic
DDC1	YPL194W	DNA damage checkpoint protein	genetic	4	3	3	Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression
NUP170	YBL079W	Subunit of inner ring of nuclear pore complex (NPC)	genetic	4	3	3	Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic, Negative Genetic
CCS1	YMR038C	Copper chaperone for superoxide dismutase Sod1p	genetic	4	3	3	Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
POL31	YJR006W	Subunit of DNA polymerase delta (polymerase III)	genetic	4	3	3	Synthetic Lethality, Negative Genetic, Negative Genetic, Positive Genetic
DFR1	YOR236W	Dihydrofolate reductase involved in tetrahydrofolate biosynthesis	genetic	4	3	3	Synthetic Lethality, Negative Genetic, Negative Genetic, Positive Genetic
NSE3	YDR288W	Component of the SMC5-SMC6 complex	genetic	4	2	3	Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic
CDC23	YHR166C	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C)	genetic	4	2	3	Positive Genetic, Positive Genetic, Negative Genetic, Positive Genetic
SMT3	YDR510W	Ubiquitin-like protein of the SUMO family	physical	4	2	3	Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex
MRE11	YMR224C	Nuclease subunit of the MRX complex with Rad50p and Xrs2p	physical	4	2	3	Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid
CSM1	YCR086W	Nucleolar protein that mediates homolog segregation during meiosis I	genetic	4	2	3	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
POL12	YBL035C	B subunit of DNA polymerase alpha-primase complex	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PRI2	YKL045W	Subunit of DNA primase	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NSE5	YML023C	Component of the SMC5-SMC6 complex	genetic	4	2	2	Negative Genetic, Negative Genetic, Positive Genetic, Negative Genetic
RPB3	YIL021W	RNA polymerase II third largest subunit B44	genetic	3	3	3	Synthetic Lethality, Positive Genetic, Negative Genetic
LST8	YNL006W	Protein required for the transport of Gap1p	genetic	3	3	3	Synthetic Lethality, Negative Genetic, Positive Genetic
MLH1	YMR167W	Protein required for mismatch repair in mitosis and meiosis	genetic	3	3	3	Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic
PCF11	YDR228C	mRNA 3' end processing factor	genetic	3	3	3	Synthetic Lethality, Phenotypic Enhancement, Negative Genetic
RFC1	YOR217W	Subunit of heteropentameric Replication factor C (RF-C)	genetic	3	3	3	Phenotypic Enhancement, Synthetic Lethality, Negative Genetic
MSH4	YFL003C	Protein involved in meiotic recombination	genetic	3	3	3	Phenotypic Suppression, Positive Genetic, Synthetic Rescue
SWE1	YJL187C	Protein kinase that regulates the G2/M transition	genetic	3	3	3	Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
SIS2	YKR072C	Negative regulatory subunit of protein phosphatase 1 (Ppz1p)	genetic	3	3	3	Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
YCG1	YDR325W	Subunit of the condensin complex	genetic	3	3	3	Synthetic Lethality, Phenotypic Enhancement, Positive Genetic
SRM1	YGL097W	Nucleotide exchange factor for Gsp1p	genetic	3	3	3	Synthetic Lethality, Phenotypic Enhancement, Positive Genetic
TAH11	YJR046W	DNA replication licensing factor	genetic	3	3	3	Synthetic Lethality, Phenotypic Enhancement, Positive Genetic
VTI1	YMR197C	Protein involved in cis-Golgi membrane traffic	genetic	3	3	3	Synthetic Lethality, Phenotypic Enhancement, Negative Genetic
SRB2	YHR041C	Subunit of the RNA polymerase II mediator complex	genetic	3	3	3	Synthetic Rescue, Phenotypic Enhancement, Negative Genetic
YEN1	YER041W	Holliday junction resolvase	genetic	3	3	3	Dosage Rescue, Synthetic Growth Defect, Phenotypic Suppression
POL30	YBR088C	Proliferating cell nuclear antigen (PCNA)	genetic	3	3	3	Negative Genetic, Synthetic Lethality, Phenotypic Enhancement
RTT109	YLL002W	Histone acetyltransferase	genetic	3	3	3	Phenotypic Enhancement, Synthetic Rescue, Negative Genetic
RPL24A	YGL031C	Ribosomal 60S subunit protein L24A	genetic	3	3	3	Synthetic Lethality, Synthetic Growth Defect, Positive Genetic
FLX1	YIL134W	Mitochondrial flavin adenine dinucleotide transporter	genetic	3	3	3	Synthetic Growth Defect, Negative Genetic, Positive Genetic
BRE1	YDL074C	E3 ubiquitin ligase	genetic	3	2	3	Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
LSM1	YJL124C	Lsm (Like Sm) protein	genetic	3	2	3	Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
ORC2	YBR060C	Subunit of the origin recognition complex (ORC)	genetic	3	2	3	Synthetic Lethality, Synthetic Lethality, Negative Genetic
HMO1	YDR174W	Chromatin associated high mobility group (HMG) family member	genetic	3	2	3	Synthetic Rescue, Negative Genetic, Negative Genetic
RFC5	YBR087W	Subunit of heteropentameric Replication factor C (RF-C)	genetic	3	2	3	Phenotypic Enhancement, Phenotypic Enhancement, Positive Genetic
NUP84	YDL116W	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC)	genetic	3	2	3	Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
CDC9	YDL164C	DNA ligase I found in nucleus and mitochondria	genetic	3	2	3	Negative Genetic, Phenotypic Enhancement, Negative Genetic
MLH3	YPL164C	Protein involved in DNA mismatch repair and meiotic recombination	genetic	3	2	3	Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement
SPH1	YLR313C	Protein involved in shmoo formation and bipolar bud site selection	genetic	3	2	3	Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
UME6	YDR207C	Rpd3L histone deacetylase complex subunit	genetic	3	2	3	Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
SPT2	YER161C	Protein involved in negative regulation of transcription	genetic	3	2	3	Negative Genetic, Phenotypic Enhancement, Negative Genetic
TOP2	YNL088W	Topoisomerase II	genetic	3	2	3	Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement
SGT1	YOR057W	Cochaperone protein	genetic	3	2	3	Synthetic Lethality, Positive Genetic, Positive Genetic
STN1	YDR082W	Telomere end-binding and capping protein	genetic	3	2	3	Positive Genetic, Phenotypic Enhancement, Positive Genetic
RLF2	YPR018W	Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1)	genetic	3	2	3	Phenotypic Enhancement, Phenotypic Enhancement, Positive Genetic
MCM10	YIL150C	Essential chromatin-associated protein	genetic	3	2	3	Negative Genetic, Phenotypic Enhancement, Negative Genetic
RRD1	YIL153W	Peptidyl-prolyl cis/trans-isomerase	genetic	3	2	3	Phenotypic Suppression, Phenotypic Suppression, Negative Genetic
SEC31	YDL195W	Component of the Sec13p-Sec31p complex of the COPII vesicle coat	genetic	3	2	3	Synthetic Lethality, Negative Genetic, Negative Genetic
CLA4	YNL298W	Cdc42p-activated signal transducing kinase	genetic	3	2	3	Synthetic Growth Defect, Negative Genetic, Negative Genetic
RTT101	YJL047C	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex	genetic	3	2	3	Synthetic Growth Defect, Negative Genetic, Negative Genetic
CDC73	YLR418C	Component of the Paf1p complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
BUD31	YCR063W	Component of the SF3b subcomplex of the U2 snRNP	genetic	3	1	3	Positive Genetic, Positive Genetic, Positive Genetic
HIR1	YBL008W	Subunit of the HIR complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
RAD2	YGR258C	Single-stranded DNA endonuclease	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
NSL1	YPL233W	Essential component of the MIND kinetochore complex	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
PSF1	YDR013W	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p)	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
PSF2	YJL072C	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p)	genetic	3	3	2	Synthetic Lethality, Negative Genetic, Positive Genetic
MAK21	YDR060W	Constituent of 66S pre-ribosomal particles	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
MFT1	YML062C	Subunit of the THO complex	genetic	3	3	2	Phenotypic Enhancement, Positive Genetic, Negative Genetic
MED4	YOR174W	Subunit of the RNA polymerase II mediator complex	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
ARP3	YJR065C	Essential component of the Arp2/3 complex	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
CDC24	YAL041W	Guanine nucleotide exchange factor (GEF) for Cdc42p	genetic	3	3	2	Synthetic Lethality, Negative Genetic, Positive Genetic
CDC28	YBR160W	Cyclin-dependent kinase (CDK) catalytic subunit	genetic	3	3	2	Phenotypic Enhancement, Negative Genetic, Positive Genetic
CDC11	YJR076C	Component of the septin ring that is required for cytokinesis	genetic	3	3	2	Synthetic Lethality, Negative Genetic, Positive Genetic
HRP1	YOL123W	Subunit of cleavage factor I	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
LCB1	YMR296C	Component of serine palmitoyltransferase	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
LCB2	YDR062W	Component of serine palmitoyltransferase	genetic	3	3	2	Synthetic Lethality, Negative Genetic, Positive Genetic
MAK5	YBR142W	Essential nucleolar protein	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
NHP10	YDL002C	Non-essential INO80 chromatin remodeling complex subunit	genetic	3	3	2	Synthetic Growth Defect, Positive Genetic, Negative Genetic
NUP60	YAR002W	FG-nucleoporin component of central core of the nuclear pore complex	genetic	3	3	2	Synthetic Growth Defect, Synthetic Rescue, Negative Genetic
PRP31	YGR091W	Splicing factor	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
PSE1	YMR308C	Karyopherin/importin that interacts with the nuclear pore complex	genetic	3	3	2	Synthetic Lethality, Negative Genetic, Positive Genetic
RFA1	YAR007C	Subunit of heterotrimeric Replication Protein A (RPA)	genetic	3	3	2	Phenotypic Enhancement, Synthetic Lethality, Phenotypic Suppression
MED8	YBR193C	Subunit of the RNA polymerase II mediator complex	genetic	3	3	2	Synthetic Lethality, Negative Genetic, Positive Genetic
SEC23	YPR181C	GTPase-activating protein, stimulates the GTPase activity of Sar1p	genetic	3	3	2	Phenotypic Enhancement, Positive Genetic, Negative Genetic
PRP18	YGR006W	Splicing factor and component of snRNP U5	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
EFB1	YAL003W	Translation elongation factor 1 beta	genetic	3	3	2	Synthetic Lethality, Negative Genetic, Positive Genetic
ASA1	YPR085C	Subunit of the ASTRA complex, involved in chromatin remodeling	genetic	3	3	2	Synthetic Lethality, Negative Genetic, Positive Genetic
HTB1	YDR224C	Histone H2B	genetic	3	3	2	Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement
STU2	YLR045C	Microtubule polymerase of the XMAP215/Dis1 family	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
TBF1	YPL128C	Telobox-containing general regulatory factor	genetic	3	3	2	Synthetic Growth Defect, Negative Genetic, Positive Genetic
TIM22	YDL217C	Essential core component of mitochondrial TIM22 complex	genetic	3	3	2	Synthetic Lethality, Negative Genetic, Positive Genetic
SMD1	YGR074W	Core Sm protein Sm D1	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
SMC3	YJL074C	Subunit of the multiprotein cohesin complex	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
SPC24	YMR117C	Component of the kinetochore-associated Ndc80 complex	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
CLB2	YPR119W	B-type cyclin involved in cell cycle progression	genetic	3	3	2	Synthetic Growth Defect, Phenotypic Suppression, Positive Genetic
MOB2	YFL034C-B	Activator of Cbk1p kinase	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
APN1	YKL114C	Major apurinic/apyrimidinic endonuclease	genetic	3	3	2	Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic
DBP5	YOR046C	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family	genetic	3	3	2	Synthetic Lethality, Negative Genetic, Positive Genetic
BBP1	YPL255W	Protein required for the spindle pole body (SPB) duplication	genetic	3	3	2	Synthetic Lethality, Negative Genetic, Positive Genetic
REV3	YPL167C	Catalytic subunit of DNA polymerase zeta	genetic	3	3	2	Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic
RRS1	YOR294W	Essential protein that binds ribosomal protein L11	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
SEC39	YLR440C	Component of the Dsl1p tethering complex	genetic	3	3	2	Phenotypic Enhancement, Positive Genetic, Negative Genetic
GPI13	YLL031C	ER membrane localized phosphoryltransferase	genetic	3	3	2	Synthetic Lethality, Negative Genetic, Positive Genetic
CDC1	YDR182W	Putative mannose-ethanolamine phosphate phosphodiesterase	genetic	3	3	2	Phenotypic Enhancement, Positive Genetic, Negative Genetic
RIB2	YOL066C	Bifunctional DRAP deaminase tRNA:pseudouridine synthase	genetic	3	3	2	Synthetic Lethality, Positive Genetic, Negative Genetic
CCR4	YAL021C	Component of the CCR4-NOT transcriptional complex	genetic	3	2	2	Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
ABD1	YBR236C	Methyltransferase	genetic	3	2	2	Positive Genetic, Positive Genetic, Negative Genetic
CIA2	YHR122W	Component of cytosolic iron-sulfur protein assembly (CIA) machinery	genetic	3	2	2	Negative Genetic, Negative Genetic, Positive Genetic
ACE2	YLR131C	Transcription factor required for septum destruction after cytokinesis	genetic	3	2	2	Positive Genetic, Negative Genetic, Positive Genetic
IRA2	YOL081W	GTPase-activating protein	genetic	3	2	2	Negative Genetic, Negative Genetic, Positive Genetic
SMC5	YOL034W	Subunit of the SMC5-SMC6 complex	physical	3	2	2	Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
ZRT1	YGL255W	High-affinity zinc transporter of the plasma membrane	genetic	3	2	2	Negative Genetic, Positive Genetic, Negative Genetic
TAF1	YGR274C	TFIID subunit, involved in RNA pol II transcription initiation	genetic	3	2	2	Negative Genetic, Positive Genetic, Negative Genetic
MMS22	YLR320W	Subunit of E3 ubiquitin ligase complex involved in replication repair	genetic	3	2	2	Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
OKP1	YGR179C	Outer kinetochore protein required for accurate chromosome segregation	genetic	3	2	2	Positive Genetic, Negative Genetic, Positive Genetic
PDC2	YDR081C	Transcription factor for thiamine-regulated genes	genetic	3	2	2	Negative Genetic, Negative Genetic, Positive Genetic
MRM2	YGL136C	Mitochondrial 2' O-ribose methyltransferase	genetic	3	2	2	Positive Genetic, Negative Genetic, Positive Genetic
KAP95	YLR347C	Karyopherin beta	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
POP2	YNR052C	Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation	genetic	3	1	2	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
SRS2	YJL092W	DNA helicase and DNA-dependent ATPase	physical	3	2	1	Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
FKH1	YIL131C	Forkhead family transcription factor	regulation	2	2	2	chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
ARP4	YJL081C	Nuclear actin-related protein involved in chromatin remodeling	genetic	2	2	2	Synthetic Lethality, Negative Genetic
BRX1	YOL077C	Nucleolar protein	genetic	2	2	2	Synthetic Lethality, Negative Genetic
NOP2	YNL061W	rRNA m5C methyltransferase	genetic	2	2	2	Synthetic Lethality, Negative Genetic
NOP7	YGR103W	Component of several different pre-ribosomal particles	genetic	2	2	2	Synthetic Lethality, Positive Genetic
RLP7	YNL002C	Nucleolar protein similar to large ribosomal subunit L7 proteins	genetic	2	2	2	Synthetic Lethality, Negative Genetic
PRP43	YGL120C	RNA helicase in the DEAH-box family	genetic	2	2	2	Synthetic Lethality, Positive Genetic
KRE29	YER038C	Subunit of the SMC5-SMC6 complex	genetic	2	2	2	Negative Genetic, Phenotypic Enhancement
NHP2	YDL208W	Protein related to mammalian high mobility group (HMG) proteins	genetic	2	2	2	Synthetic Lethality, Positive Genetic
PAT1	YCR077C	Deadenylation-dependent mRNA-decapping factor	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
RPC40	YPR110C	RNA polymerase subunit AC40	genetic	2	2	2	Synthetic Lethality, Negative Genetic
RRP42	YDL111C	Exosome non-catalytic core component	genetic	2	2	2	Synthetic Lethality, Positive Genetic
RPC25	YKL144C	RNA polymerase III subunit C25	genetic	2	2	2	Synthetic Lethality, Positive Genetic
RPA190	YOR341W	RNA polymerase I largest subunit A190	genetic	2	2	2	Synthetic Lethality, Positive Genetic
RPB7	YDR404C	RNA polymerase II subunit B16	genetic	2	2	2	Synthetic Lethality, Positive Genetic
HPR1	YDR138W	Subunit of THO/TREX complexes	genetic	2	2	2	Phenotypic Enhancement, Synthetic Growth Defect
RSC4	YKR008W	Component of the RSC chromatin remodeling complex	genetic	2	2	2	Synthetic Lethality, Positive Genetic
RSC58	YLR033W	Component of the RSC chromatin remodeling complex	genetic	2	2	2	Synthetic Lethality, Positive Genetic
PRP39	YML046W	U1 snRNP protein involved in splicing	genetic	2	2	2	Synthetic Lethality, Positive Genetic
RPN11	YFR004W	Metalloprotease subunit of 19S regulatory particle	genetic	2	2	2	Synthetic Lethality, Positive Genetic
RPN5	YDL147W	Subunit of the CSN and 26S proteasome lid complexes	genetic	2	2	2	Synthetic Lethality, Positive Genetic
RPN6	YDL097C	Essential, non-ATPase regulatory subunit of the 26S proteasome lid	genetic	2	2	2	Synthetic Lethality, Positive Genetic
PRT1	YOR361C	eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3)	genetic	2	2	2	Synthetic Lethality, Positive Genetic
PRE2	YPR103W	Beta 5 subunit of the 20S proteasome	genetic	2	2	2	Negative Genetic, Positive Genetic
RNT1	YMR239C	Nuclear dsRNA-specific ribonuclease (RNase III)	genetic	2	2	2	Synthetic Lethality, Negative Genetic
ARC15	YIL062C	Subunit of the ARP2/3 complex	genetic	2	2	2	Synthetic Lethality, Positive Genetic
ARP2	YDL029W	Essential component of the Arp2/3 complex	genetic	2	2	2	Synthetic Lethality, Positive Genetic
BET3	YKR068C	Core component of transport protein particle (TRAPP) complexes I-III	genetic	2	2	2	Synthetic Lethality, Positive Genetic
ASC1	YMR116C	G-protein beta subunit and guanine dissociation inhibitor for Gpa2p	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
CDC45	YLR103C	DNA replication initiation factor	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
ERG26	YGL001C	C-3 sterol dehydrogenase	genetic	2	2	2	Synthetic Lethality, Negative Genetic
SDA1	YGR245C	Protein required for actin organization and passage through Start	genetic	2	2	2	Synthetic Lethality, Positive Genetic
DCP2	YNL118C	Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex	genetic	2	2	2	Phenotypic Enhancement, Positive Genetic
DNA2	YHR164C	ATP-dependent 5'-flap endonuclease and DNA helicase	physical	2	2	2	Affinity Capture-Western, Two-hybrid
ERG13	YML126C	3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase	genetic	2	2	2	Synthetic Lethality, Positive Genetic
ESP1	YGR098C	Separase/separin, a caspase-like cysteine protease	genetic	2	2	2	Dosage Growth Defect, Positive Genetic
IRR1	YIL026C	Subunit of the cohesin complex	genetic	2	2	2	Synthetic Lethality, Positive Genetic
ISW2	YOR304W	ATP-dependent DNA translocase involved in chromatin remodeling	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
DIB1	YPR082C	17-kDa component of the U4/U6aU5 tri-snRNP	genetic	2	2	2	Synthetic Lethality, Positive Genetic
LUC7	YDL087C	Essential protein associated with the U1 snRNP complex	genetic	2	2	2	Synthetic Lethality, Positive Genetic
MCD1	YDL003W	Essential alpha-kleisin subunit of the cohesin complex	genetic	2	2	2	Phenotypic Suppression, Positive Genetic
MCM5	YLR274W	Component of the Mcm2-7 hexameric helicase complex	genetic	2	2	2	Synthetic Lethality, Phenotypic Enhancement
MED11	YMR112C	Subunit of the RNA polymerase II mediator complex	genetic	2	2	2	Positive Genetic, Negative Genetic
BUD3	YCL014W	Guanine nucleotide exchange factor (GEF) for Cdc42p	genetic	2	2	2	Synthetic Growth Defect, Positive Genetic
MSH6	YDR097C	Protein required for mismatch repair in mitosis and meiosis	physical	2	2	2	Affinity Capture-MS, Reconstituted Complex
HTZ1	YOL012C	Histone variant H2AZ	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
ARP8	YOR141C	Nuclear actin-related protein involved in chromatin remodeling	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
NUP159	YIL115C	FG-nucleoporin component of central core of the nuclear pore complex	genetic	2	2	2	Synthetic Lethality, Negative Genetic
AFG2	YLR397C	ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex	genetic	2	2	2	Synthetic Lethality, Negative Genetic
PPH3	YDR075W	Catalytic subunit of protein phosphatase PP4 complex	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
HTA1	YDR225W	Histone H2A	genetic	2	2	2	Phenotypic Suppression, Synthetic Growth Defect
PUB1	YNL016W	Poly (A)+ RNA-binding protein	genetic	2	2	2	Synthetic Lethality, Synthetic Growth Defect
RAD3	YER171W	5' to 3' DNA helicase	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
RAD51	YER095W	Strand exchange protein	physical	2	2	2	Two-hybrid, Reconstituted Complex
CSI1	YMR025W	Subunit of the Cop9 signalosome	genetic	2	2	2	Negative Genetic, Positive Genetic
NUP145	YGL092W	Essential protein with distinct roles in two nuclear pore subcomplexes	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
RET3	YPL010W	Zeta subunit of the coatomer complex (COPI)	genetic	2	2	2	Synthetic Lethality, Negative Genetic
SEC26	YDR238C	Essential beta-coat protein of the COPI coatomer	genetic	2	2	2	Synthetic Lethality, Phenotypic Enhancement
LTE1	YAL024C	Protein similar to GDP/GTP exchange factors	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
MCM2	YBL023C	Protein involved in DNA replication	genetic	2	2	2	Synthetic Lethality, Phenotypic Enhancement
BET5	YML077W	Core component of transport protein particle (TRAPP) complexes I-III	genetic	2	2	2	Synthetic Lethality, Positive Genetic
GET1	YGL020C	Subunit of the GET complex	genetic	2	2	2	Positive Genetic, Negative Genetic
DOP1	YDR141C	Protein involved in vesicular transport at trans-Golgi network (TGN)	genetic	2	2	2	Synthetic Lethality, Negative Genetic
UBC9	YDL064W	SUMO-conjugating enzyme involved in the Smt3p conjugation pathway	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
SPO13	YHR014W	Meiotic regulator	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
VIP1	YLR410W	Bifunctional inositol pyrophosphate kinase and phosphatase	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
SGV1	YPR161C	Cyclin (Bur2p)-dependent protein kinase	genetic	2	2	2	Negative Genetic, Positive Genetic
TDP1	YBR223C	Tyrosyl-DNA phosphodiesterase I	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
YKU80	YMR106C	Subunit of telomeric Ku complex (Yku70p-Yku80p)	genetic	2	2	2	Phenotypic Suppression, Positive Genetic
ULP2	YIL031W	Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins	genetic	2	2	2	Synthetic Rescue, Phenotypic Enhancement
TAF5	YBR198C	Subunit (90 kDa) of TFIID and SAGA complexes	genetic	2	2	2	Synthetic Lethality, Positive Genetic
TRS20	YBR254C	Core component of transport protein particle (TRAPP) complexes I-III	genetic	2	2	2	Synthetic Lethality, Positive Genetic
TFB1	YDR311W	Subunit of TFIIH and nucleotide excision repair factor 3 complexes	genetic	2	2	2	Synthetic Lethality, Positive Genetic
TFB3	YDR460W	Subunit of TFIIH and nucleotide excision repair factor 3 complexes	genetic	2	2	2	Synthetic Lethality, Positive Genetic
SNM1	YDR478W	Ribonuclease MRP complex subunit	genetic	2	2	2	Synthetic Lethality, Positive Genetic
TUB2	YFL037W	Beta-tubulin	genetic	2	2	2	Synthetic Lethality, Negative Genetic
SNU71	YGR013W	Component of U1 snRNP required for mRNA splicing via spliceosome	genetic	2	2	2	Synthetic Lethality, Positive Genetic
UFD1	YGR048W	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase	genetic	2	2	2	Synthetic Lethality, Negative Genetic
SSL2	YIL143C	Component of RNA polymerase transcription factor TFIIH holoenzyme	genetic	2	2	2	Synthetic Lethality, Negative Genetic
SNU114	YKL173W	GTPase component of U5 snRNP involved in mRNA splicing via spliceosome	genetic	2	2	2	Synthetic Lethality, Positive Genetic
SPC34	YKR037C	Essential subunit of the Dam1 complex (aka DASH complex)	genetic	2	2	2	Synthetic Lethality, Positive Genetic
SPC3	YLR066W	Subunit of signal peptidase complex	genetic	2	2	2	Synthetic Lethality, Negative Genetic
TUB4	YLR212C	Gamma-tubulin	genetic	2	2	2	Synthetic Lethality, Positive Genetic
UTP13	YLR222C	Nucleolar protein	genetic	2	2	2	Synthetic Lethality, Positive Genetic
YCS4	YLR272C	Subunit of the condensin complex	genetic	2	2	2	Synthetic Lethality, Negative Genetic
STT4	YLR305C	Phosphatidylinositol-4-kinase	genetic	2	2	2	Synthetic Lethality, Positive Genetic
TAF4	YMR005W	TFIID subunit (48 kDa)	genetic	2	2	2	Synthetic Lethality, Positive Genetic
TAP42	YMR028W	Essential protein involved in the TOR signaling pathway	genetic	2	2	2	Synthetic Lethality, Negative Genetic
UTP15	YMR093W	Nucleolar protein	genetic	2	2	2	Synthetic Lethality, Negative Genetic
SRP1	YNL189W	Karyopherin alpha homolog	genetic	2	2	2	Synthetic Lethality, Negative Genetic
TPT1	YOL102C	tRNA 2'-phosphotransferase that catalyzes final step in tRNA splicing	genetic	2	2	2	Synthetic Lethality, Positive Genetic
YTM1	YOR272W	Ribosomal assembly factor and 66S pre-ribosomal particle constituent	genetic	2	2	2	Synthetic Lethality, Negative Genetic
ULP1	YPL020C	Protease that specifically cleaves Smt3p protein conjugates	genetic	2	2	2	Synthetic Lethality, Negative Genetic
TIF6	YPR016C	Constituent of 66S pre-ribosomal particles	genetic	2	2	2	Synthetic Lethality, Negative Genetic
UBC13	YDR092W	E2 ubiquitin-conjugating enzyme	genetic	2	2	2	Synthetic Rescue, Positive Genetic
SIC1	YLR079W	Cyclin-dependent kinase inhibitor (CKI)	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
UFE1	YOR075W	t-SNARE protein required for retrograde vesicular traffic	genetic	2	2	2	Phenotypic Enhancement, Positive Genetic
SLY1	YDR189W	Hydrophilic protein involved in ER/Golgi vesicle trafficking	genetic	2	2	2	Phenotypic Enhancement, Positive Genetic
THP2	YHR167W	Subunit of the THO and TREX complexes	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
SLT2	YHR030C	Serine/threonine MAP kinase	genetic	2	2	2	Negative Genetic, Positive Genetic
SUM1	YDR310C	Transcriptional repressor that regulates middle-sporulation genes	genetic	2	2	2	Positive Genetic, Negative Genetic
SNF5	YBR289W	Subunit of the SWI/SNF chromatin remodeling complex	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
IPA1	YJR141W	Protein implicated in pre-mRNA processing and proteasomal degradation	genetic	2	2	2	Synthetic Lethality, Positive Genetic
GLE1	YDL207W	Cytoplasmic nucleoporin required for polyadenylated mRNA export	genetic	2	2	2	Synthetic Lethality, Positive Genetic
DNL4	YOR005C	DNA ligase required for nonhomologous end-joining (NHEJ)	genetic	2	2	2	Phenotypic Suppression, Negative Genetic
FAL1	YDR021W	Nucleolar protein required for maturation of 18S rRNA	genetic	2	2	2	Synthetic Lethality, Positive Genetic
MCM4	YPR019W	Essential helicase component of heterohexameric MCM2-7 complexes	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
IST3	YIR005W	Component of the U2 snRNP	genetic	2	2	2	Phenotypic Enhancement, Positive Genetic
FCF1	YDR339C	PINc domain endonuclease	genetic	2	2	2	Synthetic Lethality, Negative Genetic
DHR2	YKL078W	Predominantly nucleolar DEAH-box ATP-dependent RNA helicase	genetic	2	2	2	Synthetic Lethality, Negative Genetic
CTK3	YML112W	Gamma subunit of C-terminal domain kinase I	genetic	2	2	2	Synthetic Rescue, Negative Genetic
PKC1	YBL105C	Protein serine/threonine kinase	genetic	2	2	2	Synthetic Lethality, Positive Genetic
SEC10	YLR166C	Essential 100kDa subunit of the exocyst complex	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
ASK1	YKL052C	Essential subunit of the Dam1 complex (aka DASH complex)	genetic	2	2	2	Synthetic Lethality, Positive Genetic
BOS1	YLR078C	v-SNARE (vesicle specific SNAP receptor)	genetic	2	2	2	Synthetic Lethality, Positive Genetic
GRC3	YLL035W	Polynucleotide kinase present on rDNA	genetic	2	2	2	Synthetic Lethality, Positive Genetic
NFI1	YOR156C	SUMO E3 ligase	genetic	2	2	2	Synthetic Lethality, Negative Genetic
CDC31	YOR257W	Calcium-binding component of the spindle pole body (SPB) half-bridge	genetic	2	2	2	Synthetic Lethality, Negative Genetic
SAC3	YDR159W	mRNA export factor	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
PRP2	YNR011C	RNA-dependent DExD/H-box ATPase	genetic	2	2	2	Synthetic Lethality, Positive Genetic
BRN1	YBL097W	Subunit of the condensin complex	genetic	2	2	2	Phenotypic Enhancement, Positive Genetic
CTF8	YHR191C	Subunit of a complex with Ctf18p	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
MCM3	YEL032W	Protein involved in DNA replication	genetic	2	2	2	Negative Genetic, Phenotypic Enhancement
PAN1	YIR006C	Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p	genetic	2	2	2	Synthetic Lethality, Negative Genetic
SEC6	YIL068C	Essential 88kDa subunit of the exocyst complex	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
SED5	YLR026C	cis-Golgi t-SNARE syntaxin	genetic	2	2	2	Synthetic Lethality, Positive Genetic
SEC16	YPL085W	COPII vesicle coat protein required for ER transport vesicle budding	genetic	2	2	2	Phenotypic Enhancement, Positive Genetic
SEC5	YDR166C	Essential 107kDa subunit of the exocyst complex	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
HSF1	YGL073W	Trimeric heat shock transcription factor	genetic	2	2	2	Synthetic Lethality, Negative Genetic
KAR2	YJL034W	ATPase involved in protein import into the ER	genetic	2	2	2	Synthetic Lethality, Negative Genetic
RRN7	YJL025W	Component of the core factor (CF) rDNA transcription factor complex	genetic	2	2	2	Synthetic Lethality, Positive Genetic
HFM1	YGL251C	Meiosis specific DNA helicase	genetic	2	2	2	Phenotypic Suppression, Positive Genetic
OTU1	YFL044C	Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p	genetic	2	2	2	Negative Genetic, Positive Genetic
PRP16	YKR086W	DEAH-box RNA helicase	genetic	2	2	2	Synthetic Lethality, Positive Genetic
SEN2	YLR105C	Subunit of the tRNA splicing endonuclease	genetic	2	2	2	Synthetic Lethality, Positive Genetic
PFY1	YOR122C	Profilin	genetic	2	2	2	Synthetic Lethality, Positive Genetic
MSL5	YLR116W	Component of commitment complex	genetic	2	2	2	Synthetic Lethality, Positive Genetic
DOM34	YNL001W	Protein that facilitates ribosomal subunit dissociation	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
PDS5	YMR076C	Cohesion maintenance factor	genetic	2	2	2	Synthetic Lethality, Positive Genetic
RPL16B	YNL069C	Ribosomal 60S subunit protein L16B	genetic	2	2	2	Phenotypic Enhancement, Positive Genetic
SEC8	YPR055W	Essential 121 kDa subunit of the exocyst complex	genetic	2	2	2	Phenotypic Enhancement, Positive Genetic
FTR1	YER145C	High affinity iron permease	genetic	2	2	2	Phenotypic Enhancement, Positive Genetic
SDO1	YLR022C	Guanine nucleotide exchange factor (GEF) for Ria1p	genetic	2	2	2	Synthetic Lethality, Positive Genetic
ROT1	YMR200W	Molecular chaperone involved in protein folding in ER	genetic	2	2	2	Synthetic Lethality, Negative Genetic
MRS2	YOR334W	Mitochondrial inner membrane Mg(2+) channel	genetic	2	2	2	Phenotypic Enhancement, Positive Genetic
ACL4	YDR161W	Specific assembly chaperone for ribosomal protein Rpl4a/Rpl4b	genetic	2	2	2	Synthetic Growth Defect, Positive Genetic
RTT107	YHR154W	BRCA1 C-terminal domain protein needed for recovery from DNA damage	physical	2	2	2	Two-hybrid, Affinity Capture-MS
CAB1	YDR531W	Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase	genetic	2	2	2	Synthetic Lethality, Positive Genetic
SCH9	YHR205W	AGC family protein kinase	genetic	2	2	2	Phenotypic Suppression, Negative Genetic
GPI19	YDR437W	Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI	genetic	2	2	2	Phenotypic Enhancement, Positive Genetic
RIF2	YLR453C	Protein that binds to the Rap1p C-terminus	genetic	2	2	2	Phenotypic Enhancement, Positive Genetic
ALG14	YBR070C	Component of UDP-GlcNAc transferase	genetic	2	2	2	Synthetic Lethality, Positive Genetic
RIB7	YBR153W	Diaminohydroxyphoshoribosylaminopyrimidine deaminase	genetic	2	2	2	Synthetic Lethality, Negative Genetic
RAM2	YKL019W	Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I	genetic	2	2	2	Synthetic Lethality, Negative Genetic
NSG2	YNL156C	Protein involved in regulation of sterol biosynthesis	genetic	2	2	2	Synthetic Growth Defect, Positive Genetic
GPI15	YNL038W	Protein involved in the synthesis of GlcNAc-PI	genetic	2	2	2	Synthetic Lethality, Positive Genetic
PUS2	YGL063W	Mitochondrial tRNA:pseudouridine synthase	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
NIT1	YIL164C	Nitrilase	genetic	2	2	2	Phenotypic Enhancement, Positive Genetic
PGA1	YNL158W	Essential component of GPI-mannosyltransferase II	genetic	2	2	2	Synthetic Lethality, Positive Genetic
RAT1	YOR048C	Nuclear 5' to 3' single-stranded RNA exonuclease	genetic	2	1	2	Negative Genetic, Negative Genetic
RPS4B	YHR203C	Protein component of the small (40S) ribosomal subunit	genetic	2	1	2	Negative Genetic, Negative Genetic
NPL3	YDR432W	RNA-binding protein	genetic	2	1	2	Synthetic Growth Defect, Synthetic Growth Defect
AAH1	YNL141W	Adenine deaminase (adenine aminohydrolase)	genetic	2	1	2	Positive Genetic, Positive Genetic
CTK1	YKL139W	Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I)	genetic	2	1	2	Negative Genetic, Negative Genetic
MAS1	YLR163C	Beta subunit of the mitochondrial processing protease (MPP)	genetic	2	1	2	Positive Genetic, Positive Genetic
MEC1	YBR136W	Genome integrity checkpoint protein and PI kinase superfamily member	physical	2	1	2	Biochemical Activity, Biochemical Activity
RET2	YFR051C	Delta subunit of the coatomer complex (COPI)	genetic	2	1	2	Positive Genetic, Positive Genetic
HIR3	YJR140C	Subunit of the HIR complex	genetic	2	1	2	Negative Genetic, Negative Genetic
UBC9	YDL064W	SUMO-conjugating enzyme involved in the Smt3p conjugation pathway	physical	2	1	2	Two-hybrid, Two-hybrid
URC2	YDR520C	Putative Zn(II)2Cys6 motif containing transcription factor	genetic	2	1	2	Synthetic Growth Defect, Synthetic Growth Defect
TPP1	YMR156C	DNA 3'-phosphatase	genetic	2	1	2	Negative Genetic, Negative Genetic
SPN1	YPR133C	Protein involved in RNA polymerase II transcription	genetic	2	1	2	Negative Genetic, Negative Genetic
SLM3	YDL033C	tRNA-specific 2-thiouridylase	genetic	2	1	2	Positive Genetic, Positive Genetic
SPO11	YHL022C	Meiosis-specific protein required for meiotic recombination	genetic	2	1	2	Phenotypic Suppression, Phenotypic Suppression
UPF3	YGR072W	Component of the nonsense-mediated mRNA decay (NMD) pathway	genetic	2	1	2	Negative Genetic, Negative Genetic
SPE2	YOL052C	S-adenosylmethionine decarboxylase	genetic	2	1	2	Positive Genetic, Positive Genetic
SPE1	YKL184W	Ornithine decarboxylase	genetic	2	1	2	Positive Genetic, Positive Genetic
SIN3	YOL004W	Component of both the Rpd3S and Rpd3L histone deacetylase complexes	genetic	2	1	2	Positive Genetic, Positive Genetic
MAG1	YER142C	3-methyl-adenine DNA glycosylase	genetic	2	1	2	Negative Genetic, Negative Genetic
RNR1	YER070W	Major isoform of large subunit of ribonucleotide-diphosphate reductase	genetic	2	1	2	Synthetic Lethality, Synthetic Lethality
MTF1	YMR228W	Mitochondrial RNA polymerase specificity factor	genetic	2	1	2	Synthetic Growth Defect, Synthetic Growth Defect
PBY1	YBR094W	Putative tubulin tyrosine ligase associated with P-bodies	genetic	2	1	2	Negative Genetic, Negative Genetic
CDC21	YOR074C	Thymidylate synthase	genetic	2	1	2	Negative Genetic, Negative Genetic
RTG1	YOL067C	Transcription factor (bHLH) involved in interorganelle communication	genetic	2	1	2	Positive Genetic, Positive Genetic
BUB1	YGR188C	Protein kinase involved in the cell cycle checkpoint into anaphase	genetic	2	1	2	Negative Genetic, Negative Genetic
EAF7	YNL136W	Subunit of the NuA4 histone acetyltransferase complex	genetic	2	1	2	Negative Genetic, Negative Genetic
PIH1	YHR034C	Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1)	genetic	2	1	2	Negative Genetic, Negative Genetic
AGP2	YBR132C	Plasma membrane regulator of polyamine and carnitine transport	genetic	2	1	2	Positive Genetic, Positive Genetic
NDT80	YHR124W	Meiosis-specific transcription factor	genetic	2	1	2	Phenotypic Enhancement, Phenotypic Enhancement
PGA3	YML125C	Putative cytochrome b5 reductase, localized to the plasma membrane	genetic	2	1	2	Negative Genetic, Negative Genetic
RPO21	YDL140C	RNA polymerase II largest subunit B220	genetic	2	2	1	Positive Genetic, Negative Genetic
EBP2	YKL172W	Required for 25S rRNA maturation and 60S ribosomal subunit assembly	genetic	2	2	1	Negative Genetic, Positive Genetic
RAX2	YLR084C	Protein required for the maintenance of bud site selection	genetic	2	2	1	Positive Genetic, Negative Genetic
PRP19	YLL036C	Splicing factor associated with the spliceosome	genetic	2	2	1	Negative Genetic, Positive Genetic
POP4	YBR257W	Subunit of both RNase MRP and nuclear RNase P	genetic	2	2	1	Negative Genetic, Positive Genetic
NTR2	YKR022C	Essential protein that forms a dimer with Ntr1p	genetic	2	2	1	Positive Genetic, Negative Genetic
HAP5	YOR358W	Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex	genetic	2	2	1	Negative Genetic, Positive Genetic
KEL3	YPL263C	Cytoplasmic protein of unknown function	genetic	2	2	1	Positive Genetic, Negative Genetic
DED1	YOR204W	ATP-dependent DEAD-box RNA helicase with strand-annealing activity	genetic	2	2	1	Positive Genetic, Negative Genetic
RPB5	YBR154C	RNA polymerase subunit ABC27	genetic	2	2	1	Negative Genetic, Positive Genetic
RPC34	YNR003C	RNA polymerase III subunit C34	genetic	2	2	1	Positive Genetic, Negative Genetic
MED7	YOL135C	Subunit of the RNA polymerase II mediator complex	genetic	2	2	1	Positive Genetic, Negative Genetic
NUT1	YGL151W	Component of the RNA polymerase II mediator complex	genetic	2	2	1	Negative Genetic, Positive Genetic
ARX1	YDR101C	Nuclear export factor for the ribosomal pre-60S subunit	genetic	2	2	1	Positive Genetic, Negative Genetic
REI1	YBR267W	Cytoplasmic pre-60S factor	genetic	2	2	1	Negative Genetic, Positive Genetic
RPG1	YBR079C	eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3)	genetic	2	2	1	Positive Genetic, Negative Genetic
ACT1	YFL039C	Actin, structural protein in cytoskeleton	genetic	2	2	1	Positive Genetic, Negative Genetic
CFT2	YLR115W	Subunit of the mRNA cleavage and polyadenlylation factor (CPF)	genetic	2	2	1	Negative Genetic, Positive Genetic
PRE10	YOR362C	Alpha 7 subunit of the 20S proteasome	genetic	2	2	1	Positive Genetic, Negative Genetic
NAM7	YMR080C	ATP-dependent RNA helicase of the SFI superfamily	genetic	2	2	1	Negative Genetic, Positive Genetic
ARO1	YDR127W	Pentafunctional arom protein	genetic	2	2	1	Negative Genetic, Positive Genetic
BEM1	YBR200W	Protein containing SH3-domains	genetic	2	2	1	Positive Genetic, Negative Genetic
CDC3	YLR314C	Component of the septin ring that is required for cytokinesis	genetic	2	2	1	Negative Genetic, Positive Genetic
NOG2	YNR053C	Putative GTPase	genetic	2	2	1	Positive Genetic, Negative Genetic
CEG1	YGL130W	Guanylyltransferase involved in mRNA 5' capping	genetic	2	2	1	Positive Genetic, Negative Genetic
CLP1	YOR250C	Component of the cleavage and polyadenylation factor I (CF I)	genetic	2	2	1	Negative Genetic, Positive Genetic
DOA1	YKL213C	WD-repeat protein involved in ubiquitin-mediated protein degradation	genetic	2	2	1	Positive Genetic, Negative Genetic
EMG1	YLR186W	Methyltransferase for rRNA	genetic	2	2	1	Positive Genetic, Negative Genetic
FKS1	YLR342W	Catalytic subunit of 1,3-beta-D-glucan synthase	genetic	2	2	1	Negative Genetic, Positive Genetic
HAP2	YGL237C	Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex	genetic	2	2	1	Positive Genetic, Negative Genetic
CRM1	YGR218W	Nuclear export factor, exportin	genetic	2	2	1	Positive Genetic, Negative Genetic
GLT1	YDL171C	NAD(+)-dependent glutamate synthase (GOGAT)	genetic	2	2	1	Negative Genetic, Positive Genetic
CSE2	YNR010W	Subunit of the RNA polymerase II mediator complex	genetic	2	2	1	Negative Genetic, Positive Genetic
MOT1	YPL082C	Essential protein involved in regulation of transcription	genetic	2	2	1	Positive Genetic, Negative Genetic
GIM3	YNL153C	Subunit of the heterohexameric cochaperone prefoldin complex	genetic	2	2	1	Positive Genetic, Negative Genetic
DAM1	YGR113W	Essential subunit of the Dam1 complex (aka DASH complex)	genetic	2	2	1	Positive Genetic, Negative Genetic
INO4	YOL108C	Transcription factor involved in phospholipid synthesis	genetic	2	2	1	Positive Genetic, Negative Genetic
BUD21	YOR078W	Component of small ribosomal subunit (SSU) processosome	genetic	2	2	1	Negative Genetic, Positive Genetic
RAD16	YBR114W	Nucleotide excision repair (NER) protein	physical	2	2	1	Affinity Capture-Western, Two-hybrid
PTI1	YGR156W	Essential component of CPF (cleavage and polyadenylation factor)	genetic	2	2	1	Positive Genetic, Negative Genetic
NUT2	YPR168W	Subunit of the RNA polymerase II mediator complex	genetic	2	2	1	Positive Genetic, Negative Genetic
RCO1	YMR075W	Essential component of the Rpd3S histone deacetylase complex	genetic	2	2	1	Positive Genetic, Negative Genetic
OPI1	YHL020C	Transcriptional regulator of a variety of genes	genetic	2	2	1	Negative Genetic, Positive Genetic
NUP85	YJR042W	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC)	genetic	2	2	1	Negative Genetic, Positive Genetic
SER3	YER081W	3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase	genetic	2	2	1	Positive Genetic, Negative Genetic
SET2	YJL168C	Histone methyltransferase with a role in transcriptional elongation	genetic	2	2	1	Negative Genetic, Positive Genetic
CDC25	YLR310C	Membrane bound guanine nucleotide exchange factor	genetic	2	2	1	Negative Genetic, Positive Genetic
SGF73	YGL066W	Subunit of DUBm module of SAGA and SLIK	genetic	2	2	1	Negative Genetic, Positive Genetic
HEM13	YDR044W	Coproporphyrinogen III oxidase	genetic	2	2	1	Positive Genetic, Negative Genetic
CAM1	YPL048W	One of two isoforms of the gamma subunit of eEF1B	genetic	2	2	1	Positive Genetic, Negative Genetic
RPT4	YOR259C	ATPase of the 19S regulatory particle of the 26S proteasome	genetic	2	2	1	Positive Genetic, Negative Genetic
GPP1	YIL053W	Constitutively expressed DL-glycerol-3-phosphate phosphatase	genetic	2	2	1	Positive Genetic, Negative Genetic
SDH2	YLL041C	Iron-sulfur protein subunit of succinate dehydrogenase	genetic	2	2	1	Negative Genetic, Positive Genetic
BUB2	YMR055C	Mitotic exit network regulator	genetic	2	2	1	Negative Genetic, Positive Genetic
GET2	YER083C	Subunit of the GET complex	genetic	2	2	1	Positive Genetic, Negative Genetic
COF1	YLL050C	Cofilin, involved in pH-dependent actin filament depolarization	genetic	2	2	1	Positive Genetic, Negative Genetic
CDC20	YGL116W	Activator of anaphase-promoting complex/cyclosome (APC/C)	genetic	2	2	1	Positive Genetic, Negative Genetic
VAM7	YGL212W	Vacuolar SNARE protein	genetic	2	2	1	Positive Genetic, Negative Genetic
UGA1	YGR019W	Gamma-aminobutyrate (GABA) transaminase	genetic	2	2	1	Positive Genetic, Negative Genetic
THR1	YHR025W	Homoserine kinase	genetic	2	2	1	Positive Genetic, Negative Genetic
YIL152W	YIL152W	Putative protein of unknown function	genetic	2	2	1	Positive Genetic, Negative Genetic
YJR120W	YJR120W	Protein of unknown function	genetic	2	2	1	Positive Genetic, Negative Genetic
YNL046W	YNL046W	Putative protein of unknown function	genetic	2	2	1	Positive Genetic, Negative Genetic
STE50	YCL032W	Adaptor protein for various signaling pathways	genetic	2	2	1	Negative Genetic, Positive Genetic
TAH1	YCR060W	Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1)	genetic	2	2	1	Negative Genetic, Positive Genetic
UBP1	YDL122W	Ubiquitin-specific protease	genetic	2	2	1	Negative Genetic, Positive Genetic
WWM1	YFL010C	WW domain containing protein of unknown function	genetic	2	2	1	Negative Genetic, Positive Genetic
SOD2	YHR008C	Mitochondrial manganese superoxide dismutase	genetic	2	2	1	Negative Genetic, Positive Genetic
SPO16	YHR153C	Meiosis-specific protein involved in synaptonemal complex assembly	genetic	2	2	1	Negative Genetic, Positive Genetic
YUR1	YJL139C	Mannosyltransferase involved in protein N-glycosylation	genetic	2	2	1	Negative Genetic, Positive Genetic
UTH1	YKR042W	Mitochondrial inner membrane protein	genetic	2	2	1	Negative Genetic, Positive Genetic
TDA1	YMR291W	Protein kinase of unknown cellular role	genetic	2	2	1	Negative Genetic, Positive Genetic
YDJ1	YNL064C	Type I HSP40 co-chaperone	genetic	2	2	1	Negative Genetic, Positive Genetic
TOM70	YNL121C	Component of the TOM (translocase of outer membrane) complex	genetic	2	2	1	Negative Genetic, Positive Genetic
YPR089W	YPR089W	Protein of unknown function	genetic	2	2	1	Negative Genetic, Positive Genetic
TVS1	YCR061W	Protein of unknown function	genetic	2	2	1	Positive Genetic, Negative Genetic
VAM6	YDL077C	Guanine nucleotide exchange factor for the GTPase Gtr1p	genetic	2	2	1	Negative Genetic, Positive Genetic
YTA7	YGR270W	Chromatin-binding ATPase that regulates histone gene expression	genetic	2	2	1	Negative Genetic, Positive Genetic
YIL060W	YIL060W	Mitochondrial protein of unknown function	genetic	2	2	1	Negative Genetic, Positive Genetic
SIR1	YKR101W	Protein involved in silencing at mating-type loci HML and HMR	genetic	2	2	1	Negative Genetic, Positive Genetic
TDA5	YLR426W	Putative protein of unknown function	genetic	2	2	1	Negative Genetic, Positive Genetic
SUB1	YMR039C	Transcriptional regulator	genetic	2	2	1	Negative Genetic, Positive Genetic
YNL050C	YNL050C	Putative protein of unknown function	genetic	2	2	1	Negative Genetic, Positive Genetic
VPS27	YNR006W	Endosomal protein that forms a complex with Hse1p	genetic	2	2	1	Negative Genetic, Positive Genetic
TRM7	YBR061C	2'-O-ribose methyltransferase	genetic	2	2	1	Positive Genetic, Negative Genetic
ZDS2	YML109W	Protein with a role in regulating Swe1p-dependent polarized growth	genetic	2	2	1	Positive Genetic, Negative Genetic
UBC11	YOR339C	Ubiquitin-conjugating enzyme	genetic	2	2	1	Positive Genetic, Negative Genetic
SPR3	YGR059W	Sporulation-specific homolog of the CDC3/10/11/12 family of genes	genetic	2	2	1	Negative Genetic, Positive Genetic
STP2	YHR006W	Transcription factor	genetic	2	2	1	Negative Genetic, Positive Genetic
TMA19	YKL056C	Protein that associates with ribosomes	genetic	2	2	1	Negative Genetic, Positive Genetic
SUR1	YPL057C	Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit	genetic	2	2	1	Negative Genetic, Positive Genetic
SNF4	YGL115W	Activating gamma subunit of the AMP-activated Snf1p kinase complex	genetic	2	2	1	Positive Genetic, Negative Genetic
VBA1	YMR088C	Permease of basic amino acids in the vacuolar membrane	genetic	2	2	1	Positive Genetic, Negative Genetic
SHE4	YOR035C	Protein containing a UCS (UNC-45/CRO1/SHE4) domain	genetic	2	2	1	Positive Genetic, Negative Genetic
YGR067C	YGR067C	Putative protein of unknown function	genetic	2	2	1	Positive Genetic, Negative Genetic
VPS51	YKR020W	Component of the GARP (Golgi-associated retrograde protein) complex	genetic	2	2	1	Positive Genetic, Negative Genetic
SPT15	YER148W	TATA-binding protein (TBP)	genetic	2	2	1	Negative Genetic, Positive Genetic
STU1	YBL034C	Microtubule plus-end-tracking non-motor protein	genetic	2	2	1	Positive Genetic, Negative Genetic
TAF12	YDR145W	Subunit (61/68 kDa) of TFIID and SAGA complexes	genetic	2	2	1	Positive Genetic, Negative Genetic
VPS21	YOR089C	Endosomal Rab family GTPase	genetic	2	2	1	Positive Genetic, Negative Genetic
SPC42	YKL042W	Central plaque component of spindle pole body (SPB)	genetic	2	2	1	Positive Genetic, Negative Genetic
TOR2	YKL203C	PIK-related protein kinase and rapamycin target	genetic	2	2	1	Positive Genetic, Negative Genetic
SSL1	YLR005W	Subunit of the core form of RNA polymerase transcription factor TFIIH	genetic	2	2	1	Positive Genetic, Negative Genetic
YHC1	YLR298C	Component of the U1 snRNP complex required for pre-mRNA splicing	genetic	2	2	1	Positive Genetic, Negative Genetic
SPT5	YML010W	Spt4p/5p (DSIF) transcription elongation factor complex subunit	genetic	2	2	1	Positive Genetic, Negative Genetic
SPC97	YHR172W	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex	genetic	2	2	1	Negative Genetic, Positive Genetic
SNP1	YIL061C	Component of U1 snRNP required for mRNA splicing via spliceosome	genetic	2	2	1	Negative Genetic, Positive Genetic
STH1	YIL126W	ATPase component of the RSC chromatin remodeling complex	genetic	2	2	1	Negative Genetic, Positive Genetic
YEF3	YLR249W	Translation elongation factor 3	genetic	2	2	1	Negative Genetic, Positive Genetic
TAF13	YML098W	TFIID subunit (19 kDa)	genetic	2	2	1	Negative Genetic, Positive Genetic
SUA7	YPR086W	Transcription factor TFIIB	genetic	2	2	1	Negative Genetic, Positive Genetic
UBA1	YKL210W	Ubiquitin activating enzyme (E1)	genetic	2	2	1	Positive Genetic, Negative Genetic
TAF11	YML015C	TFIID subunit (40 kDa)	genetic	2	2	1	Negative Genetic, Positive Genetic
YAH1	YPL252C	Ferredoxin of the mitochondrial matrix	genetic	2	2	1	Negative Genetic, Positive Genetic
UTP9	YHR196W	Nucleolar protein	genetic	2	2	1	Positive Genetic, Negative Genetic
THI80	YOR143C	Thiamine pyrophosphokinase	genetic	2	2	1	Positive Genetic, Negative Genetic
RVS167	YDR388W	Calmodulin-binding actin-associated protein	genetic	2	2	1	Positive Genetic, Negative Genetic
CDC4	YFL009W	F-box protein required for both the G1/S and G2/M phase transitions	genetic	2	2	1	Negative Genetic, Positive Genetic
CWC21	YDR482C	Protein involved in RNA splicing by the spliceosome	genetic	2	2	1	Negative Genetic, Positive Genetic
EPT1	YHR123W	sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase	genetic	2	2	1	Positive Genetic, Negative Genetic
HAP3	YBL021C	Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex	genetic	2	2	1	Positive Genetic, Negative Genetic
MAS2	YHR024C	Alpha subunit of the mitochondrial processing protease (MPP)	genetic	2	2	1	Positive Genetic, Negative Genetic
DBF2	YGR092W	Ser/Thr kinase involved in transcription and stress response	genetic	2	2	1	Negative Genetic, Positive Genetic
HOM2	YDR158W	Aspartic beta semi-aldehyde dehydrogenase	genetic	2	2	1	Positive Genetic, Negative Genetic
MDH3	YDL078C	Peroxisomal malate dehydrogenase	genetic	2	2	1	Negative Genetic, Positive Genetic
ERG11	YHR007C	Lanosterol 14-alpha-demethylase	genetic	2	2	1	Positive Genetic, Negative Genetic
INO2	YDR123C	Transcription factor	genetic	2	2	1	Negative Genetic, Positive Genetic
RAD4	YER162C	Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2	genetic	2	2	1	Positive Genetic, Negative Genetic
ELP4	YPL101W	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex	genetic	2	2	1	Positive Genetic, Negative Genetic
IPL1	YPL209C	Aurora kinase of chromosomal passenger complex	genetic	2	2	1	Positive Genetic, Negative Genetic
BRF1	YGR246C	TFIIIB B-related factor	genetic	2	2	1	Negative Genetic, Positive Genetic
RPL9B	YNL067W	Ribosomal 60S subunit protein L9B	genetic	2	2	1	Positive Genetic, Negative Genetic
BRE5	YNR051C	Ubiquitin protease cofactor	genetic	2	2	1	Negative Genetic, Positive Genetic
MSN2	YMR037C	Stress-responsive transcriptional activator	genetic	2	2	1	Positive Genetic, Negative Genetic
MCM1	YMR043W	Transcription factor	genetic	2	2	1	Negative Genetic, Positive Genetic
RPS9B	YBR189W	Protein component of the small (40S) ribosomal subunit	genetic	2	2	1	Positive Genetic, Negative Genetic
MPS1	YDL028C	Dual-specificity kinase	genetic	2	2	1	Positive Genetic, Negative Genetic
CBF2	YGR140W	Essential kinetochore protein	genetic	2	2	1	Positive Genetic, Negative Genetic
SEC61	YLR378C	Conserved ER protein translocation channel	genetic	2	2	1	Positive Genetic, Negative Genetic
SEC9	YGR009C	t-SNARE protein required for secretory vesicle-plasma membrane fusion	genetic	2	2	1	Negative Genetic, Positive Genetic
MPS2	YGL075C	Essential membrane protein localized at nuclear envelope and SPBs	genetic	2	2	1	Negative Genetic, Positive Genetic
CCZ1	YBR131W	Subunit of a heterodimeric guanine nucleotide exchange factor (GEF)	genetic	2	2	1	Positive Genetic, Negative Genetic
MOB1	YIL106W	Component of the mitotic exit network	genetic	2	2	1	Positive Genetic, Negative Genetic
BUD6	YLR319C	Actin- and formin-interacting protein	genetic	2	2	1	Positive Genetic, Negative Genetic
CMR2	YOR093C	Putative protein of unknown function	genetic	2	2	1	Positive Genetic, Negative Genetic
ATP10	YLR393W	Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase	genetic	2	2	1	Positive Genetic, Negative Genetic
ENT2	YLR206W	Epsin-like protein required for endocytosis and actin patch assembly	genetic	2	2	1	Negative Genetic, Positive Genetic
NUP188	YML103C	Subunit of the inner ring of the nuclear pore complex (NPC)	genetic	2	2	1	Positive Genetic, Negative Genetic
DBP6	YNR038W	Essential protein involved in ribosome biogenesis	genetic	2	2	1	Positive Genetic, Negative Genetic
GAB1	YLR459W	Subunit of the glycosylphosphatidylinositol transamidase complex	genetic	2	2	1	Negative Genetic, Positive Genetic
FRA1	YLL029W	Protein involved in negative regulation of iron regulon transcription	genetic	2	2	1	Negative Genetic, Positive Genetic
CSF1	YLR087C	Protein with structural similarity to lipid transport protein Vps13p	genetic	2	2	1	Negative Genetic, Positive Genetic
BSC6	YOL137W	Protein of unknown function with 8 putative transmembrane segments	genetic	2	2	1	Positive Genetic, Negative Genetic
PEX1	YKL197C	AAA-peroxin	genetic	2	2	1	Positive Genetic, Negative Genetic
SCC4	YER147C	Subunit of cohesin loading factor (Scc2p-Scc4p)	genetic	2	2	1	Positive Genetic, Negative Genetic
GRX4	YER174C	Glutathione-dependent oxidoreductase and glutathione S-transferase	genetic	2	2	1	Negative Genetic, Positive Genetic
ARA2	YMR041C	NAD-dependent arabinose dehydrogenase	genetic	2	2	1	Positive Genetic, Negative Genetic
ETR1	YBR026C	2-enoyl thioester reductase	genetic	2	2	1	Negative Genetic, Positive Genetic
IZH3	YLR023C	Membrane protein involved in zinc ion homeostasis	genetic	2	2	1	Positive Genetic, Negative Genetic
OLE1	YGL055W	Delta(9) fatty acid desaturase	genetic	2	2	1	Positive Genetic, Negative Genetic
MBR1	YKL093W	Protein involved in mitochondrial functions and stress response	genetic	2	2	1	Negative Genetic, Positive Genetic
SAC1	YKL212W	Phosphatidylinositol phosphate phosphatase	genetic	2	2	1	Positive Genetic, Negative Genetic
PDR15	YDR406W	Plasma membrane ATP binding cassette (ABC) transporter	genetic	2	2	1	Negative Genetic, Positive Genetic
PKR1	YMR123W	V-ATPase assembly factor	genetic	2	2	1	Positive Genetic, Negative Genetic
KRE28	YDR532C	Subunit of a kinetochore-microtubule binding complex	genetic	2	2	1	Negative Genetic, Positive Genetic
MUB1	YMR100W	MYND domain-containing protein	genetic	2	2	1	Positive Genetic, Negative Genetic
RPL6B	YLR448W	Ribosomal 60S subunit protein L6B	genetic	2	2	1	Negative Genetic, Positive Genetic
DPH5	YLR172C	Methyltransferase required for synthesis of diphthamide	genetic	2	2	1	Positive Genetic, Negative Genetic
OCA5	YHL029C	Cytoplasmic protein required for replication of Brome mosaic virus	genetic	2	2	1	Positive Genetic, Negative Genetic
RPL26B	YGR034W	Ribosomal 60S subunit protein L26B	genetic	2	2	1	Negative Genetic, Positive Genetic
APJ1	YNL077W	Hsp40 chaperone with a role in SUMO-mediated protein degradation	genetic	2	2	1	Negative Genetic, Positive Genetic
ENT4	YLL038C	Protein of unknown function	genetic	2	2	1	Positive Genetic, Negative Genetic
RCI37	YIL077C	Protein that associates with the large mitoribosomal subunit	genetic	2	2	1	Negative Genetic, Positive Genetic
HUR1	YGL168W	Protein with a role in DNA repair	genetic	2	2	1	Negative Genetic, Positive Genetic
PCK1	YKR097W	Phosphoenolpyruvate carboxykinase	genetic	2	2	1	Negative Genetic, Positive Genetic
PDE1	YGL248W	Low-affinity cyclic AMP phosphodiesterase	genetic	2	2	1	Positive Genetic, Negative Genetic
MDM34	YGL219C	Mitochondrial component of the ERMES complex	genetic	2	2	1	Negative Genetic, Positive Genetic
CCW12	YLR110C	Cell wall mannoprotein	genetic	2	2	1	Positive Genetic, Negative Genetic
NIT3	YLR351C	Nit protein	genetic	2	2	1	Positive Genetic, Negative Genetic
BRR6	YGL247W	Essential nuclear envelope integral membrane protein	genetic	2	2	1	Negative Genetic, Positive Genetic
PHS1	YJL097W	Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane	genetic	2	2	1	Positive Genetic, Negative Genetic
DAK1	YML070W	Dihydroxyacetone kinase	genetic	2	2	1	Negative Genetic, Positive Genetic
MUP3	YHL036W	Low affinity methionine permease	genetic	2	2	1	Negative Genetic, Positive Genetic
QRI1	YDL103C	UDP-N-acetylglucosamine pyrophosphorylase	genetic	2	2	1	Positive Genetic, Negative Genetic
SAM37	YMR060C	Component of the Sorting and Assembly Machinery (SAM) complex	genetic	2	2	1	Negative Genetic, Positive Genetic
RPS6B	YBR181C	Protein component of the small (40S) ribosomal subunit	genetic	2	2	1	Positive Genetic, Negative Genetic
MTE1	YGR042W	Protein of unknown function	genetic	2	2	1	Synthetic Growth Defect, Phenotypic Suppression
GCV1	YDR019C	T subunit of the mitochondrial glycine decarboxylase complex	genetic	2	2	1	Negative Genetic, Positive Genetic
CIS1	YLR346C	Protein of unknown function found in mitochondria	genetic	2	2	1	Negative Genetic, Positive Genetic
LDH1	YBR204C	Serine hydrolase	genetic	2	2	1	Positive Genetic, Negative Genetic
PPM2	YOL141W	AdoMet-dependent tRNA methyltransferase	genetic	2	2	1	Positive Genetic, Negative Genetic
APQ12	YIL040W	Nuclear envelope/ER integral membrane protein	genetic	2	2	1	Positive Genetic, Negative Genetic
KCH1	YJR054W	Potassium transporter that mediates K+ influx	genetic	2	2	1	Negative Genetic, Positive Genetic
ARD1	YHR013C	Subunit of protein N-terminal acetyltransferase NatA	genetic	2	1	1	Synthetic Growth Defect, Synthetic Growth Defect
MSH2	YOL090W	Protein that binds to DNA mismatches	physical	2	1	1	Reconstituted Complex, Reconstituted Complex
LRS4	YDR439W	Nucleolar protein that forms a complex with Csm1p	genetic	2	1	1	Synthetic Growth Defect, Synthetic Growth Defect
GRE3	YHR104W	Aldose reductase	genetic	2	1	1	Positive Genetic, Positive Genetic
RTC3	YHR087W	Protein of unknown function involved in RNA metabolism	genetic	2	1	1	Negative Genetic, Negative Genetic
SPT10	YJL127C	Histone H3 acetylase with a role in transcriptional regulation	regulation	1	1	1	DNA to cDNA expression microarray evidence
FKH2	YNL068C	Forkhead family transcription factor	regulation	1	1	1	ChEC-Seq experiments
MED2	YDL005C	Subunit of the RNA polymerase II mediator complex	regulation	1	1	1	chromatin immunoprecipitation-chip evidence
TFC7	YOR110W	RNA pol III transcription initiation factor complex (TFIIIC) subunit	regulation	1	1	1	chromatin immunoprecipitation-chip evidence
REB1	YBR049C	RNA polymerase I enhancer binding protein	regulation	1	1	1	chromatin immunoprecipitation-chip evidence
MED4	YOR174W	Subunit of the RNA polymerase II mediator complex	regulation	1	1	1	chromatin immunoprecipitation-chip evidence
CEF1	YMR213W	Essential splicing factor	genetic	1	1	1	Negative Genetic
CLF1	YLR117C	Member of the NineTeen Complex (NTC)	genetic	1	1	1	Positive Genetic
CWC2	YDL209C	Member of the NineTeen Complex (NTC)	genetic	1	1	1	Positive Genetic
CWC25	YNL245C	Splicing factor required for the first step of pre-mRNA splicing	genetic	1	1	1	Synthetic Lethality
CTF19	YPL018W	Outer kinetochore protein, needed for accurate chromosome segregation	genetic	1	1	1	Negative Genetic
DSN1	YIR010W	Essential component of the outer kinetochore MIND complex	genetic	1	1	1	Positive Genetic
DED81	YHR019C	Cytosolic asparaginyl-tRNA synthetase	genetic	1	1	1	Positive Genetic
GWT1	YJL091C	Protein involved in the inositol acylation of GlcN-PI	genetic	1	1	1	Positive Genetic
AIM25	YJR100C	Mitochondria protein of unknown function	genetic	1	1	1	Positive Genetic
LEO1	YOR123C	Component of the Paf1 complex	genetic	1	1	1	Positive Genetic
MCM22	YJR135C	Outer kinetochore protein and component of the Ctf3 subcomplex	genetic	1	1	1	Positive Genetic
MTW1	YAL034W-A	Essential component of the MIND kinetochore complex	genetic	1	1	1	Positive Genetic
RTF1	YGL244W	Subunit of RNAPII-associated chromatin remodeling Paf1 complex	genetic	1	1	1	Positive Genetic
GLC7	YER133W	Type 1 S/T protein phosphatase (PP1) catalytic subunit	genetic	1	1	1	Positive Genetic
SDS22	YKL193C	Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p	genetic	1	1	1	Negative Genetic
IKI3	YLR384C	Subunit of Elongator complex	genetic	1	1	1	Positive Genetic
RVB2	YPL235W	ATP-dependent DNA helicase, also known as reptin	genetic	1	1	1	Negative Genetic
EAF1	YDR359C	Component of the NuA4 histone acetyltransferase complex	genetic	1	1	1	Synthetic Growth Defect
DBP9	YLR276C	DEAD-box protein required for 27S rRNA processing	genetic	1	1	1	Positive Genetic
HAS1	YMR290C	ATP-dependent RNA helicase	genetic	1	1	1	Positive Genetic
NIP7	YPL211W	Nucleolar protein required for 60S ribosome subunit biogenesis	genetic	1	1	1	Negative Genetic
NOG1	YPL093W	Putative GTPase	genetic	1	1	1	Negative Genetic
NOP4	YPL043W	Nucleolar protein	genetic	1	1	1	Synthetic Lethality
RPF1	YHR088W	Protein involved in assembly and export of the large ribosomal subunit	genetic	1	1	1	Negative Genetic
RPF2	YKR081C	Essential protein involved in rRNA maturation and ribosomal assembly	genetic	1	1	1	Positive Genetic
RPL16A	YIL133C	Ribosomal 60S subunit protein L16A	genetic	1	1	1	Positive Genetic
RPL32	YBL092W	Ribosomal 60S subunit protein L32	genetic	1	1	1	Synthetic Lethality
RPL38	YLR325C	Ribosomal 60S subunit protein L38	genetic	1	1	1	Positive Genetic
RRP1	YDR087C	Essential evolutionarily conserved nucleolar protein	genetic	1	1	1	Negative Genetic
IPI1	YHR085W	Component of the Rix1 complex and possibly pre-replicative complexes	genetic	1	1	1	Negative Genetic
PEX7	YDR142C	Peroxisomal signal receptor for peroxisomal matrix proteins	genetic	1	1	1	Negative Genetic
PLB1	YMR008C	Phospholipase B (lysophospholipase) involved in lipid metabolism	genetic	1	1	1	Positive Genetic
CAB3	YKL088W	Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis	genetic	1	1	1	Positive Genetic
ADH1	YOL086C	Alcohol dehydrogenase	genetic	1	1	1	Positive Genetic
NUC1	YJL208C	Major mitochondrial nuclease	genetic	1	1	1	Negative Genetic
PEX19	YDL065C	Chaperone and import receptor for newly-synthesized class I PMPs	genetic	1	1	1	Positive Genetic
PFK27	YOL136C	6-phosphofructo-2-kinase	genetic	1	1	1	Negative Genetic
POP3	YNL282W	Subunit of both RNase MRP and nuclear RNase P	genetic	1	1	1	Synthetic Lethality
POP5	YAL033W	Subunit of both RNase MRP and nuclear RNase P	genetic	1	1	1	Synthetic Lethality
RMP1	YLR145W	Subunit of RNase MRP	genetic	1	1	1	Positive Genetic
PRP45	YAL032C	Protein required for pre-mRNA splicing	physical	1	1	1	Two-hybrid
NOC3	YLR002C	Subunit of a nuclear complex with Noc2p and pre-replicative complexes	genetic	1	1	1	Negative Genetic
ARL1	YBR164C	Soluble GTPase with a role in regulation of membrane traffic	genetic	1	1	1	Positive Genetic
MRT4	YKL009W	Protein involved in mRNA turnover and ribosome assembly	genetic	1	1	1	Positive Genetic
CIC1	YHR052W	Essential protein that interacts with proteasome components	genetic	1	1	1	Negative Genetic
ARC1	YGL105W	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases	genetic	1	1	1	Positive Genetic
NOP58	YOR310C	Protein involved in producing mature rRNAs and snoRNAs	genetic	1	1	1	Synthetic Lethality
NOP56	YLR197W	Essential evolutionarily-conserved nucleolar protein	genetic	1	1	1	Positive Genetic
DBP7	YKR024C	Putative ATP-dependent RNA helicase of the DEAD-box family	genetic	1	1	1	Positive Genetic
RCK2	YLR248W	Protein kinase involved in response to oxidative and osmotic stress	genetic	1	1	1	Negative Genetic
SAP155	YFR040W	Protein required for function of the Sit4p protein phosphatase	genetic	1	1	1	Negative Genetic
SAP190	YKR028W	Protein that forms a complex with the Sit4p protein phosphatase	genetic	1	1	1	Negative Genetic
LSM3	YLR438C-A	Lsm (Like Sm) protein	genetic	1	1	1	Synthetic Lethality
LSM6	YDR378C	Lsm (Like Sm) protein	genetic	1	1	1	Positive Genetic
NOP1	YDL014W	Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus	genetic	1	1	1	Positive Genetic
CDC33	YOL139C	Translation initiation factor eIF4E	genetic	1	1	1	Positive Genetic
DIS3	YOL021C	Exosome core complex catalytic subunit	genetic	1	1	1	Negative Genetic
LRP1	YHR081W	Nuclear exosome-associated nucleic acid binding protein	genetic	1	1	1	Negative Genetic
RRP4	YHR069C	Exosome non-catalytic core component	genetic	1	1	1	Negative Genetic
RRP46	YGR095C	Exosome non-catalytic core component	genetic	1	1	1	Synthetic Lethality
RPA34	YJL148W	RNA polymerase I subunit A34.5	genetic	1	1	1	Negative Genetic
RPC17	YJL011C	RNA polymerase III subunit C17	genetic	1	1	1	Positive Genetic
RPA49	YNL248C	RNA polymerase I subunit A49	genetic	1	1	1	Synthetic Rescue
RPA43	YOR340C	RNA polymerase I subunit A43	genetic	1	1	1	Synthetic Lethality
RRB1	YMR131C	Specific assembly chaperone for ribosomal protein Rpl3p	genetic	1	1	1	Synthetic Lethality
CBC2	YPL178W	Small subunit of the heterodimeric cap binding complex with Sto1p	genetic	1	1	1	Positive Genetic
GCD11	YER025W	Gamma subunit of the translation initiation factor eIF2	genetic	1	1	1	Synthetic Lethality
ARP7	YPR034W	Component of both the SWI/SNF and RSC chromatin remodeling complexes	genetic	1	1	1	Positive Genetic
ARP9	YMR033W	Component of both the SWI/SNF and RSC chromatin remodeling complexes	genetic	1	1	1	Positive Genetic
RSC2	YLR357W	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Positive Genetic
RSC3	YDR303C	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Synthetic Lethality
RSC6	YCR052W	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Synthetic Lethality
RSC8	YFR037C	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Positive Genetic
RSC9	YML127W	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Positive Genetic
RTT102	YGR275W	Component of both the SWI/SNF and RSC chromatin remodeling complexes	genetic	1	1	1	Positive Genetic
RGR1	YLR071C	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Negative Genetic
MUD1	YBR119W	U1 snRNP A protein	genetic	1	1	1	Positive Genetic
DST1	YGL043W	General transcription elongation factor TFIIS	genetic	1	1	1	Negative Genetic
NOP12	YOL041C	Nucleolar protein involved in pre-25S rRNA processing	genetic	1	1	1	Negative Genetic
PWP1	YLR196W	Protein with WD-40 repeats involved in rRNA processing	genetic	1	1	1	Synthetic Lethality
RPN1	YHR027C	Non-ATPase base subunit of the 19S RP of the 26S proteasome	genetic	1	1	1	Positive Genetic
RPN10	YHR200W	Proteasome polyubiquitin receptor	genetic	1	1	1	Positive Genetic
RPN12	YFR052W	Subunit of the 19S regulatory particle of the 26S proteasome lid	genetic	1	1	1	Synthetic Lethality
RPN7	YPR108W	Essential non-ATPase regulatory subunit of the 26S proteasome	genetic	1	1	1	Synthetic Lethality
RPT1	YKL145W	ATPase of the 19S regulatory particle of the 26S proteasome	genetic	1	1	1	Positive Genetic
RPT6	YGL048C	ATPase of the 19S regulatory particle of the 26S proteasome	genetic	1	1	1	Positive Genetic
RPT3	YDR394W	ATPase of the 19S regulatory particle of the 26S proteasome	genetic	1	1	1	Positive Genetic
HCR1	YLR192C	eIF3j component of translation initiation factor 3 (eIF3)	genetic	1	1	1	Positive Genetic
GCD1	YOR260W	Gamma subunit of the translation initiation factor eIF2B	genetic	1	1	1	Positive Genetic
RLI1	YDR091C	Essential Fe-S protein	genetic	1	1	1	Positive Genetic
CFT1	YDR301W	RNA-binding subunit of the mRNA cleavage and polyadenylation factor	genetic	1	1	1	Synthetic Lethality
PTA1	YAL043C	Subunit of holo-CPF	genetic	1	1	1	Synthetic Lethality
IMD3	YLR432W	Inosine monophosphate dehydrogenase	genetic	1	1	1	Positive Genetic
RBG2	YGR173W	Protein with a role in translation	genetic	1	1	1	Positive Genetic
PRE6	YOL038W	Alpha 4 subunit of the 20S proteasome	genetic	1	1	1	Positive Genetic
PRE3	YJL001W	Beta 1 subunit of the 20S proteasome	genetic	1	1	1	Positive Genetic
PRE7	YBL041W	Beta 6 subunit of the 20S proteasome	genetic	1	1	1	Negative Genetic
ALA1	YOR335C	Cytoplasmic and mitochondrial alanyl-tRNA synthetase	genetic	1	1	1	Positive Genetic
BCP1	YDR361C	Essential nuclear chaperone for ribosomal protein Rpl23p	genetic	1	1	1	Synthetic Lethality
CCR4	YAL021C	Component of the CCR4-NOT transcriptional complex	physical	1	1	1	Affinity Capture-RNA
PUF6	YDR496C	Pumilio-homology domain protein	genetic	1	1	1	Negative Genetic
BMS1	YPL217C	GTPase required for ribosomal subunit synthesis and rRNA processing	genetic	1	1	1	Negative Genetic
RTT10	YPL183C	WD40 domain-containing protein involved in endosomal recycling	genetic	1	1	1	Positive Genetic
OLA1	YBR025C	P-loop ATPase with similarity to human OLA1 and bacterial YchF	genetic	1	1	1	Positive Genetic
HGH1	YGR187C	Chaperone protein for translation factor eEF2	genetic	1	1	1	Positive Genetic
ADE4	YMR300C	Phosphoribosylpyrophosphate amidotransferase (PRPPAT)	genetic	1	1	1	Negative Genetic
AOS1	YPR180W	Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p	genetic	1	1	1	Negative Genetic
APC2	YLR127C	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C)	genetic	1	1	1	Positive Genetic
ARC18	YLR370C	Subunit of the ARP2/3 complex	genetic	1	1	1	Positive Genetic
ARC35	YNR035C	Subunit of the ARP2/3 complex	genetic	1	1	1	Synthetic Lethality
ARC40	YBR234C	Subunit of the ARP2/3 complex	genetic	1	1	1	Positive Genetic
BDF1	YLR399C	BET family transcriptional regulator	genetic	1	1	1	Negative Genetic
BET2	YPR176C	Beta subunit of Type II geranylgeranyltransferase	genetic	1	1	1	Negative Genetic
BMH2	YDR099W	14-3-3 protein, minor isoform	genetic	1	1	1	Negative Genetic
BEM2	YER155C	Rho GTPase activating protein (RhoGAP)	genetic	1	1	1	Positive Genetic
AIM21	YIR003W	Subunit of a complex that associates with actin filaments	genetic	1	1	1	Positive Genetic
CCA1	YER168C	ATP (CTP):tRNA-specific tRNA nucleotidyltransferase	genetic	1	1	1	Synthetic Lethality
CCL1	YPR025C	Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p	genetic	1	1	1	Positive Genetic
CAF130	YGR134W	Subunit of the CCR4-NOT transcriptional regulatory complex	genetic	1	1	1	Negative Genetic
CDC14	YFR028C	Protein phosphatase required for mitotic exit	genetic	1	1	1	Positive Genetic
CDC28	YBR160W	Cyclin-dependent kinase (CDK) catalytic subunit	physical	1	1	1	Biochemical Activity
CDC10	YCR002C	Component of the septin ring, required for cytokinesis	genetic	1	1	1	Negative Genetic
CDC12	YHR107C	Component of the septin ring that is required for cytokinesis	genetic	1	1	1	Negative Genetic
CDC36	YDL165W	Component of the CCR4-NOT core complex, involved in mRNA decapping	genetic	1	1	1	Positive Genetic
DBP10	YDL031W	Putative ATP-dependent RNA helicase of the DEAD-box protein family	genetic	1	1	1	Synthetic Lethality
CKS1	YBR135W	Cyclin-dependent protein kinase regulatory subunit and adaptor	genetic	1	1	1	Positive Genetic
CNS1	YBR155W	TPR-containing co-chaperone	genetic	1	1	1	Positive Genetic
COP1	YDL145C	Alpha subunit of COPI vesicle coatomer complex	genetic	1	1	1	Positive Genetic
COX5A	YNL052W	Subunit Va of cytochrome c oxidase	genetic	1	1	1	Positive Genetic
CPR1	YDR155C	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin)	genetic	1	1	1	Positive Genetic
CUS1	YMR240C	Protein required for assembly of U2 snRNP into the spliceosome	genetic	1	1	1	Negative Genetic
CYR1	YJL005W	Adenylate cyclase	genetic	1	1	1	Positive Genetic
DCP1	YOL149W	Subunit of the Dcp1p-Dcp2p decapping enzyme complex	genetic	1	1	1	Synthetic Lethality
CDC16	YKL022C	Subunit of the anaphase-promoting complex/cyclosome (APC/C)	genetic	1	1	1	Positive Genetic
DPB2	YPR175W	Second largest subunit of DNA polymerase II (DNA polymerase epsilon)	genetic	1	1	1	Negative Genetic
ELP2	YGR200C	Subunit of Elongator complex	genetic	1	1	1	Positive Genetic
ENP1	YBR247C	Protein associated with U3 and U14 snoRNAs	genetic	1	1	1	Negative Genetic
EAF3	YPR023C	Component of the Rpd3S histone deacetylase complex	genetic	1	1	1	Positive Genetic
ERP2	YAL007C	Member of the p24 family involved in ER to Golgi transport	genetic	1	1	1	Negative Genetic
EXO84	YBR102C	Exocyst subunit with dual roles in exocytosis and spliceosome assembly	genetic	1	1	1	Positive Genetic
FIP1	YJR093C	Subunit of cleavage polyadenylation factor (CPF)	genetic	1	1	1	Negative Genetic
FPR1	YNL135C	Peptidyl-prolyl cis-trans isomerase (PPIase)	genetic	1	1	1	Positive Genetic
FET5	YFL041W	Multicopper oxidase	genetic	1	1	1	Negative Genetic
GCN1	YGL195W	Positive regulator of the Gcn2p kinase activity	genetic	1	1	1	Negative Genetic
GCD7	YLR291C	Beta subunit of translation initiation factor eIF2B	genetic	1	1	1	Positive Genetic
GDI1	YER136W	GDP dissociation inhibitor	genetic	1	1	1	Positive Genetic
ERV25	YML012W	Member of the p24 family involved in ER to Golgi transport	genetic	1	1	1	Negative Genetic
BDF2	YDL070W	Protein involved in transcription initiation	genetic	1	1	1	Negative Genetic
ECM5	YMR176W	Subunit of the Snt2C complex	genetic	1	1	1	Negative Genetic
DHH1	YDL160C	Cytoplasmic DEAD-box helicase and mRNA decapping activator	physical	1	1	1	Affinity Capture-RNA
AEP2	YMR282C	Mitochondrial protein	genetic	1	1	1	Negative Genetic
HRT1	YOL133W	RING-H2 domain core subunit of multiple ubiquitin ligase complexes	genetic	1	1	1	Synthetic Lethality
HHF2	YNL030W	Histone H4	genetic	1	1	1	Positive Genetic
HSM3	YBR272C	Evolutionarily conserved 19S regulatory particle assembly-chaperone	physical	1	1	1	Affinity Capture-MS
DPB4	YDR121W	Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex	genetic	1	1	1	Negative Genetic
IPP1	YBR011C	Cytoplasmic inorganic pyrophosphatase (PPase)	genetic	1	1	1	Synthetic Lethality
COG8	YML071C	Component of the conserved oligomeric Golgi complex	genetic	1	1	1	Positive Genetic
IOC3	YFR013W	Subunit of the Isw1a complex	genetic	1	1	1	Negative Genetic
ISW1	YBR245C	ATPase subunit of imitation-switch (ISWI) class chromatin remodelers	physical	1	1	1	Affinity Capture-RNA
ISW1	YBR245C	ATPase subunit of imitation-switch (ISWI) class chromatin remodelers	genetic	1	1	1	Negative Genetic
CLU1	YMR012W	Subunit of the eukaryotic translation initiation factor 3 (eIF3)	genetic	1	1	1	Positive Genetic
ECM29	YHL030W	Scaffold protein	genetic	1	1	1	Positive Genetic
KGD1	YIL125W	Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex	genetic	1	1	1	Positive Genetic
KIN3	YAR018C	Nonessential serine/threonine protein kinase	genetic	1	1	1	Positive Genetic
ARB1	YER036C	ATPase of the ATP-binding cassette (ABC) family	genetic	1	1	1	Synthetic Lethality
HSL1	YKL101W	Nim1p-related protein kinase	genetic	1	1	1	Positive Genetic
KRR1	YCL059C	Nucleolar protein required for rRNA synthesis and ribosomal assembly	genetic	1	1	1	Negative Genetic
KRS1	YDR037W	Lysyl-tRNA synthetase	genetic	1	1	1	Synthetic Lethality
LAS17	YOR181W	Actin assembly factor	genetic	1	1	1	Positive Genetic
GFA1	YKL104C	Glutamine-fructose-6-phosphate amidotransferase	genetic	1	1	1	Positive Genetic
KEL1	YHR158C	Protein required for proper cell fusion and cell morphology	genetic	1	1	1	Negative Genetic
MAK3	YPR051W	Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT)	genetic	1	1	1	Negative Genetic
INP2	YMR163C	Peroxisome-specific receptor important for peroxisome inheritance	genetic	1	1	1	Negative Genetic
MBP1	YDL056W	Transcription factor	genetic	1	1	1	Negative Genetic
MCM6	YGL201C	Protein involved in DNA replication	genetic	1	1	1	Synthetic Lethality
MED1	YPR070W	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Negative Genetic
FAB1	YFR019W	1-phosphatidylinositol-3-phosphate 5-kinase	genetic	1	1	1	Synthetic Growth Defect
FBA1	YKL060C	Fructose 1,6-bisphosphate aldolase	genetic	1	1	1	Positive Genetic
MED6	YHR058C	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Negative Genetic
HSC82	YMR186W	Cytoplasmic chaperone of the Hsp90 family	genetic	1	1	1	Negative Genetic
EHD3	YDR036C	3-hydroxyisobutyryl-CoA hydrolase	genetic	1	1	1	Negative Genetic
HRR25	YPL204W	Conserved casein kinase, monopolin subunit	genetic	1	1	1	Positive Genetic
IMG2	YCR071C	Mitochondrial ribosomal protein of the large subunit	genetic	1	1	1	Negative Genetic
MRPL1	YDR116C	Mitochondrial ribosomal protein of the large subunit	genetic	1	1	1	Negative Genetic
ATG26	YLR189C	UDP-glucose:sterol glucosyltransferase	genetic	1	1	1	Negative Genetic
MRP49	YKL167C	Mitochondrial ribosomal protein of the large subunit	genetic	1	1	1	Positive Genetic
MRPL36	YBR122C	Mitochondrial ribosomal protein of the large subunit	genetic	1	1	1	Positive Genetic
FYV4	YHR059W	Protein of unknown function	genetic	1	1	1	Positive Genetic
MRPS18	YNL306W	Mitochondrial ribosomal protein of the small subunit	genetic	1	1	1	Synthetic Lethality
HDA3	YPR179C	Subunit of HDA1 histone deacetylase complex	genetic	1	1	1	Positive Genetic
MPH1	YIR002C	3'-5' DNA helicase involved in error-free bypass of DNA lesions	physical	1	1	1	Affinity Capture-MS
MSH3	YCR092C	Mismatch repair protein	genetic	1	1	1	Negative Genetic
MSH6	YDR097C	Protein required for mismatch repair in mitosis and meiosis	genetic	1	1	1	Negative Genetic
CMR1	YDL156W	Nuclear protein with role in transcription, protein quality control	physical	1	1	1	Affinity Capture-MS
ATG3	YNR007C	E2-like enzyme	genetic	1	1	1	Negative Genetic
MTR10	YOR160W	Nuclear import receptor	genetic	1	1	1	Negative Genetic
CMD1	YBR109C	Calmodulin	genetic	1	1	1	Negative Genetic
MYO2	YOR326W	Type V myosin motor involved in actin-based transport of cargos	genetic	1	1	1	Positive Genetic
NAM8	YHR086W	RNA binding protein, component of the U1 snRNP protein	genetic	1	1	1	Negative Genetic
KAP114	YGL241W	Karyopherin, responsible for nuclear import of specific proteins	genetic	1	1	1	Negative Genetic
KCC4	YCL024W	Protein kinase of the bud neck involved in the septin checkpoint	genetic	1	1	1	Negative Genetic
NBP35	YGL091C	Essential cytoplasmic iron-sulfur cluster binding protein	genetic	1	1	1	Positive Genetic
NCL1	YBL024W	S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase	genetic	1	1	1	Positive Genetic
ITC1	YGL133W	Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex	genetic	1	1	1	Positive Genetic
IES5	YER092W	Non-essential INO80 chromatin remodeling complex subunit	genetic	1	1	1	Positive Genetic
IES1	YFL013C	Subunit of the INO80 chromatin remodeling complex	genetic	1	1	1	Positive Genetic
NMD3	YHR170W	Protein involved in nuclear export of the large ribosomal subunit	genetic	1	1	1	Negative Genetic
ATG18	YFR021W	Phosphoinositide binding protein	genetic	1	1	1	Positive Genetic
HER1	YOR227W	Protein of unknown function	genetic	1	1	1	Negative Genetic
NPL4	YBR170C	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase	genetic	1	1	1	Negative Genetic
ORC1	YML065W	Largest subunit of the origin recognition complex	genetic	1	1	1	Positive Genetic
GIM5	YML094W	Subunit of the heterohexameric cochaperone prefoldin complex	genetic	1	1	1	Positive Genetic
PAN2	YGL094C	Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex	genetic	1	1	1	Negative Genetic
PAP1	YKR002W	Poly(A) polymerase	genetic	1	1	1	Positive Genetic
PBP2	YBR233W	RNA binding protein	genetic	1	1	1	Negative Genetic
LAT1	YNL071W	Dihydrolipoamide acetyltransferase component (E2) of the PDC	genetic	1	1	1	Positive Genetic
LPD1	YFL018C	Dihydrolipoamide dehydrogenase	genetic	1	1	1	Positive Genetic
PDA1	YER178W	E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex	genetic	1	1	1	Positive Genetic
PDB1	YBR221C	E1 beta subunit of the pyruvate dehydrogenase (PDH) complex	genetic	1	1	1	Positive Genetic
AAP1	YHR047C	Arginine/alanine amino peptidase	genetic	1	1	1	Negative Genetic
IDH2	YOR136W	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase	genetic	1	1	1	Positive Genetic
POP7	YBR167C	Subunit of RNase MRP, nuclear RNase P and telomerase	genetic	1	1	1	Negative Genetic
BLM10	YFL007W	Proteasome activator	genetic	1	1	1	Negative Genetic
EST3	YIL009C-A	Component of the telomerase holoenzyme	genetic	1	1	1	Negative Genetic
PRP4	YPR178W	Splicing factor	genetic	1	1	1	Positive Genetic
LEA1	YPL213W	Component of U2 snRNP complex	genetic	1	1	1	Positive Genetic
CWC22	YGR278W	Spliceosome-associated protein that is required for pre-mRNA splicing	genetic	1	1	1	Positive Genetic
PRP6	YBR055C	Splicing factor	genetic	1	1	1	Positive Genetic
MDS3	YGL197W	Putative component of the TOR regulatory pathway	genetic	1	1	1	Positive Genetic
NAB3	YPL190C	RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p)	genetic	1	1	1	Negative Genetic
POL2	YNL262W	Catalytic subunit of DNA polymerase (II) epsilon	genetic	1	1	1	Negative Genetic
IMP4	YNL075W	Component of the SSU processome	genetic	1	1	1	Positive Genetic
NOP14	YDL148C	Nucleolar protein	genetic	1	1	1	Positive Genetic
PRE9	YGR135W	Alpha 3 subunit of the 20S proteasome	genetic	1	1	1	Positive Genetic
ESF2	YNR054C	Essential nucleolar protein involved in pre-18S rRNA processing	genetic	1	1	1	Synthetic Lethality
MIR1	YJR077C	Mitochondrial phosphate carrier	genetic	1	1	1	Positive Genetic
RAD16	YBR114W	Nucleotide excision repair (NER) protein	genetic	1	1	1	Phenotypic Enhancement
GCN20	YFR009W	Positive regulator of the Gcn2p kinase activity	genetic	1	1	1	Positive Genetic
RAM1	YDL090C	Beta subunit of the CAAX farnesyltransferase (FTase)	genetic	1	1	1	Positive Genetic
GPT2	YKR067W	Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase	genetic	1	1	1	Negative Genetic
RFC2	YJR068W	Subunit of heteropentameric Replication factor C (RF-C)	genetic	1	1	1	Phenotypic Enhancement
RFC4	YOL094C	Subunit of heteropentameric Replication factor C (RF-C)	genetic	1	1	1	Phenotypic Enhancement
FYV8	YGR196C	Protein of unknown function	genetic	1	1	1	Negative Genetic
RNH1	YMR234W	Ribonuclease H1	genetic	1	1	1	Positive Genetic
ROX3	YBL093C	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Negative Genetic
RPB11	YOL005C	RNA polymerase II subunit B12.5	genetic	1	1	1	Synthetic Lethality
DEP1	YAL013W	Component of the Rpd3L histone deacetylase complex	genetic	1	1	1	Positive Genetic
PHO23	YNL097C	Component of the Rpd3L histone deacetylase complex	genetic	1	1	1	Positive Genetic
RPL23A	YBL087C	Ribosomal 60S subunit protein L23A	genetic	1	1	1	Positive Genetic
DBP2	YNL112W	ATP-dependent RNA helicase of the DEAD-box protein family	genetic	1	1	1	Synthetic Lethality
RPL2A	YFR031C-A	Ribosomal 60S subunit protein L2A	genetic	1	1	1	Negative Genetic
PUP3	YER094C	Beta 3 subunit of the 20S proteasome	genetic	1	1	1	Negative Genetic
RPN13	YLR421C	Subunit of the 19S regulatory particle of the 26S proteasome lid	genetic	1	1	1	Positive Genetic
MAF1	YDR005C	Highly conserved negative regulator of RNA polymerase III	genetic	1	1	1	Negative Genetic
CDC6	YJL194W	Essential ATP-binding protein required for DNA replication	genetic	1	1	1	Positive Genetic
CSN9	YDR179C	Subunit of the Cop9 signalosome	genetic	1	1	1	Positive Genetic
RRI1	YDL216C	Catalytic subunit of the COP9 signalosome (CSN) complex	genetic	1	1	1	Positive Genetic
MTR3	YGR158C	Exosome non-catalytic core component	genetic	1	1	1	Negative Genetic
PPH21	YDL134C	Catalytic subunit of protein phosphatase 2A, PP2A	genetic	1	1	1	Positive Genetic
RTS1	YOR014W	B-type regulatory subunit of protein phosphatase 2A (PP2A)	genetic	1	1	1	Positive Genetic
SCS2	YER120W	Integral ER membrane protein, regulates phospholipid metabolism	genetic	1	1	1	Negative Genetic
RSA4	YCR072C	Ribosomal large subunit (60S) assembly factor	genetic	1	1	1	Synthetic Lethality
PGI1	YBR196C	Glycolytic enzyme phosphoglucose isomerase	genetic	1	1	1	Positive Genetic
NUP120	YKL057C	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC)	genetic	1	1	1	Synthetic Lethality
SEC27	YGL137W	Essential beta'-coat protein of the COPI coatomer	genetic	1	1	1	Positive Genetic
MNN10	YDR245W	Subunit of a Golgi mannosyltransferase complex	genetic	1	1	1	Negative Genetic
SEC62	YPL094C	Essential subunit of Sec63 complex	genetic	1	1	1	Positive Genetic
SEC63	YOR254C	Essential subunit of Sec63 complex	genetic	1	1	1	Negative Genetic
SEC66	YBR171W	Non-essential subunit of Sec63 complex	genetic	1	1	1	Negative Genetic
KTR3	YBR205W	Putative alpha-1,2-mannosyltransferase	genetic	1	1	1	Negative Genetic
SAM1	YLR180W	S-adenosylmethionine synthetase	genetic	1	1	1	Positive Genetic
RIE1	YGR250C	RNA binding protein and negative regulator of START	genetic	1	1	1	Negative Genetic
HOS2	YGL194C	Histone deacetylase and subunit of Set3 and Rpd3L complexes	genetic	1	1	1	Negative Genetic
SET3	YKR029C	Defining member of the SET3 histone deacetylase complex	genetic	1	1	1	Negative Genetic
SAP30	YMR263W	Component of Rpd3L histone deacetylase complex	genetic	1	1	1	Negative Genetic
SDS3	YIL084C	Component of the Rpd3L histone deacetylase complex	genetic	1	1	1	Positive Genetic
HRK1	YOR267C	Protein kinase	genetic	1	1	1	Positive Genetic
BSP1	YPR171W	Adapter that links synaptojanins to the cortical actin cytoskeleton	genetic	1	1	1	Negative Genetic
PRP9	YDL030W	Subunit of the SF3a splicing factor complex	genetic	1	1	1	Positive Genetic
RSE1	YML049C	Protein involved in pre-mRNA splicing	genetic	1	1	1	Positive Genetic
PRP11	YDL043C	Subunit of the SF3a splicing factor complex	genetic	1	1	1	Positive Genetic
GAL83	YER027C	One of three alternate beta-subunits of the Snf1 kinase complex	physical	1	1	1	Affinity Capture-MS
PRP38	YGR075C	Unique component of the U4/U6.U5 tri-snRNP particle	genetic	1	1	1	Synthetic Lethality
PFK2	YMR205C	Beta subunit of heterooctameric phosphofructokinase	genetic	1	1	1	Negative Genetic
SGF29	YCL010C	Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes	genetic	1	1	1	Negative Genetic
MLP1	YKR095W	Myosin-like protein associated with the nuclear envelope	genetic	1	1	1	Negative Genetic
SEC65	YML105C	Subunit of the signal recognition particle (SRP)	genetic	1	1	1	Positive Genetic
IST2	YBR086C	Cortical ER protein involved in ER-plasma membrane (PM) tethering	genetic	1	1	1	Positive Genetic
MIP6	YHR015W	Putative RNA-binding protein	genetic	1	1	1	Positive Genetic
ROM2	YLR371W	Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p	genetic	1	1	1	Positive Genetic
CCT6	YDR188W	Subunit of the cytosolic chaperonin Cct ring complex	genetic	1	1	1	Positive Genetic
SBP1	YHL034C	Protein that binds eIF4G and has a role in repression of translation	genetic	1	1	1	Negative Genetic
MGA2	YIR033W	ER membrane protein involved in regulation of OLE1 transcription	genetic	1	1	1	Positive Genetic
NEW1	YPL226W	Translation termination and ribosome biogenesis factor	genetic	1	1	1	Negative Genetic
ATG9	YDL149W	Transmembrane protein involved in forming Cvt and autophagic vesicles	genetic	1	1	1	Negative Genetic
SCJ1	YMR214W	One of several homologs of bacterial chaperone DnaJ	genetic	1	1	1	Negative Genetic
RRD2	YPL152W	Peptidyl-prolyl cis/trans-isomerase	genetic	1	1	1	Positive Genetic
RTS3	YGR161C	Putative component of the protein phosphatase type 2A complex	genetic	1	1	1	Positive Genetic
MKS1	YNL076W	Pleiotropic negative transcriptional regulator	genetic	1	1	1	Positive Genetic
GTO3	YMR251W	Omega class glutathione transferase	genetic	1	1	1	Positive Genetic
ECM30	YLR436C	Protein of unknown function	genetic	1	1	1	Positive Genetic
ALT2	YDR111C	Catalytically inactive alanine transaminase	genetic	1	1	1	Negative Genetic
RAV1	YJR033C	Subunit of RAVE complex (Rav1p, Rav2p, Skp1p)	genetic	1	1	1	Positive Genetic
RAD10	YML095C	Single-stranded DNA endonuclease (with Rad1p)	genetic	1	1	1	Negative Genetic
SAW1	YAL027W	5'- and 3'-flap DNA binding protein	genetic	1	1	1	Negative Genetic
DRS2	YAL026C	Trans-golgi network aminophospholipid translocase (flippase)	genetic	1	1	1	Negative Genetic
BRE2	YLR015W	Subunit of COMPASS (Set1C) complex	genetic	1	1	1	Negative Genetic
SDC1	YDR469W	Subunit of the COMPASS (Set1C) complex	genetic	1	1	1	Negative Genetic
PIN4	YBL051C	Protein involved in G2/M phase progression and response to DNA damage	genetic	1	1	1	Positive Genetic
GET3	YDL100C	Guanine nucleotide exchange factor for Gpa1p	genetic	1	1	1	Positive Genetic
DTD1	YDL219W	D-Tyr-tRNA(Tyr) deacylase	genetic	1	1	1	Positive Genetic
CAB5	YDR196C	Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC)	genetic	1	1	1	Positive Genetic
CMS1	YLR003C	Putative subunit of the 90S preribosome processome complex	genetic	1	1	1	Positive Genetic
AIM17	YHL021C	Protein of unknown function	genetic	1	1	1	Negative Genetic
LPL1	YOR059C	Phospholipase	genetic	1	1	1	Negative Genetic
NTE1	YML059C	Serine esterase	genetic	1	1	1	Negative Genetic
LAP2	YNL045W	Leucyl aminopeptidase yscIV with epoxide hydrolase activity	genetic	1	1	1	Positive Genetic
FAR11	YNL127W	Protein involved in recovery from cell cycle arrest	genetic	1	1	1	Negative Genetic
NOB1	YOR056C	Protein involved in proteasomal and 40S ribosomal subunit biogenesis	genetic	1	1	1	Synthetic Lethality
FPR3	YML074C	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase)	genetic	1	1	1	Negative Genetic
AIM41	YOR215C	Protein of unknown function	genetic	1	1	1	Positive Genetic
GAS1	YMR307W	Beta-1,3-glucanosyltransferase required for cell wall assembly	genetic	1	1	1	Negative Genetic
RHO2	YNL090W	Non-essential small GTPase of the Rho/Rac family of Ras-like proteins	genetic	1	1	1	Positive Genetic
AKL1	YBR059C	Ser/Thr protein kinase	genetic	1	1	1	Positive Genetic
FAR8	YMR029C	Protein involved in recovery from arrest in response to pheromone	genetic	1	1	1	Positive Genetic
LSP1	YPL004C	Eisosome core component	genetic	1	1	1	Negative Genetic
ADR1	YDR216W	Carbon source-responsive zinc-finger transcription factor	genetic	1	1	1	Positive Genetic
FIN1	YDR130C	Spindle pole body-related intermediate filament protein	genetic	1	1	1	Negative Genetic
MDH1	YKL085W	Mitochondrial malate dehydrogenase	genetic	1	1	1	Negative Genetic
ADH2	YMR303C	Glucose-repressible alcohol dehydrogenase II	genetic	1	1	1	Negative Genetic
ACH1	YBL015W	Protein with CoA transferase activity	genetic	1	1	1	Negative Genetic
HYP2	YEL034W	Translation elongation factor eIF-5A	genetic	1	1	1	Synthetic Lethality
PPQ1	YPL179W	Protein phosphatase that regulates the mating response	genetic	1	1	1	Positive Genetic
RIM15	YFL033C	Protein kinase involved in cell proliferation in response to nutrients	genetic	1	1	1	Negative Genetic
AAC3	YBR085W	Mitochondrial inner membrane ADP/ATP translocator	genetic	1	1	1	Positive Genetic
APP1	YNL094W	Phosphatidate phosphatase, converts phosphatidate to diacylglycerol	genetic	1	1	1	Positive Genetic
ARF1	YDL192W	ADP-ribosylation factor	genetic	1	1	1	Positive Genetic
IDH1	YNL037C	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase	genetic	1	1	1	Positive Genetic
SER1	YOR184W	3-phosphoserine aminotransferase	genetic	1	1	1	Positive Genetic
KIN1	YDR122W	S/T protein kinase	genetic	1	1	1	Negative Genetic
MGE1	YOR232W	Mitochondrial matrix cochaperone	genetic	1	1	1	Synthetic Lethality
CMP2	YML057W	Calcineurin A	genetic	1	1	1	Positive Genetic
GSP1	YLR293C	Ran GTPase	genetic	1	1	1	Negative Genetic
CDC53	YDL132W	Cullin	genetic	1	1	1	Positive Genetic
GRR1	YJR090C	F-box protein component of an SCF ubiquitin-ligase complex	genetic	1	1	1	Positive Genetic
GSF2	YML048W	Endoplasmic reticulum (ER) localized integral membrane protein	genetic	1	1	1	Negative Genetic
FET3	YMR058W	Ferro-O2-oxidoreductase	genetic	1	1	1	Positive Genetic
OYE2	YHR179W	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN)	genetic	1	1	1	Negative Genetic
MPC54	YOR177C	Component of the meiotic outer plaque	genetic	1	1	1	Negative Genetic
PST2	YDR032C	FMN-dependent NAD(P)H:quinone oxidoreductase	genetic	1	1	1	Negative Genetic
RVS161	YCR009C	Amphiphysin-like lipid raft protein	genetic	1	1	1	Negative Genetic
FYV10	YIL097W	Subunit of GID complex	genetic	1	1	1	Negative Genetic
FDO1	YMR144W	Protein involved in directionality of mating type switching	genetic	1	1	1	Negative Genetic
NOP6	YDL213C	rRNA-binding protein required for 40S ribosomal subunit biogenesis	genetic	1	1	1	Positive Genetic
KOG1	YHR186C	Subunit of TORC1	genetic	1	1	1	Negative Genetic
PMA2	YPL036W	Plasma membrane H+-ATPase	genetic	1	1	1	Negative Genetic
DIG2	YDR480W	MAP kinase-responsive inhibitor of the Ste12p transcription factor	genetic	1	1	1	Positive Genetic
BUD13	YGL174W	Subunit of the RES complex	genetic	1	1	1	Positive Genetic
PTC5	YOR090C	Mitochondrial type 2C protein phosphatase (PP2C)	genetic	1	1	1	Positive Genetic
GLC8	YMR311C	Regulatory subunit of protein phosphatase 1 (Glc7p)	genetic	1	1	1	Positive Genetic
QCR2	YPR191W	Subunit 2 of ubiquinol cytochrome-c reductase (Complex III)	genetic	1	1	1	Negative Genetic
EGD1	YPL037C	Subunit beta1 of the nascent polypeptide-associated complex (NAC)	genetic	1	1	1	Positive Genetic
PCL7	YIL050W	Pho85p cyclin of the Pho80p subfamily	genetic	1	1	1	Positive Genetic
PHO81	YGR233C	Cyclin-dependent kinase (CDK) inhibitor	genetic	1	1	1	Positive Genetic
CLN1	YMR199W	G1 cyclin involved in regulation of the cell cycle	genetic	1	1	1	Negative Genetic
PGM2	YMR105C	Phosphoglucomutase	genetic	1	1	1	Positive Genetic
DIP5	YPL265W	Dicarboxylic amino acid permease	genetic	1	1	1	Negative Genetic
MDM30	YLR368W	F-box component of an SCF ubiquitin protein ligase complex	genetic	1	1	1	Positive Genetic
FAR1	YJL157C	CDK inhibitor and nuclear anchor	genetic	1	1	1	Negative Genetic
AAC1	YMR056C	Mitochondrial inner membrane ADP/ATP translocator	genetic	1	1	1	Positive Genetic
ATG12	YBR217W	Ubiquitin-like modifier involved in autophagy and the Cvt pathway	genetic	1	1	1	Positive Genetic
KDX1	YKL161C	Protein kinase	genetic	1	1	1	Positive Genetic
AXL1	YPR122W	Haploid specific endoprotease of a-factor mating pheromone	genetic	1	1	1	Negative Genetic
PET9	YBL030C	Major ADP/ATP carrier of the mitochondrial inner membrane	genetic	1	1	1	Synthetic Lethality
ERG27	YLR100W	3-keto sterol reductase	genetic	1	1	1	Positive Genetic
SEC18	YBR080C	AAA ATPase and SNARE disassembly chaperone	genetic	1	1	1	Positive Genetic
PCT1	YGR202C	Cholinephosphate cytidylyltransferase	genetic	1	1	1	Negative Genetic
PAC11	YDR488C	Dynein intermediate chain, microtubule motor protein	genetic	1	1	1	Negative Genetic
MTC5	YDR128W	Subunit of SEACAT, a subcomplex of the SEA complex	genetic	1	1	1	Negative Genetic
APT1	YML022W	Adenine phosphoribosyltransferase	genetic	1	1	1	Positive Genetic
ERG10	YPL028W	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase)	genetic	1	1	1	Positive Genetic
RHO1	YPR165W	GTP-binding protein of the rho subfamily of Ras-like proteins	genetic	1	1	1	Positive Genetic
FUM1	YPL262W	Fumarase	genetic	1	1	1	Positive Genetic
MET30	YIL046W	F-box protein containing five copies of the WD40 motif	genetic	1	1	1	Positive Genetic
MRS6	YOR370C	Rab escort protein	genetic	1	1	1	Negative Genetic
MLH3	YPL164C	Protein involved in DNA mismatch repair and meiotic recombination	physical	1	1	1	Affinity Capture-Western
LAF1	YMR102C	Sterol-binding beta-propeller protein	genetic	1	1	1	Positive Genetic
HEM15	YOR176W	Ferrochelatase	genetic	1	1	1	Synthetic Lethality
KAP122	YGL016W	Karyopherin beta	genetic	1	1	1	Positive Genetic
PSH1	YOL054W	E3 ubiquitin ligase targeting centromere-binding protein Cse4p	genetic	1	1	1	Negative Genetic
AIP1	YMR092C	Actin cortical patch component	genetic	1	1	1	Positive Genetic
ELM1	YKL048C	Serine/threonine protein kinase	genetic	1	1	1	Negative Genetic
MSI1	YBR195C	Subunit of chromatin assembly factor I (CAF-1)	genetic	1	1	1	Positive Genetic
DAS1	YJL149W	Putative SCF ubiquitin ligase F-box protein	genetic	1	1	1	Negative Genetic
CAT5	YOR125C	Protein required for ubiquinone (Coenzyme Q) biosynthesis	genetic	1	1	1	Positive Genetic
IMD4	YML056C	Inosine monophosphate dehydrogenase	genetic	1	1	1	Positive Genetic
GID8	YMR135C	Subunit of GID Complex, binds strongly to central component Vid30p	genetic	1	1	1	Negative Genetic
MOH1	YBL049W	Protein of unknown function, essential for stationary phase survival	genetic	1	1	1	Negative Genetic
PSK2	YOL045W	PAS-domain containing serine/threonine protein kinase	genetic	1	1	1	Negative Genetic
SWD3	YBR175W	Essential subunit of the COMPASS (Set1C) complex	physical	1	1	1	Affinity Capture-MS
YCK2	YNL154C	Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform	physical	1	1	1	Biochemical Activity
YCK2	YNL154C	Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform	genetic	1	1	1	Positive Genetic
STU2	YLR045C	Microtubule polymerase of the XMAP215/Dis1 family	physical	1	1	1	Two-hybrid
UTP14	YML093W	Subunit of U3-containing Small Subunit (SSU) processome complex	physical	1	1	1	Affinity Capture-MS
UTP14	YML093W	Subunit of U3-containing Small Subunit (SSU) processome complex	genetic	1	1	1	Synthetic Lethality
THI20	YOL055C	Trifunctional enzyme of thiamine biosynthesis, degradation and salvage	physical	1	1	1	Affinity Capture-MS
SKT5	YBL061C	Activator of Chs3p (chitin synthase III) during vegetative growth	genetic	1	1	1	Synthetic Growth Defect
UAF30	YOR295W	Subunit of UAF (upstream activation factor) complex	genetic	1	1	1	Synthetic Growth Defect
TEC1	YBR083W	Transcription factor targeting filamentation genes and Ty1 expression	genetic	1	1	1	Positive Genetic
UBP9	YER098W	Ubiquitin-specific protease that cleaves ubiquitin-protein fusions	genetic	1	1	1	Positive Genetic
SIR2	YDL042C	Conserved NAD+ dependent histone deacetylase of the Sirtuin family	genetic	1	1	1	Dosage Rescue
TIM12	YBR091C	Essential protein of the inner mitochondrial membrane	genetic	1	1	1	Synthetic Lethality
TSC10	YBR265W	3-ketosphinganine reductase	genetic	1	1	1	Synthetic Lethality
SHR3	YDL212W	Endoplasmic reticulum packaging chaperone	genetic	1	1	1	Synthetic Lethality
YRB1	YDR002W	Ran GTPase binding protein	genetic	1	1	1	Synthetic Lethality
UBC1	YDR177W	Ubiquitin-conjugating enzyme	genetic	1	1	1	Synthetic Lethality
SRB7	YDR308C	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Synthetic Lethality
UTR5	YEL035C	Protein of unknown function	genetic	1	1	1	Synthetic Lethality
SPB4	YFL002C	Putative ATP-dependent RNA helicase	genetic	1	1	1	Synthetic Lethality
SUA5	YGL169W	Protein involved in threonylcarbamoyl adenosine biosynthesis	genetic	1	1	1	Synthetic Lethality
VHT1	YGR065C	High-affinity plasma membrane H+-biotin (vitamin H) symporter	genetic	1	1	1	Synthetic Lethality
TYS1	YGR185C	Cytoplasmic tyrosyl-tRNA synthetase	genetic	1	1	1	Synthetic Lethality
TFG1	YGR186W	TFIIF (Transcription Factor II) largest subunit	genetic	1	1	1	Synthetic Lethality
TFA1	YKL028W	TFIIE large subunit	genetic	1	1	1	Synthetic Lethality
TFA2	YKR062W	TFIIE small subunit	genetic	1	1	1	Synthetic Lethality
TRZ1	YKR079C	tRNA 3'-end processing endonuclease tRNase Z	genetic	1	1	1	Synthetic Lethality
USB1	YLR132C	Putative poly(U)-specific 3'-to-5' RNA exonuclease	genetic	1	1	1	Synthetic Lethality
YSH1	YLR277C	Endoribonuclease	genetic	1	1	1	Synthetic Lethality
UTP21	YLR409C	Subunit of U3-containing 90S preribosome and SSU processome complexes	genetic	1	1	1	Synthetic Lethality
TOM40	YMR203W	Component of the TOM (translocase of outer membrane) complex	genetic	1	1	1	Synthetic Lethality
TIF11	YMR260C	Translation initiation factor eIF1A	genetic	1	1	1	Synthetic Lethality
SIS1	YNL007C	Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p	genetic	1	1	1	Synthetic Lethality
TOM22	YNL131W	Component of the TOM (Translocase of Outer Membrane) complex	genetic	1	1	1	Synthetic Lethality
TRM112	YNR046W	Protein involved in methylation of tRNA, rRNA, and translation factors	genetic	1	1	1	Synthetic Lethality
WRS1	YOL097C	Cytoplasmic tryptophanyl-tRNA synthetase	genetic	1	1	1	Synthetic Lethality
SLD7	YOR060C	Protein with a role in chromosomal DNA replication	genetic	1	1	1	Synthetic Lethality
TOA1	YOR194C	TFIIA large subunit	genetic	1	1	1	Synthetic Lethality
SOG2	YOR353C	Key component of the RAM signaling network	genetic	1	1	1	Synthetic Lethality
TIF5	YPR041W	Translation initiation factor eIF5	genetic	1	1	1	Synthetic Lethality
SNF2	YOR290C	Catalytic subunit of the SWI/SNF chromatin remodeling complex	genetic	1	1	1	Synthetic Growth Defect
VPS15	YBR097W	Serine/threonine protein kinase involved in vacuolar protein sorting	genetic	1	1	1	Positive Genetic
VPS53	YJL029C	Component of the GARP (Golgi-associated retrograde protein) complex	genetic	1	1	1	Positive Genetic
XRN1	YGL173C	Evolutionarily-conserved 5'-3' exonuclease	genetic	1	1	1	Negative Genetic
ZIP1	YDR285W	Transverse filament protein of the synaptonemal complex	genetic	1	1	1	Phenotypic Enhancement
UBP7	YIL156W	Ubiquitin-specific protease that cleaves ubiquitin-protein fusions	genetic	1	1	1	Synthetic Growth Defect
YBL081W	YBL081W	Non-essential protein of unknown function	genetic	1	1	1	Positive Genetic
YBR016W	YBR016W	Tail-anchored plasma membrane protein with a conserved CYSTM module	genetic	1	1	1	Positive Genetic
UBS1	YBR165W	Ubiquitin-conjugating enzyme suppressor that regulates Cdc34p	genetic	1	1	1	Positive Genetic
YCR050C	YCR050C	Non-essential protein of unknown function	genetic	1	1	1	Positive Genetic
YOS9	YDR057W	ER quality-control lectin	genetic	1	1	1	Positive Genetic
TVP23	YDR084C	Integral membrane protein	genetic	1	1	1	Positive Genetic
YIP4	YGL198W	Protein that interacts with Rab GTPases	genetic	1	1	1	Positive Genetic
VMA21	YGR105W	Integral membrane protein required for V-ATPase function	genetic	1	1	1	Positive Genetic
SPO1	YNL012W	Meiosis-specific prospore protein	genetic	1	1	1	Positive Genetic
SSP1	YHR184W	Protein involved in the control of meiotic nuclear division	genetic	1	1	1	Positive Genetic
TIF2	YJL138C	Translation initiation factor eIF4A	genetic	1	1	1	Positive Genetic
TOH1	YJL171C	GPI-anchored cell wall protein of unknown function	genetic	1	1	1	Positive Genetic
TIF1	YKR059W	Translation initiation factor eIF4A	genetic	1	1	1	Positive Genetic
SND2	YLR065C	Protein involved in SRP-independent targeting of substrates to the ER	genetic	1	1	1	Positive Genetic
YKE2	YLR200W	Subunit of the heterohexameric Gim/prefoldin protein complex	genetic	1	1	1	Positive Genetic
YMD8	YML038C	Putative nucleotide sugar transporter	genetic	1	1	1	Positive Genetic
STB4	YMR019W	Putative transcription factor	genetic	1	1	1	Positive Genetic
SWS2	YNL081C	Putative mitochondrial ribosomal protein of the small subunit	genetic	1	1	1	Positive Genetic
YNL095C	YNL095C	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
YOL162W	YOL162W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
VAM3	YOR106W	Syntaxin-like vacuolar t-SNARE	genetic	1	1	1	Positive Genetic
SNU66	YOR308C	Component of the U4/U6.U5 snRNP complex	genetic	1	1	1	Positive Genetic
UBA3	YPR066W	Protein that activates Rub1p (NEDD8) before neddylation	genetic	1	1	1	Positive Genetic
SIF2	YBR103W	WD40 repeat-containing subunit of Set3C histone deacetylase complex	genetic	1	1	1	Negative Genetic
YBR137W	YBR137W	Protein with a role in ER delivery of tail-anchored membrane proteins	genetic	1	1	1	Negative Genetic
SWC5	YBR231C	Component of the SWR1 complex	genetic	1	1	1	Negative Genetic
UBX7	YBR273C	UBX (ubiquitin regulatory X) domain-containing protein	genetic	1	1	1	Negative Genetic
SMF2	YHR050W	Divalent metal ion transporter involved in manganese homeostasis	genetic	1	1	1	Positive Genetic
SNT1	YCR033W	Set3C histone deacetylase scaffold	genetic	1	1	1	Negative Genetic
VMA1	YDL185W	Subunit A of the V1 peripheral membrane domain of V-ATPase	genetic	1	1	1	Negative Genetic
SOK1	YDR006C	Protein of unknown function	genetic	1	1	1	Negative Genetic
TGL2	YDR058C	Triacylglycerol lipase that is localized to the mitochondria	genetic	1	1	1	Negative Genetic
SWR1	YDR334W	Swi2/Snf2-related ATPase	genetic	1	1	1	Negative Genetic
SPT8	YLR055C	Subunit of the SAGA transcriptional regulatory complex	genetic	1	1	1	Negative Genetic
SWI4	YER111C	DNA binding component of the SBF complex (Swi4p-Swi6p)	genetic	1	1	1	Negative Genetic
VFA1	YER128W	Protein that interacts with Vps4p and has a role in vacuolar sorting	genetic	1	1	1	Negative Genetic
TIM13	YGR181W	Mitochondrial intermembrane space protein	genetic	1	1	1	Negative Genetic
YSC83	YHR017W	Non-essential mitochondrial protein of unknown function	genetic	1	1	1	Negative Genetic
YKL069W	YKL069W	Methionine-R-sulfoxide reductase	genetic	1	1	1	Negative Genetic
YJU3	YKL094W	Monoglyceride lipase (MGL) that hydrolyzes fatty acid ethyl esters	genetic	1	1	1	Negative Genetic
SPO12	YHR152W	Nucleolar protein of unknown function	genetic	1	1	1	Positive Genetic
YLR177W	YLR177W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YLR225C	YLR225C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YML096W	YML096W	Putative protein with similarity to asparagine synthetases	genetic	1	1	1	Negative Genetic
YMR027W	YMR027W	A metal-dependent phosphatase, part of the DUF89 protein family	genetic	1	1	1	Negative Genetic
YNL134C	YNL134C	NADH-dependent aldehyde reductase	genetic	1	1	1	Negative Genetic
YNL143C	YNL143C	Protein of unknown function	genetic	1	1	1	Negative Genetic
YOL107W	YOL107W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YSP3	YOR003W	Putative precursor of the subtilisin-like protease III	genetic	1	1	1	Negative Genetic
TIM18	YOR297C	Component of the mitochondrial TIM22 complex	genetic	1	1	1	Negative Genetic
YPL034W	YPL034W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
TGS1	YPL157W	Trimethyl guanosine synthase, conserved nucleolar methyl transferase	genetic	1	1	1	Negative Genetic
YME1	YPR024W	Catalytic subunit of i-AAA protease complex	genetic	1	1	1	Negative Genetic
YBR071W	YBR071W	Protein of unknown function found in the cytoplasm and bud neck	genetic	1	1	1	Positive Genetic
THI2	YBR240C	Transcriptional activator of thiamine biosynthetic genes	genetic	1	1	1	Positive Genetic
TAE1	YBR261C	AdoMet-dependent proline methyltransferase	genetic	1	1	1	Positive Genetic
YDR109C	YDR109C	D-ribulokinase	genetic	1	1	1	Positive Genetic
SWI5	YDR146C	Transcription factor that recruits Mediator and Swi/Snf complexes	genetic	1	1	1	Positive Genetic
UBP6	YFR010W	Ubiquitin-specific protease	genetic	1	1	1	Positive Genetic
YGL114W	YGL114W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
TRS65	YGR166W	Component of transport protein particle (TRAPP) complex II	genetic	1	1	1	Positive Genetic
UBR1	YGR184C	E3 ubiquitin ligase (N-recognin)	genetic	1	1	1	Positive Genetic
TDA10	YGR205W	ATP-binding protein of unknown function	genetic	1	1	1	Positive Genetic
TOS2	YGR221C	Protein involved in localization of Cdc24p to the site of bud growth	genetic	1	1	1	Positive Genetic
YGR237C	YGR237C	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
SNF6	YHL025W	Subunit of the SWI/SNF chromatin remodeling complex	genetic	1	1	1	Positive Genetic
YHR045W	YHR045W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
SVP26	YHR181W	ER exit adaptor for Golgi mannosyltransferases	genetic	1	1	1	Positive Genetic
SMN1	YHR202W	Putative AMP hydrolase	genetic	1	1	1	Positive Genetic
SKN7	YHR206W	Nuclear response regulator and transcription factor	genetic	1	1	1	Positive Genetic
SOA1	YIL166C	Sulfonate and inorganic sulfur transporter	genetic	1	1	1	Positive Genetic
SIP4	YJL089W	C6 zinc cluster transcriptional activator	genetic	1	1	1	Positive Genetic
TOR1	YJR066W	PIK-related protein kinase and rapamycin target	genetic	1	1	1	Positive Genetic
STR2	YJR130C	Cystathionine gamma-synthase, converts cysteine into cystathionine	genetic	1	1	1	Positive Genetic
TSR2	YLR435W	Protein with a potential role in pre-rRNA processing	genetic	1	1	1	Positive Genetic
USA1	YML029W	Scaffold subunit of the Hrd1p ubiquitin ligase	genetic	1	1	1	Positive Genetic
WHI2	YOR043W	Negative regulator of TORC1 in response to limiting leucine	genetic	1	1	1	Positive Genetic
YAR028W	YAR028W	Putative integral membrane protein	genetic	1	1	1	Negative Genetic
URA7	YBL039C	Major CTP synthase isozyme (see also URA8)	genetic	1	1	1	Negative Genetic
SNF11	YDR073W	Subunit of the SWI/SNF chromatin remodeling complex	genetic	1	1	1	Negative Genetic
STL1	YDR536W	Glycerol proton symporter of the plasma membrane	genetic	1	1	1	Negative Genetic
YGL036W	YGL036W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YGR054W	YGR054W	Eukaryotic initiation factor eIF2A	genetic	1	1	1	Negative Genetic
YGR111W	YGR111W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YOR1	YGR281W	Plasma membrane ATP-binding cassette (ABC) transporter	genetic	1	1	1	Negative Genetic
TFS1	YLR178C	Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p)	genetic	1	1	1	Negative Genetic
YJR084W	YJR084W	Protein that forms a complex with Thp3p	genetic	1	1	1	Negative Genetic
TVP38	YKR088C	Integral membrane protein	genetic	1	1	1	Negative Genetic
URA4	YLR420W	Dihydroorotase	genetic	1	1	1	Negative Genetic
UBX2	YML013W	Bridging factor involved in ER-associated protein degradation (ERAD)	genetic	1	1	1	Negative Genetic
VPS71	YML041C	Nucleosome-binding component of the SWR1 complex	genetic	1	1	1	Negative Genetic
TRM11	YOL124C	Catalytic subunit of adoMet-dependent tRNA methyltransferase complex	genetic	1	1	1	Negative Genetic
YPL247C	YPL247C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
SLM4	YBR077C	Subunit of the EGO/GSE complex	genetic	1	1	1	Positive Genetic
TPS1	YBR126C	Synthase subunit of trehalose-6-P synthase/phosphatase complex	genetic	1	1	1	Positive Genetic
YCL001W-A	YCL001W-A	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
UFD2	YDL190C	Ubiquitin (Ub) chain assembly factor (E4)	genetic	1	1	1	Positive Genetic
YDL199C	YDL199C	Putative transporter	genetic	1	1	1	Positive Genetic
YDL211C	YDL211C	Protein of unknown function	genetic	1	1	1	Positive Genetic
UFD4	YKL010C	Ubiquitin-protein ligase (E3)	genetic	1	1	1	Positive Genetic
YDL218W	YDL218W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
WHI4	YDL224C	Putative RNA binding protein	genetic	1	1	1	Positive Genetic
SSB1	YDL229W	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone	genetic	1	1	1	Positive Genetic
YDL241W	YDL241W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
YER079W	YER079W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
YER187W	YER187W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
SPO74	YGL170C	Component of the meiotic outer plaque of the spindle pole body	genetic	1	1	1	Positive Genetic
VEL1	YGL258W	Protein of unknown function	genetic	1	1	1	Positive Genetic
SPG1	YGR236C	Protein required for high temperature survival during stationary phase	genetic	1	1	1	Positive Genetic
VID28	YIL017C	GID Complex subunit, serves as adaptor for regulatory subunit Vid24p	genetic	1	1	1	Positive Genetic
VPS70	YJR126C	Protein of unknown function involved in vacuolar protein sorting	genetic	1	1	1	Positive Genetic
YLR001C	YLR001C	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
SRL2	YLR082C	Protein of unknown function	genetic	1	1	1	Positive Genetic
TOS4	YLR183C	Putative transcription factor, contains Forkhead Associated domain	genetic	1	1	1	Positive Genetic
UPS1	YLR193C	Phosphatidic acid transfer protein	genetic	1	1	1	Positive Genetic
SYM1	YLR251W	Protein required for ethanol metabolism	genetic	1	1	1	Positive Genetic
TRM12	YML005W	S-adenosylmethionine-dependent methyltransferase	genetic	1	1	1	Positive Genetic
YML037C	YML037C	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
SUR7	YML052W	Plasma membrane protein, component of eisosomes	genetic	1	1	1	Positive Genetic
WAR1	YML076C	Homodimeric Zn2Cys6 zinc finger transcription factor	genetic	1	1	1	Positive Genetic
TUB3	YML124C	Alpha-tubulin	genetic	1	1	1	Positive Genetic
YET2	YMR040W	Protein of unknown function that may interact with ribosomes	genetic	1	1	1	Positive Genetic
STV1	YMR054W	Subunit a of the vacuolar-ATPase V0 domain	genetic	1	1	1	Positive Genetic
UBX4	YMR067C	UBX domain-containing protein that interacts with Cdc48p	genetic	1	1	1	Positive Genetic
YMR085W	YMR085W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
SNO1	YMR095C	Protein of unconfirmed function	genetic	1	1	1	Positive Genetic
SNZ1	YMR096W	Subunit of a two-component pyridoxal-5'-phosphate synthase	genetic	1	1	1	Positive Genetic
YMR099C	YMR099C	Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase)	genetic	1	1	1	Positive Genetic
SRT1	YMR101C	Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1	genetic	1	1	1	Positive Genetic
YPK2	YMR104C	AGC-type S/T protein kinase	genetic	1	1	1	Positive Genetic
SPG4	YMR107W	Protein required for high temperature survival during stationary phase	genetic	1	1	1	Positive Genetic
YJL213W	YJL213W	Protein of unknown function that may interact with ribosomes	genetic	1	1	1	Negative Genetic
UBP8	YMR223W	Ubiquitin-specific protease component of the SAGA acetylation complex	genetic	1	1	1	Positive Genetic
YMR226C	YMR226C	NADP(+)-dependent serine dehydrogenase and carbonyl reductase	genetic	1	1	1	Positive Genetic
TRI1	YMR233W	Non-essential sumoylated protein of unknown function	genetic	1	1	1	Positive Genetic
YHM2	YMR241W	Citrate and oxoglutarate carrier protein	genetic	1	1	1	Positive Genetic
ZRC1	YMR243C	Vacuolar membrane zinc transporter	genetic	1	1	1	Positive Genetic
YME2	YMR302C	Integral inner mitochondrial membrane protein	genetic	1	1	1	Positive Genetic
YNL140C	YNL140C	Protein of unknown function	genetic	1	1	1	Positive Genetic
YNL144C	YNL144C	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
YNL146W	YNL146W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
YOL036W	YOL036W	Protein of unknown function	genetic	1	1	1	Positive Genetic
SSP2	YOR242C	Sporulation specific protein that localizes to the spore wall	genetic	1	1	1	Positive Genetic
SSE1	YPL106C	ATPase component of heat shock protein Hsp90 chaperone complex	genetic	1	1	1	Positive Genetic
TYW1	YPL207W	Iron-sulfur protein required for synthesis of wybutosine modified tRNA	genetic	1	1	1	Positive Genetic
YAR1	YPL239W	Nucleocytoplasmic shuttling assembly chaperone	genetic	1	1	1	Positive Genetic
SPE3	YPR069C	Spermidine synthase	genetic	1	1	1	Positive Genetic
YDL180W	YDL180W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
UBP12	YJL197W	Ubiquitin-specific protease	genetic	1	1	1	Negative Genetic
SWD1	YAR003W	Subunit of the COMPASS (Set1C) complex	genetic	1	1	1	Negative Genetic
SHE1	YBL031W	Mitotic spindle protein	genetic	1	1	1	Negative Genetic
VBA3	YCL069W	Permease of basic amino acids in the vacuolar membrane	genetic	1	1	1	Negative Genetic
TVP15	YDR100W	Integral membrane protein	genetic	1	1	1	Negative Genetic
TMN2	YDR107C	Protein with a role in cellular adhesion and filamentous growth	genetic	1	1	1	Negative Genetic
TRM1	YDR120C	tRNA methyltransferase	genetic	1	1	1	Negative Genetic
YDR124W	YDR124W	Mitochondrial protein of unknown function	genetic	1	1	1	Negative Genetic
SWF1	YDR126W	Palmitoyltransferase that acts on transmembrane proteins	genetic	1	1	1	Negative Genetic
SND1	YDR186C	Protein involved in SRP-independent targeting of substrates to the ER	genetic	1	1	1	Negative Genetic
VPS72	YDR485C	Htz1p-binding component of the SWR1 complex	genetic	1	1	1	Negative Genetic
YGK1	YGL101W	5'-deoxynucleotidase	genetic	1	1	1	Negative Genetic
STF2	YGR008C	Protein involved in resistance to desiccation stress	genetic	1	1	1	Negative Genetic
YGR017W	YGR017W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YGR026W	YGR026W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
VPS62	YGR141W	Vacuolar protein sorting (VPS) protein	genetic	1	1	1	Negative Genetic
SNG1	YGR197C	Protein involved in resistance to nitrosoguanidine and 6-azauracil	genetic	1	1	1	Negative Genetic
YIL161W	YIL161W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
VTH1	YIL173W	Putative membrane glycoprotein	genetic	1	1	1	Negative Genetic
TPK1	YJL164C	cAMP-dependent protein kinase catalytic subunit	genetic	1	1	1	Negative Genetic
SUL2	YLR092W	High affinity sulfate permease	genetic	1	1	1	Negative Genetic
SST2	YLR452C	GTPase-activating protein for Gpa1p	genetic	1	1	1	Negative Genetic
YML020W	YML020W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
SMA2	YML066C	Meiosis-specific prospore membrane protein	genetic	1	1	1	Negative Genetic
SIP5	YMR140W	Protein of unknown function	genetic	1	1	1	Negative Genetic
YMR155W	YMR155W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YMR158C-A	YMR158C-A	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
SIP18	YMR175W	Phospholipid-binding hydrophilin	genetic	1	1	1	Negative Genetic
SPT21	YMR179W	Protein with a role in transcriptional silencing	genetic	1	1	1	Negative Genetic
YMR181C	YMR181C	Protein of unknown function	genetic	1	1	1	Negative Genetic
SSO2	YMR183C	Plasma membrane t-SNARE	genetic	1	1	1	Negative Genetic
YMR187C	YMR187C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
SGS1	YMR190C	RecQ family nucleolar DNA helicase	genetic	1	1	1	Negative Genetic
SPG5	YMR191W	Protein required for proteasome assembly during quiescence	genetic	1	1	1	Negative Genetic
YMR196W	YMR196W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YMR206W	YMR206W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YMR209C	YMR209C	Putative S-adenosylmethionine-dependent methyltransferase	genetic	1	1	1	Negative Genetic
YMR253C	YMR253C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
TRM732	YMR259C	Protein involved in 2'-O-methylation of C32 of substrate tRNAs	genetic	1	1	1	Negative Genetic
YMR262W	YMR262W	Protein of unknown function	genetic	1	1	1	Negative Genetic
YMR265C	YMR265C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
TMA23	YMR269W	Nucleolar protein implicated in ribosome biogenesis	genetic	1	1	1	Negative Genetic
SSK2	YNR031C	MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway	genetic	1	1	1	Negative Genetic
SWT1	YOR166C	RNA endoribonuclease involved in perinuclear mRNP quality control	genetic	1	1	1	Negative Genetic
SYC1	YOR179C	Subunit of the APT subcomplex of cleavage and polyadenylation factor	genetic	1	1	1	Negative Genetic
THI72	YOR192C	Transporter of thiamine or related compound	genetic	1	1	1	Negative Genetic
YOR238W	YOR238W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
VTS1	YOR359W	Flap-structured DNA-binding and RNA-binding protein	genetic	1	1	1	Negative Genetic
ULA1	YPL003W	Protein that activates Rub1p (NEDD8) before neddylation	genetic	1	1	1	Negative Genetic
TCO89	YPL180W	Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p)	genetic	1	1	1	Negative Genetic
YPL245W	YPL245W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
THI21	YPL258C	Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase	genetic	1	1	1	Negative Genetic
TIP41	YPR040W	Tap42p-interacting protein	genetic	1	1	1	Negative Genetic
VAC17	YCL063W	Phosphoprotein involved in vacuole inheritance	genetic	1	1	1	Positive Genetic
SLA1	YBL007C	Cytoskeletal protein binding protein	genetic	1	1	1	Positive Genetic
SMY2	YBR172C	GYF domain protein	genetic	1	1	1	Positive Genetic
SSK22	YCR073C	MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway	genetic	1	1	1	Positive Genetic
YDL124W	YDL124W	NADPH-dependent alpha-keto amide reductase	genetic	1	1	1	Positive Genetic
VPS41	YDR080W	Subunit of the HOPS endocytic tethering complex	genetic	1	1	1	Positive Genetic
SNA2	YDR525W-A	Protein of unknown function	genetic	1	1	1	Positive Genetic
YER121W	YER121W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
YGL039W	YGL039W	Aldehyde reductase	genetic	1	1	1	Positive Genetic
THI4	YGR144W	Thiazole synthase	genetic	1	1	1	Positive Genetic
STE20	YHL007C	Cdc42p-activated signal transducing kinase	genetic	1	1	1	Positive Genetic
YHR022C	YHR022C	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
YHK8	YHR048W	Presumed antiporter of the major facilitator superfamily	genetic	1	1	1	Positive Genetic
SNX4	YJL036W	Sorting nexin	genetic	1	1	1	Positive Genetic
URA1	YKL216W	Dihydroorotate dehydrogenase	genetic	1	1	1	Positive Genetic
TRK2	YKR050W	Component of the Trk1p-Trk2p potassium transport system	genetic	1	1	1	Positive Genetic
UCC1	YLR224W	F-box protein and component of SCF ubiquitin ligase complexes	genetic	1	1	1	Positive Genetic
VRP1	YLR337C	Verprolin, proline-rich actin-associated protein	genetic	1	1	1	Positive Genetic
SPO77	YLR341W	Meiosis-specific protein of unknown function	genetic	1	1	1	Positive Genetic
VPS38	YLR360W	Part of a Vps34p phosphatidylinositol 3-kinase complex	genetic	1	1	1	Positive Genetic
VAC14	YLR386W	Enzyme regulator	genetic	1	1	1	Positive Genetic
YML002W	YML002W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
YMR114C	YMR114C	Protein of unknown function	genetic	1	1	1	Positive Genetic
YMR310C	YMR310C	Putative methyltransferase	genetic	1	1	1	Positive Genetic
SIW14	YNL032W	Inositol phosphatase involved in inositol pyrophosphate metabolism	genetic	1	1	1	Positive Genetic
YNL034W	YNL034W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
SUN4	YNL066W	Cell wall protein related to glucanases localized in birth scars	genetic	1	1	1	Positive Genetic
TPM1	YNL079C	Major isoform of tropomyosin	genetic	1	1	1	Positive Genetic
SWM2	YNR004W	Protein with a role in snRNA and snoRNA cap trimethylation	genetic	1	1	1	Positive Genetic
TLG2	YOL018C	Syntaxin-like t-SNARE	genetic	1	1	1	Positive Genetic
SPO21	YOL091W	Component of the meiotic outer plaque of the spindle pole body	genetic	1	1	1	Positive Genetic
YOR131C	YOR131C	Putative haloacid dehalogenase-like hydrolase	genetic	1	1	1	Positive Genetic
TKL1	YPR074C	Transketolase	genetic	1	1	1	Positive Genetic
YPR096C	YPR096C	Protein of unknown function	genetic	1	1	1	Positive Genetic
YAR023C	YAR023C	Putative integral membrane protein	genetic	1	1	1	Negative Genetic
UBP14	YBR058C	Ubiquitin-specific protease	genetic	1	1	1	Negative Genetic
VID24	YBR105C	GID Complex regulatory subunit	genetic	1	1	1	Negative Genetic
TEF2	YBR118W	Translational elongation factor EF-1 alpha	genetic	1	1	1	Negative Genetic
YBR225W	YBR225W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YIH1	YCR059C	Negative regulator of eIF2 kinase Gcn2p	genetic	1	1	1	Negative Genetic
YDL012C	YDL012C	Tail-anchored plasma membrane protein with a conserved CYSTM module	genetic	1	1	1	Negative Genetic
YDR061W	YDR061W	Protein with similarity to ABC transporter family members	genetic	1	1	1	Negative Genetic
TRS85	YDR108W	Component of transport protein particle (TRAPP) complex III	genetic	1	1	1	Negative Genetic
YIM1	YMR152W	Aldehyde reductase	genetic	1	1	1	Negative Genetic
TMN3	YER113C	Protein with a role in cellular adhesion and filamentous growth	genetic	1	1	1	Negative Genetic
UBP3	YER151C	Ubiquitin-specific protease that cleaves Ub-protein fusions	genetic	1	1	1	Negative Genetic
YER152C	YER152C	Protein with 2-aminoadipate transaminase activity	genetic	1	1	1	Negative Genetic
SWP82	YFL049W	Member of the SWI/SNF chromatin remodeling complex	genetic	1	1	1	Negative Genetic
SIP2	YGL208W	One of three alternate beta subunits of the Snf1 kinase complex	genetic	1	1	1	Negative Genetic
SLI1	YGR212W	N-acetyltransferase	genetic	1	1	1	Negative Genetic
YHL044W	YHL044W	Putative integral membrane protein	genetic	1	1	1	Negative Genetic
TIR3	YIL011W	Cell wall mannoprotein	genetic	1	1	1	Negative Genetic
YIL024C	YIL024C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
VHR1	YIL056W	Transcriptional activator	genetic	1	1	1	Negative Genetic
YJR124C	YJR124C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
XPT1	YJR133W	Xanthine-guanine phosphoribosyl transferase	genetic	1	1	1	Negative Genetic
YJR149W	YJR149W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
VPS24	YKL041W	One of four subunits of the ESCRT-III complex	genetic	1	1	1	Negative Genetic
TGL1	YKL140W	Steryl ester hydrolase	genetic	1	1	1	Negative Genetic
ZRT3	YKL175W	Vacuolar membrane zinc transporter	genetic	1	1	1	Negative Genetic
YEH1	YLL012W	Steryl ester hydrolase	genetic	1	1	1	Negative Genetic
YEH2	YLR020C	Steryl ester hydrolase	genetic	1	1	1	Negative Genetic
SPO20	YMR017W	Meiosis-specific subunit of the t-SNARE complex	genetic	1	1	1	Negative Genetic
YNR066C	YNR066C	Putative membrane-localized protein of unknown function	genetic	1	1	1	Negative Genetic
STE13	YOR219C	Dipeptidyl aminopeptidase	genetic	1	1	1	Negative Genetic
SPS4	YOR313C	Protein whose expression is induced during sporulation	genetic	1	1	1	Negative Genetic
YPR148C	YPR148C	Protein of unknown function	genetic	1	1	1	Negative Genetic
VPS4	YPR173C	AAA-ATPase involved in multivesicular body (MVB) protein sorting	genetic	1	1	1	Negative Genetic
SOL2	YCR073W-A	Protein with a possible role in tRNA export	genetic	1	1	1	Positive Genetic
YDR514C	YDR514C	Protein of unknown function that localizes to mitochondria	genetic	1	1	1	Positive Genetic
YDR541C	YDR541C	Aldehyde reductase	genetic	1	1	1	Positive Genetic
YER085C	YER085C	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
UBP5	YER144C	Putative ubiquitin-specific protease	genetic	1	1	1	Positive Genetic
YPT32	YGL210W	Rab family GTPase involved in the exocytic pathway	genetic	1	1	1	Positive Genetic
YGL262W	YGL262W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
YHL012W	YHL012W	Putative UTP glucose-1-phosphate uridylyltransferase	genetic	1	1	1	Positive Genetic
YLF2	YHL014C	Protein of unknown function	genetic	1	1	1	Positive Genetic
SSF1	YHR066W	Constituent of 66S pre-ribosomal particles	genetic	1	1	1	Positive Genetic
SSM4	YIL030C	Membrane-embedded ubiquitin-protein ligase and retrotranslocase	genetic	1	1	1	Positive Genetic
VHS2	YIL135C	Regulator of septin dynamics	genetic	1	1	1	Positive Genetic
TPM2	YIL138C	Minor isoform of tropomyosin	genetic	1	1	1	Positive Genetic
STE24	YJR117W	Highly conserved zinc metalloprotease	genetic	1	1	1	Positive Genetic
YKR041W	YKR041W	Protein of unknown function	genetic	1	1	1	Positive Genetic
SKG1	YKR100C	Transmembrane protein with a role in cell wall polymer composition	genetic	1	1	1	Positive Genetic
SWI6	YLR182W	Transcription cofactor	genetic	1	1	1	Positive Genetic
YLR446W	YLR446W	Putative hexokinase	genetic	1	1	1	Positive Genetic
YLR460C	YLR460C	Member of the quinone oxidoreductase family	genetic	1	1	1	Positive Genetic
YML108W	YML108W	Protein of unknown function	genetic	1	1	1	Positive Genetic
YMR295C	YMR295C	Protein of unknown function that associates with ribosomes	genetic	1	1	1	Positive Genetic
YNL011C	YNL011C	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
YIP3	YNL044W	Protein localized to COPII vesicles	genetic	1	1	1	Positive Genetic
URK1	YNR012W	Uridine/cytidine kinase	genetic	1	1	1	Positive Genetic
YNR029C	YNR029C	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
YNR064C	YNR064C	Epoxide hydrolase	genetic	1	1	1	Positive Genetic
YAP7	YOL028C	Transcriptional repressor of nitric oxide oxidase	genetic	1	1	1	Positive Genetic
WSC3	YOL105C	Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway	genetic	1	1	1	Positive Genetic
TSR3	YOR006C	Protein required for 20S pre-rRNA processing	genetic	1	1	1	Positive Genetic
YOR012W	YOR012W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
TMC1	YOR052C	AN1-type zinc finger protein, effector of proteotoxic stress response	genetic	1	1	1	Positive Genetic
SKS1	YPL026C	Putative serine/threonine protein kinase	genetic	1	1	1	Positive Genetic
THI6	YPL214C	Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase	genetic	1	1	1	Positive Genetic
VIK1	YPL253C	Protein that forms a kinesin-14 heterodimeric motor with Kar3p	genetic	1	1	1	Positive Genetic
THI22	YPR121W	Protein with similarity to hydroxymethylpyrimidine phosphate kinases	genetic	1	1	1	Positive Genetic
YBR220C	YBR220C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
THR4	YCR053W	Threonine synthase	genetic	1	1	1	Negative Genetic
TMA64	YDR117C	Protein of unknown function that associates with ribosomes	genetic	1	1	1	Negative Genetic
VBA4	YDR119W	Protein of unknown function	genetic	1	1	1	Negative Genetic
YCF1	YDR135C	Vacuolar glutathione S-conjugate transporter	genetic	1	1	1	Negative Genetic
TOS8	YGL096W	Homeodomain-containing protein and putative transcription factor	genetic	1	1	1	Negative Genetic
SOH1	YGL127C	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Negative Genetic
YGR266W	YGR266W	Protein of unknown function	genetic	1	1	1	Negative Genetic
TCD1	YHR003C	tRNA threonylcarbamoyladenosine dehydratase	genetic	1	1	1	Negative Genetic
YHI9	YHR029C	Protein of unknown function	genetic	1	1	1	Negative Genetic
YHR112C	YHR112C	Protein of unknown function	genetic	1	1	1	Negative Genetic
STB5	YHR178W	Transcription factor	genetic	1	1	1	Negative Genetic
XBP1	YIL101C	Transcriptional repressor	genetic	1	1	1	Negative Genetic
YIR016W	YIR016W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YJR026W	YJR026W	Retrotransposon TYA Gag gene co-transcribed with TYB Pol	genetic	1	1	1	Negative Genetic
YJR154W	YJR154W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
SRY1	YKL218C	3-hydroxyaspartate dehydratase	genetic	1	1	1	Negative Genetic
YPS3	YLR121C	Aspartic protease	genetic	1	1	1	Negative Genetic
YLR125W	YLR125W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
ZRT2	YLR130C	Low-affinity zinc transporter of the plasma membrane	genetic	1	1	1	Negative Genetic
YML053C	YML053C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
TSL1	YML100W	Large subunit of trehalose 6-phosphate synthase/phosphatase complex	genetic	1	1	1	Negative Genetic
YMR160W	YMR160W	Protein of unknown function	genetic	1	1	1	Negative Genetic
SOL1	YNR034W	Protein with a possible role in tRNA export	genetic	1	1	1	Negative Genetic
SIL1	YOL031C	Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p	genetic	1	1	1	Negative Genetic
YVC1	YOR087W	Vacuolar cation channel	genetic	1	1	1	Negative Genetic
WTM1	YOR230W	Transcriptional modulator	genetic	1	1	1	Negative Genetic
YOR342C	YOR342C	Protein of unknown function	genetic	1	1	1	Negative Genetic
SMA1	YPL027W	Protein of unknown function involved in prospore membrane assembly	genetic	1	1	1	Negative Genetic
SVL3	YPL032C	Protein of unknown function	genetic	1	1	1	Negative Genetic
YPL162C	YPL162C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
TBS1	YBR150C	Protein of unknown function	genetic	1	1	1	Positive Genetic
TOS1	YBR162C	Covalently-bound cell wall protein of unknown function	genetic	1	1	1	Positive Genetic
SMP1	YBR182C	MADS-box transcription factor involved in osmotic stress response	genetic	1	1	1	Positive Genetic
SRO9	YCL037C	Cytoplasmic RNA-binding protein	genetic	1	1	1	Positive Genetic
VCX1	YDL128W	Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity	genetic	1	1	1	Positive Genetic
YDL144C	YDL144C	Protein of unknown function	genetic	1	1	1	Positive Genetic
SHE9	YDR393W	Protein required for normal mitochondrial morphology	genetic	1	1	1	Positive Genetic
YOX1	YML027W	Homeobox transcriptional repressor	genetic	1	1	1	Positive Genetic
YFR006W	YFR006W	Putative X-Pro aminopeptidase	genetic	1	1	1	Positive Genetic
TYW3	YGL050W	tRNA methyltransferase required for synthesis of wybutosine	genetic	1	1	1	Positive Genetic
SNT2	YGL131C	Subunit of Snt2C complex, RING finger ubiquitin ligase (E3)	genetic	1	1	1	Positive Genetic
YGL176C	YGL176C	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
VID30	YGL227W	Central component of GID Complex, involved in FBPase degradation	genetic	1	1	1	Positive Genetic
SHE10	YGL228W	Protein involved in outer spore wall assembly	genetic	1	1	1	Positive Genetic
YGR122W	YGR122W	Protein that may be involved in pH regulation	genetic	1	1	1	Positive Genetic
SUC2	YIL162W	Invertase	genetic	1	1	1	Positive Genetic
YLR179C	YLR179C	Protein of unknown function with similarity to Tfs1p	genetic	1	1	1	Positive Genetic
SML1	YML058W	Ribonucleotide reductase inhibitor	genetic	1	1	1	Positive Genetic
URA5	YML106W	Major orotate phosphoribosyltransferase (OPRTase) isozyme	genetic	1	1	1	Positive Genetic
STB2	YMR053C	Protein that interacts with Sin3p in a two-hybrid assay	genetic	1	1	1	Positive Genetic
YMR316C-A	YMR316C-A	Protein of unknown function	genetic	1	1	1	Positive Genetic
TOM7	YNL070W	Component of the TOM (translocase of outer membrane) complex	genetic	1	1	1	Positive Genetic
YPQ1	YOL092W	Putative vacuolar membrane transporter for cationic amino acids	genetic	1	1	1	Positive Genetic
SLG1	YOR008C	Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway	genetic	1	1	1	Positive Genetic
YOR008C-A	YOR008C-A	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
TUM1	YOR251C	Rhodanese domain sulfur transferase	genetic	1	1	1	Positive Genetic
TEA1	YOR337W	Ty1 enhancer activator involved in Ty enhancer-mediated transcription	genetic	1	1	1	Positive Genetic
SVS1	YPL163C	Cell wall and vacuolar protein	genetic	1	1	1	Positive Genetic
USV1	YPL230W	Putative transcription factor containing a C2H2 zinc finger	genetic	1	1	1	Positive Genetic
YPR147C	YPR147C	Bifunctional triacylglycerol lipase and short chain ester hydrolase	genetic	1	1	1	Positive Genetic
YBR238C	YBR238C	Mitochondrial membrane protein	genetic	1	1	1	Negative Genetic
TRP1	YDR007W	Phosphoribosylanthranilate isomerase	genetic	1	1	1	Negative Genetic
SNQ2	YDR011W	Plasma membrane ATP-binding cassette (ABC) transporter	genetic	1	1	1	Negative Genetic
YDR018C	YDR018C	Probable membrane protein with three predicted transmembrane domains	genetic	1	1	1	Negative Genetic
VTC5	YDR089W	Novel subunit of the vacuolar transporter chaperone complex	genetic	1	1	1	Negative Genetic
YFL012W	YFL012W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YFH7	YFR007W	Putative kinase with similarity to the PRK/URK/PANK kinase subfamily	genetic	1	1	1	Negative Genetic
YGL235W	YGL235W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YIL067C	YIL067C	Uncharacterized protein of unknown function	genetic	1	1	1	Negative Genetic
VPS55	YJR044C	Late endosomal protein involved in late endosome to vacuole transport	genetic	1	1	1	Negative Genetic
YJR098C	YJR098C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
URA8	YJR103W	Minor CTP synthase isozyme (see also URA7)	genetic	1	1	1	Negative Genetic
TCD2	YKL027W	tRNA threonylcarbamoyladenosine dehydratase	genetic	1	1	1	Negative Genetic
SRX1	YKL086W	Sulfiredoxin	genetic	1	1	1	Negative Genetic
TGL3	YMR313C	Bifunctional triacylglycerol lipase and LPE acyltransferase	genetic	1	1	1	Negative Genetic
YMR315W	YMR315W	Protein with NADP(H) oxidoreductase activity	genetic	1	1	1	Negative Genetic
YPT53	YNL093W	Stress-induced Rab family GTPase	genetic	1	1	1	Negative Genetic
TEP1	YNL128W	PTEN homolog with no demonstrated inositol lipid phosphatase activity	genetic	1	1	1	Negative Genetic
YNR048W	YNR048W	Potential noncatalytic subunit for phospholipid translocase Dnf3p	genetic	1	1	1	Negative Genetic
TMA16	YOR252W	Protein of unknown function that associates with ribosomes	genetic	1	1	1	Negative Genetic
YOR365C	YOR365C	Putative protein involved in sphingolipid biosynthesis	genetic	1	1	1	Negative Genetic
YPL264C	YPL264C	Endoplasmic reticulum protein of unknown function	genetic	1	1	1	Negative Genetic
THP3	YPR045C	Protein that may have a role in transcription elongation	genetic	1	1	1	Negative Genetic
YPR084W	YPR084W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
SWC4	YGR002C	Component of the Swr1p complex that incorporates Htz1p into chromatin	genetic	1	1	1	Negative Genetic
SUP45	YBR143C	Polypeptide release factor (eRF1) in translation termination	genetic	1	1	1	Positive Genetic
SMC4	YLR086W	Subunit of the condensin complex	genetic	1	1	1	Positive Genetic
VMS1	YDR049W	Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes,	genetic	1	1	1	Positive Genetic
TCP1	YDR212W	Alpha subunit of chaperonin-containing T-complex	genetic	1	1	1	Positive Genetic
SSD1	YDR293C	Translational repressor	genetic	1	1	1	Positive Genetic
SMC2	YFR031C	Subunit of the condensin complex	genetic	1	1	1	Positive Genetic
STT3	YGL022W	Catalytic subunit of the oligosaccharyltransferase complex of the ER l	genetic	1	1	1	Positive Genetic
SPC105	YGL093W	Subunit of a kinetochore-microtubule binding complex	genetic	1	1	1	Positive Genetic
SSC1	YJR045C	Hsp70 family ATPase	genetic	1	1	1	Positive Genetic
YJU2	YKL095W	Essential protein required for pre-mRNA splicing	genetic	1	1	1	Positive Genetic
SOF1	YLL011W	Protein required for biogenesis of 40S (small) ribosomal subunit	genetic	1	1	1	Positive Genetic
TAF8	YML114C	TFIID subunit (65 kDa)	genetic	1	1	1	Positive Genetic
SRV2	YNL138W	CAP (cyclase-associated protein)	genetic	1	1	1	Positive Genetic
SMP3	YOR149C	Alpha 1,2-mannosyltransferase	genetic	1	1	1	Positive Genetic
UTP5	YDR398W	Subunit of U3-containing Small Subunit (SSU) processome complex	genetic	1	1	1	Negative Genetic
UTP6	YDR449C	Nucleolar protein	genetic	1	1	1	Negative Genetic
TEL2	YGR099W	Subunit of the ASTRA complex, involved in chromatin remodeling	genetic	1	1	1	Negative Genetic
SPT6	YGR116W	Nucleosome remodeling protein	genetic	1	1	1	Negative Genetic
UBP15	YMR304W	Ubiquitin-specific protease involved in protein deubiquitination	genetic	1	1	1	Negative Genetic
SWC3	YAL011W	Protein of unknown function	genetic	1	1	1	Positive Genetic
SPC19	YDR201W	Essential subunit of the Dam1 complex (aka DASH complex)	genetic	1	1	1	Positive Genetic
SNU56	YDR240C	Component of U1 snRNP required for mRNA splicing via spliceosome	genetic	1	1	1	Positive Genetic
TSC11	YER093C	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p)	genetic	1	1	1	Positive Genetic
STS1	YIR011C	Protein required for localizing proteasomes to the nucleus	genetic	1	1	1	Positive Genetic
YPT7	YML001W	Rab family GTPase	genetic	1	1	1	Positive Genetic
SWD2	YKL018W	Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex	genetic	1	1	1	Negative Genetic
SPC29	YPL124W	Inner plaque spindle pole body (SPB) component	genetic	1	1	1	Negative Genetic
TSC13	YDL015C	Enoyl reductase	genetic	1	1	1	Positive Genetic
SUP35	YDR172W	Translation termination factor eRF3	genetic	1	1	1	Positive Genetic
SYF1	YDR416W	Member of the NineTeen Complex (NTC)	genetic	1	1	1	Positive Genetic
VSB1	YGR125W	Vacuolar membrane protein required for uptake and storage of arginine	genetic	1	1	1	Positive Genetic
SKI6	YGR195W	Exosome non-catalytic core component	genetic	1	1	1	Positive Genetic
SQT1	YIR012W	Specific assembly chaperone for ribosomal protein Rpl10p	genetic	1	1	1	Positive Genetic
TAD3	YLR316C	Subunit of tRNA-specific adenosine-34 deaminase	genetic	1	1	1	Positive Genetic
UTP23	YOR004W	Component of the small subunit processome	genetic	1	1	1	Positive Genetic
SRP54	YPR088C	Signal recognition particle (SRP) subunit (homolog of mammalian SRP54)	genetic	1	1	1	Positive Genetic
SLU7	YDR088C	RNA splicing factor	genetic	1	1	1	Negative Genetic
TFG2	YGR005C	TFIIF (Transcription Factor II) middle subunit	genetic	1	1	1	Negative Genetic
TAF9	YMR236W	Subunit (17 kDa) of TFIID and SAGA complexes	genetic	1	1	1	Negative Genetic
VPS30	YPL120W	Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II	genetic	1	1	1	Negative Genetic
SPT16	YGL207W	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p)	genetic	1	1	1	Positive Genetic
VPS8	YAL002W	Membrane-binding component of the CORVET complex	genetic	1	1	1	Positive Genetic
TSC3	YBR058C-A	Protein that stimulates the activity of serine palmitoyltransferase	genetic	1	1	1	Positive Genetic
SNU23	YDL098C	Component of the U4/U6.U5 snRNP complex	genetic	1	1	1	Positive Genetic
TAF10	YDR167W	Subunit (145 kDa) of TFIID and SAGA complexes	genetic	1	1	1	Positive Genetic
SLD5	YDR489W	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p)	genetic	1	1	1	Positive Genetic
SKI8	YGL213C	Ski complex component and WD-repeat protein	genetic	1	1	1	Positive Genetic
TFC4	YGR047C	Subunit of RNA polymerase III transcription initiation factor complex	genetic	1	1	1	Positive Genetic
YHR020W	YHR020W	Prolyl-tRNA synthetase	genetic	1	1	1	Positive Genetic
URA6	YKL024C	Uridylate kinase	genetic	1	1	1	Positive Genetic
SLI15	YBR156C	Subunit of the conserved chromosomal passenger complex (CPC)	genetic	1	1	1	Negative Genetic
SRB6	YBR253W	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Negative Genetic
USO1	YDL058W	Essential protein involved in vesicle-mediated ER to Golgi transport	genetic	1	1	1	Negative Genetic
SPT3	YDR392W	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes	genetic	1	1	1	Negative Genetic
STP1	YDR463W	Transcription factor	genetic	1	1	1	Negative Genetic
VAS1	YGR094W	Mitochondrial and cytoplasmic valyl-tRNA synthetase	genetic	1	1	1	Negative Genetic
SUI2	YJR007W	Alpha subunit of the translation initiation factor eIF2	genetic	1	1	1	Negative Genetic
TPI1	YDR050C	Triose phosphate isomerase, abundant glycolytic enzyme	genetic	1	1	1	Positive Genetic
SHQ1	YIL104C	Chaperone protein	genetic	1	1	1	Positive Genetic
YIP1	YGR172C	Integral membrane protein	genetic	1	1	1	Negative Genetic
SLN1	YIL147C	Transmembrane histidine phosphotransfer kinase and osmosensor	genetic	1	1	1	Negative Genetic
TFC3	YAL001C	Subunit of RNA polymerase III transcription initiation factor complex	genetic	1	1	1	Positive Genetic
SMI1	YGR229C	Protein involved in the regulation of cell wall synthesis	genetic	1	1	1	Positive Genetic
TIM44	YIL022W	Essential component of the TIM23 complex	genetic	1	1	1	Positive Genetic
UBA4	YHR111W	E1-like protein that activates Urm1p before urmylation	genetic	1	1	1	Negative Genetic
ARE2	YNR019W	Acyl-CoA:sterol acyltransferase	genetic	1	1	1	Negative Genetic
SGD1	YLR336C	Essential nuclear protein	genetic	1	1	1	Synthetic Lethality
DSK2	YMR276W	Nuclear-enriched ubiquitin-like polyubiquitin-binding protein	genetic	1	1	1	Negative Genetic
ATG7	YHR171W	Autophagy-related protein and dual specificity member of the E1 family	genetic	1	1	1	Positive Genetic
FAR10	YLR238W	Protein involved in recovery from arrest in response to pheromone	genetic	1	1	1	Negative Genetic
RSP5	YER125W	NEDD4 family E3 ubiquitin ligase	genetic	1	1	1	Positive Genetic
BUL1	YMR275C	Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex	genetic	1	1	1	Negative Genetic
GRS1	YBR121C	Cytoplasmic and mitochondrial glycyl-tRNA synthase	genetic	1	1	1	Negative Genetic
OCA1	YNL099C	Putative protein tyrosine phosphatase	genetic	1	1	1	Negative Genetic
RNA1	YMR235C	GTPase activating protein (GAP) for Gsp1p	genetic	1	1	1	Negative Genetic
GYP5	YPL249C	GTPase-activating protein (GAP) for yeast Rab family members	genetic	1	1	1	Negative Genetic
GPN3	YLR243W	Putative GTPase with a role in biogenesis of RNA pol II and polIII	genetic	1	1	1	Synthetic Lethality
HOM6	YJR139C	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase)	genetic	1	1	1	Positive Genetic
RAD6	YGL058W	Ubiquitin-conjugating enzyme (E2)	genetic	1	1	1	Positive Genetic
RSN1	YMR266W	Membrane protein of unknown function	genetic	1	1	1	Negative Genetic
SAH1	YER043C	S-adenosyl-L-homocysteine hydrolase	genetic	1	1	1	Synthetic Lethality
MET6	YER091C	Cobalamin-independent methionine synthase	genetic	1	1	1	Positive Genetic
FRS2	YFL022C	Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase	genetic	1	1	1	Synthetic Lethality
RPP0	YLR340W	Conserved ribosomal protein P0 of the ribosomal stalk	genetic	1	1	1	Negative Genetic
CTF13	YMR094W	Subunit of the CBF3 complex	genetic	1	1	1	Negative Genetic
ADD66	YKL206C	Protein involved in 20S proteasome assembly	genetic	1	1	1	Negative Genetic
GAL7	YBR018C	Galactose-1-phosphate uridyl transferase	genetic	1	1	1	Negative Genetic
HYM1	YKL189W	Component of the RAM signaling network	genetic	1	1	1	Positive Genetic
MCX1	YBR227C	Non-proteolytic ATPase of the AAA family	genetic	1	1	1	Positive Genetic
CDC15	YAR019C	Hippo-like kinase of the Mitotic Exit Network	genetic	1	1	1	Positive Genetic
LAS1	YKR063C	Endonuclease involved in pre-rRNA processing at both ends of ITS2	genetic	1	1	1	Synthetic Lethality
KEL2	YGR238C	Protein that negatively regulates mitotic exit	genetic	1	1	1	Negative Genetic
GIS4	YML006C	CAAX box containing protein of unknown function	genetic	1	1	1	Positive Genetic
DOG1	YHR044C	2-deoxyglucose-6-phosphate phosphatase	genetic	1	1	1	Negative Genetic
CAC2	YML102W	Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p	genetic	1	1	1	Positive Genetic
KSP1	YHR082C	Serine/threonine protein kinase	physical	1	1	1	Biochemical Activity
HIR2	YOR038C	Subunit of HIR nucleosome assembly complex	genetic	1	1	1	Negative Genetic
ADE17	YMR120C	Enzyme of 'de novo' purine biosynthesis	genetic	1	1	1	Positive Genetic
ISU1	YPL135W	Conserved protein of the mitochondrial matrix	genetic	1	1	1	Positive Genetic
HHT1	YBR010W	Histone H3	genetic	1	1	1	Negative Genetic
HHO1	YPL127C	Histone H1, linker histone with roles in meiosis and sporulation	genetic	1	1	1	Negative Genetic
DIA2	YOR080W	Origin-binding F-box protein	physical	1	1	1	Affinity Capture-Western
SEG1	YMR086W	Component of eisosome required for proper eisosome assembly	genetic	1	1	1	Positive Genetic
CDC123	YLR215C	Assembly factor for the eIF2 translation initiation factor complex	genetic	1	1	1	Positive Genetic
CAF4	YKR036C	WD40 repeat-containing protein associated with the CCR4-NOT complex	genetic	1	1	1	Negative Genetic
RCN2	YOR220W	Protein of unknown function	genetic	1	1	1	Negative Genetic
MKK2	YPL140C	MAPKK involved in the protein kinase C signaling pathway	genetic	1	1	1	Negative Genetic
BEM4	YPL161C	Protein involved in establishment of cell polarity and bud emergence	genetic	1	1	1	Positive Genetic
BCK2	YER167W	Serine/threonine-rich protein involved in PKC1 signaling pathway	genetic	1	1	1	Negative Genetic
NUS1	YDL193W	Forms dehydrodolichyl diphosphate synthase complex with RER2 or SRT1	genetic	1	1	1	Positive Genetic
PGM1	YKL127W	Phosphoglucomutase, minor isoform	genetic	1	1	1	Positive Genetic
RAD14	YMR201C	Subunit of Nucleotide Excision Repair Factor 1 (NEF1)	genetic	1	1	1	Positive Genetic
KIN28	YDL108W	Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly	genetic	1	1	1	Negative Genetic
ATG20	YDL113C	Sorting nexin family member	genetic	1	1	1	Negative Genetic
SDP1	YIL113W	Stress-inducible dual-specificity MAP kinase phosphatase	genetic	1	1	1	Negative Genetic
SEC4	YFL005W	Rab family GTPase	genetic	1	1	1	Phenotypic Enhancement
MIH1	YMR036C	Protein tyrosine phosphatase	genetic	1	1	1	Positive Genetic
MAP2	YBL091C	Methionine aminopeptidase	genetic	1	1	1	Negative Genetic
AIR1	YIL079C	Zinc knuckle protein	genetic	1	1	1	Negative Genetic
NUP2	YLR335W	Nucleoporin involved in nucleocytoplasmic transport	genetic	1	1	1	Negative Genetic
HMG2	YLR450W	HMG-CoA reductase	genetic	1	1	1	Negative Genetic
FKH2	YNL068C	Forkhead family transcription factor	genetic	1	1	1	Positive Genetic
GTO1	YGR154C	Omega-class glutathione transferase	genetic	1	1	1	Negative Genetic
LAA1	YJL207C	AP-1 accessory protein	genetic	1	1	1	Negative Genetic
NDE1	YMR145C	Mitochondrial external NADH dehydrogenase	genetic	1	1	1	Negative Genetic
RMT2	YDR465C	Arginine N5 methyltransferase	genetic	1	1	1	Negative Genetic
LIF1	YGL090W	Component of the DNA ligase IV complex	genetic	1	1	1	Positive Genetic
GDT1	YBR187W	Calcium and manganese transporter with higher affinity for Ca2+	genetic	1	1	1	Positive Genetic
EAP1	YKL204W	eIF4E-associated protein, competes with eIF4G for binding to eIF4E	genetic	1	1	1	Positive Genetic
MEH1	YKR007W	Subunit of the EGO/GSE complex	genetic	1	1	1	Negative Genetic
BIO3	YNR058W	7,8-diamino-pelargonic acid aminotransferase (DAPA)	genetic	1	1	1	Negative Genetic
CPR3	YML078W	Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin)	genetic	1	1	1	Positive Genetic
GID10	YGR066C	Recognition component (N-recognin) of the Pro/N-degron pathway	genetic	1	1	1	Positive Genetic
LOS1	YKL205W	Nuclear pore protein	genetic	1	1	1	Negative Genetic
MIG1	YGL035C	Transcription factor involved in glucose repression	genetic	1	1	1	Negative Genetic
BUB3	YOR026W	Kinetochore checkpoint WD40 repeat protein	genetic	1	1	1	Negative Genetic
FUS3	YBL016W	Mitogen-activated serine/threonine protein kinase involved in mating	genetic	1	1	1	Positive Genetic
MIC19	YFR011C	Component of the MICOS complex	genetic	1	1	1	Negative Genetic
NUP53	YMR153W	FG-nucleoporin component of central core of nuclear pore complex (NPC)	genetic	1	1	1	Negative Genetic
GPA1	YHR005C	Subunit of G protein involved in pheromone response	genetic	1	1	1	Negative Genetic
CLN2	YPL256C	G1 cyclin involved in regulation of the cell cycle	genetic	1	1	1	Positive Genetic
RAD26	YJR035W	Protein involved in transcription-coupled nucleotide excision repair	genetic	1	1	1	Synthetic Growth Defect
ADH6	YMR318C	NADPH-dependent medium chain alcohol dehydrogenase	genetic	1	1	1	Positive Genetic
GCR2	YNL199C	Transcriptional activator of genes involved in glycolysis	genetic	1	1	1	Positive Genetic
DAP1	YPL170W	Heme-binding protein	genetic	1	1	1	Negative Genetic
APE2	YKL157W	Aminopeptidase yscII	genetic	1	1	1	Negative Genetic
ATG5	YPL149W	Conserved protein involved in autophagy and the Cvt pathway	genetic	1	1	1	Negative Genetic
RRP3	YHR065C	Protein involved in rRNA processing	genetic	1	1	1	Negative Genetic
PHO86	YJL117W	Endoplasmic reticulum (ER) resident protein	genetic	1	1	1	Positive Genetic
CMG1	YLR271W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
EXO70	YJL085W	Subunit of the exocyst complex	genetic	1	1	1	Positive Genetic
GAL2	YLR081W	Galactose permease	genetic	1	1	1	Positive Genetic
PEX15	YOL044W	Tail-anchored type II integral peroxisomal membrane protein	genetic	1	1	1	Positive Genetic
IGO1	YNL157W	Protein required for initiation of G0 program	genetic	1	1	1	Positive Genetic
MGT1	YDL200C	DNA repair methyltransferase (6-O-methylguanine-DNA methylase)	genetic	1	1	1	Positive Genetic
CHZ1	YER030W	Histone chaperone for Htz1p/H2A-H2B dimer	genetic	1	1	1	Phenotypic Enhancement
POL4	YCR014C	DNA polymerase IV	genetic	1	1	1	Positive Genetic
RNR3	YIL066C	Minor isoform of large subunit of ribonucleotide-diphosphate reductase	genetic	1	1	1	Negative Genetic
RED1	YLR263W	Protein component of the synaptonemal complex axial elements	genetic	1	1	1	Synthetic Rescue
PSO2	YMR137C	Nuclease required for DNA single- and double-strand break repair	genetic	1	1	1	Negative Genetic
GDH2	YDL215C	NAD(+)-dependent glutamate dehydrogenase	genetic	1	1	1	Positive Genetic
FMP48	YGR052W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
APM4	YOL062C	Cargo-binding mu subunit of AP-2	genetic	1	1	1	Positive Genetic
ESS1	YJR017C	Peptidylprolyl-cis/trans-isomerase (PPIase)	genetic	1	1	1	Negative Genetic
NBP2	YDR162C	Protein involved in the HOG (high osmolarity glycerol) pathway	genetic	1	1	1	Positive Genetic
ADH5	YBR145W	Alcohol dehydrogenase isoenzyme V	genetic	1	1	1	Negative Genetic
IME2	YJL106W	Serine/threonine protein kinase involved in activation of meiosis	genetic	1	1	1	Negative Genetic
DAD2	YKR083C	Essential subunit of the Dam1 complex (aka DASH complex)	genetic	1	1	1	Positive Genetic
FZF1	YGL254W	Transcription factor involved in sulfite metabolism	genetic	1	1	1	Negative Genetic
HOF1	YMR032W	F-BAR protein that regulates actin cytoskeleton organization	genetic	1	1	1	Positive Genetic
BUD27	YFL023W	Unconventional prefoldin protein involved in translation initiation	physical	1	1	1	Two-hybrid
BUD27	YFL023W	Unconventional prefoldin protein involved in translation initiation	genetic	1	1	1	Negative Genetic
NAS2	YIL007C	Evolutionarily conserved 19S regulatory particle assembly-chaperone	genetic	1	1	1	Positive Genetic
ADE2	YOR128C	Phosphoribosylaminoimidazole carboxylase	genetic	1	1	1	Positive Genetic
ALR1	YOL130W	Plasma membrane Mg(2+) transporter	genetic	1	1	1	Negative Genetic
ATG1	YGL180W	Protein serine/threonine kinase	genetic	1	1	1	Negative Genetic
ATG13	YPR185W	Regulatory subunit of the Atg1p signaling complex	genetic	1	1	1	Negative Genetic
ATG16	YMR159C	Conserved protein involved in autophagy	genetic	1	1	1	Negative Genetic
ATP20	YPR020W	Subunit g of the mitochondrial F1F0 ATP synthase	genetic	1	1	1	Positive Genetic
CDC43	YGL155W	Beta subunit of geranylgeranyltransferase type I	genetic	1	1	1	Positive Genetic
ENT3	YJR125C	Protein containing an N-terminal epsin-like domain	genetic	1	1	1	Negative Genetic
FAR3	YMR052W	Protein of unknown function	genetic	1	1	1	Positive Genetic
GNA1	YFL017C	Glucosamine-6-phosphate acetyltransferase	genetic	1	1	1	Positive Genetic
GTR1	YML121W	Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex	genetic	1	1	1	Positive Genetic
GZF3	YJL110C	GATA zinc finger protein	genetic	1	1	1	Positive Genetic
GDS1	YOR355W	Protein involved in histone H4 acetylation at ribosomal protein genes	genetic	1	1	1	Negative Genetic
ISC10	YER180C	Meiosis-specific MAPK inhibitor	genetic	1	1	1	Negative Genetic
LPP1	YDR503C	Lipid phosphate phosphatase	genetic	1	1	1	Negative Genetic
MPD2	YOL088C	Member of the protein disulfide isomerase (PDI) family	physical	1	1	1	Affinity Capture-MS
MSB2	YGR014W	Mucin family member involved in various signaling pathways	genetic	1	1	1	Positive Genetic
MSH5	YDL154W	Protein of the MutS family	genetic	1	1	1	Phenotypic Suppression
COG2	YGR120C	Essential component of the conserved oligomeric Golgi complex	genetic	1	1	1	Positive Genetic
ASM4	YDL088C	FG-nucleoporin component of central core of nuclear pore complex (NPC)	genetic	1	1	1	Positive Genetic
NDC1	YML031W	Subunit of the transmembrane ring of the nuclear pore complex (NPC)	genetic	1	1	1	Positive Genetic
NDC80	YIL144W	Component of the kinetochore-associated Ndc80 complex	genetic	1	1	1	Positive Genetic
NUF2	YOL069W	Component of the kinetochore-associated Ndc80 complex	genetic	1	1	1	Positive Genetic
HSP10	YOR020C	Mitochondrial matrix co-chaperonin	genetic	1	1	1	Positive Genetic
NUP57	YGR119C	FG-nucleoporin component of central core of the nuclear pore complex	genetic	1	1	1	Negative Genetic
MMR1	YLR190W	Phosphorylated protein of the mitochondrial outer membrane	genetic	1	1	1	Positive Genetic
CLG1	YGL215W	Cyclin-like protein that interacts with Pho85p	genetic	1	1	1	Negative Genetic
PCL9	YDL179W	Cyclin	genetic	1	1	1	Negative Genetic
PRP5	YBR237W	RNA helicase in the DEAD-box family	genetic	1	1	1	Positive Genetic
RIM101	YHL027W	Cys2His2 zinc-finger transcriptional repressor	genetic	1	1	1	Positive Genetic
IME1	YJR094C	Master regulator of meiosis that is active only during meiotic events	genetic	1	1	1	Negative Genetic
RPS26B	YER131W	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
RRN6	YBL014C	Component of the core factor (CF) rDNA transcription factor complex	genetic	1	1	1	Synthetic Lethality
RRN10	YBL025W	Protein involved in promoting high level transcription of rDNA	genetic	1	1	1	Positive Genetic
CDC34	YDR054C	Ubiquitin-conjugating enzyme (E2)	genetic	1	1	1	Negative Genetic
PET191	YJR034W	Protein required for assembly of cytochrome c oxidase	genetic	1	1	1	Negative Genetic
QCR6	YFR033C	Subunit 6 of the ubiquinol cytochrome-c reductase complex	genetic	1	1	1	Negative Genetic
RUB1	YDR139C	Ubiquitin-like protein with similarity to mammalian NEDD8	genetic	1	1	1	Negative Genetic
BAS1	YKR099W	Myb-related transcription factor	genetic	1	1	1	Positive Genetic
PRR2	YDL214C	Serine/threonine protein kinase	genetic	1	1	1	Positive Genetic
JSN1	YJR091C	Member of the Puf family of RNA-binding proteins	genetic	1	1	1	Negative Genetic
NBA1	YOL070C	Protein involved in axial bud site selection	genetic	1	1	1	Negative Genetic
AIM18	YHR198C	Protein of unknown function	genetic	1	1	1	Negative Genetic
RBD2	YPL246C	Possible rhomboid protease	genetic	1	1	1	Positive Genetic
PRM9	YAR031W	Pheromone-regulated protein	genetic	1	1	1	Negative Genetic
CTL1	YMR180C	RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm	genetic	1	1	1	Negative Genetic
PPA2	YMR267W	Mitochondrial inorganic pyrophosphatase	genetic	1	1	1	Negative Genetic
BNA6	YFR047C	Quinolinate phosphoribosyl transferase	genetic	1	1	1	Positive Genetic
ERC1	YHR032W	Member of the multi-drug and toxin extrusion (MATE) family	genetic	1	1	1	Positive Genetic
CHA4	YLR098C	DNA binding transcriptional activator	genetic	1	1	1	Negative Genetic
PUT3	YKL015W	Transcriptional activator	genetic	1	1	1	Negative Genetic
ADY3	YDL239C	Protein required for spore wall formation	genetic	1	1	1	Positive Genetic
NMA2	YGR010W	Nicotinic acid mononucleotide adenylyltransferase	genetic	1	1	1	Negative Genetic
PEF1	YGR058W	Penta-EF-hand protein	genetic	1	1	1	Negative Genetic
ART5	YGR068C	Protein proposed to regulate endocytosis of plasma membrane proteins	genetic	1	1	1	Positive Genetic
PIR5	YJL160C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
GPN2	YOR262W	Putative GTPase with a specific role in RNA pol II and polIII biogenes	genetic	1	1	1	Negative Genetic
ASK10	YGR097W	Regulator of the Fps1p glycerol channel	genetic	1	1	1	Negative Genetic
ITT1	YML068W	Protein that modulates the efficiency of translation termination	genetic	1	1	1	Negative Genetic
AVO2	YMR068W	Component of a complex containing the Tor2p kinase and other proteins	genetic	1	1	1	Positive Genetic
MGL2	YMR210W	Monoacylglycerol and triacylglycerol lipase	genetic	1	1	1	Negative Genetic
ELP6	YMR312W	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex	genetic	1	1	1	Positive Genetic
HUA1	YGR268C	Cytoplasmic protein containing a zinc finger domain	genetic	1	1	1	Positive Genetic
OCA2	YNL056W	Protein of unknown function	genetic	1	1	1	Positive Genetic
BLI1	YKL061W	Subunit of the BLOC-1 complex involved in endosomal maturation	genetic	1	1	1	Negative Genetic
NST1	YNL091W	Translational inhibitor and suppressor of proteasome-assembly defects	genetic	1	1	1	Positive Genetic
CUB1	YPL260W	Conserved fungal gene linked to DNA repair and proteasome function	genetic	1	1	1	Positive Genetic
AIM4	YBR194W	Protein proposed to be associated with the nuclear pore complex	genetic	1	1	1	Negative Genetic
APC11	YDL008W	Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C)	genetic	1	1	1	Positive Genetic
APC4	YDR118W	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C)	genetic	1	1	1	Positive Genetic
APC9	YLR102C	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C)	genetic	1	1	1	Negative Genetic
CDC27	YBL084C	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C)	genetic	1	1	1	Positive Genetic
CDC26	YFR036W	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C)	genetic	1	1	1	Positive Genetic
CEP3	YMR168C	Essential kinetochore protein	genetic	1	1	1	Negative Genetic
CLB1	YGR108W	B-type cyclin involved in cell cycle progression	genetic	1	1	1	Positive Genetic
CWC15	YDR163W	Non-essential protein involved in pre-mRNA splicing	genetic	1	1	1	Negative Genetic
COG7	YGL005C	Component of the conserved oligomeric Golgi complex	genetic	1	1	1	Positive Genetic
COG6	YNL041C	Component of the conserved oligomeric Golgi complex	genetic	1	1	1	Positive Genetic
COG5	YNL051W	Component of the conserved oligomeric Golgi complex	genetic	1	1	1	Positive Genetic
GIP3	YPL137C	Cytoplasmic protein that regulates protein phosphatase 1 Glc7p	genetic	1	1	1	Positive Genetic
RPL4A	YBR031W	Ribosomal 60S subunit protein L4A	genetic	1	1	1	Positive Genetic
NNF1	YJR112W	Essential component of the outer kinetochore MIND complex	genetic	1	1	1	Synthetic Lethality
RNA15	YGL044C	Component of the cleavage and polyadenylation factor I (CF I)	genetic	1	1	1	Negative Genetic
PEX12	YMR026C	C3HC4-type RING-finger peroxin and E3 ubiquitin ligase	genetic	1	1	1	Positive Genetic
PEX13	YLR191W	Peroxisomal importomer complex component	genetic	1	1	1	Positive Genetic
PEX2	YJL210W	RING-finger peroxin and E3 ubiquitin ligase	genetic	1	1	1	Positive Genetic
CHL1	YPL008W	Probable DNA helicase	genetic	1	1	1	Positive Genetic
RPS13	YDR064W	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
HOT1	YMR172W	Transcription factor for glycerol biosynthetic genes	genetic	1	1	1	Negative Genetic
RPL23B	YER117W	Ribosomal 60S subunit protein L23B	genetic	1	1	1	Negative Genetic
SFH1	YLR321C	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Positive Genetic
AMD1	YML035C	AMP deaminase	genetic	1	1	1	Positive Genetic
CET1	YPL228W	RNA 5'-triphosphatase involved in mRNA 5' capping	genetic	1	1	1	Negative Genetic
CRP1	YHR146W	Protein that binds to cruciform DNA structures	genetic	1	1	1	Dosage Rescue
NHP6A	YPR052C	High-mobility group (HMG) protein	genetic	1	1	1	Negative Genetic
JIP5	YPR169W	Protein required for biogenesis of the large ribosomal subunit	genetic	1	1	1	Synthetic Lethality
ARP6	YLR085C	Actin-related protein that binds nucleosomes	genetic	1	1	1	Negative Genetic
DAL81	YIR023W	Positive regulator of genes in multiple nitrogen degradation pathways	genetic	1	1	1	Positive Genetic
IES4	YOR189W	Component of the INO80 chromatiin remodeling complex	genetic	1	1	1	Positive Genetic
PHO4	YFR034C	Basic helix-loop-helix (bHLH) transcription factor of the myc-family	genetic	1	1	1	Positive Genetic
RTG3	YBL103C	bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways	genetic	1	1	1	Positive Genetic
SCL1	YGL011C	Alpha 1 subunit of the 20S proteasome	genetic	1	1	1	Positive Genetic
RPS8A	YBL072C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Negative Genetic
RPL20B	YOR312C	Ribosomal 60S subunit protein L20B	genetic	1	1	1	Positive Genetic
RPS1B	YML063W	Ribosomal protein of the small (40S) subunit	genetic	1	1	1	Positive Genetic
RPS11B	YBR048W	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
RPL22A	YLR061W	Ribosomal 60S subunit protein L22A	genetic	1	1	1	Positive Genetic
CSE4	YKL049C	Centromeric histone H3-like protein	genetic	1	1	1	Positive Genetic
MIF2	YKL089W	Centromeric CDEIII region binding protein	genetic	1	1	1	Positive Genetic
CPT1	YNL130C	Cholinephosphotransferase	genetic	1	1	1	Negative Genetic
AMA1	YGR225W	Activator of meiotic anaphase promoting complex (APC/C)	genetic	1	1	1	Negative Genetic
ATG8	YBL078C	Ub-like protein	genetic	1	1	1	Negative Genetic
CLB5	YPR120C	B-type cyclin involved in DNA replication during S phase	genetic	1	1	1	Phenotypic Enhancement
ELO2	YCR034W	Fatty acid elongase, involved in sphingolipid biosynthesis	genetic	1	1	1	Positive Genetic
ELO3	YLR372W	Elongase	genetic	1	1	1	Positive Genetic
EPS1	YIL005W	ER protein with chaperone and co-chaperone activity	genetic	1	1	1	Positive Genetic
GCD10	YNL062C	Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p	genetic	1	1	1	Positive Genetic
GEA1	YJR031C	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs)	genetic	1	1	1	Negative Genetic
HXK2	YGL253W	Hexokinase isoenzyme 2	genetic	1	1	1	Positive Genetic
IOC4	YMR044W	Member of a complex (Isw1b) with Isw1p and Ioc2p	genetic	1	1	1	Positive Genetic
KAR3	YPR141C	Minus-end-directed microtubule motor	genetic	1	1	1	Positive Genetic
KAR9	YPL269W	Spindle positioning factor	genetic	1	1	1	Positive Genetic
MEX67	YPL169C	Poly(A)RNA binding protein involved in nuclear mRNA export	genetic	1	1	1	Positive Genetic
MTR2	YKL186C	mRNA transport regulator	genetic	1	1	1	Synthetic Lethality
MYO5	YMR109W	One of two type I myosin motors	genetic	1	1	1	Positive Genetic
BIK1	YCL029C	Microtubule-associated protein	genetic	1	1	1	Positive Genetic
NYV1	YLR093C	v-SNARE component of the vacuolar SNARE complex	genetic	1	1	1	Negative Genetic
ORC3	YLL004W	Subunit of the origin recognition complex (ORC)	genetic	1	1	1	Phenotypic Enhancement
OST2	YOR103C	Epsilon subunit of the oligosaccharyltransferase complex	genetic	1	1	1	Negative Genetic
OST3	YOR085W	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen	genetic	1	1	1	Positive Genetic
PHO80	YOL001W	Cyclin	genetic	1	1	1	Negative Genetic
PRK1	YIL095W	Ser/Thr protein kinase	genetic	1	1	1	Positive Genetic
PUP1	YOR157C	Beta 2 subunit of the 20S proteasome	genetic	1	1	1	Positive Genetic
REC102	YLR329W	Protein involved in early stages of meiotic recombination	genetic	1	1	1	Negative Genetic
RPA14	YDR156W	RNA polymerase I subunit A14	genetic	1	1	1	Negative Genetic
RTG2	YGL252C	Sensor of mitochondrial dysfunction	genetic	1	1	1	Positive Genetic
SAS4	YDR181C	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p)	genetic	1	1	1	Negative Genetic
SEC1	YDR164C	Sm-like protein involved in docking and fusion of exocytic vesicles	genetic	1	1	1	Negative Genetic
ERV41	YML067C	Protein localized to COPII-coated vesicles	genetic	1	1	1	Positive Genetic
SEC22	YLR268W	R-SNARE protein	genetic	1	1	1	Negative Genetic
PAM18	YLR008C	Subunit of the import motor (PAM complex)	genetic	1	1	1	Negative Genetic
NMD2	YHR077C	Protein involved in the nonsense-mediated mRNA decay (NMD) pathway	genetic	1	1	1	Negative Genetic
DPH1	YIL103W	Protein required for synthesis of diphthamide	genetic	1	1	1	Positive Genetic
HRB1	YNL004W	Poly(A+) RNA-binding protein	genetic	1	1	1	Positive Genetic
PHO2	YDL106C	Homeobox transcription factor	genetic	1	1	1	Negative Genetic
SCC2	YDR180W	Subunit of cohesin loading factor (Scc2p-Scc4p)	genetic	1	1	1	Positive Genetic
GOS1	YHL031C	v-SNARE protein involved in Golgi transport	genetic	1	1	1	Positive Genetic
SFI1	YLL003W	Centrin (Cdc31p)-binding protein required for SPB duplication	genetic	1	1	1	Positive Genetic
OST4	YDL232W	Subunit of the oligosaccharyltransferase complex of the ER lumen	genetic	1	1	1	Positive Genetic
SFK1	YKL051W	Protein that regulates phospholipid asymmetry at plasma membrane	genetic	1	1	1	Positive Genetic
EMP46	YLR080W	Integral membrane component of ER-derived COPII-coated vesicles	genetic	1	1	1	Positive Genetic
HAP4	YKL109W	Transcription factor	genetic	1	1	1	Positive Genetic
GAP1	YKR039W	General amino acid permease	genetic	1	1	1	Positive Genetic
SEC24	YIL109C	Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat	genetic	1	1	1	Positive Genetic
CSG2	YBR036C	Endoplasmic reticulum membrane protein	genetic	1	1	1	Negative Genetic
GYP1	YOR070C	Cis-golgi GTPase-activating protein (GAP) for yeast Rabs	genetic	1	1	1	Negative Genetic
PPR1	YLR014C	Zinc finger transcription factor	genetic	1	1	1	Positive Genetic
GAL80	YML051W	Transcriptional regulator involved in the repression of GAL genes	genetic	1	1	1	Synthetic Growth Defect
ABF1	YKL112W	DNA binding protein with possible chromatin-reorganizing activity	genetic	1	1	1	Negative Genetic
BNR1	YIL159W	Formin	genetic	1	1	1	Negative Genetic
MUD2	YKL074C	Protein involved in early pre-mRNA splicing	genetic	1	1	1	Positive Genetic
FBP1	YLR377C	Fructose-1,6-bisphosphatase	genetic	1	1	1	Positive Genetic
GIC1	YHR061C	Rho-family GTPase interacting protein and Cdc42p effector	genetic	1	1	1	Negative Genetic
MSO1	YNR049C	Lipid-interacting protein in SNARE complex assembly machinery	genetic	1	1	1	Positive Genetic
NUP100	YKL068W	FG-nucleoporin component of central core of the nuclear pore complex	genetic	1	1	1	Positive Genetic
FCP1	YMR277W	Carboxy-terminal domain (CTD) phosphatase	genetic	1	1	1	Negative Genetic
SFT1	YKL006C-A	Intra-Golgi v-SNARE	genetic	1	1	1	Positive Genetic
EMC5	YIL027C	Member of conserved ER transmembrane complex	genetic	1	1	1	Positive Genetic
CAT8	YMR280C	Zinc cluster transcriptional activator	genetic	1	1	1	Negative Genetic
AFI1	YOR129C	Arf3p polarization-specific docking factor	genetic	1	1	1	Negative Genetic
DAL80	YKR034W	Negative regulator of genes in multiple nitrogen degradation pathways	genetic	1	1	1	Positive Genetic
ESC1	YMR219W	Protein involved in telomeric silencing	genetic	1	1	1	Negative Genetic
CAD1	YDR423C	AP-1-like basic leucine zipper (bZIP) transcriptional activator	genetic	1	1	1	Negative Genetic
GPB2	YAL056W	Multistep regulator of cAMP-PKA signaling	genetic	1	1	1	Negative Genetic
JEM1	YJL073W	DnaJ-like chaperone required for nuclear membrane fusion during mating	genetic	1	1	1	Positive Genetic
LRG1	YDL240W	GTPase-activating protein (GAP)	genetic	1	1	1	Positive Genetic
GAD1	YMR250W	Glutamate decarboxylase	genetic	1	1	1	Negative Genetic
DCN1	YLR128W	Scaffold-type E3 ligase	genetic	1	1	1	Positive Genetic
FMP42	YMR221C	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
AAD3	YCR107W	Putative aryl-alcohol dehydrogenase	genetic	1	1	1	Positive Genetic
HMT1	YBR034C	Nuclear SAM-dependent mono- and asymmetric methyltransferase	genetic	1	1	1	Positive Genetic
MAC1	YMR021C	Copper-sensing transcription factor	genetic	1	1	1	Positive Genetic
CDC19	YAL038W	Pyruvate kinase	genetic	1	1	1	Synthetic Lethality
MON1	YGL124C	Subunit of a heterodimeric guanine nucleotide exchange factor (GEF)	genetic	1	1	1	Positive Genetic
HKR1	YDR420W	Mucin family member that functions as an osmosensor in the HOG pathway	genetic	1	1	1	Negative Genetic
PET122	YER153C	Mitochondrial translational activator specific for the COX3 mRNA	genetic	1	1	1	Positive Genetic
PET494	YNR045W	Mitochondrial translational activator specific for the COX3 mRNA	genetic	1	1	1	Negative Genetic
PEX28	YHR150W	Peroxisomal integral membrane peroxin	genetic	1	1	1	Positive Genetic
GPR1	YDL035C	Plasma membrane G protein coupled receptor (GPCR)	genetic	1	1	1	Negative Genetic
REC114	YMR133W	Protein involved in early stages of meiotic recombination	genetic	1	1	1	Positive Genetic
NNF2	YGR089W	Protein that exhibits physical and genetic interactions with Rpb8p	genetic	1	1	1	Positive Genetic
NNK1	YKL171W	Protein kinase	genetic	1	1	1	Positive Genetic
GYL1	YMR192W	Putative GTPase activating protein (GAP) with a role in exocytosis	genetic	1	1	1	Negative Genetic
ARK1	YNL020C	Ser/Thr protein kinase	genetic	1	1	1	Positive Genetic
BAT2	YJR148W	Cytosolic branched-chain amino acid (BCAA) aminotransferase	genetic	1	1	1	Positive Genetic
MRI1	YPR118W	5'-methylthioribose-1-phosphate isomerase	genetic	1	1	1	Positive Genetic
NBP1	YLR457C	Spindle pole body (SPB) component	genetic	1	1	1	Positive Genetic
BUD17	YNR027W	Putative pyridoxal kinase	genetic	1	1	1	Positive Genetic
SAM2	YDR502C	S-adenosylmethionine synthetase	genetic	1	1	1	Negative Genetic
PBP1	YGR178C	Component of glucose deprivation induced stress granules	genetic	1	1	1	Positive Genetic
DFG5	YMR238W	Putative mannosidase	genetic	1	1	1	Positive Genetic
MSB4	YOL112W	GTPase-activating protein of the Ras superfamily	genetic	1	1	1	Positive Genetic
ACF2	YLR144C	Intracellular beta-1,3-endoglucanase	genetic	1	1	1	Positive Genetic
CHS5	YLR330W	Component of the exomer complex	genetic	1	1	1	Negative Genetic
GTT2	YLL060C	Glutathione S-transferase capable of homodimerization	genetic	1	1	1	Positive Genetic
GAT1	YFL021W	Transcriptional activator of nitrogen catabolite repression genes	genetic	1	1	1	Positive Genetic
HHT2	YNL031C	Histone H3	genetic	1	1	1	Positive Genetic
RDI1	YDL135C	Rho GDP dissociation inhibitor	genetic	1	1	1	Negative Genetic
ERT1	YBR239C	Transcriptional regulator	genetic	1	1	1	Positive Genetic
KEX2	YNL238W	Kexin, a subtilisin-like protease (proprotein convertase)	genetic	1	1	1	Positive Genetic
AUR1	YKL004W	Phosphatidylinositol:ceramide phosphoinositol transferase	genetic	1	1	1	Positive Genetic
HRD1	YOL013C	Ubiquitin-protein ligase involved in ER-associated degradation (ERAD)	genetic	1	1	1	Negative Genetic
REC8	YPR007C	Meiosis-specific component of the sister chromatid cohesion complex	genetic	1	1	1	Negative Genetic
MFA2	YNL145W	Mating pheromone a-factor	genetic	1	1	1	Positive Genetic
PAM16	YJL104W	Subunit of the import motor (PAM complex)	genetic	1	1	1	Negative Genetic
MNN11	YJL183W	Subunit of a Golgi mannosyltransferase complex	genetic	1	1	1	Negative Genetic
NVJ1	YHR195W	Nuclear envelope protein	genetic	1	1	1	Positive Genetic
RIM20	YOR275C	Protein involved in proteolytic activation of Rim101p	genetic	1	1	1	Positive Genetic
MDL1	YLR188W	Mitochondrial inner membrane half-type ABC transporter	genetic	1	1	1	Positive Genetic
EIS1	YMR031C	Component of the eisosome required for proper eisosome assembly	genetic	1	1	1	Positive Genetic
ENV11	YGR071C	Protein proposed to be involved in vacuolar functions	genetic	1	1	1	Negative Genetic
KAP120	YPL125W	Karyopherin responsible for the nuclear import of Rpf1p	genetic	1	1	1	Negative Genetic
PAN3	YKL025C	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex	genetic	1	1	1	Negative Genetic
RPL11B	YGR085C	Ribosomal 60S subunit protein L11B	genetic	1	1	1	Positive Genetic
HBT1	YDL223C	Shmoo tip protein, substrate of Hub1p ubiquitin-like protein	genetic	1	1	1	Positive Genetic
RDS3	YPR094W	Component of the SF3b subcomplex of the U2 snRNP	genetic	1	1	1	Positive Genetic
SGF11	YPL047W	Integral subunit of SAGA histone acetyltransferase complex	genetic	1	1	1	Positive Genetic
RNR4	YGR180C	Ribonucleotide-diphosphate reductase (RNR) small subunit	genetic	1	1	1	Negative Genetic
RPN4	YDL020C	Transcription factor that stimulates expression of proteasome genes	genetic	1	1	1	Positive Genetic
PDR12	YPL058C	Plasma membrane ATP-binding cassette (ABC) transporter	genetic	1	1	1	Negative Genetic
NOP8	YOL144W	Nucleolar protein required for 60S ribosomal subunit biogenesis	genetic	1	1	1	Synthetic Lethality
RPS20	YHL015W	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Synthetic Lethality
PUP2	YGR253C	Alpha 5 subunit of the 20S proteasome	genetic	1	1	1	Positive Genetic
RAX1	YOR301W	Protein involved in establishing bud site selection	genetic	1	1	1	Negative Genetic
RPS23A	YGR118W	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
MCR1	YKL150W	Mitochondrial NADH-cytochrome b5 reductase	genetic	1	1	1	Negative Genetic
MOG1	YJR074W	Conserved nuclear protein that interacts with GTP-Gsp1p	genetic	1	1	1	Negative Genetic
GDH3	YAL062W	NADP(+)-dependent glutamate dehydrogenase	genetic	1	1	1	Negative Genetic
RPS14A	YCR031C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
RPL13A	YDL082W	Ribosomal 60S subunit protein L13A	genetic	1	1	1	Positive Genetic
MDM31	YHR194W	Mitochondrial protein that may have a role in phospholipid metabolism	genetic	1	1	1	Positive Genetic
MLS1	YNL117W	Malate synthase, enzyme of the glyoxylate cycle	genetic	1	1	1	Negative Genetic
SED1	YDR077W	Major stress-induced structural GPI-cell wall glycoprotein	genetic	1	1	1	Negative Genetic
IXR1	YKL032C	Transcriptional repressor that regulates hypoxic genes during normoxia	genetic	1	1	1	Negative Genetic
RPL15A	YLR029C	Ribosomal 60S subunit protein L15A	genetic	1	1	1	Positive Genetic
RPL19B	YBL027W	Ribosomal 60S subunit protein L19B	genetic	1	1	1	Negative Genetic
RPL27B	YDR471W	Ribosomal 60S subunit protein L27B	genetic	1	1	1	Positive Genetic
PET127	YOR017W	Protein with a role in 5'-end processing of mitochondrial RNAs	genetic	1	1	1	Negative Genetic
ERG5	YMR015C	C-22 sterol desaturase	genetic	1	1	1	Positive Genetic
EUC1	YMR111C	Sequence-specific DNA binding protein	genetic	1	1	1	Positive Genetic
PRP24	YMR268C	Splicing factor that reanneals snRNPs during spliceosome recycling	genetic	1	1	1	Synthetic Lethality
ADI1	YMR009W	Acireductone dioxygenease involved in methionine salvage pathway	genetic	1	1	1	Positive Genetic
KIP1	YBL063W	Kinesin-related motor protein	genetic	1	1	1	Negative Genetic
CRG1	YHR209W	S-AdoMet-dependent methyltransferase involved in lipid homeostasis	genetic	1	1	1	Positive Genetic
KAR5	YMR065W	Protein required for nuclear membrane fusion during karyogamy	genetic	1	1	1	Positive Genetic
SAC7	YDR389W	GTPase activating protein (GAP) for Rho1p	genetic	1	1	1	Negative Genetic
MTD1	YKR080W	NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase	genetic	1	1	1	Positive Genetic
ECM21	YBL101C	Alpha-arrestin, ubiquitin ligase adaptor for Rsp5p	genetic	1	1	1	Positive Genetic
AUS1	YOR011W	Plasma membrane sterol transporter of the ATP-binding cassette family	genetic	1	1	1	Negative Genetic
HBS1	YKR084C	GTPase with similarity to translation release factors	genetic	1	1	1	Negative Genetic
INH1	YDL181W	Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase	genetic	1	1	1	Positive Genetic
EPO1	YMR124W	Protein involved in septin-ER tethering	genetic	1	1	1	Positive Genetic
MET4	YNL103W	Leucine-zipper transcriptional activator	genetic	1	1	1	Synthetic Lethality
POM152	YMR129W	Glycoprotein subunit of transmembrane ring of nuclear pore complex	genetic	1	1	1	Negative Genetic
PAC1	YOR269W	Regulator of dynein, involved in intracellular transport	genetic	1	1	1	Negative Genetic
CNN1	YFR046C	Kinetochore protein	genetic	1	1	1	Positive Genetic
PBN1	YCL052C	Component of glycosylphosphatidylinositol-mannosyltransferase I	genetic	1	1	1	Positive Genetic
SDH1	YKL148C	Flavoprotein subunit of succinate dehydrogenase	genetic	1	1	1	Positive Genetic
POG1	YIL122W	DNA-binding transcriptional activator	genetic	1	1	1	Negative Genetic
CPS1	YJL172W	Vacuolar carboxypeptidase S	genetic	1	1	1	Negative Genetic
ROY1	YMR258C	GTPase inhibitor with similarity to F-box proteins	genetic	1	1	1	Negative Genetic
ATP18	YML081C-A	Subunit of the mitochondrial F1F0 ATP synthase	genetic	1	1	1	Positive Genetic
CAT2	YML042W	Carnitine acetyl-CoA transferase	genetic	1	1	1	Negative Genetic
HSP31	YDR533C	Methylglyoxalase that converts methylglyoxal to D-lactate	genetic	1	1	1	Positive Genetic
BTS1	YPL069C	Geranylgeranyl diphosphate synthase (GGPPS)	genetic	1	1	1	Negative Genetic
FRK1	YPL141C	Protein kinase of unknown cellular role	physical	1	1	1	Biochemical Activity
CUE4	YML101C	Protein of unknown function	genetic	1	1	1	Positive Genetic
BCH2	YKR027W	Member of the ChAPs (Chs5p-Arf1p-binding proteins) family	genetic	1	1	1	Negative Genetic
NDJ1	YOL104C	Protein that regulates meiotic SPB cohesion and telomere clustering	genetic	1	1	1	Negative Genetic
ORC6	YHR118C	Subunit of the origin recognition complex (ORC)	genetic	1	1	1	Positive Genetic
HEH2	YDR458C	Inner nuclear membrane (INM) protein	genetic	1	1	1	Negative Genetic
PSG1	YKL077W	Protein that promotes the transport and maturation of Pma1 with Exp1	genetic	1	1	1	Negative Genetic
ERG2	YMR202W	C-8 sterol isomerase	genetic	1	1	1	Negative Genetic
INP1	YMR204C	Peripheral membrane protein of peroxisomes	genetic	1	1	1	Negative Genetic
BAP3	YDR046C	Amino acid permease	genetic	1	1	1	Positive Genetic
PAM17	YKR065C	Constituent of the TIM23 complex	genetic	1	1	1	Negative Genetic
MF(ALPHA)1	YPL187W	Mating pheromone alpha-factor, made by alpha cells	genetic	1	1	1	Positive Genetic
MSS11	YMR164C	Transcription factor	genetic	1	1	1	Negative Genetic
RIO1	YOR119C	Serine kinase involved in cell cycle regulation and rDNA integrity	physical	1	1	1	Two-hybrid
RIO1	YOR119C	Serine kinase involved in cell cycle regulation and rDNA integrity	genetic	1	1	1	Negative Genetic
RFA2	YNL312W	Subunit of heterotrimeric Replication Protein A (RPA)	genetic	1	1	1	Negative Genetic
PYK2	YOR347C	Pyruvate kinase	genetic	1	1	1	Negative Genetic
RPS31	YLR167W	Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin	genetic	1	1	1	Synthetic Lethality
PAH1	YMR165C	Mg2+-dependent phosphatidate (PA) phosphatase	genetic	1	1	1	Negative Genetic
GAS5	YOL030W	1,3-beta-glucanosyltransferase	genetic	1	1	1	Synthetic Growth Defect
ERV15	YBR210W	Protein involved in export of proteins from the endoplasmic reticulum	genetic	1	1	1	Positive Genetic
CUE1	YMR264W	Ubiquitin-binding protein	genetic	1	1	1	Positive Genetic
SEC11	YIR022W	18kDa catalytic subunit of the Signal Peptidase Complex (SPC)	genetic	1	1	1	Negative Genetic
NCE102	YPR149W	Protein of unknown function	genetic	1	1	1	Positive Genetic
EHT1	YBR177C	Octanoyl-CoA:ethanol acyltransferase	genetic	1	1	1	Negative Genetic
HRD3	YLR207W	ER membrane protein that plays a central role in ERAD	genetic	1	1	1	Positive Genetic
IRC7	YFR055W	Cysteine desulphydrase, enables growth on cysteine as nitrogen source	genetic	1	1	1	Positive Genetic
RPL43B	YJR094W-A	Ribosomal 60S subunit protein L43B	genetic	1	1	1	Negative Genetic
NGR1	YBR212W	RNA binding protein that negatively regulates growth rate	genetic	1	1	1	Positive Genetic
HYR1	YIR037W	Glutathione peroxidase	genetic	1	1	1	Negative Genetic
GLO4	YOR040W	Mitochondrial glyoxalase II	genetic	1	1	1	Positive Genetic
MBA1	YBR185C	Membrane-associated mitochondrial ribosome receptor	genetic	1	1	1	Positive Genetic
ARI1	YGL157W	NADPH-dependent aldehyde reductase	genetic	1	1	1	Positive Genetic
PBP4	YDL053C	Pbp1p binding protein	genetic	1	1	1	Negative Genetic
COQ10	YOL008W	Coenzyme Q (ubiquinone) binding protein	genetic	1	1	1	Positive Genetic
NTH1	YDR001C	Neutral trehalase, degrades trehalose	genetic	1	1	1	Negative Genetic
HXK1	YFR053C	Hexokinase isoenzyme 1	genetic	1	1	1	Negative Genetic
RPS10B	YMR230W	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
BUL2	YML111W	Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex	genetic	1	1	1	Positive Genetic
NAT5	YOR253W	Subunit of protein N-terminal acetyltransferase NatA	genetic	1	1	1	Positive Genetic
AIM22	YJL046W	Lipoate-protein ligase	genetic	1	1	1	Positive Genetic
HTD2	YHR067W	Mitochondrial 3-hydroxyacyl-thioester dehydratase	genetic	1	1	1	Negative Genetic
FPR2	YDR519W	Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase)	genetic	1	1	1	Negative Genetic
GUK1	YDR454C	Guanylate kinase	genetic	1	1	1	Positive Genetic
COQ11	YLR290C	Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes	genetic	1	1	1	Positive Genetic
ACP1	YKL192C	Mitochondrial matrix acyl carrier protein	genetic	1	1	1	Synthetic Lethality
BRL1	YHR036W	Essential nuclear envelope/ER integral membrane protein	genetic	1	1	1	Negative Genetic
DDR48	YMR173W	DNA damage-responsive protein	genetic	1	1	1	Negative Genetic
ATG38	YLR211C	Homodimeric subunit of autophagy-specific PtdIns-3-kinase complex I	genetic	1	1	1	Positive Genetic
BNA1	YJR025C	3-hydroxyanthranilic acid dioxygenase	genetic	1	1	1	Negative Genetic
PMR1	YGL167C	High affinity Ca2+/Mn2+ P-type ATPase	genetic	1	1	1	Positive Genetic
NEL1	YHR035W	Activator of Sar1p GTPase activity	genetic	1	1	1	Positive Genetic
IPF1	YDL176W	Protein of unknown function involved in actin patch formation	genetic	1	1	1	Positive Genetic
ACB1	YGR037C	Acyl-CoA-binding protein	genetic	1	1	1	Positive Genetic
PSD2	YGR170W	Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes	genetic	1	1	1	Positive Genetic
NKP2	YLR315W	Central kinetochore protein and subunit of the Ctf19 complex	genetic	1	1	1	Negative Genetic
MVB12	YGR206W	ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers	genetic	1	1	1	Negative Genetic
IMP21	YIL154C	Transcriptional activator involved in maintenance of ion homeostasis	genetic	1	1	1	Negative Genetic
CAB4	YGR277C	Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC)	genetic	1	1	1	Positive Genetic
BIO2	YGR286C	Biotin synthase	genetic	1	1	1	Negative Genetic
MRP35	YNL122C	Mitochondrial ribosomal protein of the large subunit	genetic	1	1	1	Positive Genetic
RRP15	YPR143W	Nucleolar protein	genetic	1	1	1	Synthetic Lethality
ORC4	YPR162C	Subunit of the origin recognition complex (ORC)	genetic	1	1	1	Positive Genetic
PPN1	YDR452W	Dual endo- and exopolyphosphatase with a role in phosphate metabolism	genetic	1	1	1	Positive Genetic
SEC28	YIL076W	Epsilon-COP subunit of the coatomer	genetic	1	1	1	Negative Genetic
ALD6	YPL061W	Cytosolic aldehyde dehydrogenase	genetic	1	1	1	Positive Genetic
CYB5	YNL111C	Cytochrome b5	genetic	1	1	1	Negative Genetic
ADH7	YCR105W	NADPH-dependent medium chain alcohol dehydrogenase	genetic	1	1	1	Positive Genetic
GCD14	YJL125C	Subunit of tRNA (1-methyladenosine) methyltransferase	genetic	1	1	1	Synthetic Lethality
CGI121	YML036W	Component of the EKC/KEOPS complex	genetic	1	1	1	Positive Genetic
CTP1	YBR291C	Mitochondrial inner membrane citrate transporter	genetic	1	1	1	Positive Genetic
RPP1A	YDL081C	Ribosomal stalk protein P1 alpha	genetic	1	1	1	Positive Genetic
RPL37A	YLR185W	Ribosomal 60S subunit protein L37A	genetic	1	1	1	Positive Genetic
DTR1	YBR180W	Putative dityrosine transporter of the major facilitator superfamily	genetic	1	1	1	Negative Genetic
PMU1	YKL128C	Putative phosphomutase	genetic	1	1	1	Negative Genetic
CYK3	YDL117W	SH3-domain protein located in the bud neck and cytokinetic actin ring	genetic	1	1	1	Negative Genetic
ALD2	YMR170C	Cytoplasmic aldehyde dehydrogenase	genetic	1	1	1	Negative Genetic
APS1	YLR170C	Small subunit of the clathrin-associated adaptor complex AP-1	genetic	1	1	1	Negative Genetic
COA4	YLR218C	Twin Cx(9)C protein involved in cytochrome c oxidase organization	genetic	1	1	1	Negative Genetic
RPS25B	YLR333C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
RAD33	YML011C	Protein involved in nucleotide excision repair	genetic	1	1	1	Negative Genetic
MDM36	YPR083W	Mitochondrial protein	genetic	1	1	1	Negative Genetic
ANY1	YMR010W	Protein involved in phospholipid flippase function	genetic	1	1	1	Positive Genetic
FMS1	YMR020W	Polyamine oxidase	genetic	1	1	1	Positive Genetic
SEC14	YMR079W	Phosphatidylinositol/phosphatidylcholine transfer protein	genetic	1	1	1	Synthetic Lethality
MGR1	YCL044C	Subunit of the mitochondrial (mt) i-AAA protease supercomplex	genetic	1	1	1	Positive Genetic
HFD1	YMR110C	Dehydrogenase involved in ubiquinone and sphingolipid metabolism	genetic	1	1	1	Positive Genetic
POC4	YPL144W	Component of a heterodimeric Poc4p-Irc25p chaperone	genetic	1	1	1	Positive Genetic
MRPS17	YMR188C	Mitochondrial ribosomal protein of the small subunit	genetic	1	1	1	Negative Genetic
PRC1	YMR297W	Vacuolar carboxypeptidase Y (proteinase C, CPY)	genetic	1	1	1	Positive Genetic
PAD1	YDR538W	Phenylacrylic acid decarboxylase	genetic	1	1	1	Negative Genetic
EFM6	YNL024C	Putative S-adenosylmethionine-dependent lysine methyltransferase	genetic	1	1	1	Positive Genetic
SFB2	YNL049C	Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat	genetic	1	1	1	Positive Genetic
RPL42A	YNL162W	Ribosomal 60S subunit protein L42A	genetic	1	1	1	Synthetic Lethality
ERV2	YPR037C	Flavin-linked sulfhydryl oxidase localized to the ER lumen	genetic	1	1	1	Positive Genetic
GIP4	YAL031C	Cytoplasmic protein that regulates protein phosphatase 1 Glc7p	genetic	1	1	1	Positive Genetic
LAG2	YOL025W	Protein that negatively regulates the SCF E3-ubiquitin ligase	genetic	1	1	1	Positive Genetic
PGS1	YCL004W	Phosphatidylglycerolphosphate synthase	genetic	1	1	1	Positive Genetic
DNF1	YER166W	Aminophospholipid translocase (flippase)	genetic	1	1	1	Negative Genetic
LEU9	YOR108W	Alpha-isopropylmalate synthase II (2-isopropylmalate synthase)	genetic	1	1	1	Negative Genetic
GLN4	YOR168W	Glutamine tRNA synthetase	genetic	1	1	1	Synthetic Lethality
MSB1	YOR188W	Protein of unknown function	genetic	1	1	1	Negative Genetic
LIP5	YOR196C	Protein involved in biosynthesis of the coenzyme lipoic acid	genetic	1	1	1	Negative Genetic
NPT1	YOR209C	Nicotinate phosphoribosyltransferase	genetic	1	1	1	Synthetic Growth Defect
POM33	YLL023C	Transmembrane nucleoporin	genetic	1	1	1	Negative Genetic
MCY1	YGR012W	Putative cysteine synthase	genetic	1	1	1	Negative Genetic
AHC2	YCR082W	Component of the ADA histone acetyltransferase complex	genetic	1	1	1	Negative Genetic
GYP7	YDL234C	GTPase-activating protein for yeast Rab family members	genetic	1	1	1	Positive Genetic
PHO13	YDL236W	Conserved phosphatase acting as a metabolite repair enzyme	genetic	1	1	1	Positive Genetic
IDP3	YNL009W	Peroxisomal NADP-dependent isocitrate dehydrogenase	genetic	1	1	1	Positive Genetic
HEM12	YDR047W	Uroporphyrinogen decarboxylase	genetic	1	1	1	Synthetic Lethality
PEX32	YBR168W	Peroxisomal integral membrane protein	genetic	1	1	1	Negative Genetic
IMO32	YGR031W	Conserved mitochondrial protein of unknown function	genetic	1	1	1	Positive Genetic
ATF2	YGR177C	Alcohol acetyltransferase	genetic	1	1	1	Negative Genetic
ABZ2	YMR289W	Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase)	genetic	1	1	1	Positive Genetic
ALT1	YLR089C	Alanine transaminase (glutamic pyruvic transaminase)	genetic	1	1	1	Negative Genetic
OGG1	YML060W	Nuclear and mitochondrial glycosylase/lyase	genetic	1	1	1	Positive Genetic
PML39	YML107C	Protein required for nuclear retention of unspliced pre-mRNAs	genetic	1	1	1	Negative Genetic
APD1	YBR151W	2Fe-2S cytosolic protein of unknown function	genetic	1	1	1	Negative Genetic
PSF3	YOL146W	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p)	genetic	1	1	1	Synthetic Lethality
LDB19	YOR322C	Alpha-arrestin, Ub-ligase adaptor for Rsp5p	genetic	1	1	1	Positive Genetic
MSS18	YPR134W	Nuclear encoded protein needed for splicing of mitochondrial intron	genetic	1	1	1	Positive Genetic
PHB2	YGR231C	Subunit of the prohibitin complex (Phb1p-Phb2p)	genetic	1	1	1	Negative Genetic
RPS22B	YLR367W	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
GAA1	YLR088W	Subunit of the GPI:protein transamidase complex	genetic	1	1	1	Positive Genetic
SDD3	YOL098C	Putative metalloprotease	genetic	1	1	1	Negative Genetic
PTM1	YKL039W	Protein of unknown function	genetic	1	1	1	Negative Genetic
KTR6	YPL053C	Probable mannosylphosphate transferase	genetic	1	1	1	Positive Genetic
RPL8B	YLL045C	Ribosomal 60S subunit protein L8A	genetic	1	1	1	Positive Genetic
RPS7B	YNL096C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
PMS1	YNL082W	ATP-binding protein required for mismatch repair	genetic	1	1	1	Negative Genetic
RPL17B	YJL177W	Ribosomal 60S subunit protein L17B	genetic	1	1	1	Positive Genetic
RPS10A	YOR293W	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
RPS14B	YJL191W	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
RPL19A	YBR084C-A	Ribosomal 60S subunit protein L19A	genetic	1	1	1	Positive Genetic
GSH1	YJL101C	Gamma glutamylcysteine synthetase	genetic	1	1	1	Positive Genetic
GPI17	YDR434W	Transmembrane protein	genetic	1	1	1	Positive Genetic
RPS21A	YKR057W	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Negative Genetic
RPL8A	YHL033C	Ribosomal 60S subunit protein L8A	genetic	1	1	1	Positive Genetic
MIL1	YFL034W	Predicted lipase	genetic	1	1	1	Negative Genetic
RPL43A	YPR043W	Ribosomal 60S subunit protein L43A	genetic	1	1	1	Negative Genetic
NUP192	YJL039C	Essential subunit of inner ring of nuclear pore complex (NPC)	genetic	1	1	1	Positive Genetic
DOS2	YDR068W	Protein of unknown function	genetic	1	1	1	Positive Genetic
ISR1	YPR106W	Predicted protein kinase	genetic	1	1	1	Negative Genetic
RPP2A	YOL039W	Ribosomal protein P2 alpha	genetic	1	1	1	Positive Genetic
IPT1	YDR072C	Inositolphosphotransferase	genetic	1	1	1	Positive Genetic
GCS1	YDL226C	ADP-ribosylation factor GTPase activating protein (ARF GAP)	genetic	1	1	1	Positive Genetic
ARO2	YGL148W	Bifunctional chorismate synthase and flavin reductase	genetic	1	1	1	Positive Genetic
RPL35B	YDL136W	Ribosomal 60S subunit protein L35B	genetic	1	1	1	Positive Genetic
RPL36A	YMR194W	Ribosomal 60S subunit protein L36A	genetic	1	1	1	Negative Genetic
RPS29B	YDL061C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Negative Genetic
RPL34B	YIL052C	Ribosomal 60S subunit protein L34B	genetic	1	1	1	Negative Genetic
AIM29	YKR074W	Protein of unknown function	genetic	1	1	1	Negative Genetic
CMK2	YOL016C	Calmodulin-dependent protein kinase	genetic	1	1	1	Negative Genetic
AVT3	YKL146W	Vacuolar transporter	genetic	1	1	1	Positive Genetic
ARV1	YLR242C	Cortical ER protein	genetic	1	1	1	Positive Genetic
DFM1	YDR411C	Endoplasmic reticulum (ER) localized protein	genetic	1	1	1	Negative Genetic
DEG1	YFL001W	tRNA:pseudouridine synthase	genetic	1	1	1	Positive Genetic
AIM11	YER093C-A	Protein of unknown function	genetic	1	1	1	Positive Genetic
HXT10	YFL011W	Hexose transporter	genetic	1	1	1	Negative Genetic
DGA1	YOR245C	Diacylglycerol acyltransferase	genetic	1	1	1	Positive Genetic
MSN4	YKL062W	Stress-responsive transcriptional activator	genetic	1	1	1	Negative Genetic
PHO90	YJL198W	Low-affinity phosphate transporter	genetic	1	1	1	Positive Genetic
INP54	YOL065C	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase	genetic	1	1	1	Positive Genetic
PTK2	YJR059W	Serine/threonine protein kinase	genetic	1	1	1	Negative Genetic
NGL3	YML118W	3'-5' exonuclease specific for poly-A RNAs	genetic	1	1	1	Positive Genetic
PHO91	YNR013C	Low-affinity vacuolar phosphate transporter	genetic	1	1	1	Positive Genetic
ICS2	YBR157C	Protein of unknown function	genetic	1	1	1	Negative Genetic
NMT1	YLR195C	N-myristoyl transferase	genetic	1	1	1	Negative Genetic
POX1	YGL205W	Fatty-acyl coenzyme A oxidase	genetic	1	1	1	Positive Genetic
MNR2	YKL064W	Vacuolar membrane protein required for magnesium homeostasis	genetic	1	1	1	Negative Genetic
LAG1	YHL003C	Ceramide synthase component	genetic	1	1	1	Negative Genetic
MGR3	YMR115W	Subunit of the mitochondrial (mt) i-AAA protease supercomplex	genetic	1	1	1	Positive Genetic
PTP1	YDL230W	Phosphotyrosine-specific protein phosphatase	genetic	1	1	1	Positive Genetic
PIK1	YNL267W	Phosphatidylinositol 4-kinase	genetic	1	1	1	Synthetic Lethality
AIM39	YOL053W	Protein of unknown function	genetic	1	1	1	Positive Genetic
GAS3	YMR215W	Putative 1,3-beta-glucanosyltransferase	genetic	1	1	1	Negative Genetic
PUF2	YPR042C	PUF family mRNA-binding protein	genetic	1	1	1	Positive Genetic
NSG1	YHR133C	Protein involved in regulation of sterol biosynthesis	genetic	1	1	1	Negative Genetic
PIB2	YGL023C	Phosphatidylinositol 3-phosphate binding protein	genetic	1	1	1	Negative Genetic
NEJ1	YLR265C	DNA end-binding protein required for nonhomologous end joining (NHEJ)	physical	1	1	1	Two-hybrid
NEJ1	YLR265C	DNA end-binding protein required for nonhomologous end joining (NHEJ)	genetic	1	1	1	Phenotypic Suppression
RUD3	YOR216C	Golgi matrix protein	genetic	1	1	1	Positive Genetic
BNA2	YJR078W	Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase	genetic	1	1	1	Positive Genetic
ECM22	YLR228C	Sterol regulatory element binding protein	genetic	1	1	1	Negative Genetic
PRM10	YJL108C	Pheromone-regulated protein	genetic	1	1	1	Negative Genetic
RTT106	YNL206C	Histone chaperone	genetic	1	1	1	Synthetic Lethality
OTU2	YHL013C	Protein of unknown function	genetic	1	1	1	Negative Genetic
RNY1	YPL123C	Vacuolar RNase of the T(2) family	genetic	1	1	1	Negative Genetic
RGM1	YMR182C	Putative zinc finger DNA binding transcription factor	genetic	1	1	1	Negative Genetic
DIA1	YMR316W	Protein of unknown function	genetic	1	1	1	Negative Genetic
MIC26	YGR235C	Component of the MICOS complex	genetic	1	1	1	Positive Genetic
LCL1	YPL056C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
ALG6	YOR002W	ER-luminal alpha 1,3 glucosyltransferase	genetic	1	1	1	Positive Genetic
AAD4	YDL243C	Putative aryl-alcohol dehydrogenase	genetic	1	1	1	Positive Genetic
IRC4	YDR540C	Protein similar to bacterial secreted DfsB proteins	genetic	1	1	1	Positive Genetic
DOT5	YIL010W	Nuclear thiol peroxidase	genetic	1	1	1	Positive Genetic
PRX1	YBL064C	Mitochondrial peroxiredoxin with thioredoxin peroxidase activity	genetic	1	1	1	Positive Genetic
RGS2	YOR107W	Negative regulator of glucose-induced cAMP signaling	genetic	1	1	1	Negative Genetic
RPS18B	YML026C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
EOS1	YNL080C	Protein involved in N-glycosylation	genetic	1	1	1	Positive Genetic
PKP2	YGL059W	Mitochondrial protein kinase	genetic	1	1	1	Positive Genetic
COX10	YPL172C	Heme A:farnesyltransferase	genetic	1	1	1	Negative Genetic
RGI2	YIL057C	Protein of unknown function	genetic	1	1	1	Negative Genetic
CYT1	YOR065W	Cytochrome c1	genetic	1	1	1	Positive Genetic
NRM1	YNR009W	Transcriptional co-repressor of MBF-regulated gene expression	genetic	1	1	1	Positive Genetic
RPS27B	YHR021C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Negative Genetic
DER1	YBR201W	ER membrane protein that promotes export of misfolded polypeptides	genetic	1	1	1	Negative Genetic
RPL14A	YKL006W	Ribosomal 60S subunit protein L14A	genetic	1	1	1	Positive Genetic
RKI1	YOR095C	Ribose-5-phosphate ketol-isomerase	genetic	1	1	1	Synthetic Lethality
ALG13	YGL047W	Catalytic component of UDP-GlcNAc transferase	genetic	1	1	1	Synthetic Lethality
LIP1	YMR298W	Ceramide synthase subunit	genetic	1	1	1	Positive Genetic
DCR2	YLR361C	Protein phosphatase	genetic	1	1	1	Positive Genetic
GIS1	YDR096W	Histone demethylase and transcription factor	physical	1	1	1	Two-hybrid
GIS1	YDR096W	Histone demethylase and transcription factor	genetic	1	1	1	Negative Genetic
GUT2	YIL155C	Mitochondrial glycerol-3-phosphate dehydrogenase	genetic	1	1	1	Negative Genetic
ASI1	YMR119W	Subunit of the inner nuclear membrane Asi ubiquitin ligase complex	genetic	1	1	1	Positive Genetic
FMP45	YDL222C	Integral membrane protein localized to mitochondria	genetic	1	1	1	Positive Genetic
RRT2	YBR246W	Methylesterase performing penultimate step of diphthamide biosynthesis	genetic	1	1	1	Negative Genetic
GUD1	YDL238C	Guanine deaminase	genetic	1	1	1	Positive Genetic
ECL1	YGR146C	Protein of unknown function	genetic	1	1	1	Negative Genetic
PHD1	YKL043W	Transcriptional activator that enhances pseudohyphal growth	genetic	1	1	1	Positive Genetic
RSF1	YMR030W	Protein required for respiratory growth	genetic	1	1	1	Positive Genetic
COQ2	YNR041C	Para hydroxybenzoate polyprenyl transferase	genetic	1	1	1	Positive Genetic
RPP1B	YDL130W	Ribosomal protein P1 beta	genetic	1	1	1	Positive Genetic
RIM13	YMR154C	Calpain-like cysteine protease	genetic	1	1	1	Negative Genetic
PNC1	YGL037C	Nicotinamidase that converts nicotinamide to nicotinic acid	genetic	1	1	1	Negative Genetic
PNP1	YLR209C	Purine nucleoside phosphorylase	genetic	1	1	1	Negative Genetic
CYC2	YOR037W	Mitochondrial peripheral inner membrane protein	genetic	1	1	1	Positive Genetic
RDL1	YOR285W	Thiosulfate sulfurtransferase	genetic	1	1	1	Negative Genetic
AIM6	YDL237W	Protein of unknown function	genetic	1	1	1	Positive Genetic
RHO3	YIL118W	Non-essential small GTPase of the Rho/Rac family of Ras-like proteins	genetic	1	1	1	Positive Genetic
EAR1	YMR171C	Specificity factor required for Rsp5p-dependent ubiquitination	genetic	1	1	1	Negative Genetic
MPS3	YJL019W	Nuclear envelope protein	genetic	1	1	1	Positive Genetic
COA1	YIL157C	Mitochondrial inner membrane protein	genetic	1	1	1	Positive Genetic
ARF3	YOR094W	Glucose-repressible ADP-ribosylation factor	genetic	1	1	1	Negative Genetic
HXT2	YMR011W	High-affinity glucose transporter of the major facilitator superfamily	genetic	1	1	1	Positive Genetic
FRE1	YLR214W	Ferric reductase and cupric reductase	genetic	1	1	1	Negative Genetic
PTR2	YKR093W	Integral membrane peptide transporter	genetic	1	1	1	Positive Genetic
DFG16	YOR030W	Probable multiple transmembrane protein	genetic	1	1	1	Positive Genetic
MAM1	YER106W	Monopolin	genetic	1	1	1	Positive Genetic
FPY1	YMR178W	FAD pyrophosphatase	genetic	1	1	1	Negative Genetic
MFG1	YDL233W	Regulator of filamentous growth	genetic	1	1	1	Positive Genetic
SAD1	YFR005C	Conserved zinc-finger domain protein involved in pre-mRNA splicing	genetic	1	1	1	Positive Genetic
POM34	YLR018C	Subunit of the transmembrane ring of the nuclear pore complex (NPC)	genetic	1	1	1	Positive Genetic
SCY1	YGL083W	Putative kinase	genetic	1	1	1	Positive Genetic
CIS3	YJL158C	Mannose-containing glycoprotein constituent of the cell wall	genetic	1	1	1	Positive Genetic
PRY1	YJL079C	Lipid binding protein	genetic	1	1	1	Negative Genetic
LDB18	YLL049W	Component of the dynactin complex	genetic	1	1	1	Positive Genetic
MSA1	YOR066W	Activator of G1-specific transcription factors MBF and SBF	genetic	1	1	1	Positive Genetic
MUP1	YGR055W	High affinity methionine permease	genetic	1	1	1	Negative Genetic
HSP30	YCR021C	Negative regulator of the H(+)-ATPase Pma1p	genetic	1	1	1	Positive Genetic
NEO1	YIL048W	Phospholipid translocase (flippase)	genetic	1	1	1	Negative Genetic
ITR1	YDR497C	Myo-inositol transporter	genetic	1	1	1	Positive Genetic
GRX3	YDR098C	Glutathione-dependent oxidoreductase	genetic	1	1	1	Negative Genetic
BAP2	YBR068C	High-affinity leucine permease	genetic	1	1	1	Negative Genetic
SCS7	YMR272C	Sphingolipid alpha-hydroxylase	genetic	1	1	1	Negative Genetic
ILM1	YJR118C	Protein of unknown function	genetic	1	1	1	Positive Genetic
MET8	YBR213W	Bifunctional dehydrogenase and ferrochelatase	genetic	1	1	1	Negative Genetic
LGE1	YPL055C	Protein involved in histone H2B ubiquitination	genetic	1	1	1	Negative Genetic
FRM2	YCL026C-A	Type II nitroreductase, using NADH as reductant	genetic	1	1	1	Negative Genetic
MDM32	YOR147W	Mitochondrial inner membrane protein with similarity to Mdm31p	genetic	1	1	1	Negative Genetic
COX7	YMR256C	Subunit VII of cytochrome c oxidase (Complex IV)	genetic	1	1	1	Negative Genetic
MRL1	YPR079W	Membrane protein	genetic	1	1	1	Negative Genetic
RRP17	YDR412W	5' exoribonuclease required for 5' end processing of pre-60S rRNA	genetic	1	1	1	Synthetic Lethality
PIN2	YOR104W	Exomer-dependent cargo protein	genetic	1	1	1	Negative Genetic
MSP1	YGR028W	Highly-conserved N-terminally anchored AAA-ATPase	genetic	1	1	1	Negative Genetic
DYN3	YMR299C	Dynein light intermediate chain (LIC)	genetic	1	1	1	Positive Genetic
MSC3	YLR219W	Protein of unknown function	genetic	1	1	1	Positive Genetic
KRE9	YJL174W	Glycoprotein involved in cell wall beta-glucan assembly	genetic	1	1	1	Positive Genetic
ALG12	YNR030W	Alpha-1,6-mannosyltransferase localized to the ER	genetic	1	1	1	Negative Genetic
ERG29	YMR134W	Protein of unknown function involved in ergosterol biosynthesis	genetic	1	1	1	Negative Genetic
MOT3	YMR070W	Transcriptional repressor, activator	genetic	1	1	1	Positive Genetic
KRE1	YNL322C	Cell wall glycoprotein involved in beta-glucan assembly	genetic	1	1	1	Positive Genetic
MEP2	YNL142W	Ammonium permease involved in regulation of pseudohyphal growth	genetic	1	1	1	Positive Genetic
ARO7	YPR060C	Chorismate mutase	genetic	1	1	1	Positive Genetic
DAL2	YIR029W	Allantoicase	genetic	1	1	1	Positive Genetic
BIG1	YHR101C	Integral membrane protein of the endoplasmic reticulum	genetic	1	1	1	Positive Genetic
CDS1	YBR029C	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase)	genetic	1	1	1	Synthetic Lethality
MRN1	YPL184C	RNA-binding protein that may be involved in translational regulation	genetic	1	1	1	Negative Genetic
NNR2	YKL151C	Widely-conserved NADHX dehydratase	genetic	1	1	1	Negative Genetic
PET18	YCR020C	Protein of unknown function	genetic	1	1	1	Positive Genetic
ATG15	YCR068W	Phospholipase	genetic	1	1	1	Positive Genetic
FAD1	YDL045C	Flavin adenine dinucleotide (FAD) synthetase	genetic	1	1	1	Positive Genetic
RMR1	YGL250W	Protein required for meiotic recombination and gene conversion	genetic	1	1	1	Negative Genetic
ALG2	YGL065C	Mannosyltransferase in the N-linked glycosylation pathway	genetic	1	1	1	Positive Genetic
RPI1	YIL119C	Transcription factor, allelic differences between S288C and Sigma1278b	genetic	1	1	1	Negative Genetic
NRE1	YIR035C	Putative cytoplasmic short-chain dehydrogenase/reductase	genetic	1	1	1	Positive Genetic
MRX12	YJR003C	Protein that associates with mitochondrial ribosome	genetic	1	1	1	Positive Genetic
MTC2	YKL098W	Protein of unknown function	genetic	1	1	1	Positive Genetic
AVL9	YLR114C	Conserved protein involved in exocytic transport from the Golgi	genetic	1	1	1	Positive Genetic
ASP3-2	YLR157C	Cell-wall L-asparaginase II involved in asparagine catabolism	genetic	1	1	1	Negative Genetic
PDL32	YMR087W	Putative ADP-ribose-1''-monophosphatase	genetic	1	1	1	Positive Genetic
HAL9	YOL089C	Putative transcription factor containing a zinc finger	genetic	1	1	1	Negative Genetic
GRX2	YDR513W	Cytoplasmic glutaredoxin	genetic	1	1	1	Positive Genetic
EDC1	YGL222C	RNA-binding protein that activates mRNA decapping directly	genetic	1	1	1	Positive Genetic
DAT1	YML113W	DNA binding protein that recognizes oligo(dA).oligo(dT) tracts	genetic	1	1	1	Negative Genetic
AGA2	YGL032C	Adhesion subunit of a-agglutinin of a-cells	genetic	1	1	1	Positive Genetic
DDL1	YOR022C	DDHD domain-containing phospholipase A1	genetic	1	1	1	Positive Genetic
EDS1	YBR033W	Putative zinc cluster protein, predicted to be a transcription factor	genetic	1	1	1	Positive Genetic
ATG41	YPL250C	Protein of unknown function	genetic	1	1	1	Positive Genetic
FLC3	YGL139W	Putative FAD transporter, similar to Flc1p and Flc2p	genetic	1	1	1	Negative Genetic
EMI1	YDR512C	Non-essential protein of unknown function	genetic	1	1	1	Positive Genetic
FRE6	YLL051C	Putative ferric reductase with similarity to Fre2p	genetic	1	1	1	Negative Genetic
BRE4	YDL231C	Zinc finger protein containing five transmembrane domains	genetic	1	1	1	Positive Genetic
FKS3	YMR306W	Protein involved in spore wall assembly	genetic	1	1	1	Negative Genetic
AIM14	YGL160W	NADPH oxidase localized to the perinuclear ER	genetic	1	1	1	Positive Genetic
PEX4	YGR133W	Peroxisomal ubiquitin conjugating enzyme	genetic	1	1	1	Positive Genetic
CSM4	YPL200W	Protein required for accurate chromosome segregation during meiosis	genetic	1	1	1	Positive Genetic
PAI3	YMR174C	Cytoplasmic proteinase A (Pep4p) inhibitor	genetic	1	1	1	Negative Genetic
FSF1	YOR271C	Putative protein	genetic	1	1	1	Negative Genetic
COX12	YLR038C	Subunit VIb of cytochrome c oxidase	genetic	1	1	1	Positive Genetic
PIR3	YKL163W	O-glycosylated covalently-bound cell wall protein	genetic	1	1	1	Positive Genetic
AVT5	YBL089W	Putative transporter	genetic	1	1	1	Positive Genetic
RMD8	YFR048W	Cytosolic protein required for sporulation	genetic	1	1	1	Positive Genetic
OPI3	YJR073C	Methylene-fatty-acyl-phospholipid synthase	genetic	1	1	1	Positive Genetic
PEX8	YGR077C	Intraperoxisomal organizer of the peroxisomal import machinery	genetic	1	1	1	Positive Genetic
MHO1	YJR008W	Protein of unknown function	genetic	1	1	1	Negative Genetic
APT2	YDR441C	Potential adenine phosphoribosyltransferase	genetic	1	1	1	Negative Genetic
PUN1	YLR414C	Plasma membrane protein with a role in cell wall integrity	genetic	1	1	1	Positive Genetic
LCB4	YOR171C	Sphingoid long-chain base kinase	genetic	1	1	1	Positive Genetic
ROQ1	YJL144W	Ub-ligase substrate-specificity factor	genetic	1	1	1	Negative Genetic
SCW10	YMR305C	Cell wall protein with similarity to glucanases	genetic	1	1	1	Negative Genetic
SET6	YPL165C	SET domain protein of unknown function	genetic	1	1	1	Positive Genetic
KHA1	YJL094C	Putative K+/H+ antiporter	genetic	1	1	1	Negative Genetic
PIR1	YKL164C	O-glycosylated protein required for cell wall stability	genetic	1	1	1	Negative Genetic
RPS25A	YGR027C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
GPM3	YOL056W	Nonfunctional homolog of Gpm1p phosphoglycerate mutase	genetic	1	1	1	Positive Genetic
MIC60	YKR016W	Component of the MICOS complex	genetic	1	1	1	Negative Genetic
REX4	YOL080C	Putative RNA exonuclease	genetic	1	1	1	Positive Genetic
ATH1	YPR026W	Acid trehalase required for utilization of extracellular trehalose	genetic	1	1	1	Positive Genetic
RPO41	YFL036W	Mitochondrial RNA polymerase	genetic	1	1	1	Positive Genetic
NCS6	YGL211W	Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs	genetic	1	1	1	Positive Genetic
ERG9	YHR190W	Farnesyl-diphosphate farnesyl transferase (squalene synthase)	genetic	1	1	1	Positive Genetic
HTS1	YPR033C	Cytoplasmic and mitochondrial histidine tRNA synthetase	genetic	1	1	1	Positive Genetic
DNF3	YMR162C	Trans-golgi network aminophospholipid translocase (flippase)	genetic	1	1	1	Negative Genetic
ERD1	YDR414C	Predicted membrane protein required for lumenal ER protein retention	genetic	1	1	1	Positive Genetic
MTC3	YGL226W	Protein of unknown function	genetic	1	1	1	Positive Genetic
SFH5	YJL145W	Unusual phosphatidylinositol transfer protein (PITP) that binds heme	genetic	1	1	1	Negative Genetic
LDO45	YMR147W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
HOR7	YMR251W-A	Protein of unknown function	genetic	1	1	1	Negative Genetic
CBP4	YGR174C	Mitochondrial protein required for assembly of cytochrome bc1 complex	genetic	1	1	1	Negative Genetic
MDM35	YKL053C-A	Mitochondrial intermembrane space protein	genetic	1	1	1	Negative Genetic
COX5B	YIL111W	Subunit Vb of cytochrome c oxidase	genetic	1	1	1	Negative Genetic
CMC1	YKL137W	Copper-binding protein of the mitochondrial intermembrane space	genetic	1	1	1	Positive Genetic
IGO2	YHR132W-A	Protein required for initiation of G0 program	genetic	1	1	1	Negative Genetic
MIX23	YBL107C	Mitochondrial intermembrane space protein of unknown function	genetic	1	1	1	Positive Genetic
MRK1	YDL079C	Glycogen synthase kinase 3 (GSK-3) homolog	genetic	1	1	1	Positive Genetic
LSC2	YGR244C	Beta subunit of succinyl-CoA ligase	genetic	1	1	1	Positive Genetic
IRC18	YJL037W	Protein involved in outer spore wall assembly	genetic	1	1	1	Positive Genetic
JLP2	YMR132C	Protein of unknown function	genetic	1	1	1	Negative Genetic
MAL11	YGR289C	High-affinity maltose transporter (alpha-glucoside transporter)	genetic	1	1	1	Positive Genetic
MCP1	YOR228C	Mitochondrial protein of unknown function involved in lipid homeostas	genetic	1	1	1	Negative Genetic
GPI10	YGL142C	Integral membrane protein involved in GPI anchor synthesis	genetic	1	1	1	Positive Genetic
MNT2	YGL257C	Mannosyltransferase	genetic	1	1	1	Positive Genetic
MSC1	YML128C	Protein of unknown function	genetic	1	1	1	Positive Genetic
MZM1	YDR493W	Protein required for assembly of the cytochrome bc(1) complex	genetic	1	1	1	Positive Genetic
MPC2	YHR162W	Highly conserved subunit of the mitochondrial pyruvate carrier (MPC)	genetic	1	1	1	Positive Genetic
MDL2	YPL270W	Mitochondrial inner membrane half-type ABC transporter	genetic	1	1	1	Negative Genetic
MAL33	YBR297W	MAL-activator protein	genetic	1	1	1	Positive Genetic
EFM4	YIL064W	Lysine methyltransferase	genetic	1	1	1	Positive Genetic
IMP2	YMR035W	Catalytic subunit of mitochondrial inner membrane peptidase complex	genetic	1	1	1	Positive Genetic
FRE4	YNR060W	Ferric reductase	genetic	1	1	1	Negative Genetic
CPR8	YNR028W	Peptidyl-prolyl cis-trans isomerase (cyclophilin)	genetic	1	1	1	Positive Genetic
LCL2	YLR104W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
EMC3	YKL207W	Member of conserved ER transmembrane complex	genetic	1	1	1	Negative Genetic
ICY1	YMR195W	Protein of unknown function	genetic	1	1	1	Negative Genetic
ECM18	YDR125C	Protein of unknown function	genetic	1	1	1	Negative Genetic
DIT2	YDR402C	N-formyltyrosine oxidase	genetic	1	1	1	Positive Genetic
CAB2	YIL083C	Phosphopantothenoylcysteine synthetase (PPCS)	genetic	1	1	1	Negative Genetic
CHM7	YJL049W	Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum	genetic	1	1	1	Negative Genetic
GMC2	YLR445W	Protein involved in meiotic crossing over	genetic	1	1	1	Positive Genetic
ECM34	YHL043W	Protein of unknown function	genetic	1	1	1	Negative Genetic
MOD5	YOR274W	Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase	genetic	1	1	1	Positive Genetic
LDO16	YMR148W	Protein of unknown function with possible role in spore wall assembly	genetic	1	1	1	Negative Genetic
LEE1	YPL054W	Zinc-finger protein of unknown function	genetic	1	1	1	Negative Genetic
HEM25	YDL119C	Mitochondrial glycine transporter	genetic	1	1	1	Positive Genetic
ERG8	YMR220W	Phosphomevalonate kinase	genetic	1	1	1	Negative Genetic
ALD3	YMR169C	Cytoplasmic aldehyde dehydrogenase	genetic	1	1	1	Negative Genetic
LOH1	YJL038C	Protein involved in outer spore wall assembly	genetic	1	1	1	Negative Genetic
ICL2	YPR006C	2-methylisocitrate lyase of the mitochondrial matrix	genetic	1	1	1	Negative Genetic
DPI34	YOR114W	Putative mitochondrial protein of unknown function	genetic	1	1	1	Negative Genetic
RPL24B	YGR148C	Ribosomal 60S subunit protein L24B	genetic	1	1	1	Positive Genetic
GCV2	YMR189W	P subunit of the mitochondrial glycine decarboxylase complex	genetic	1	1	1	Negative Genetic
RPL21B	YPL079W	Ribosomal 60S subunit protein L21B	genetic	1	1	1	Positive Genetic
AGP1	YCL025C	Broad-specificity, low-affinity amino acid permease	genetic	1	1	1	Positive Genetic
GAS2	YLR343W	1,3-beta-glucanosyltransferase	genetic	1	1	1	Positive Genetic
PMP3	YDR276C	Small plasma membrane protein	genetic	1	1	1	Negative Genetic
GPI8	YDR331W	Catalytic subunit of the ER membrane GPI transamidase complex	genetic	1	1	1	Positive Genetic
ERD2	YBL040C	HDEL receptor	genetic	1	1	1	Negative Genetic
DGK1	YOR311C	Diacylglycerol kinase	genetic	1	1	1	Positive Genetic
PET8	YNL003C	S-adenosylmethionine transporter of the mitochondrial inner membrane	genetic	1	1	1	Negative Genetic
CIN10	YDR387C	Putative transporter	genetic	1	1	1	Negative Genetic
HXT17	YNR072W	Putative transmembrane polyol transporter	genetic	1	1	1	Positive Genetic
OPT2	YPR194C	Oligopeptide transporter	genetic	1	1	1	Negative Genetic
PHO5	YBR093C	Repressible acid phosphatase	genetic	1	1	1	Negative Genetic
PRM7	YDL039C	Pheromone-regulated protein	genetic	1	1	1	Negative Genetic
ENV9	YOR246C	Conserved oxidoreductase involved in lipid droplet morphology	genetic	1	1	1	Positive Genetic
COA6	YMR244C-A	Protein involved in cytochrome c oxidase (Complex IV) assembly	genetic	1	1	1	Negative Genetic
BCD1	YHR040W	Essential protein required for the accumulation of box C/D snoRNA	genetic	1	1	1	Positive Genetic
NPR3	YHL023C	Subunit of the Iml1p/SEACIT complex	genetic	1	1	1	Positive Genetic
FSH1	YHR049W	Lysophospholipase	genetic	1	1	1	Positive Genetic
AIM33	YML087C	Protein of unknown function, highly conserved across species	genetic	1	1	1	Positive Genetic
MRX19	YDL183C	Protein that may form an active mitochondrial KHE system	genetic	1	1	1	Positive Genetic
OSW2	YLR054C	Protein of unknown function reputedly involved in spore wall assembly	genetic	1	1	1	Positive Genetic
PTH1	YHR189W	One of two mitochondrially-localized peptidyl-tRNA hydrolases	genetic	1	1	1	Positive Genetic
RPS30B	YOR182C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Negative Genetic
ECM32	YER176W	DNA dependent ATPase/DNA helicase	genetic	1	1	1	Positive Genetic
BMT6	YLR063W	Methyltransferase required for m3U2843 methylation of the 25S rRNA	genetic	1	1	1	Negative Genetic
SCM4	YGR049W	Mitochondrial outer membrane protein of unknown function	genetic	1	1	1	Negative Genetic
AIM36	YMR157C	Protein of unknown function	genetic	1	1	1	Negative Genetic
RCF2	YNR018W	Cytochrome c oxidase subunit	genetic	1	1	1	Negative Genetic
RCF1	YML030W	Cytochrome c oxidase subunit	genetic	1	1	1	Positive Genetic
MFA1	YDR461W	Mating pheromone a-factor	genetic	1	1	1	Negative Genetic
RPL37B	YDR500C	Ribosomal 60S subunit protein L37B	genetic	1	1	1	Negative Genetic
PUS6	YGR169C	tRNA:pseudouridine synthase	genetic	1	1	1	Positive Genetic
RPS21B	YJL136C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Negative Genetic
REE1	YJL217W	Cytoplasmic protein involved in the regulation of enolase (ENO1)	genetic	1	1	1	Positive Genetic
RPS29A	YLR388W	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Positive Genetic
MTQ1	YNL063W	S-adenosylmethionine-dependent methyltransferase	genetic	1	1	1	Positive Genetic
OPI10	YOL032W	Protein with a possible role in phospholipid biosynthesis	genetic	1	1	1	Positive Genetic
SDH5	YOL071W	Protein required for flavinylation of Sdh1p	genetic	1	1	1	Positive Genetic
CSS3	YOL159C	Protein of unknown function, secreted when constitutively expressed	genetic	1	1	1	Positive Genetic
POA1	YBR022W	Phosphatase that is highly specific for ADP-ribose 1''-phosphate	genetic	1	1	1	Positive Genetic
RTC2	YBR147W	Putative vacuolar membrane transporter for cationic amino acids	genetic	1	1	1	Negative Genetic
SEI1	YLR404W	Seipin involved in lipid droplet (LD) assembly	genetic	1	1	1	Negative Genetic
MET22	YOL064C	Bisphosphate-3'-nucleotidase	genetic	1	1	1	Positive Genetic
IAH1	YOR126C	Isoamyl acetate-hydrolyzing esterase	genetic	1	1	1	Negative Genetic
LCL3	YGL085W	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
PAN6	YIL145C	Pantothenate synthase	genetic	1	1	1	Negative Genetic
PUT1	YLR142W	Proline oxidase	genetic	1	1	1	Positive Genetic
SEC12	YNR026C	Guanine nucleotide exchange factor (GEF)	genetic	1	1	1	Positive Genetic
AIF1	YNR074C	Mitochondrial cell death effector	genetic	1	1	1	Negative Genetic
HMS2	YJR147W	Protein with similarity to heat shock transcription factors	genetic	1	1	1	Positive Genetic
HMI1	YOL095C	Mitochondrial inner membrane localized ATP-dependent DNA helicase	genetic	1	1	1	Positive Genetic
RSM28	YDR494W	Mitochondrial ribosomal protein of the small subunit	genetic	1	1	1	Positive Genetic
FDC1	YDR539W	Ferulic acid decarboxylase	genetic	1	1	1	Negative Genetic
CWP1	YKL096W	Cell wall mannoprotein that localizes to birth scars of daughter cells	genetic	1	1	1	Negative Genetic
ATP23	YNR020C	Putative metalloprotease of the mitochondrial inner membrane	genetic	1	1	1	Positive Genetic
ICE2	YIL090W	Integral ER membrane protein with type-III transmembrane domains	genetic	1	1	1	Positive Genetic
NCE101	YJL205C	Protein of unknown function	genetic	1	1	1	Positive Genetic
IRC21	YMR073C	Protein of unknown function	genetic	1	1	1	Positive Genetic
MME1	YMR166C	Transporter of the mitochondrial inner membrane that exports magnesium	genetic	1	1	1	Negative Genetic
PDE2	YOR360C	High-affinity cyclic AMP phosphodiesterase	genetic	1	1	1	Negative Genetic
PRM4	YPL156C	Pheromone-regulated protein proposed to be involved in mating	genetic	1	1	1	Negative Genetic
MCH5	YOR306C	Plasma membrane riboflavin transporter	genetic	1	1	1	Negative Genetic
RRT6	YGL146C	Integral membrane protein, member of the p24 family	genetic	1	1	1	Negative Genetic
QRI7	YDL104C	Protein involved in threonylcarbamoyl adenosine biosynthesis	genetic	1	1	1	Positive Genetic
PPM1	YDR435C	Carboxyl methyltransferase	genetic	1	1	1	Positive Genetic
PRM15	YMR278W	Phosphoribomutase	genetic	1	1	1	Positive Genetic
MRX11	YPL041C	Protein that associates with mitochondrial ribosome	genetic	1	1	1	Positive Genetic
PCP1	YGR101W	Mitochondrial serine protease	genetic	1	1	1	Positive Genetic
RME1	YGR044C	Zinc finger protein involved in control of meiosis	genetic	1	1	1	Negative Genetic
SAL1	YNL083W	ADP/ATP transporter	genetic	1	1	1	Positive Genetic
RTP1	YMR185W	Protein required for the nuclear import and biogenesis of RNA pol II	genetic	1	1	1	Synthetic Lethality
RSO55	YLR281C	Mitochondrial protein of unknown function	genetic	1	1	1	Negative Genetic
MRX15	YNR040W	Membrane-associated mitoribosome receptor	genetic	1	1	1	Positive Genetic
MMT1	YMR177W	Putative metal transporter involved in mitochondrial iron accumulation	genetic	1	1	1	Negative Genetic
PLB2	YMR006C	Phospholipase B (lysophospholipase) involved in lipid metabolism	genetic	1	1	1	Positive Genetic
IZH1	YDR492W	Membrane protein involved in zinc ion homeostasis	genetic	1	1	1	Positive Genetic
PHM7	YOL084W	Protein of unknown function	genetic	1	1	1	Positive Genetic
REG2	YBR050C	Regulatory subunit of the Glc7p type-1 protein phosphatase	genetic	1	1	1	Negative Genetic
IRS4	YKR019C	EH domain-containing protein	genetic	1	1	1	Negative Genetic
FLO10	YKR102W	Member of the FLO family of cell wall flocculation proteins	genetic	1	1	1	Positive Genetic
MPO1	YGL010W	Dioxygenase that catalyzes alpha-oxygenation of 2-hydroxy fatty acids	genetic	1	1	1	Negative Genetic
RIT1	YMR283C	Initiator methionine 2'-O-ribosyl phosphate transferase	genetic	1	1	1	Negative Genetic
MAY24	YPR153W	Peripheral ER membrane protein	genetic	1	1	1	Positive Genetic
KRE5	YOR336W	Protein required for beta-1,6 glucan biosynthesis	genetic	1	1	1	Positive Genetic
PAU23	YLR037C	Cell wall mannoprotein	genetic	1	1	1	Negative Genetic
PCD1	YLR151C	8-oxo-dGTP diphosphatase	genetic	1	1	1	Negative Genetic
HES1	YOR237W	Protein implicated in the regulation of ergosterol biosynthesis	genetic	1	1	1	Negative Genetic
PAU13	YHL046C	Protein of unknown function	genetic	1	1	1	Positive Genetic
PRM6	YML047C	Potassium transporter that mediates K+ influx	genetic	1	1	1	Negative Genetic
RIM9	YMR063W	Plasma membrane protein of unknown function	genetic	1	1	1	Positive Genetic
PZF1	YPR186C	Transcription factor IIIA (TFIIIA)	genetic	1	1	1	Synthetic Lethality
SEC59	YMR013C	Dolichol kinase	genetic	1	1	1	Negative Genetic
ANS1	YHR126C	Putative GPI protein	genetic	1	1	1	Positive Genetic
ECM8	YBR076W	Non-essential protein of unknown function	genetic	1	1	1	Negative Genetic
RNP1	YLL046C	Ribonucleoprotein that contains two RNA recognition motifs (RRM)	genetic	1	1	1	Positive Genetic
PEX9	YMR018W	Peroxisomal membrane signal receptor for peroxisomal matrix proteins	genetic	1	1	1	Positive Genetic
FYV12	YOR183W	Protein of unknown function	genetic	1	1	1	Positive Genetic
OAF3	YKR064W	Putative transcriptional repressor with Zn(2)-Cys(6) finger	genetic	1	1	1	Positive Genetic
ICS3	YJL077C	Protein with a role in copper homeostasis	genetic	1	1	1	Negative Genetic
PAU24	YBR301W	Cell wall mannoprotein	genetic	1	1	1	Negative Genetic
PUL3	YNR062C	Putative pulcherrimin transporter	genetic	1	1	1	Negative Genetic
RCH1	YMR034C	Negative regulator of cytosolic calcium homeostasis	genetic	1	1	1	Positive Genetic
FHN1	YGR131W	Protein of unknown function	genetic	1	1	1	Negative Genetic